Asa Petersen

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice
    Joana M A C Gil
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A10, SE 221 84 Lund, Sweden
    Neurobiol Dis 20:744-51. 2005
  2. ncbi Impact of a preceding striatal excitotoxic lesion and treatment with ciliary neurotrophic factor on striatal graft survival
    A Petersen
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Sweden
    Brain Res Bull 50:275-81. 1999
  3. ncbi Orexin loss in Huntington's disease
    Asa Petersen
    Department of Physiological Sciences, Section for Neuronal Survival, Lund, Sweden
    Hum Mol Genet 14:39-47. 2005
  4. pmc Asialoerythropoietin is not effective in the R6/2 line of Huntington's disease mice
    Joana M A C Gil
    Section for Neuronal Survival, Wallenberg Neuroscience Center, BMC A10, Lund University, Sweden
    BMC Neurosci 5:17. 2004
  5. ncbi Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine
    A Petersen
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Sweden
    Eur J Neurosci 14:1425-35. 2001
  6. ncbi Grafting of nigral tissue hibernated with tirilazad mesylate and glial cell line-derived neurotrophic factor
    A Petersen
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Sweden
    Cell Transplant 9:577-84. 2000
  7. ncbi Oxidative stress, mitochondrial permeability transition and activation of caspases in calcium ionophore A23187-induced death of cultured striatal neurons
    A Petersen
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Department of Physiological Sciences, Solvegatan 17, S 223 62, Lund, Sweden
    Brain Res 857:20-9. 2000
  8. ncbi Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease
    Maria Björkqvist
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, Lund, Sweden
    Hum Mol Genet 15:1713-21. 2006
  9. doi Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors
    Sanaz Gabery
    Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden
    Eur J Neurosci 36:2789-800. 2012
  10. ncbi Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease
    Eugenia Papalexi
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 221 84 Lund, Sweden
    Eur J Neurosci 22:1541-6. 2005

Detail Information

Publications36

  1. ncbi Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice
    Joana M A C Gil
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A10, SE 221 84 Lund, Sweden
    Neurobiol Dis 20:744-51. 2005
    ..Reduced hippocampal neurogenesis may be a novel neuropathological feature in R6/2 mice that could be assessed when evaluating potential therapies...
  2. ncbi Impact of a preceding striatal excitotoxic lesion and treatment with ciliary neurotrophic factor on striatal graft survival
    A Petersen
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Sweden
    Brain Res Bull 50:275-81. 1999
    ..CNTF has previously been shown to protect striatal neurons against excitotoxic insults both in vitro and in vivo, but it did not improve striatal graft survival when added to the cell suspension prior to implantation...
  3. ncbi Orexin loss in Huntington's disease
    Asa Petersen
    Department of Physiological Sciences, Section for Neuronal Survival, Lund, Sweden
    Hum Mol Genet 14:39-47. 2005
    ..Our results show that the loss of orexin is a novel and potentially very important pathology in HD...
  4. pmc Asialoerythropoietin is not effective in the R6/2 line of Huntington's disease mice
    Joana M A C Gil
    Section for Neuronal Survival, Wallenberg Neuroscience Center, BMC A10, Lund University, Sweden
    BMC Neurosci 5:17. 2004
    ..R6/2 transgenic HD mice were treated with this cytokine from five to twelve weeks of age...
  5. ncbi Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine
    A Petersen
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Sweden
    Eur J Neurosci 14:1425-35. 2001
    ..We conclude that striatal neurons of R6 mice develop resistance to DA-induced toxicity with age...
  6. ncbi Grafting of nigral tissue hibernated with tirilazad mesylate and glial cell line-derived neurotrophic factor
    A Petersen
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Sweden
    Cell Transplant 9:577-84. 2000
    ..Furthermore, we show that the addition of GDNF to the hibernation medium and/or to the final cell suspension does not significantly increase the survival of the dopaminergic neurons...
  7. ncbi Oxidative stress, mitochondrial permeability transition and activation of caspases in calcium ionophore A23187-induced death of cultured striatal neurons
    A Petersen
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Department of Physiological Sciences, Solvegatan 17, S 223 62, Lund, Sweden
    Brain Res 857:20-9. 2000
    ..These results suggest that oxidative stress, opening of the mitochondrial permeability transition pore and activation of caspases are important steps in A23187-induced cell death...
  8. ncbi Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease
    Maria Björkqvist
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, Lund, Sweden
    Hum Mol Genet 15:1713-21. 2006
    ..This progressive increase in cortisol may contribute to the clinical symptoms, such as muscular wasting, mood changes and some of the cognitive deficits that occur in HD...
