Ramin Massoumi

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. doi request reprint CYLD: a deubiquitination enzyme with multiple roles in cancer
    Ramin Massoumi
    Department of Laboratory Medicine, Molecular Tumor Pathology, Lund University, Malmo, Sweden
    Future Oncol 7:285-97. 2011
  2. pmc Serum response factor controls CYLD expression via MAPK signaling pathway
    Gang Liang
    Department of Laboratory Medicine, Lund University, UMAS, Malmo, Sweden
    PLoS ONE 6:e19613. 2011
  3. pmc CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin
    Sara A Wickström
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 29:131-44. 2010
  4. pmc Tumor Suppressor Function of CYLD in Nonmelanoma Skin Cancer
    K C Masoumi
    Molecular Tumor Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, 205 02 Malmo, Sweden
    J Skin Cancer 2011:614097. 2011
  5. doi request reprint Ubiquitin chain cleavage: CYLD at work
    Ramin Massoumi
    Department of Laboratory Medicine, Clinical Research Center, Lund University, SE 205 Malmö, Sweden
    Trends Biochem Sci 35:392-9. 2010
  6. ncbi request reprint Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control
    Ramin Massoumi
    Department of Laboratory Medicine, Clinical Research Center, Lund University, Malmo University Hospital, Malmo, Sweden
    Bioessays 29:1203-14. 2007
  7. pmc Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma
    Ramin Massoumi
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Exp Med 206:221-32. 2009
  8. ncbi request reprint Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling
    Ramin Massoumi
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Cell 125:665-77. 2006
  9. doi request reprint CYLD controls c-MYC expression through the JNK-dependent signaling pathway in hepatocellular carcinoma
    Rajeswara Rao Pannem
    Department of Laboratory Medicine, Skane University Hospital, Lund University, Malmö SE 20502, Sweden
    Carcinogenesis 35:461-8. 2014
  10. ncbi request reprint Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activation
    Christian Kamp Nielsen
    Department of Laboratory Medicine, Experimental Pathology, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Exp Cell Res 302:31-9. 2005

