Olle Melander

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Validation of plasma proneurotensin as a novel biomarker for the prediction of incident breast cancer
    Olle Melander
    Department of Clinical Sciences, Lund University, Malmö Center of Emergency Medicine, Departments of
    Cancer Epidemiol Biomarkers Prev 23:1672-6. 2014
  2. doi request reprint Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality
    Olle Melander
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    JAMA 308:1469-75. 2012
  3. pmc Multilevel analysis of systolic blood pressure and ACE gene I/D polymorphism in 438 Swedish families--a public health perspective
    Juan Merlo
    Department of Health and Health Care Management Epidemiology, Region Skåne, Lund, Sweden
    BMC Med Genet 7:14. 2006
  4. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
  5. pmc Novel and conventional biomarkers for prediction of incident cardiovascular events in the community
    Olle Melander
    Department of Clinical Sciences, Lund University, Clinical Research Center, Malmo University Hospital, SE 205 02 Malmo, Sweden
    JAMA 302:49-57. 2009
  6. ncbi request reprint Moderate salt restriction effectively lowers blood pressure and degree of salt sensitivity is related to baseline concentration of renin and N-terminal atrial natriuretic peptide in plasma
    Olle Melander
    Department of Clinical Sciences, Malmö University Hospital and Lund University, Malmo, Sweden
    J Hypertens 25:619-27. 2007
  7. doi request reprint Smoking and obesity associated BDNF gene variance predicts total and cardiovascular mortality in smokers
    Sara Halldén
    Department of Clinical Sciences, Lund University, Clinical Research Center, Entrance 72, Building 91, Floor 12, Malmo University Hospital, Malmo SE 205 02, Sweden
    Heart 99:949-53. 2013
  8. pmc Assessment of conventional cardiovascular risk factors and multiple biomarkers for the prediction of incident heart failure and atrial fibrillation
    J Gustav Smith
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    J Am Coll Cardiol 56:1712-9. 2010
  9. doi request reprint A variant upstream of the CDH13 adiponectin receptor gene and metabolic syndrome in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Malmo, Sweden
    Am J Cardiol 108:1432-7. 2011
  10. doi request reprint Prediction of blood pressure changes over time and incidence of hypertension by a genetic risk score in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    Hypertension 61:319-26. 2013

Detail Information

Publications99

  1. ncbi request reprint Validation of plasma proneurotensin as a novel biomarker for the prediction of incident breast cancer
    Olle Melander
    Department of Clinical Sciences, Lund University, Malmö Center of Emergency Medicine, Departments of
    Cancer Epidemiol Biomarkers Prev 23:1672-6. 2014
    ..High fasting plasma proneurotensin concentration was associated with the development of breast cancer in the Malmö Diet and Cancer Study (MDCS). Here, we aimed at replicating the initial finding in an independent second cohort...
  2. doi request reprint Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality
    Olle Melander
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    JAMA 308:1469-75. 2012
    ..Neurotensin regulates both satiety and breast cancer growth in the experimental setting, but little is known about its role in the development of breast cancer or cardiometabolic disease in humans...
  3. pmc Multilevel analysis of systolic blood pressure and ACE gene I/D polymorphism in 438 Swedish families--a public health perspective
    Juan Merlo
    Department of Health and Health Care Management Epidemiology, Region Skåne, Lund, Sweden
    BMC Med Genet 7:14. 2006
    ..We aimed to combine genetic epidemiology with public health ideas concerning life-course and multilevel epidemiology in order to understand the role of familial factors regarding individual SBP...
  4. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
    ..Genome-wide association is a promising approach to map genetic loci related to these heritable phenotypes...
  5. pmc Novel and conventional biomarkers for prediction of incident cardiovascular events in the community
    Olle Melander
    Department of Clinical Sciences, Lund University, Clinical Research Center, Malmo University Hospital, SE 205 02 Malmo, Sweden
    JAMA 302:49-57. 2009
    ..Prior studies have demonstrated conflicting results regarding how much information novel biomarkers add to cardiovascular risk assessment...
  6. ncbi request reprint Moderate salt restriction effectively lowers blood pressure and degree of salt sensitivity is related to baseline concentration of renin and N-terminal atrial natriuretic peptide in plasma
    Olle Melander
    Department of Clinical Sciences, Malmö University Hospital and Lund University, Malmo, Sweden
    J Hypertens 25:619-27. 2007
    ..Furthermore, we tested whether the basal plasma concentration of renin or N-terminal atrial natriuretic peptide (Nt-proANP) predict the degree of salt sensitivity...
