Ramin MassoumiSummaryAffiliation: Lund University Country: Sweden Publications
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CYLD: a deubiquitination enzyme with multiple roles in cancerRamin Massoumi
Department of Laboratory Medicine, Molecular Tumor Pathology, Lund University, Malmo, Sweden
Future Oncol 7:285-97. 2011..Identification of CYLD-mediated signaling pathways during the progression of cancer will provide a solid foundation for diagnosis and lead to the development of novel tools for cancer therapy...- Ubiquitin chain cleavage: CYLD at workRamin Massoumi
Department of Laboratory Medicine, Clinical Research Center, Lund University, SE 205 Malmö, Sweden
Trends Biochem Sci 35:392-9. 2010..Recent work also shows that CYLD activity can be governed by different regulatory mechanisms including phosphorylation, thus providing another layer of control for diverse physiological processes... 
Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth controlRamin Massoumi
Department of Laboratory Medicine, Clinical Research Center, Lund University, Malmo University Hospital, Malmo, Sweden
Bioessays 29:1203-14. 2007..We argue that these recent insights into CYLD function and cylindroma pathogenesis may lead to the development of novel molecular strategies for cancer prevention and treatment...- The role of leukotriene receptor signaling in inflammation and cancerRamin Massoumi
Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
ScientificWorldJournal 7:1413-21. 2007..In addition, we delineate how continuous CysLT1 receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity... - The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancerChristian K Nielsen
Department of Laboratory Medicine, Lund University, , Sweden
Adv Exp Med Biol 525:201-4. 2003 - Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cellsAstrid M L Bengtsson
Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
Prostaglandins Other Lipid Mediat 85:100-6. 2008..Our findings show for the first time that JNK/AP-1 but not NFkappaB is a downstream target of LTD(4) in intestinal epithelial cells, suggesting that AP-1 is an important mediator of LTD(4)-induced mitogenic effects... - Alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cellsOliver Jay Broom
Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
J Cell Physiol 209:950-8. 2006..This signalling pathway suggests a mechanism whereby inflammation-induced modulations of the ECM, can promote cancer transformation in the intestinal epithelial cells... - Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activationChristian Kamp Nielsen
Department of Laboratory Medicine, Experimental Pathology, Lund University, , SE-205 02 Malm, Sweden
Exp Cell Res 302:31-9. 2005..Consequently, the CysLT1 receptor has the capacity to activate at least two distinctly different heterotrimeric G-proteins that transduce activation of unique downstream cellular events... - Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrinRamin Massoumi
Experimental Pathology, Department of Laboratory Medicine, Lund University, , SE-205 02 Malm, Sweden
Exp Cell Res 289:342-51. 2003..This suggests that inflammatory mediators such as LTD4 can be involved in the dissemination and survival of colon cancer cells... - Leukotriene D(4) induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKCdeltaRamin Massoumi
Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
J Cell Sci 115:3509-15. 2002..We conclude that PKC-delta is located downstream of RhoA and that active RhoA and PKCdelta are both necessary for LTD(4)-induced stress-fibre formation... - Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signalingRamin Massoumi
Department of Molecular Medicine, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
Cell 125:665-77. 2006.... 
Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activationJiabin An
Department of Medicine, VA Greater Los Angeles Healthcare System West Los Angeles, Los Angeles, CA 90095, USA
Cancer Cell 14:394-407. 2008..Given the established role of NF-kappaB in human carcinogenesis, these findings provide a potential molecular/viral link between hypoxia and the adverse clinical outcomes observed in HPV-associated malignancies...- Reduced expression of CYLD in human colon and hepatocellular carcinomasClaus Hellerbrand
Department of Internal Medicine I, University Regensburg, 93053 Regensburg, Germany
Carcinogenesis 28:21-7. 2007..Thus, functional relevant loss of CYLD expression may contribute to tumor development and progression, and may provide a new target for therapeutic strategies... - Cylindroma as tumor of hair follicle originRamin Massoumi
J Invest Dermatol 126:1182-4. 2006