Collaborators

Detail Information

Publications23

  1. doi request reprint CYLD: a deubiquitination enzyme with multiple roles in cancer
    Ramin Massoumi
    Department of Laboratory Medicine, Molecular Tumor Pathology, Lund University, Malmo, Sweden
    Future Oncol 7:285-97. 2011
    ..Identification of CYLD-mediated signaling pathways during the progression of cancer will provide a solid foundation for diagnosis and lead to the development of novel tools for cancer therapy...
  2. pmc Serum response factor controls CYLD expression via MAPK signaling pathway
    Gang Liang
    Department of Laboratory Medicine, Lund University, UMAS, Malmo, Sweden
    PLoS ONE 6:e19613. 2011
    ..These results show that SRF acts as a positive regulator of CYLD expression, which in turn reduces the mitogenic activation of serum for aberrant proliferation of MEF cells...
  3. pmc CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin
    Sara A Wickström
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 29:131-44. 2010
    ..Altogether these results identify a mechanism by which CYLD regulates cell proliferation at distinct cell-cycle phases...
  4. pmc Tumor Suppressor Function of CYLD in Nonmelanoma Skin Cancer
    K C Masoumi
    Molecular Tumor Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, 205 02 Malmo, Sweden
    J Skin Cancer 2011:614097. 2011
    ....
  5. doi request reprint Ubiquitin chain cleavage: CYLD at work
    Ramin Massoumi
    Department of Laboratory Medicine, Clinical Research Center, Lund University, SE 205 Malmö, Sweden
    Trends Biochem Sci 35:392-9. 2010
    ..Recent work also shows that CYLD activity can be governed by different regulatory mechanisms including phosphorylation, thus providing another layer of control for diverse physiological processes...
  6. ncbi request reprint Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control
    Ramin Massoumi
    Department of Laboratory Medicine, Clinical Research Center, Lund University, Malmo University Hospital, Malmo, Sweden
    Bioessays 29:1203-14. 2007
    ..We argue that these recent insights into CYLD function and cylindroma pathogenesis may lead to the development of novel molecular strategies for cancer prevention and treatment...
  7. pmc Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma
    Ramin Massoumi
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Exp Med 206:221-32. 2009
    ..Importantly, tumor thickness and progression-free and overall survival inversely correlated with CYLD expression. Our data suggest that Snail1-mediated suppression of CYLD plays a key role in melanoma malignancy...
  8. ncbi request reprint Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling
    Ramin Massoumi
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Cell 125:665-77. 2006
    ....
  9. doi request reprint CYLD controls c-MYC expression through the JNK-dependent signaling pathway in hepatocellular carcinoma
    Rajeswara Rao Pannem
    Department of Laboratory Medicine, Skane University Hospital, Lund University, Malmö SE 20502, Sweden
    Carcinogenesis 35:461-8. 2014
    ..Our findings suggest that CYLD holds potential to serve as a marker for HCC progression, and its link to c-MYC via JNK1 may provide the foundation for new therapeutic strategies for HCC patients. ..
  10. ncbi request reprint Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activation
    Christian Kamp Nielsen
    Department of Laboratory Medicine, Experimental Pathology, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Exp Cell Res 302:31-9. 2005
    ..Consequently, the CysLT1 receptor has the capacity to activate at least two distinctly different heterotrimeric G-proteins that transduce activation of unique downstream cellular events...
  11. ncbi request reprint Alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells
    Oliver Jay Broom
    Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Cell Physiol 209:950-8. 2006
    ..This signalling pathway suggests a mechanism whereby inflammation-induced modulations of the ECM, can promote cancer transformation in the intestinal epithelial cells...
  12. ncbi request reprint Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells
    Astrid M L Bengtsson
    Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    Prostaglandins Other Lipid Mediat 85:100-6. 2008
    ..Our findings show for the first time that JNK/AP-1 but not NFkappaB is a downstream target of LTD(4) in intestinal epithelial cells, suggesting that AP-1 is an important mediator of LTD(4)-induced mitogenic effects...
  13. ncbi request reprint Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin
    Ramin Massoumi
    Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Exp Cell Res 289:342-51. 2003
    ..This suggests that inflammatory mediators such as LTD4 can be involved in the dissemination and survival of colon cancer cells...
  14. ncbi request reprint The role of leukotriene receptor signaling in inflammation and cancer
    Ramin Massoumi
    Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    ScientificWorldJournal 7:1413-21. 2007
    ..In addition, we delineate how continuous CysLT1 receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity...
  15. pmc CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration
    Oliver Jay Broom
    Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Clinical Research Centre, Malmö University Hospital UMAS, Malmo, Sweden
    PLoS ONE 4:e6371. 2009
    ..In conclusion, we present novel data that identifies the G-protein-dependent CD47 protein as a key regulator of collagen I-induced COX-2 expression and a promoter of intestinal epithelial cell migration...
  16. ncbi request reprint The central role of Bcl-3 in atopic dermatitis
    Ramin Massoumi
    Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    J Invest Dermatol 129:2088-90. 2009
    ..identify and characterize B-cell leukemia-3 as an important modulator of AMP expression during the innate immune response in keratinocytes as well as in the chronic inflammatory skin disorder atopic dermatitis...
  17. doi request reprint A20 and CYLD do not share significant overlapping functions during B cell development and activation
    Yuanyuan Chu
    Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Immunol 189:4437-43. 2012
    ..Taken together, our results demonstrate that A20 and CYLD do not share significant functions during B cell development and activation...
  18. ncbi request reprint The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer
    Christian K Nielsen
    Department of Laboratory Medicine, Lund University, Malmo University Hospital, Sweden
    Adv Exp Med Biol 525:201-4. 2003
  19. ncbi request reprint Leukotriene D(4) induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKCdelta
    Ramin Massoumi
    Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Cell Sci 115:3509-15. 2002
    ..We conclude that PKC-delta is located downstream of RhoA and that active RhoA and PKCdelta are both necessary for LTD(4)-induced stress-fibre formation...
  20. pmc Association of nuclear-localized nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells
    Gina Shaw-Hallgren
    Translational Cancer Research, Molecular Tumor Pathology, Department of Laboratory Medicine, Lund University, Lund, Sweden
    PLoS ONE 9:e96506. 2014
    ..The present study provides evidence of a novel mechanism by which HSP27 recognizes NLK in the breast cancer cells and prevents NLK-mediated cell apoptosis. ..
  21. pmc Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation
    Jiabin An
    Department of Medicine, VA Greater Los Angeles Healthcare System West Los Angeles, Los Angeles, CA 90095, USA
    Cancer Cell 14:394-407. 2008
    ..Given the established role of NF-kappaB in human carcinogenesis, these findings provide a potential molecular/viral link between hypoxia and the adverse clinical outcomes observed in HPV-associated malignancies...
  22. ncbi request reprint Reduced expression of CYLD in human colon and hepatocellular carcinomas
    Claus Hellerbrand
    Department of Internal Medicine I, University Regensburg, 93053 Regensburg, Germany
    Carcinogenesis 28:21-7. 2007
    ..Thus, functional relevant loss of CYLD expression may contribute to tumor development and progression, and may provide a new target for therapeutic strategies...
  23. ncbi request reprint Cylindroma as tumor of hair follicle origin
    Ramin Massoumi
    J Invest Dermatol 126:1182-4. 2006