  7. doi request reprint Smoking and obesity associated BDNF gene variance predicts total and cardiovascular mortality in smokers
    Sara Halldén
    Department of Clinical Sciences, Lund University, Clinical Research Center, Entrance 72, Building 91, Floor 12, Malmo University Hospital, Malmo SE 205 02, Sweden
    Heart 99:949-53. 2013
    ..Our aim was to test whether genetic BDNF variation alters the risk of smoking related morbidity and mortality...
  8. pmc Assessment of conventional cardiovascular risk factors and multiple biomarkers for the prediction of incident heart failure and atrial fibrillation
    J Gustav Smith
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    J Am Coll Cardiol 56:1712-9. 2010
    ....
  9. doi request reprint A variant upstream of the CDH13 adiponectin receptor gene and metabolic syndrome in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Malmo, Sweden
    Am J Cardiol 108:1432-7. 2011
    ..In light of the role of cadherin-13 as a vascular receptor for adiponectin, our study supports the genetic basis for the role of adiponectin in MetS pathogenesis...
  10. doi request reprint Prediction of blood pressure changes over time and incidence of hypertension by a genetic risk score in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    Hypertension 61:319-26. 2013
    ..Our data from a large cohort study show that a GRS is independently associated with BP increase and incidence of hypertension...
  11. pmc The Renalase Asp37Glu polymorphism is not associated with hypertension and cardiovascular events in an urban-based prospective cohort: the Malmö Diet and cancer study
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    BMC Med Genet 13:57. 2012
    ..We tested the hypothesis that these polymorphisms could affect BP levels, hypertension prevalence, and risk of incident cardiovascular events in middle-aged Swedes...
  12. pmc Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality
    Eero Lindholm
    Department of Clinical Sciences, Clinical Research Center, University Hospital Malmö MAS, Lund University, Malmo, Sweden
    PLoS ONE 1:e64. 2006
    ..Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI)...
  13. pmc Plasma copeptin and the risk of diabetes mellitus
    Sofia Enhörning
    Department of Clinical Sciences, Lund University, Clinical Research Center, Entrance 72, Bldg 91, Floor 12, Malmo University Hospital, SE 20502 Malmo, Sweden
    Circulation 121:2102-8. 2010
    ..Animal studies suggest that the arginine vasopressin system may play a role in glucose metabolism, but data from humans are limited...
  14. pmc A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene
    Håkan Lövkvist
    Department of Clinical Sciences, Neurology, Lund University, Lund, Sweden
    Eur J Hum Genet 20:783-9. 2012
    ..042). No effect from rs12188950 on IS was found from either our pooled multi-centre data or the performed meta-analysis. We did not find any association between the examined subgroups and rs12188950 either...
  15. pmc Low plasma level of atrial natriuretic peptide predicts development of diabetes: the prospective Malmo Diet and Cancer study
    Martin Magnusson
    Departments of Clinical Sciences, Lund University, Skane University Hospital, Ent 35, Floor 2, SE 205 02 Malmo, Sweden
    J Clin Endocrinol Metab 97:638-45. 2012
    ....
  16. ncbi request reprint Association between adducin-1 G460W variant and blood pressure in Swedes is dependent on interaction with body mass index and gender
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Malmo, Sweden
    Am J Hypertens 20:981-9. 2007
    ..The aim of this study was to test whether the G460W variant is associated with BP levels and BP progression rate and whether G460W associations with BP are affected by sex, body mass index (BMI), or age...
  17. ncbi request reprint Determinants of kidney function in Swedish families: role of heritable factors
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Malmo, Sweden
    J Hypertens 26:1773-9. 2008
    ..The association of the circadian rhythm of blood pressure with kidney function in this sample deserves further investigation...
  18. ncbi request reprint Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    Pharmacogenet Genomics 20:94-103. 2010
    ..The aim of this study was to evaluate the effect of four polymorphisms in the EPHX2 gene on blood pressure levels, hypertension prevalence, and risk of incident cardiovascular events in a large sample of middle-aged Swedes...
  19. ncbi request reprint The common functional polymorphism -50G>T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    J Hypertens 28:294-9. 2010
    ....
  20. doi request reprint A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients
    Patrik Svensson-Färbom
    Department of Clinical Sciences, Lund University and Center for Emergency Medicine, Malmo University Hospital, Malmo, Sweden
    J Hypertens 29:388-95. 2011
    ....
  21. pmc A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events
    Olof Gidlöf
    Department of Clinical Sciences, Lund University, Lund, Sweden
    PLoS ONE 7:e37491. 2012
    ..We hypothesized that polymorphisms in P2RX7 influence the risk of ischemic heart disease (IHD), ischemic stroke (IS) and cardiovascular risk factors and tested this hypothesis using genetic association studies...
