Malin Parmar

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. doi request reprint Reprogramming of neonatal SVZ progenitors by islet-1 and neurogenin-2
    Nina Rogelius
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, SE 221 84 Lund, Sweden
    Mol Cell Neurosci 38:453-9. 2008
  2. pmc Early specification of dopaminergic phenotype during ES cell differentiation
    Malin Parmar
    Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK
    BMC Dev Biol 7:86. 2007
  3. ncbi request reprint Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon
    Lachlan H Thompson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, and Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, BMC A11, SE 221 84 Lund, Sweden
    Exp Neurol 198:183-98. 2006
  4. ncbi request reprint Retrovirally delivered Islet-1 increases recruitment of Ng2 expressing cells from the postnatal SVZ into the striatum
    Nina Rogelius
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, Lund, Sweden
    Exp Neurol 201:388-98. 2006
  5. pmc Generation of induced neurons via direct conversion in vivo
    Olof Torper
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 110:7038-43. 2013
  6. ncbi request reprint Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristics
    Josephine B Hebsgaard
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Glia 57:1648-58. 2009
  7. doi request reprint Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions
    Agnete Kirkeby
    Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
    Cell Rep 1:703-14. 2012
  8. ncbi request reprint Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse
    Perrine Barraud
    Wallenberg Neuroscience Center, BMC A11, Section of Neurobiology, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, University, SE 221 84 Lund, Sweden
    Eur J Neurosci 22:1555-69. 2005
  9. doi request reprint Organization of the human embryonic ventral mesencephalon
    Jenny Nelander
    Department of Experimental Medical Science and Lund Strategic Center for Stem Cell, Biology and Cell Therapy, Lund University, Sweden
    Gene Expr Patterns 9:555-61. 2009
  10. ncbi request reprint Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells
    Elin K I Andersson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, S 221 84 Lund, Sweden
    Exp Cell Res 313:1172-80. 2007