  9. doi Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors
    Sanaz Gabery
    Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden
    Eur J Neurosci 36:2789-800. 2012
    ....
  10. ncbi Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease
    Eugenia Papalexi
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 221 84 Lund, Sweden
    Eur J Neurosci 22:1541-6. 2005
    ..Gonadotropic hormone replacement did not mitigate weight loss or restore motor function in R6/2 males...
  11. doi Increased numbers of orexin/hypocretin neurons in a genetic rat depression model
    Elli Mikrouli
    Translational Neuroendocrine Research Unit, BMC D11, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden
    Neuropeptides 45:401-6. 2011
    ..These findings support the view that orexin may be involved in depression and strengthen the notion that the "depressed" brain responds differently to pharmacological interventions than the normal brain...
  12. doi Nortriptyline mediates behavioral effects without affecting hippocampal cytogenesis in a genetic rat depression model
    Asa Petersen
    Translational Neuroendocrine Research Unit, BMC D11, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    Neurosci Lett 451:148-51. 2009
    ....
  13. ncbi Depletion of rabphilin 3A in a transgenic mouse model (R6/1) of Huntington's disease, a possible culprit in synaptic dysfunction
    Ruben Smith
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A10, 221 84 Lund, Sweden
    Neurobiol Dis 20:673-84. 2005
    ..Our results indicate that a decrease in mRNA levels underlie the depletion of protein levels of rabphilin 3A, and we suggest that this reduction may be involved in causing impaired synaptic transmission in R6/1 mice...
  14. doi Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits
    Sofia Hult
    Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden
    Cell Metab 13:428-39. 2011
    ....
  15. doi Increased levels of cocaine and amphetamine regulated transcript in two animal models of depression and anxiety
    Sara Wiehager
    Department of Experimental Medical Science, Lund University, Sweden
    Neurobiol Dis 34:375-80. 2009
    ..Our results confirm human genetic studies indicating CART as a neurobiological correlate of depression and anxiety, and suggest that its differential regulation in specific brain regions may play a role for the behavioral phenotypes...
  16. doi Islet beta-cell area and hormone expression are unaltered in Huntington's disease
    Karl Bacos
    Unit of Molecular Metabolism, Department of Experimental Medical Science, Lund University, CRC 91 11, 205 02 Malmo, Sweden
    Histochem Cell Biol 129:623-9. 2008
    ..This may lead to a better understanding of HD and provide novel therapeutic targets for symptomatic treatment in HD...
  17. ncbi The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis
    Maria Björkqvist
    Department of Cell and Molecular Biology, Lund, Sweden
    Hum Mol Genet 14:565-74. 2005
    ..The blunting of exocytosis could be attributed to a 96% reduction in the number of insulin-containing secretory vesicles. Thus, diabetes in R6/2 mice is caused by a combination of deficient beta-cell mass and disrupted exocytosis...
  18. doi Increased orexin levels in the cerebrospinal fluid the first year after a suicide attempt
    Lena Brundin
    Division of Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden
    J Affect Disord 113:179-82. 2009
    ..We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms...
  19. ncbi Increased metabolism in the R6/2 mouse model of Huntington's disease
    Jorien M M van der Burg
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University BMC A10, Lund, Sweden
    Neurobiol Dis 29:41-51. 2008
    ..Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors...
  20. ncbi Cocaine and amphetamine regulated transcript (CART) in suicide attempters
    Lena Brundin
    Division of Psychiatry, Department of Clinical Sciences, Lund University, Kioskgatan 19, SE 221 85, Lund, Sweden
    Psychiatry Res 158:117-22. 2008
    ..Further studies on the role of CART in psychiatric diseases where concentration difficulties are prominent, such as attention deficit disorder, are warranted...
  21. ncbi Huntington's disease: the mystery unfolds?
    Asa Petersen
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Lund, Sweden
    Int Rev Neurobiol 53:315-39. 2002
  22. ncbi Hypothalamic-endocrine aspects in Huntington's disease
    Asa Petersen
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 22184 Lund, Sweden
    Eur J Neurosci 24:961-7. 2006
    ..Investigating neuroendocrine changes in HD opens up the possibility of finding biomarkers to evaluate future therapies for HD, as well as of identifying novel targets for therapeutic interventions...
  23. ncbi Cocaine- and amphetamine-regulated transcript is increased in Huntington disease
    Maria Björkqvist
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, Sweden
    Mov Disord 22:1952-4. 2007
    ..Increased CART levels in HD therefore hold promise as a biomarker as well as a potential pathogenic mediator of symptoms...
