Research Topics
Genomes and Genes | Malin ParmarSummaryAffiliation: Lund University Country: Sweden Publications
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Publications
Early specification of dopaminergic phenotype during ES cell differentiationMalin Parmar
Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK
BMC Dev Biol 7:86. 2007..However, the exact identity of the responding cells and the timing of inductive activity that specify a dopaminergic fate in neural stem/progenitors still remain elusive...
Reprogramming of neonatal SVZ progenitors by islet-1 and neurogenin-2Nina Rogelius
Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, SE 221 84 Lund, Sweden
Mol Cell Neurosci 38:453-9. 2008..When located in the striatum, the reprogrammed cells displayed neuroblast-like morphology. Once removed from the striatal parenchyma and allowed to further differentiation in vitro they developed into beta-III-tubulin positive neurons...
Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalonLachlan H Thompson
Wallenberg Neuroscience Center, Department of Experimental Medical Science, and Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, BMC A11, SE 221 84 Lund, Sweden
Exp Neurol 198:183-98. 2006..The Ngn2-GFP reporter construct used here thus provides a tool for the identification of mesDA neuron precursors in the VM and selective isolation of transplantable mesDA neuron precursors for transplantation...- Retrovirally delivered Islet-1 increases recruitment of Ng2 expressing cells from the postnatal SVZ into the striatumNina Rogelius
Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, Lund, Sweden
Exp Neurol 201:388-98. 2006..Thus, although ectopic expression of Islet-1 is sufficient to direct the migration of cells into the striatum in neonatal animals, it does not specify a striatal projection neuron phenotype in cells generated from the SVZ after birth... - Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristicsJosephine B Hebsgaard
Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
Glia 57:1648-58. 2009.... - Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mousePerrine Barraud
Wallenberg Neuroscience Center, BMC A11, Section of Neurobiology, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, University, SE-221 84 Lund, Sweden
Eur J Neurosci 22:1555-69. 2005..Thus, not all Sox1-GFP cells possess the same capacity for neuronal differentiation in vivo... - Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cellsElin K I Andersson
Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, S 221 84 Lund, Sweden
Exp Cell Res 313:1172-80. 2007..Over-expression of Nurr1 and Ngn2 in combination generates morphologically mature TH-expressing neurons that also express additional mesencephalic markers... - Organization of the human embryonic ventral mesencephalonJenny Nelander
Department of Experimental Medical Science and Lund Strategic Center for Stem Cell, Biology and Cell Therapy, Lund University, Sweden
Gene Expr Patterns 9:555-61. 2009..This data therefore suggest similar roles for these factors also in human VM development and dopamine neurogenesis... - Phenotypic and molecular identity of cells in the adult subventricular zone. in vivo and after expansion in vitroMalin Parmar
Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, SE 221 84 Lund, Sweden
Mol Cell Neurosci 24:741-52. 2003..However, under normal conditions, GSH2-expressing cells in the adult SVZ and in the in vitro expanded neurospheres appear to specify only olfactory bulb progenitors and not striatal progenitors... - Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectorsRohit Sachdeva
Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
Proc Natl Acad Sci U S A 107:11602-7. 2010..The properties and versatility of the microRNA-regulated vectors allows broad use of these vectors in stem cell applications... - Direct conversion of human fibroblasts to dopaminergic neuronsUlrich Pfisterer
Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, SE 221 84 Lund, Sweden
Proc Natl Acad Sci U S A 108:10343-8. 2011..Such subtype-specific induced neurons derived from human somatic cells could be valuable for disease modeling and cell replacement therapy... - Striatal neuron differentiation from neurosphere-expanded progenitors depends on Gsh2 expressionJosephine B Jensen
Wallenberg Neuroscience Center, Section of Neurobiology, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, SE-221 84 Lund, Sweden
J Neurosci 24:6958-67. 2004..Furthermore, we show that the ability of the expanded LGE cells to respond to the developmental cues presented by the primary cells depends on the maintained expression of Gsh2 in the expanded cells... - A transplantation study of expanded human embryonic forebrain precursors: evidence for selection of a specific progenitor populationMalin Parmar
Wallenberg Neuroscience Center, BMC A11, Section of Neurobiology, Lund University, SE 221 84 Lund, Sweden
Mol Cell Neurosci 23:531-43. 2003..However, the human LGE cells do not migrate or undergo region-specific differentiation when placed outside the SVZ and RMS... - Efficient induction of functional neurons from adult human fibroblastsUlrich Pfisterer
Department of Experimental Medical Science, Lund University, Lund, Sweden
Cell Cycle 10:3311-6. 2011..Thus, this technology is an attractive alternative to iPS cells for generating patient- and disease-specific neurons suitable for disease modeling and autologous transplantation... - Regional specification of neurosphere cultures derived from subregions of the embryonic telencephalonMalin Parmar
Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Solvegatan 17, BMC A11, S 221 84 Lund, Sweden
Mol Cell Neurosci 21:645-56. 2002.... - In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133Perrine Barraud
Research Center for Stem Cell Biology and Cell Therapy, BMC A11, Lund University, Lund, Sweden
J Neurosci Res 85:250-9. 2007..Therefore, we propose that SSEA4 associated with CD133 can be used for both the positive selection and the enrichment of neural stem/progenitor cells from human embryonic forebrain... - Neural grafting in Parkinson's disease Problems and possibilitiesPatrik Brundin
Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
Prog Brain Res 184:265-94. 2010..Finally, we discuss future possibilities offered by stem cells as potential sources of dopamine neurons that can be used for transplantation in PD... - Strengths and limitations of the neurosphere culture systemJosephine B Jensen
Department of Experimental Medical Science and Lund Strategic Center for Stem Cell Biology and Cell Therapy, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
Mol Neurobiol 34:153-61. 2006.... - Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditionsAgnete Kirkeby
Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
Cell Rep 1:703-14. 2012..VM-patterned but not forebrain-patterned neurons released dopamine and reversed motor deficits in an animal model of Parkinson's disease... - Generation of transplantable striatal projection neurons from human ESCsMalin Parmar
Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
Cell Stem Cell 10:349-50. 2012..The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology of Huntington's disease...