Jure Piskur

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Yeast genome duplication was followed by asynchronous differentiation of duplicated genes
    Rikke B Langkjaer
    BioCentrum DTU, Technical University of Denmark, Building 301, DK 2800 Lyngby, Denmark
    Nature 421:848-52. 2003
  2. doi request reprint A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes
    Gorm Andersen
    Department of Cell and Organism Biology, Lund University, 223 62 Lund, Sweden
    J Mol Biol 380:656-66. 2008
  3. pmc Parallel evolution of the make-accumulate-consume strategy in Saccharomyces and Dekkera yeasts
    Elzbieta Rozpedowska
    Department of Biology, Lund University, Sölvegatan 35, 223 62 Lund, Sweden
    Nat Commun 2:302. 2011
  4. doi request reprint The genome of wine yeast Dekkera bruxellensis provides a tool to explore its food-related properties
    Jure Piskur
    Wine Research Centre, University of Nova Gorica, Nova Gorica, Slovenia
    Int J Food Microbiol 157:202-9. 2012
  5. ncbi request reprint How did Saccharomyces evolve to become a good brewer?
    Jure Piskur
    Cell and Organism Biology, Lund University, Sölvegatan 35, 22362 Lund, Sweden
    Trends Genet 22:183-6. 2006
  6. ncbi request reprint Comparative genomics reveals novel biochemical pathways
    Jure Piskur
    Department of Cell and Organism Biology, Lund University, Sölvegatan 35, 22362 Lund, Sweden
    Trends Genet 23:369-72. 2007
  7. doi request reprint Candida albicans--a pre-whole genome duplication yeast--is predominantly aerobic and a poor ethanol producer
    Elzbieta Rozpedowska
    Department of Biology, Lund University, Lund, Sweden
    FEMS Yeast Res 11:285-91. 2011
  8. pmc Small chromosomes among Danish Candida glabrata isolates originated through different mechanisms
    Khadija Mohamed Ahmad
    Department of Biology, Lund University, Sölvegatan 35, 223 62 Lund, Sweden
    Antonie Van Leeuwenhoek 104:111-22. 2013
  9. doi request reprint Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thaliana
    Anders R Clausen
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    FEBS J 279:3889-97. 2012
  10. ncbi request reprint Saccharomyces kluyveri as a model organism to study pyrimidine degradation
    Halfdan Beck
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    FEMS Yeast Res 8:1209-13. 2008

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Yeast genome duplication was followed by asynchronous differentiation of duplicated genes
    Rikke B Langkjaer
    BioCentrum DTU, Technical University of Denmark, Building 301, DK 2800 Lyngby, Denmark
    Nature 421:848-52. 2003
    ..Further evolution of each duplicated gene pair-such as specialization or differentiation of the two copies, or deletion of a single copy--has taken place independently throughout the evolution of these species...
  2. doi request reprint A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes
    Gorm Andersen
    Department of Cell and Organism Biology, Lund University, 223 62 Lund, Sweden
    J Mol Biol 380:656-66. 2008
    ..The genes of the URC pathway are not homologous to any of the eukaryotic or prokaryotic genes involved in pyrimidine degradation described to date...
  3. pmc Parallel evolution of the make-accumulate-consume strategy in Saccharomyces and Dekkera yeasts
    Elzbieta Rozpedowska
    Department of Biology, Lund University, Sölvegatan 35, 223 62 Lund, Sweden
    Nat Commun 2:302. 2011
    ..bruxellensis this promoter rewiring contributes to the observed Crabtree effect...
  4. doi request reprint The genome of wine yeast Dekkera bruxellensis provides a tool to explore its food-related properties
    Jure Piskur
    Wine Research Centre, University of Nova Gorica, Nova Gorica, Slovenia
    Int J Food Microbiol 157:202-9. 2012
    ..cerevisiae lineage. However, D. bruxellensis has several independently duplicated ADH and ADH-like genes, which are likely responsible for metabolism of alcohols, including ethanol, and also a range of aromatic compounds...
