Research Topics
| Margareta ReisSummaryAffiliation: Lund University Hospital Country: Sweden Publications
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Detail Information
Publications
Therapeutic drug monitoring of racemic venlafaxine and its main metabolites in an everyday clinical settingMargareta Reis
Department of Psychiatry, , , Sweden
Ther Drug Monit 24:545-53. 2002..A number of polycombinations of drugs were assessed for interaction screening, and a trend for lowered ODV/VEN ratio was found, predominantly with concomitant medication with CNS-active drug(s) known to inhibit CYP2D6...
Serum concentrations of antidepressant drugs in a naturalistic setting: compilation based on a large therapeutic drug monitoring databaseMargareta Reis
Department of Forensic Chemistry and Genetics, Swedish National Board of Forensic Medicine, Linkoping, Sweden
Ther Drug Monit 31:42-56. 2009..By presenting a comprehensive compilation of therapeutic drug monitoring data for each drug, a reference tool is created, in addition to improved pharmacokinetic knowledge of antidepressant drugs...- Inter- and intraindividual pharmacokinetic variations of mirtazapine and its N-demethyl metabolite in patients treated for major depressive disorder: a 6-month therapeutic drug monitoring studyMargareta Reis
Department of Medicine and Care, Division of Clinical Pharmacology, Linkoping University, Linkoping, Sweden
Ther Drug Monit 27:469-77. 2005..To help clinicians improve their treatment of patients with major depressive disorder, the possible implications on the PK with a long-term treatment are important to study... - Therapeutic drug monitoring of racemic citalopram: a 5-year experience in Sweden, 1992-1997Margareta Reis
Division of Psychiatry, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping, Sweden
Ther Drug Monit 25:183-91. 2003..Thus, this tendency of changes in the CIT disposition when multiple drugs are used (and multiple diseases are prevailing?) seems more general in character than specific for a certain drug or type of drugs... - Serum disposition of sertraline, N-desmethylsertraline and paroxetine: a pharmacokinetic evaluation of repeated drug concentration measurements during 6 months of treatment for major depressionMargareta Reis
Department of Medicine and Care, Division of Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
Hum Psychopharmacol 19:283-91. 2004..For the future, continuous efforts are warranted to perform PK investigations in the natural clinical setting in which the drugs are usually prescribed... - Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrationsMargareta Reis
Division of Clinical Pharmacology, Linkoping University, Linkoping, Sweden
J Affect Disord 82:443-6. 2004..A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood... - Serum levels of citalopram and its main metabolites in adolescent patients treated in a naturalistic clinical settingMargareta Reis
Division of Psychiatry, Department of Neuroscience and Locomotion, Faculty of Health Sciences, , , Sweden
J Clin Psychopharmacol 22:406-13. 2002..64).In summary, the present study tentatively supports influences of sex, oral contraceptives, and smoking habits on the disposition of CIT in younger patients. Hence, future studies on CIT should assess these parameters... - Therapeutic drug monitoring of ziprasidone in a clinical treatment settingMaria D Cherma
Department of Clinical Pharmacology, Faculty of Health Sciences, Linkoping University Hospital, Sweden
Ther Drug Monit 30:682-8. 2008..In summary, great interindividual and intraindividual differences in ZIPconcentrations were observed. TDM of ZIP maybe used for individual dose adjustments and monitoring medication adherence... - Therapeutic drug monitoring of escitalopram in an outpatient settingMargareta Reis
Department of Clinical Pharmacology, Faculty of Health Sciences, Linkoping University Hospital, Linkoping, Sweden
Ther Drug Monit 29:758-66. 2007..However, women taking oral contraceptives showed a lower metabolic ratio compared with age-matched women. As a result of the wide range of the ratio in this population, these findings are not considered of clinical relevance... - Therapeutic drug monitoring data on olanzapine and its N-demethyl metabolite in the naturalistic clinical settingElisabeth Skogh
Division of Psychiatry, Department of Neuroscience and Locomotion, Faculty of Health Sciences, , , Sweden
Ther Drug Monit 24:518-26. 2002..The present TDM-based follow-up suggests that the influence of gender, smoking habits, and certain drug interactions may need to be considered for optimal dosage of OLA. TDM may be used for this purpose more readily in the future... - Neonatal complications after maternal concomitant use of SSRI and other central nervous system active drugs during the second or third trimester of pregnancyBengt Kallen
Tornblad Institute, University of Lund, Lund, Sweden
J Clin Psychopharmacol 32:608-14. 2012..Polypharmacy with CNS-active drugs during the later part of the pregnancy seems to increase the occurrence of neonatal morbidity but difference in nature or strength of underlying psychiatric pathology may confound the findings... - Maternal use of antipsychotics in early pregnancy and delivery outcomeMargareta Reis
Division of Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
J Clin Psychopharmacol 28:279-88. 2008..Because there seems to be little drug specificity, it is possible that underlying pathology or unidentified confounding explains the excess risk... - [Stereochemistry and drug effects--a neglected field of knowledge]Margareta Reis
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Lakartidningen 103:1305-6, 1309-11. 2006