Ramin Massoumi

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. doi request reprint CYLD: a deubiquitination enzyme with multiple roles in cancer
    Ramin Massoumi
    Department of Laboratory Medicine, Molecular Tumor Pathology, Lund University, Malmo, Sweden
    Future Oncol 7:285-97. 2011
  2. doi request reprint Ubiquitin chain cleavage: CYLD at work
    Ramin Massoumi
    Department of Laboratory Medicine, Clinical Research Center, Lund University, SE 205 Malmö, Sweden
    Trends Biochem Sci 35:392-9. 2010
  3. ncbi request reprint Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control
    Ramin Massoumi
    Department of Laboratory Medicine, Clinical Research Center, Lund University, Malmo University Hospital, Malmo, Sweden
    Bioessays 29:1203-14. 2007
  4. ncbi request reprint The role of leukotriene receptor signaling in inflammation and cancer
    Ramin Massoumi
    Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    ScientificWorldJournal 7:1413-21. 2007
  5. ncbi request reprint The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer
    Christian K Nielsen
    Department of Laboratory Medicine, Lund University, Malmo University Hospital, Sweden
    Adv Exp Med Biol 525:201-4. 2003
  6. ncbi request reprint Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells
    Astrid M L Bengtsson
    Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    Prostaglandins Other Lipid Mediat 85:100-6. 2008
  7. ncbi request reprint Alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells
    Oliver Jay Broom
    Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Cell Physiol 209:950-8. 2006
  8. ncbi request reprint Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activation
    Christian Kamp Nielsen
    Department of Laboratory Medicine, Experimental Pathology, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Exp Cell Res 302:31-9. 2005
  9. ncbi request reprint Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin
    Ramin Massoumi
    Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Exp Cell Res 289:342-51. 2003
  10. ncbi request reprint Leukotriene D(4) induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKCdelta
    Ramin Massoumi
    Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Cell Sci 115:3509-15. 2002

Collaborators

Detail Information

Publications14

  1. doi request reprint CYLD: a deubiquitination enzyme with multiple roles in cancer
    Ramin Massoumi
    Department of Laboratory Medicine, Molecular Tumor Pathology, Lund University, Malmo, Sweden
    Future Oncol 7:285-97. 2011
    ..Identification of CYLD-mediated signaling pathways during the progression of cancer will provide a solid foundation for diagnosis and lead to the development of novel tools for cancer therapy...
  2. doi request reprint Ubiquitin chain cleavage: CYLD at work
    Ramin Massoumi
    Department of Laboratory Medicine, Clinical Research Center, Lund University, SE 205 Malmö, Sweden
    Trends Biochem Sci 35:392-9. 2010
    ..Recent work also shows that CYLD activity can be governed by different regulatory mechanisms including phosphorylation, thus providing another layer of control for diverse physiological processes...
  3. ncbi request reprint Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control
    Ramin Massoumi
    Department of Laboratory Medicine, Clinical Research Center, Lund University, Malmo University Hospital, Malmo, Sweden
    Bioessays 29:1203-14. 2007
    ..We argue that these recent insights into CYLD function and cylindroma pathogenesis may lead to the development of novel molecular strategies for cancer prevention and treatment...
  4. ncbi request reprint The role of leukotriene receptor signaling in inflammation and cancer
    Ramin Massoumi
    Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    ScientificWorldJournal 7:1413-21. 2007
    ..In addition, we delineate how continuous CysLT1 receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity...
  5. ncbi request reprint The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer
    Christian K Nielsen
    Department of Laboratory Medicine, Lund University, Malmo University Hospital, Sweden
    Adv Exp Med Biol 525:201-4. 2003
  6. ncbi request reprint Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells
    Astrid M L Bengtsson
    Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    Prostaglandins Other Lipid Mediat 85:100-6. 2008
    ..Our findings show for the first time that JNK/AP-1 but not NFkappaB is a downstream target of LTD(4) in intestinal epithelial cells, suggesting that AP-1 is an important mediator of LTD(4)-induced mitogenic effects...
  7. ncbi request reprint Alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells
    Oliver Jay Broom
    Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Cell Physiol 209:950-8. 2006
    ..This signalling pathway suggests a mechanism whereby inflammation-induced modulations of the ECM, can promote cancer transformation in the intestinal epithelial cells...
  8. ncbi request reprint Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activation
    Christian Kamp Nielsen
    Department of Laboratory Medicine, Experimental Pathology, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Exp Cell Res 302:31-9. 2005
    ..Consequently, the CysLT1 receptor has the capacity to activate at least two distinctly different heterotrimeric G-proteins that transduce activation of unique downstream cellular events...
  9. ncbi request reprint Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin
    Ramin Massoumi
    Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Exp Cell Res 289:342-51. 2003
    ..This suggests that inflammatory mediators such as LTD4 can be involved in the dissemination and survival of colon cancer cells...
  10. ncbi request reprint Leukotriene D(4) induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKCdelta
    Ramin Massoumi
    Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Cell Sci 115:3509-15. 2002
    ..We conclude that PKC-delta is located downstream of RhoA and that active RhoA and PKCdelta are both necessary for LTD(4)-induced stress-fibre formation...
  11. ncbi request reprint Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling
    Ramin Massoumi
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Cell 125:665-77. 2006
    ....
  12. pmc Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation
    Jiabin An
    Department of Medicine, VA Greater Los Angeles Healthcare System West Los Angeles, Los Angeles, CA 90095, USA
    Cancer Cell 14:394-407. 2008
    ..Given the established role of NF-kappaB in human carcinogenesis, these findings provide a potential molecular/viral link between hypoxia and the adverse clinical outcomes observed in HPV-associated malignancies...
  13. ncbi request reprint Reduced expression of CYLD in human colon and hepatocellular carcinomas
    Claus Hellerbrand
    Department of Internal Medicine I, University Regensburg, 93053 Regensburg, Germany
    Carcinogenesis 28:21-7. 2007
    ..Thus, functional relevant loss of CYLD expression may contribute to tumor development and progression, and may provide a new target for therapeutic strategies...
  14. ncbi request reprint Cylindroma as tumor of hair follicle origin
    Ramin Massoumi
    J Invest Dermatol 126:1182-4. 2006