  5. ncbi request reprint How did Saccharomyces evolve to become a good brewer?
    Jure Piskur
    Cell and Organism Biology, Lund University, Sölvegatan 35, 22362 Lund, Sweden
    Trends Genet 22:183-6. 2006
    ..Two research groups have shed light on the origin of the genes encoding alcohol dehydrogenase and the process of ethanol accumulation in Saccharomyces cerevisiae...
  6. ncbi request reprint Comparative genomics reveals novel biochemical pathways
    Jure Piskur
    Department of Cell and Organism Biology, Lund University, Sölvegatan 35, 22362 Lund, Sweden
    Trends Genet 23:369-72. 2007
    ....
  7. doi request reprint Candida albicans--a pre-whole genome duplication yeast--is predominantly aerobic and a poor ethanol producer
    Elzbieta Rozpedowska
    Department of Biology, Lund University, Lund, Sweden
    FEMS Yeast Res 11:285-91. 2011
    ..Apparently, C. albicans and several other pre-WGD yeasts still exhibit the original traits of the yeast progenitor: poor accumulation of ethanol under aerobic conditions and strong dependence on the presence of oxygen...
  8. pmc Small chromosomes among Danish Candida glabrata isolates originated through different mechanisms
    Khadija Mohamed Ahmad
    Department of Biology, Lund University, Sölvegatan 35, 223 62 Lund, Sweden
    Antonie Van Leeuwenhoek 104:111-22. 2013
    ....
  9. doi request reprint Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thaliana
    Anders R Clausen
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    FEBS J 279:3889-97. 2012
    ..The results obtained in the present study suggest a crucial role for the salvage of thymidine during early plant development...
  10. ncbi request reprint Saccharomyces kluyveri as a model organism to study pyrimidine degradation
    Halfdan Beck
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    FEMS Yeast Res 8:1209-13. 2008
    ..kluyveri and how this increases our understanding of human disease. Additionally, we discuss the possibilities and limitations of this nonconventional yeast as a laboratory organism...
  11. doi request reprint Thymidine kinase 1 regulatory fine-tuning through tetramer formation
    Zeeshan Mutahir
    Department of Biology, Lund University, Lund, Sweden
    FEBS J 280:1531-41. 2013
    ..The efficient switching mechanism was probably first established in warm-blooded animals when they separated from the rest of the vertebrates...
  12. pmc Yeast "make-accumulate-consume" life strategy evolved as a multi-step process that predates the whole genome duplication
    Arne Hagman
    Department of Biology, Molecular Cell Biology, Lund University, Lund, Sweden
    PLoS ONE 8:e68734. 2013
    ..While some of the final evolutionary events, like gene duplications of glucose transporters and glycolytic enzymes, have been deduced, the earliest molecular events initiating Crabtree effect are still to be determined. ..
  13. pmc Complex nature of the genome in a wine spoilage yeast, Dekkera bruxellensis
    Linda Hellborg
    Department of Cell and Organism Biology, Lund University, Sölvegatan 35, Lund SE 223 62, Sweden
    Eukaryot Cell 8:1739-49. 2009
    ....
  14. ncbi request reprint Plants salvage deoxyribonucleosides in mitochondria
    Anders R Clausen
    a Department of Biology, Lund University, Sweden
    Nucleosides Nucleotides Nucleic Acids 33:291-5. 2014
    ..In general, the observed localization of the plant dNK activities in the mitochondrion suggests that plants have a different organization of the deoxyribonucleoside salvage compared to mammals. ..
  15. pmc Complex evolution of the DAL5 transporter family
    Linda Hellborg
    Cell and Organism Biology, Lund University, Lund, Sweden
    BMC Genomics 9:164. 2008
    ..We studied the complex evolution of this group in species from the kingdom of fungi particularly the Ascomycetes...