  22. doi request reprint Vasoactive peptides with angiogenesis-regulating activity predict cancer risk in males
    Mattias Belting
    Department of Clinical Sciences, Lund University, Section of Oncology, Lund, Sweden
    Cancer Epidemiol Biomarkers Prev 21:513-22. 2012
    ..Here, we hypothesized that vasoactive peptides previously implicated in angiogenesis regulation predict long-term cancer risk...
  23. doi request reprint The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden
    Prostaglandins Other Lipid Mediat 98:31-6. 2012
    ..The aim of the present study was to evaluate the effect of CYP4F2 V433M, a functional polymorphism previously associated with hypertension via renal salt reabsorption, on the individual components of MetS and MetS itself...
  24. doi request reprint Orthostatic blood pressure response, carotid intima-media thickness, and plasma fibrinogen in older nondiabetic adults
    Artur Fedorowski
    Center for Emergency Medicine, Skane University Hospital, Malmo, Sweden
    J Hypertens 30:522-9. 2012
    ..Although recent studies have indicated that both orthostatic hypotension and orthostatic hypertension (OHTN) independently predict cardiovascular events, the underlying mechanisms are still debatable...
  25. doi request reprint Plasma copeptin, a unifying factor behind the metabolic syndrome
    Sofia Enhörning
    Department of Clinical Science, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Clin Endocrinol Metab 96:E1065-72. 2011
    ..We previously showed that high copeptin, the stable C-terminal fragment of AVP prohormone, is independently associated with hyperinsulinemia and future development of diabetes mellitus...
  26. ncbi request reprint The functional variant of the CLC-Kb channel T481S is not associated with blood pressure or hypertension in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    J Hypertens 25:111-6. 2007
    ..The study aim was to evaluate the association of the T481S polymorphism with blood pressure (BP) levels and the BP progression rate in Swedes...
  27. doi request reprint Soluble urokinase plasminogen activator receptor: a risk factor for carotid plaque, stroke, and coronary artery disease
    Margaretha Persson
    From the Clinical Research Unit, Medicine, Skåne University Hospital Malmö, Malmo, Sweden M P, G O, O M and Department of Clinical Sciences Malmö, Lund University, Lund, Sweden M P, G O, G S, V H, O M, B H, G E
    Stroke 45:18-23. 2014
    ..The relationships among the soluble urokinase plasminogen activator receptor (suPAR), carotid plaque, and incidence of ischemic stroke and coronary artery disease (CAD) events were studied in a prospective cohort...
  28. pmc A diabetes-predictive amino acid score and future cardiovascular disease
    Martin Magnusson
    Department of Cardiology, Skane University Hospital, Entrance 35, Floor 2, SE 205 02 Malmo, Sweden
    Eur Heart J 34:1982-9. 2013
    ....
  29. doi request reprint Serine/threonine kinase 39 is a candidate gene for primary hypertension especially in women: results from two cohort studies in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Skane University Hospital, Lund University, Malmo, Sweden
    J Hypertens 29:484-91. 2011
    ....
  30. doi request reprint Age and gender differences in the association between Nt-proBNP and glucometabolic disturbances
    Margret Leosdottir
    Department of Cardiology, Skane University Hospital, Malmo, Sweden
    Scand Cardiovasc J 45:294-300. 2011
    ..Brain natriuretic peptides (BNP) are used for detecting myocardial dysfunction in clinical practice. However, studies on elderly subjects and gender-specific analyses are sparse...
  31. ncbi request reprint Novel mutations in the SLC12A3 gene causing Gitelman's syndrome in Swedes
    Cristiano Fava
    Division of Endocrinology, Department of Clinical Sciences, University of Malmo, Malmo, Sweden
    DNA Seq 18:395-9. 2007
    ..Up to now, more than 100 mutations of the SLC12A3 gene have been described in GS patients...
  32. ncbi request reprint Interaction between the angiotensin-converting enzyme gene insertion/deletion polymorphism and obstructive sleep apnoea as a mechanism for hypertension
    Kristina Bengtsson Boström
    Department of Clinical Sciences, Diabetes and Endocrinology, Skaraborg Institute, Skovde, Sweden
    J Hypertens 25:779-83. 2007
    ..The aim of this study was to explore the interaction between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and OSA in the association with hypertension...
  33. pmc Genetic polymorphisms confer risk of atrial fibrillation in patients with heart failure: a population-based study
    J Gustav Smith
    Department of Cardiology, Lund University, Lund, Sweden
    Eur J Heart Fail 15:250-7. 2013
    ..We evaluated the association of cardiovascular and genetic risk factors with AF in HF patients...