  24. ncbi Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder
    Lena Brundin
    Division of Psychiatry, Department of Clinical Sciences, Lund University, Kioskgatan 19, SE 221 85 Lund, Sweden
    Eur Neuropsychopharmacol 17:573-9. 2007
    ..Our results suggest that suicidal patients with MDD have distinct neurobiological features, involving compromised levels of hypothalamic peptides regulating the state of arousal...
  25. ncbi Combining neuroprotective treatment of embryonic nigral donor tissue with mild hypothermia of the graft recipient
    Jenny Karlsson
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
    Cell Transplant 14:301-9. 2005
    ..The study also emphasizes the importance of the immediate time after grafting for transplant survival, with relevance both for primary mesencephalic implants and stem cell grafts...
  26. pmc Expression of mutant huntingtin in leptin receptor-expressing neurons does not control the metabolic and psychiatric phenotype of the BACHD mouse
    Sofia Hult Lundh
    Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    PLoS ONE 7:e51168. 2012
    ..The data suggest that mutant HTT disrupts critical hypothalamic pathways by other mechanisms than interfering with intracellular leptin signaling...
  27. doi Escitalopram reduces increased hippocampal cytogenesis in a genetic rat depression model
    Asa Petersen
    Translational Neuroendocrine Research Unit, BMC D11, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    Neurosci Lett 436:305-8. 2008
    ....
  28. doi Changes in key hypothalamic neuropeptide populations in Huntington disease revealed by neuropathological analyses
    Sanaz Gabery
    Department of Experimental Medical Sciences, Lund University, Sweden
    Acta Neuropathol 120:777-88. 2010
    ..They may be important in the development of psychiatric symptoms and metabolic disturbances in HD, and may provide potential targets for therapeutic interventions...
  29. doi Reduced CSF CART in dementia with Lewy bodies
    Kristofer Schultz
    Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Neurosci Lett 453:104-6. 2009
    ..Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group...
  30. doi Huntington's disease - new perspectives based on neuroendocrine changes in rodent models
    Asa Petersen
    Translational Neuroendocrine Research Unit, Lund University, Lund, Sweden
    Neurodegener Dis 6:154-64. 2009
    ..This review summarizes the current state of knowledge derived from neuroendocrine studies in rodent models of HD in light of clinical relevance and points to future implications for this emerging field...
  31. pmc Euploidy in somatic cells from R6/2 transgenic Huntington's disease mice
    Asa Petersen
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
    BMC Cell Biol 6:34. 2005
    ..Aneuploidy is normally a feature closely connected to neoplastic disease. To further explore this unexpected aspect of HD, we studied cultures derived from 6- and 12-week-old R6/2 fibroblasts, skeletal muscle cells, and liver cells...
  32. pmc Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis
    Charlotte Soneson
    Centre for Mathematical Sciences, Lund University, Sweden
    Neurobiol Dis 40:531-43. 2010
    ..In conclusion, our study shows, for the first time, that alterations in grey matter contents in the hypothalamic region occur at least a decade before clinical diagnosis in HD using MRI...
  33. ncbi Orexin and psychiatric symptoms in suicide attempters
    Lena Brundin
    Division of Psychiatry, Department of Clinical Sciences, Lund University, Sweden
    J Affect Disord 100:259-63. 2007
    ..In the present study, we investigated the relationship between cerebrospinal fluid (CSF) orexin and specific psychiatric symptoms in suicidal patients...
  34. doi Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington's disease
    Sofia Hult Lundh
    Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund SE 22184, Sweden
    Hum Mol Genet 22:3485-97. 2013
    ..Taken together, our data demonstrate that the BACHD mouse recapitulates clinical HD with early psychiatric aspects and point to the role of hypothalamic dysfunction in the development of depression and anxiety in the disease. ..
  35. pmc Maintenance of Basal Levels of Autophagy in Huntington's Disease Mouse Models Displaying Metabolic Dysfunction
    Barbara Baldo
    Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    PLoS ONE 8:e83050. 2013
    ..Taken together, our results indicate that overexpression of mutant huntingtin in mice do not significantly perturb basal levels of autophagy. ..
  36. doi Ethical aspects of undergoing a predictive genetic testing for Huntington's disease
    Petra Lilja Andersson
    Division of Nursing, Department of Health Sciences, Lund University, P O Box 157, SE 221 00 Lund, Sweden
    Nurs Ethics 20:189-99. 2013
    ....