  16. pmc Global expression analysis of the yeast Lachancea (Saccharomyces) kluyveri reveals new URC genes involved in pyrimidine catabolism
    Anna Andersson Rasmussen
    Department of Biology, Lund University, Lund, Sweden
    Eukaryot Cell 13:31-42. 2014
    ..kluyveri homologs of DUR3 and FUR4 do not have the same function that they have in S. cerevisiae, where they transport urea and uracil, respectively. In L. kluyveri, both of these deletion strains grew normally on uracil and urea. ..
  17. doi request reprint Elucidation of the sex-pheromone biosynthesis producing 5,7-dodecadienes in Dendrolimus punctatus (Lepidoptera: Lasiocampidae) reveals Delta 11- and Delta 9-desaturases with unusual catalytic properties
    Marjorie A Liénard
    Chemical Ecology and Ecotoxicology, Department of Biology, Lund University, Lund, Sweden
    Insect Biochem Mol Biol 40:440-52. 2010
    ..The combined action of three desaturases in generating a dienoic sex-pheromone component emphasizes the diversity and complexity of chemical reactions that can be catalysed by pheromone biosynthetic fatty-acyl-CoA desaturases in moths...
  18. doi request reprint Deoxyribonucleoside kinases in two aquatic bacteria with high specificity for thymidine and deoxyadenosine
    Tinkara Tinta
    Department of Biology, Lund University, Lund, Sweden
    FEMS Microbiol Lett 331:120-7. 2012
    ..When tens of available aquatic bacteria genomes were examined for the presence of dNKs, a majority had at least a TK1-like gene, but several lacked any dNKs. Apparently, among aquatic bacteria, the role of the dN salvage varies...
  19. pmc Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata
    Silvia Polakova
    Department of Cell and Organism Biology, Lund University, SE 22362 Lund, Sweden
    Proc Natl Acad Sci U S A 106:2688-93. 2009
    ..We show that the observed genome plasticity is connected with antifungal drug resistance and it is likely an advantage in the human body, where environmental conditions fluctuate a lot...
  20. ncbi request reprint Genome structure and dynamics of the yeast pathogen Candida glabrata
    Khadija M Ahmad
    Department of Biology, Lund University, Lund, Sweden
    FEMS Yeast Res 14:529-35. 2014
    ..Further genome sequencing of pathogenic isolates will provide a valuable tool to understand the mechanisms behind genome dynamics and help to elucidate the genes contributing to the virulence potential. ..
  21. doi request reprint A recruited protease is involved in catabolism of pyrimidines
    Birgit Andersen
    Department of Cell and Organism Biology, Lund University, SE 22362 Lund, Sweden
    J Mol Biol 379:243-50. 2008
    ....
  22. ncbi request reprint Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction
    Michael P B Sandrini
    Cell and Organism Biology, Lund University, Sölvegatan 35, SE 22732 Lund, Sweden
    Trends Biochem Sci 30:225-8. 2005
    ..Recently, the crystal structure of human TK1 has been solved and has revealed that enzymes with fundamentally different origins and folds catalyze similar, crucial cellular reactions...
  23. ncbi request reprint Noninvasive acoustic cell trapping in a microfluidic perfusion system for online bioassays
    Mikael Evander
    Department of Electrical Measurements, Lund University, Lund, Sweden
    Anal Chem 79:2984-91. 2007
    ..The demonstrated acoustic trapping of cells and particles enables cell- or particle-based bioassays to be performed in a continuous flow format...
  24. pmc Transfer of genetic material between pathogenic and food-borne yeasts
    Marek Mentel
    Department of Cell and Organism Biology, Lund University, Sölvegatan 35, SE 223 62 Lund, Sweden
    Appl Environ Microbiol 72:5122-5. 2006
    ..However, high-frequency transfer of plasmid DNA was observed when pathogenic and food-borne yeasts were grown together. This property could play a crucial role in the spread of virulence and drug resistance factors among yeasts...