  34. ncbi request reprint Orthostatic hypotension in genetically related hypertensive and normotensive individuals
    Artur Fedorowski
    Department of Medicine, Malmo University Hospital, Malmo, Sweden
    J Hypertens 27:976-82. 2009
    ..Prevalence and determinants of orthostatic hypotension remain largely unexplored in younger individuals without significant burden of chronic diseases...
  35. ncbi request reprint A clinically confirmed family history for early myocardial infarction is associated with increased risk of obesity, insulin resistance and metabolic syndrome
    Martin Magnusson
    Department of Cardiology, Skane University Hospital, Malmo, Sweden
    J Hypertens 30:948-53. 2012
    ..We examined whether a parental history of clinically verified early MI may promote development of insulin resistance, obesity and the metabolic syndrome (MetS)...
  36. pmc Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients
    Martin Magnusson
    Department of Cardiology, Malmo University Hospital, Lund University, Lund, Sweden
    Cardiovasc Diabetol 9:2. 2010
    ....
  37. doi request reprint Orthostatic hypotension predicts incidence of heart failure: the Malmö preventive project
    Artur Fedorowski
    Center for Emergency Medicine, Skane University Hospital, Malmo, Sweden
    Am J Hypertens 23:1209-15. 2010
    ..The presence of orthostatic hypotension (OH) predicts all-cause mortality and incident cardiovascular disease. Whether or not OH is associated with the development of heart failure (HF) remains unknown...
  38. doi request reprint Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome
    Cristiano Fava
    Department of Clinical Sciences, University Hospital MAS, Malmo, Sweden
    J Hypertens 27:1794-803. 2009
    ....
  39. ncbi request reprint Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension
    Fredrik von Wowern
    Department of Endocrinology, Wallenberg Laboratory, Ent 46, Floor 3, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Hypertension 43:592-7. 2004
    ....
  40. pmc Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations
    Marju Orho-Melander
    Department of Clinical Sciences, University Hospital Malmo, Clinical Research Center, Lund University, Malmo, Sweden
    Diabetes 57:3112-21. 2008
    ....
  41. ncbi request reprint Dipping and variability of blood pressure and heart rate at night are heritable traits
    Cristiano Fava
    Department of Endocrinology, University Hospital MAS, Malmo, Sweden
    Am J Hypertens 18:1402-7. 2005
    ..The aim of this study was to determine whether these traits are heritable...
  42. doi request reprint Diabetes mellitus and elevated copeptin levels in middle age predict low cognitive speed after long-term follow-up
    Eva Tufvesson
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    Dement Geriatr Cogn Disord 35:67-76. 2013
    ....
  43. doi request reprint Pharmacogenetic implications for eight common blood pressure-associated single-nucleotide polymorphisms
    Viktor Hamrefors
    Department of Clinical Sciences, Lund University, Malmo, Norway
    J Hypertens 30:1151-60. 2012
    ....
  44. doi request reprint Job strain, job demands and adrenergic beta1-receptor-polymorphism: a possible interaction affecting blood pressure in men
    Bertil Ohlin
    Department of Clinical Sciences Medicine, Lund University, Malmo University Hospital, Sweden
    J Hypertens 26:1583-9. 2008
    ..We aimed to study whether there is an interaction between the Arg389Gly polymorphism and job strain and its components (job demand and decision latitude) in relation to blood pressure...
  45. doi request reprint Relation between human vasopressin 1a gene variance, fat intake, and diabetes
    Sofia Enhörning
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    Am J Clin Nutr 89:400-6. 2009
    ..Male arginine vasopressin 1a receptor knockout mice (V1aR(-/-)) display a phenotype of low triglycerides and high glucose concentrations and high-fat-diet-induced obesity and diabetes...
  46. ncbi request reprint Heritability of ambulatory and office blood pressure phenotypes in Swedish families
    Cristiano Fava
    Department of Endocrinology, University Hospital MAS, Malmo, Sweden
    J Hypertens 22:1717-21. 2004
    ..The aim of this study was to estimate the heritability of 24-h ambulatory blood pressure and office blood pressure phenotypes in Swedish families...
  47. ncbi request reprint Red cell distribution width in relation to incidence of coronary events and case fatality rates: a population-based cohort study
    Yan Borné
    Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden
    Heart 100:1119-24. 2014
    ..We investigated the association between RDW and incidence of acute coronary events (CEs) and fatal outcome in subjects who subsequently experienced a first CE...