Collaborators

Detail Information

Publications22

  1. doi request reprint Reprogramming of neonatal SVZ progenitors by islet-1 and neurogenin-2
    Nina Rogelius
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, SE 221 84 Lund, Sweden
    Mol Cell Neurosci 38:453-9. 2008
    ..When located in the striatum, the reprogrammed cells displayed neuroblast-like morphology. Once removed from the striatal parenchyma and allowed to further differentiation in vitro they developed into beta-III-tubulin positive neurons...
  2. pmc Early specification of dopaminergic phenotype during ES cell differentiation
    Malin Parmar
    Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK
    BMC Dev Biol 7:86. 2007
    ..However, the exact identity of the responding cells and the timing of inductive activity that specify a dopaminergic fate in neural stem/progenitors still remain elusive...
  3. ncbi request reprint Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon
    Lachlan H Thompson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, and Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, BMC A11, SE 221 84 Lund, Sweden
    Exp Neurol 198:183-98. 2006
    ..The Ngn2-GFP reporter construct used here thus provides a tool for the identification of mesDA neuron precursors in the VM and selective isolation of transplantable mesDA neuron precursors for transplantation...
  4. ncbi request reprint Retrovirally delivered Islet-1 increases recruitment of Ng2 expressing cells from the postnatal SVZ into the striatum
    Nina Rogelius
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, Lund, Sweden
    Exp Neurol 201:388-98. 2006
    ..Thus, although ectopic expression of Islet-1 is sufficient to direct the migration of cells into the striatum in neonatal animals, it does not specify a striatal projection neuron phenotype in cells generated from the SVZ after birth...
  5. pmc Generation of induced neurons via direct conversion in vivo
    Olof Torper
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 110:7038-43. 2013
    ..Taken together, our data provide proof of principle that direct neural conversion can take place in the adult rodent brain when using transplanted human cells or endogenous mouse cells as a starting cell for neural conversion...
  6. ncbi request reprint Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristics
    Josephine B Hebsgaard
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Glia 57:1648-58. 2009
    ....
  7. doi request reprint Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions
    Agnete Kirkeby
    Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
    Cell Rep 1:703-14. 2012
    ..VM-patterned but not forebrain-patterned neurons released dopamine and reversed motor deficits in an animal model of Parkinson's disease...
  8. ncbi request reprint Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse
    Perrine Barraud
    Wallenberg Neuroscience Center, BMC A11, Section of Neurobiology, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, University, SE 221 84 Lund, Sweden
    Eur J Neurosci 22:1555-69. 2005
    ..Thus, not all Sox1-GFP cells possess the same capacity for neuronal differentiation in vivo...
  9. doi request reprint Organization of the human embryonic ventral mesencephalon
    Jenny Nelander
    Department of Experimental Medical Science and Lund Strategic Center for Stem Cell, Biology and Cell Therapy, Lund University, Sweden
    Gene Expr Patterns 9:555-61. 2009
    ..This data therefore suggest similar roles for these factors also in human VM development and dopamine neurogenesis...
  10. ncbi request reprint Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells
    Elin K I Andersson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, S 221 84 Lund, Sweden
    Exp Cell Res 313:1172-80. 2007
    ..Over-expression of Nurr1 and Ngn2 in combination generates morphologically mature TH-expressing neurons that also express additional mesencephalic markers...
  11. ncbi request reprint Phenotypic and molecular identity of cells in the adult subventricular zone. in vivo and after expansion in vitro
    Malin Parmar
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, SE 221 84 Lund, Sweden
    Mol Cell Neurosci 24:741-52. 2003
    ..However, under normal conditions, GSH2-expressing cells in the adult SVZ and in the in vitro expanded neurospheres appear to specify only olfactory bulb progenitors and not striatal progenitors...
  12. pmc Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors
    Rohit Sachdeva
    Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 107:11602-7. 2010
    ..The properties and versatility of the microRNA-regulated vectors allows broad use of these vectors in stem cell applications...
  13. ncbi request reprint Striatal neuron differentiation from neurosphere-expanded progenitors depends on Gsh2 expression
    Josephine B Jensen
    Wallenberg Neuroscience Center, Section of Neurobiology, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, SE 221 84 Lund, Sweden
    J Neurosci 24:6958-67. 2004
    ..Furthermore, we show that the ability of the expanded LGE cells to respond to the developmental cues presented by the primary cells depends on the maintained expression of Gsh2 in the expanded cells...
  14. pmc Direct conversion of human fibroblasts to dopaminergic neurons
    Ulrich Pfisterer
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, SE 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 108:10343-8. 2011
    ..Such subtype-specific induced neurons derived from human somatic cells could be valuable for disease modeling and cell replacement therapy...
  15. ncbi request reprint A transplantation study of expanded human embryonic forebrain precursors: evidence for selection of a specific progenitor population
    Malin Parmar
    Wallenberg Neuroscience Center, BMC A11, Section of Neurobiology, Lund University, SE 221 84 Lund, Sweden
    Mol Cell Neurosci 23:531-43. 2003
    ..However, the human LGE cells do not migrate or undergo region-specific differentiation when placed outside the SVZ and RMS...
  16. doi request reprint Efficient induction of functional neurons from adult human fibroblasts
    Ulrich Pfisterer
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Cell Cycle 10:3311-6. 2011
    ..Thus, this technology is an attractive alternative to iPS cells for generating patient- and disease-specific neurons suitable for disease modeling and autologous transplantation...
  17. ncbi request reprint Regional specification of neurosphere cultures derived from subregions of the embryonic telencephalon
    Malin Parmar
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Solvegatan 17, BMC A11, S 221 84 Lund, Sweden
    Mol Cell Neurosci 21:645-56. 2002
    ....
  18. ncbi request reprint In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133
    Perrine Barraud
    Research Center for Stem Cell Biology and Cell Therapy, BMC A11, Lund University, Lund, Sweden
    J Neurosci Res 85:250-9. 2007
    ..Therefore, we propose that SSEA4 associated with CD133 can be used for both the positive selection and the enrichment of neural stem/progenitor cells from human embryonic forebrain...
  19. doi request reprint Neural grafting in Parkinson's disease Problems and possibilities
    Patrik Brundin
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Prog Brain Res 184:265-94. 2010
    ..Finally, we discuss future possibilities offered by stem cells as potential sources of dopamine neurons that can be used for transplantation in PD...
  20. ncbi request reprint Strengths and limitations of the neurosphere culture system
    Josephine B Jensen
    Department of Experimental Medical Science and Lund Strategic Center for Stem Cell Biology and Cell Therapy, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Mol Neurobiol 34:153-61. 2006
    ....
  21. ncbi request reprint Human foetal brain tissue as quality control when developing stem cells towards cell replacement therapy for neurological diseases
    Jenny Nelander
    Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, Sweden
    Neuroreport 24:1025-30. 2013
    ..In this review, we highlight the value of using human foetal tissue as a reference material for quality control of acquired cell fate of in vitro generated neurons before and after transplantation. ..
  22. ncbi request reprint Generation of transplantable striatal projection neurons from human ESCs
    Malin Parmar
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
    Cell Stem Cell 10:349-50. 2012
    ..The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology of Huntington's disease...