Bilal Omar

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. pmc Alterations in cyclic nucleotide phosphodiesterase activities in omental and subcutaneous adipose tissues in human obesity
    B Omar
    Department of Experimental Medical Sciences, Division of Diabetes, Metabolism and Endocrinology, Lund University, Lund, Sweden
    Nutr Diabetes 1:e13. 2011
  2. doi request reprint Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model
    B A Omar
    Department of Clinical Sciences, Lund University, Lund, Sweden
    Diabetologia 56:1752-60. 2013
  3. pmc Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis
    Bilal Omar
    Lund University, Biomedical Center, C11 Department of Experimental Medical Science, 221 84 Lund, Sweden
    Cell Signal 21:760-6. 2009
  4. pmc Differential development of glucose intolerance and pancreatic islet adaptation in multiple diet induced obesity models
    Bilal Omar
    Department of Clinical Sciences, Medicine, Lund University, SE221 84, Lund, Sweden
    Nutrients 4:1367-81. 2012
  5. pmc From PDE3B to the regulation of energy homeostasis
    Eva Degerman
    Department of Experimental Medical Science, Division for Diabetes, Metabolism and Endocrinology, Lund University, Lund, Sweden
    Curr Opin Pharmacol 11:676-82. 2011
  6. pmc Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B
    Bilal Omar
    Department of Experimental Medical Sciences, Diabetes, Metabolism and Endocrinology, Biomedical Center, Lund University, Lund, Sweden
    Biochem Biophys Res Commun 425:812-7. 2012
  7. doi request reprint Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes
    Christine Berggreen
    Department of Experimental Medical Science, Lund University, BMC, C11, SE 221 84 Lund, Sweden
    Am J Physiol Endocrinol Metab 296:E635-46. 2009
  8. pmc Link between GIP and osteopontin in adipose tissue and insulin resistance
    Emma Ahlqvist
    Department of Clinical Sciences, Diabetes, and Endocrinology, University Hospital Malmo, Lund University, Malmo, Sweden
    Diabetes 62:2088-94. 2013
  9. ncbi request reprint Pleiotropic Mechanisms for the Glucose-Lowering Action of DPP-4 Inhibitors
    Bilal Omar
    Department of Clinical Sciences Lund, Lund University, Lund, Sweden
    Diabetes 63:2196-202. 2014

Detail Information

Publications9

  1. pmc Alterations in cyclic nucleotide phosphodiesterase activities in omental and subcutaneous adipose tissues in human obesity
    B Omar
    Department of Experimental Medical Sciences, Division of Diabetes, Metabolism and Endocrinology, Lund University, Lund, Sweden
    Nutr Diabetes 1:e13. 2011
    ..Conclusions: Multiple PDE families are present in human adipose tissue and their activities are differentially affected by obesity and T2D...
  2. doi request reprint Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model
    B A Omar
    Department of Clinical Sciences, Lund University, Lund, Sweden
    Diabetologia 56:1752-60. 2013
    ..To explore the long-term effects of DPP4 inhibition on insulin secretion and beta cell mass, we have generated a high-fat diet (HFD)-induced-obesity model in mice of advanced age (10 months old)...
  3. pmc Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis
    Bilal Omar
    Lund University, Biomedical Center, C11 Department of Experimental Medical Science, 221 84 Lund, Sweden
    Cell Signal 21:760-6. 2009
    ..Taken together, these data suggest that PDE3B and PDE4 regulate cAMP pools that affect the activation/phosphorylation state of AMPK and that the effects of cyclic AMP on AMPK involve Epac1, PKA and lipolysis...
  4. pmc Differential development of glucose intolerance and pancreatic islet adaptation in multiple diet induced obesity models
    Bilal Omar
    Department of Clinical Sciences, Medicine, Lund University, SE221 84, Lund, Sweden
    Nutrients 4:1367-81. 2012
    ..Different high fat diets are used and in order to determine which diet produces a model most accurately resembling human T2D, they need to be compared head-to-head...
  5. pmc From PDE3B to the regulation of energy homeostasis
    Eva Degerman
    Department of Experimental Medical Science, Division for Diabetes, Metabolism and Endocrinology, Lund University, Lund, Sweden
    Curr Opin Pharmacol 11:676-82. 2011
    ..This article highlights the complexity involved in the regulation of PDE3B by hormones, and in the regulation of downstream metabolic effects by PDE3B in several interacting tissues...
  6. pmc Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B
    Bilal Omar
    Department of Experimental Medical Sciences, Diabetes, Metabolism and Endocrinology, Biomedical Center, Lund University, Lund, Sweden
    Biochem Biophys Res Commun 425:812-7. 2012
    ..Given the established link between osteopontin and insulin resistance, our data suggest that GIP by stimulating osteopontin expression, also could promote insulin resistance in adipocytes...
  7. doi request reprint Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes
    Christine Berggreen
    Department of Experimental Medical Science, Lund University, BMC, C11, SE 221 84 Lund, Sweden
    Am J Physiol Endocrinol Metab 296:E635-46. 2009
    ..In summary, we propose that PKB is required for the positive effects of insulin on lipid storage and that regulation of PDE3B and AMPK by PKB is important for these effects...
  8. pmc Link between GIP and osteopontin in adipose tissue and insulin resistance
    Emma Ahlqvist
    Department of Clinical Sciences, Diabetes, and Endocrinology, University Hospital Malmo, Lund University, Malmo, Sweden
    Diabetes 62:2088-94. 2013
    ..Carriers of the GIPR rs10423928 A allele showed protective properties via reduced GIP effects. Identification of this unprecedented link between GIP and OPN in adipose tissue might open new avenues for therapeutic interventions...
  9. ncbi request reprint Pleiotropic Mechanisms for the Glucose-Lowering Action of DPP-4 Inhibitors
    Bilal Omar
    Department of Clinical Sciences Lund, Lund University, Lund, Sweden
    Diabetes 63:2196-202. 2014
    ..These pleiotropic effects may contribute to the effects of DPP-4 inhibition. This Perspectives in Diabetes outlines and discusses these nonclassical mechanisms of DPP-4 inhibition. ..