  48. pmc Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21
    Viktor Hamrefors
    Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmo, Sweden Clinical Physiology and Nuclear Medicine Unit, Skane University Hospital, Malmo, Sweden
    PLoS ONE 9:e85893. 2014
    ..We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors...
  49. ncbi request reprint Adrenomedullin is a marker of carotid plaques and intima-media thickness as well as brachial pulse pressure
    Mikael Gottsäter
    Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden
    J Hypertens 31:1959-65. 2013
    ..The aim of this study was to investigate the association between the mid-regional part of pro-ADM (MR-proADM) and brachial pulse pressure (PP), carotid intima-media thickness (cIMT) and carotid atherosclerosis...
  50. doi request reprint From circulating biomarkers to genomics and imaging in the prediction of cardiovascular events in the general population
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    Ann Med 44:433-47. 2012
    ....
  51. ncbi request reprint Incidence of coronary events and case fatality rate in relation to blood lymphocyte and neutrophil counts
    Samuel Adamsson Eryd
    Cardiovascular epidemiology research group, Department of Clinical Sciences Lund University, Skane University Hospital, Entrance 72, Bldg 60, Floor 13, 20205 Malmö, Sweden
    Arterioscler Thromb Vasc Biol 32:533-9. 2012
    ..This study aimed to explore whether blood lymphocyte and neutrophil counts are associated with incidence of CEs and with fatal outcome in subjects who subsequently experienced a first CE...
  52. doi request reprint Inflammation-sensitive proteins and risk of atrial fibrillation: a population-based cohort study
    Samuel Adamsson Eryd
    Cardiovascular epidemiology research group, Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden
    Eur J Epidemiol 26:449-55. 2011
    ..Of the individual ISPs, a significant association was observed for ceruloplasmin, a protein previously associated with copper metabolism and oxidative stress...
  53. doi request reprint Directionality of blood pressure response to standing may determine development of heart failure: prospective cohort study
    Artur Fedorowski
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    Eur J Heart Fail 13:496-503. 2011
    ..To study the prospective relationship of blood pressure response during orthostatic challenge with incidence of heart failure (HF)...
  54. ncbi request reprint Leukocyte count and incidence of hospitalizations due to heart failure
    Gunnar Engstrom
    Department of Clinical Sciences in Malmo, Lund University, Sweden
    Circ Heart Fail 2:217-22. 2009
    ..Whether high leukocyte counts are associated with incidence of heart failure (HF) is unknown. This population-based study explored whether the leukocyte concentrations were associated with incidence of hospitalizations due to HF...
  55. doi request reprint Consequences of orthostatic blood pressure variability in middle-aged men (The Malmö Preventive Project)
    Artur Fedorowski
    Center for Emergency Medicine, Malmo University Hospital, Malmo, Sweden
    J Hypertens 28:551-9. 2010
    ..To investigate the determinants and consequences of orthostatic hypotension in the middle-aged segment of the general population...
  56. doi request reprint Atrial fibrillation in the Malmö Diet and Cancer study: a study of occurrence, risk factors and diagnostic validity
    J Gustav Smith
    Department of Clinical Sciences, Lund University, Clinical Research Center, Malmo University Hospital, Malmo, Sweden
    Eur J Epidemiol 25:95-102. 2010
    ..Hypertension and obesity account for large portions of population risk in middle-aged individuals with low prevalence of manifest cardiac disease...
  57. ncbi request reprint Cardiovascular consequences of a polygenetic component of blood pressure in an urban-based longitudinal study: the Malmö Diet and Cancer
    Cristiano Fava
    aDepartment of Clinical Sciences, Lund University, University Hospital of Malmo, Malmo, Sweden bDepartment of Medicine, University Hospital of Verona, Verona, Italy Cristiano Fava and Therese Ohlsson contributed equally to the to the writing of this article
    J Hypertens 32:1424-8; discussion 1428. 2014
    ..Here, we prospectively evaluate the impact of this polygenetic BP component on CVD morbidity and mortality in a large urban-based middle-aged population...
  58. ncbi request reprint Systolic and diastolic component of orthostatic hypotension and cardiovascular events in hypertensive patients: the Captopril Prevention Project
    Artur Fedorowski
    aDepartment of Clinical Sciences, Lund University, Clinical Research Center bArrhythmia Department, Skane University Hospital, Malmö cInstitute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Hypertens 32:75-81. 2014
    ..Impact of SBP vs. DBP decrement during orthostasis on cardiovascular events in hypertension is not clear...