  25. ncbi request reprint A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast
    Gorm Andersen
    BioCentrum DTU, Technical University of Denmark, Lyngby, Denmark
    FEBS J 274:1804-17. 2007
    ..It is likely that upon duplication approximately 200 million years ago, a specialized Uga1p evolved into a 'novel' transaminase enzyme with broader substrate specificity...
  26. pmc Dihydropyrimidine amidohydrolases and dihydroorotases share the same origin and several enzymatic properties
    Zoran Gojkovic
    Eukaryote Molecular Biology, BioCentrum DTU, Technical University of Denmark, Building 301, DK 2800 Lyngby, Denmark
    Nucleic Acids Res 31:1683-92. 2003
    ..Therefore, only a few modifications might have been necessary during evolution to convert the unspecialized enzyme into anabolic and catabolic ones...
  27. ncbi request reprint Steady-state and transient-state analyses of aerobic fermentation in Saccharomyces kluyveri
    Kasper Møller
    Center for Process Biotechnology, BioCentrum DTU, Technical University of Denmark, Building 223, 2800 Lyngby, Denmark
    FEMS Yeast Res 2:233-44. 2002
    ..kluyveri led to ethanol formation after a delay of 20-50 min (depending on culture conditions prior to the pulse), which is in contrast to S. cerevisiae that ferments immediately after glucose addition...
  28. ncbi request reprint Animal deoxyribonucleoside kinases: 'forward' and 'retrograde' evolution of their substrate specificity
    Jure Piskur
    BioCentrum DTU, Eukaryote Molecular Biology Group, Building 301, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    FEBS Lett 560:3-6. 2004
    ..Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity...
  29. ncbi request reprint Triplicate genes for mitochondrial ADP/ATP carriers in the aerobic yeast Yarrowia lipolytica are regulated differentially in the absence of oxygen
    Marek Mentel
    Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina CH I, 842 15 Bratislava, Slovakia
    Mol Genet Genomics 273:84-91. 2005
    ..lipolytica and the facultative anaerobe S. cerevisiae, the three paralogs are differentially regulated in the absence of oxygen. Apparently, Y. lipolytica can sense hypoxia and down-regulate target genes in response...
  30. ncbi request reprint Yeast genome sequencing: the power of comparative genomics
    Jure Piskur
    BioCentrum DTU, Building 301, Technical University of Denmark, DK 2800 Kgl Lyngby, Denmark
    Mol Microbiol 53:381-9. 2004
    ..In addition, the accumulating sequence data provide the background to use more yeast species in model studies, to combat pathogens and for efficient manipulation of industrial strains...
  31. ncbi request reprint Fermentative lifestyle in yeasts belonging to the Saccharomyces complex
    Annamaria Merico
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Milan, Italy
    FEBS J 274:976-89. 2007
    ..However, these traits have been combined and developed to perfection only in the lineage that underwent the whole-genome duplication and led to the modern Saccharomyces cerevisiae yeast...
  32. ncbi request reprint Nucleoside analogues are activated by bacterial deoxyribonucleoside kinases in a species-specific manner
    Michael P B Sandrini
    BioCentrum DTU, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    J Antimicrob Chemother 60:510-20. 2007
    ..To investigate the bactericidal activity of antiviral and anticancer nucleoside analogues against a variety of pathogenic bacteria and characterize the activating enzymes, deoxyribonucleoside kinases (dNKs)...
  33. ncbi request reprint Deoxyribonucleoside kinases belonging to the thymidine kinase 2 (TK2)-like group vary significantly in substrate specificity, kinetics and feed-back regulation
    Wolfgang Knecht
    Section of Molecular Microbiology, BioCentrum DTU, Building 301, Technical University of Denmark, Lyngby, DK 2800, Denmark
    J Mol Biol 315:529-40. 2002
    ..The broad substrate specificity and different feedback regulation of the multisubstrate insect deoxyribonucleoside kinases may indicate that these enzymes have a different functional role than the other members of the TK2-like group...