  59. pmc Plasma procalcitonin is associated with all-cause and cancer mortality in apparently healthy men: a prospective population-based study
    Ovidiu S Cotoi
    Department of Clinical Sciences, Lund University, Lund, Sweden
    BMC Med 11:180. 2013
    ..Our aim was to assess the relationship between plasma PCT and the risk of all-cause and cause-specific mortality in apparently healthy individuals with no previous history of cardiovascular disease or cancer...
  60. ncbi request reprint A genome wide scan for early onset primary hypertension in Scandinavians
    Fredrik von Wowern
    Department of Endocrinology, Malmo University Hospital, SE 205 02, Malmo, Sweden
    Hum Mol Genet 12:2077-81. 2003
    ..Our data suggest a hypertension susceptibility locus on chromosome 14 around 41 cM. The locus on chromosome 2 is also promising as it has been implicated in hypertension and blood pressure regulation in earlier genome scans...
  61. ncbi request reprint Elevated plasma levels of Nt-proBNP in patients with type 2 diabetes without overt cardiovascular disease
    Martin Magnusson
    Department of Cardiology, University Hospital MAS, Lund University, Sweden
    Diabetes Care 27:1929-35. 2004
    ....
  62. ncbi request reprint Plasma ProANP(1-30) reflects salt sensitivity in subjects with heredity for hypertension
    Olle Melander
    Department of Endocrinology, Lund University, Malmo, Sweden
    Hypertension 39:996-9. 2002
    ....
  63. ncbi request reprint No evidence of a relation between 11beta-hydroxysteroid dehydrogenase type 2 activity and salt sensitivity
    Olle Melander
    Department of Endocrinology, Lund University, Malmö University Hospital MAS, S 205 02 Malmo, Sweden
    Am J Hypertens 16:729-33. 2003
    ..The aim of the present study was to investigate whether 11BHSD2 activity is affected by salt intake and if it is related to salt sensitivity...
  64. pmc Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP
    Jonas Dahlberg
    Department of Clinical Sciences, Malmö University Hospital and Lund University, Malmo, Sweden
    PLoS ONE 2:e432. 2007
    ..Our aim was to test if genetic variation in NEDD4L is associated with increased salt sensitivity...
  65. ncbi request reprint Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship
    Fredrik von Wowern
    Department of Endocrinology, Lund University, Malmo, Sweden
    Kidney Int 68:2164-72. 2005
    ..The aim of this study was to investigate if variation in the SGK-1 gene is associated with increased blood pressure and strength of the insulin-blood pressure relationship...
  66. doi request reprint Genetic variants in serum and glucocortocoid regulated kinase 1, a regulator of the epithelial sodium channel, are associated with ischaemic stroke
    Jonas Dahlberg
    Clinical Research Center CRC, Entrance 72, Bldg 91, Floor 12, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Hypertens 29:884-9. 2011
    ..Therefore, we tested the association of these variants with ischaemic stroke...
  67. pmc Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (The Malmo Preventive Project)
    Artur Fedorowski
    Center for Emergency Medicine, Malmo University Hospital, Entrance 33, Floor 5, 20502 Malmo, Sweden
    Eur Heart J 31:85-91. 2010
    ..Orthostatic hypotension (OH) has been linked to increased mortality and incidence of cardiovascular disease in various risk groups, but determinants and consequences of OH in the general population are poorly studied...
  68. doi request reprint Population-based study of lung function and incidence of heart failure hospitalisations
    Gunnar Engstrom
    Department of Clinical Sciences, Lund University, Malmo University Hospital, Sweden
    Thorax 65:633-8. 2010
    ..However, the relationship with incidence of heart failure (HF) is incompletely known. This population-based study explored whether reduced FEV(1) or FVC is associated with the incidence of hospitalisation for HF...
  69. pmc A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women
    Viktor Hamrefors
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    J Lipid Res 51:625-34. 2010
    ..This suggests that a gene score based on variation in nine different LDL- and HDL-associated genes is of importance for the magnitude of fluvastatin HDL increase in women with asymptomatic plaque in the carotid artery...
  70. ncbi request reprint Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: skaraborg hypertension and diabetes project
    Carl J Ostgren
    Department of Community Medicine, Malmo University Hospital, Malmo, Sweden
    J Hypertens 21:1657-62. 2003
    ..This study explored whether the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPARgamma) is associated with blood pressure in subjects with type 2 diabetes...
  71. ncbi request reprint Interaction between renal function and microalbuminuria for cardiovascular risk in hypertension: the nordic diltiazem study
    Patrik Färbom
    Department of Clinical Sciences, Clinical Research Center, Entrance 72, Bldg 91, Fl 12, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Hypertension 52:115-22. 2008
    ..Because estimation of the total cardiovascular risk is essential for the aggressiveness of risk factor interventions, simultaneous inclusion of GFR and microalbuminuria in global cardiovascular risk assessment is essential...
  72. pmc Early postural blood pressure response and cause-specific mortality among middle-aged adults
    Artur Fedorowski
    Center for Emergency Medicine, Skane University Hospital, Entrance 35, Floor 2, 205 02, Malmo, Sweden
    Eur J Epidemiol 26:537-46. 2011
    ..Moreover, both increase and pronounced decrease of SBP during early orthostasis indicate higher risk of cerebrovascular death...
  73. doi request reprint The metabolic syndrome and risk of myocardial infarction in familial hypertension (hypertension heredity in Malmö evaluation study)
    Artur Fedorowski
    Department of Medicine, Lund University, Lund, Sweden
    J Hypertens 27:109-17. 2009
    ....
  74. doi request reprint Red cell distribution width and risk for first hospitalization due to heart failure: a population-based cohort study
    Yan Borné
    Department of Clinical Sciences, Lund University, Clinical Research Center, Skane University Hospital, Malmo, Sweden
    Eur J Heart Fail 13:1355-61. 2011
    ..We investigated the association between RDW and incidence of first hospitalization due to HF in a population-based cohort...
  75. doi request reprint Carotid intima-media thickness, systemic inflammation, and incidence of heart failure hospitalizations
    Gunnar Engstrom
    Department of Clinical Sciences in Malmo, Lund University, Malmo University Hospital, Sweden
    Arterioscler Thromb Vasc Biol 29:1691-5. 2009
    ..This study explored the relationships between carotid intima-media thickness (IMT), plasma levels of C-reactive protein (CRP), and incidence of heart failure hospitalizations...
  76. doi request reprint Cardiovascular and cancer mortality in very elderly post-myocardial infarction patients receiving statin treatment
    Klas Gränsbo
    Department of Clinical Sciences, Malmo University Hospital, Malmo, Sweden Lund University, Lund, Sweden
    J Am Coll Cardiol 55:1362-9. 2010
    ..The purpose of this study was to determine whether statin treatment is effective and safe in very elderly (80 years and older) acute myocardial infarction (AMI) patients...
  77. ncbi request reprint Uromodulin gene variant is associated with type 2 diabetic nephropathy
    Tarunveer S Ahluwalia
    Department of Endocrinology and Lund University Diabetes Centre, University Hospital, Skåne, Malmo, Sweden
    J Hypertens 29:1731-4. 2011
    ..In the present study we examined the association of the common variant of the uromodulin (UMOD) gene with type 2 diabetic nephropathy and kidney function...
  78. ncbi request reprint Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3
    Liisa Koivukoski
    Department of Endocrinology, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Hum Mol Genet 13:2325-32. 2004
    ..We conclude that modest or non-significant linkage on chromosomes 3p14.1-q12.3 and 2p12-q22.1 in each individual study translates into genome-wide significant or highly suggestive linkages to HT and DBP in our GSMA analysis...
  79. ncbi request reprint Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men
    Bertil Ohlin
    Department of Clinical Sciences Medicine, Lund University, Malmo University Hospital, Sweden
    J Hypertens 25:1613-9. 2007
    ..We hypothesized that the I/D polymorphism interacts with external stress, such as job strain, in the development of hypertension...
  80. ncbi request reprint Urinary excretion rate of Tamm-Horsfall protein is related to salt intake in humans
    Ole Torffvit
    Department of Medicine, University Hospital of Lund, Lund, Sweden
    Nephron Physiol 97:p31-6. 2004
    ..The aim of the present study was to investigate whether the urinary excretion rate of Tamm-Horsfall protein (THP) is dependent on salt intake in healthy, genetically hypertension-prone individuals...
  81. doi request reprint The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure
    Cristiano Fava
    Department of Biomedical and Surgical Sciences, Division of Internal Medicine C, Piazza LA Scuro 10, 37134 Verona, Italy
    Hypertension 52:373-80. 2008
    ..A common CYP4F2 V433M polymorphism might increase the risk of incident ischemic stroke in male subjects only partially through its elevating effect on BP. Additional studies are needed to confirm these data...
  82. pmc A dedicated investigation unit improves management of syncopal attacks (Syncope Study of Unselected Population in Malmo--SYSTEMA I)
    Artur Fedorowski
    Center for Emergency Medicine, Skane University Hospital, Malmo, Sweden
    Europace 12:1322-8. 2010
    ..To investigate whether a systematic approach to unexplained syncopal attacks based on the European Society of Cardiology guidelines would improve the diagnostic and therapeutic outcomes...