  34. ncbi request reprint Inheritance and organisation of the mitochondrial genome differ between two Saccharomyces yeasts
    Randi F Petersen
    BioCentrum DTU, Technical University of Denmark, Building 301, DK 2800 Kgl Lyngby, Denmark
    J Mol Biol 318:627-36. 2002
    ..cerevisiae. The structure of one suppressive S. castellii mutant, CA38, was also determined. Apparently, a short direct intergenic repeat was involved in the generation of this petite mtDNA molecule...
  35. ncbi request reprint Transition of the ability to generate petites in the Saccharomyces/Kluyveromyces complex
    Veronika Fekete
    Comenius University, Faculty of Natural Sciences, Department of Biochemistry, Mlynska dolina, Bratislava, Slovakia
    FEMS Yeast Res 7:1237-47. 2007
    ..However, petite-positive traits could also be observed among the prewhole-genome duplication species...
  36. ncbi request reprint Crystal structures of yeast beta-alanine synthase complexes reveal the mode of substrate binding and large scale domain closure movements
    Stina Lundgren
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 17177 Stockholm, Sweden
    J Biol Chem 282:36037-47. 2007
    ..Substrate binding is achieved via a salt bridge, a number of hydrogen bonds, and coordination to one of the zinc ions of the di-metal center...
  37. ncbi request reprint High-rate evolution of Saccharomyces sensu lato chromosomes
    Mario Spirek
    Eukaryote Molecular Biology Group, BioCentrum DTU, Technical University of Denmark, Building 301, 2800, Lyngby, Denmark
    FEMS Yeast Res 3:363-73. 2003
    ..Apparently, yeast chromosomes have been frequently reshaped and therefore also the position of genes has been dynamic during the evolutionary history of yeasts...
  38. pmc Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae
    Laurence Vernis
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts, EN6 3LD, UK
    Nucleic Acids Res 31:e120. 2003
    ..We show that this strain also efficiently incorporates the thymidine analogue, BrdU, into DNA and can be used for pulse-chase labelling...
  39. ncbi request reprint Further development of the cassette-based pYC plasmid system by incorporation of the dominant hph, nat and AUR1-C gene markers and the lacZ reporter system
    Jørgen Hansen
    Carlsberg Research Laboratory, Gamle Carlsberg Vej 10, 2500, Copenhagen Valby, Denmark
    FEMS Yeast Res 4:323-7. 2003
    ..Furthermore, the lacZ system for analyzing gene expression was included in the system...
  40. pmc Genome survey sequencing of the wine spoilage yeast Dekkera (Brettanomyces) bruxellensis
    Megan Woolfit
    Department of Genetics, Smurfit Institute, Trinity College Dublin, Dublin 2, Ireland
    Eukaryot Cell 6:721-33. 2007
    ..These data provide a resource for further analyses of the population genetics and evolution of D. bruxellensis and of the genetic bases of its physiological capabilities...
  41. ncbi request reprint Aerobic glucose metabolism of Saccharomyces kluyveri: growth, metabolite production, and quantification of metabolic fluxes
    Kasper Møller
    Center for Process Biotechnology, BioCentrum DTU, Technical University of Denmark, Building 223, 2800 Lyngby, Denmark
    Biotechnol Bioeng 77:186-93. 2002
    ..cerevisiae at the same growth conditions, where the tricarboxylic acid cycle operates as two branches. This indicates that the respiratory system was not significantly repressed in S. kluyveri during batch cultivation on glucose...
  42. ncbi request reprint Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans
    Elke Zameitat
    Institute for Physiological Chemistry, Philipps University, Marburg, Germany
    FEBS J 273:3183-91. 2006
    ..albicans DHODH activity. This study provides a background for the development of antipyrimidines with high efficacy for decreasing in situ pyrimidine nucleotide pools in C. albicans...
  43. ncbi request reprint The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity
    Bernhard Lohkamp
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 17177 Stockholm
    J Biol Chem 281:13762-76. 2006
    ....