  83. ncbi request reprint Determinants of increasing pulse pressure during 23 years' follow-up as a marker of arterial stiffness and vascular ageing
    Arash Mokhtari
    Department of Clinical Sciences, Lund University, University Hospital, Malmo, Sweden
    Blood Press 17:291-7. 2008
    ..In conclusion, several well-known cardiovascular risk factors, such as glucose, BMI, heart rate, family history of hypertension and cholesterol in particular, are long-term predictors of increased PP in both genders...
  84. pmc Gastroparesis is associated with oxytocin deficiency, oesophageal dysmotility with hyperCCKemia, and autonomic neuropathy with hypergastrinemia
    Julia Borg
    Department of Clinical Sciences, Gastroenterology Division, Malmo University Hospital, Lund University, Lund, Sweden
    BMC Gastroenterol 9:17. 2009
    ..The aim of this study was to examine if concentrations of oxytocin, cholecystokinin (CCK), gastrin and vasopressin in plasma differ between diabetics with normal function and dysfunction in GI motility...
  85. pmc Pleiotropic effects of GIP on islet function involve osteopontin
    Valeriya Lyssenko
    Diabetes and Endocrinology, Department of Clinical Sciences, University Hospital Malmo, Lund University, Malmo, Sweden
    Diabetes 60:2424-33. 2011
    ..Here we explored mechanisms that could explain the protective effects of GIP on islet function...
  86. ncbi request reprint Contribution of known and unknown susceptibility genes to early-onset diabetes in scandinavia: evidence for heterogeneity
    Cecilia M Lindgren
    Department of Endocrinology, Wallenberg Laboratory, Malmo University Hospital, Malmo, Sweden
    Diabetes 51:1609-17. 2002
    ..Our data also point at putative chromosomal regions, which could harbor novel genes that contribute to EOD...
  87. ncbi request reprint Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols
    Sandosh Padmanabhan
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    J Hypertens 26:1275-81. 2008
    ..This will lead to the identification of potential targets for lifestyle and pharmacological interventions, with the ultimate goal of improving prevention, diagnosis and treatment...
  88. ncbi request reprint Salt sensitivity: a consequence of the metabolic syndrome?
    Olle Melander
    J Hypertens 24:1475-7. 2006
  89. ncbi request reprint hTERT (-1327)T/C polymorphism is not associated with age-related telomere attrition in peripheral blood
    Katarina Nordfjäll
    Department of Medical Biosciences, Pathology, By 6M, 2nd Floor, Umea University, SE 90187 Umea, Sweden
    Biochem Biophys Res Commun 358:215-8. 2007
    ..339). Moreover, no increased age-related attrition was observed for the (-1327)C/C genotype as previously indicated, rather a telomere elongation in the control group (p=0.021) not seen in the MI group (p=0.249)...
  90. ncbi request reprint Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
    Science 316:1331-6. 2007
    ..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases...
  91. ncbi request reprint Are minor gene effects of clinical importance?
    Olle Melander
    J Hypertens 25:505-7. 2007
  92. pmc Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:189-97. 2008
    ..Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care...
  93. ncbi request reprint Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11
    Stefan Amisten
    Department of Cardiology, Lund University Hospital, SE 221 85 Lund, Sweden
    Eur Heart J 28:13-8. 2007
    ..Extracellular ATP acting on the P2Y11 receptor regulates inflammatory cells. We hypothesized that polymorphisms in the receptor could influence the risk of acute myocardial infarction (AMI)...
  94. ncbi request reprint EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries
    John Danesh
    EPIC Heart Secretariat, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK
    Eur J Epidemiol 22:129-41. 2007
    ..Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors...
  95. doi request reprint Genetics of cardiovascular disease: interplay between common and rare alleles
    Olle Melander
    J Hypertens 26:394-5. 2008
  96. doi request reprint Polymorphisms associated with cholesterol and risk of cardiovascular events
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
    N Engl J Med 358:1240-9. 2008
    ..We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease...
  97. ncbi request reprint From linkage to genes in human hypertension
    Olle Melander
    J Hypertens 20:2135-8. 2002
  98. ncbi request reprint Intrauterine growth and blood pressure: what causes the relationship?
    Olle Melander
    J Hypertens 21:1245-7. 2003
  99. pmc The P2Y 13 Met-158-Thr polymorphism, which is in linkage disequilibrium with the P2Y 12 locus, is not associated with acute myocardial infarction
    Stefan Amisten
    Department of Cardiology, Lund University Hospital, Lund, Sweden
    PLoS ONE 3:e1462. 2008
    ....