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Genomes and GenesSpecies | A LundwallSummaryAffiliation: Lund University Country: Sweden Publications
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Publications
Identification of a novel protease inhibitor gene that is highly expressed in the prostateAke Lundwall
Department of Laboratory Medicine, Lund University, University Hospital MAS, S 205 02 Malmo, Sweden
Biochem Biophys Res Commun 290:452-6. 2002..By RT-PCR it was shown that the gene is highly expressed in prostate, skin, lung, and esophagus...
Genes encoding WFDC- and Kunitz-type protease inhibitor domains: are they related?Ake Lundwall
Department of Laboratory Medicine, Skane University Hospital, Lund University, SE 205 02 Malmo, Sweden
Biochem Soc Trans 39:1398-402. 2011..6 Mb in the cow. The region, which seems to be specific to ruminants, contains several genes and pseudogenes with Kunitz motifs, one of which is the much-studied BPTI (bovine pancreatic trypsin inhibitor)...- Evolution of kallikrein-related peptidases in mammals and identification of a genetic locus encoding potential regulatory inhibitorsAke Lundwall
Lund University, Clinical Chemistry, Department of Laboratory Medicine, University Hospital MAS, S 20502 Malmo, Sweden
Biol Chem 387:243-9. 2006..The linkage to a locus of possible regulatory protease inhibitors on chromosome 20 is discussed, as is the potential role of the kallikrein locus in innate immunity... - A comprehensive nomenclature for serine proteases with homology to tissue kallikreinsAke Lundwall
Lund University, Clinical Chemistry, Department of Laboratory Medicine, University Hospital MAS, S 205 02 Malmo, Sweden
Biol Chem 387:637-41. 2006..Here we present a new nomenclature in which proteins without proven kininogenase activity are denoted kallikrein-related peptidase. Names are also given to the unique rodent proteins that are closely related to kallikrein 1... 
Three genes expressing Kunitz domains in the epididymis are related to genes of WFDC-type protease inhibitors and semen coagulum proteins in spite of lacking similarity between their protein productsAdam Clauss
Lund University, Department of Laboratory Medicine, Clinical Chemistry, Skane University Hospital, SE 205 02 Malmo, Sweden
BMC Biochem 12:55. 2011..In this report, we have reinvestigated the locus for homologous genes encoding Kunitz motif only. The identified genes have been analyzed with respect to structure, expression and function...- A locus on chromosome 20 encompassing genes that are highly expressed in the epididymisAke Lundwall
Department of Laboratory Medicine, Lund University, Clinical Chemistry, University Hospital MAS, Malmo S 205 02, Sweden
Asian J Androl 9:540-4. 2007..All of these are highly expressed in the epididymis where they, similar to the semenogelins, could affect the maturation of spermatozoa or display antibacterial properties... - Kallikrein-related peptidasesA Lundwall
Department of Laboratory Medicine Malmö, Clinical Chemistry, Lund University, University Hospital MAS, Malmo, Sweden
Cell Mol Life Sci 65:2019-38. 2008..In this review on kallikrein-related peptidases, the focus is on their evolution, their role in skin homeostasis and semen liquefaction, and their utility as cancer biomarkers... - Rapidly evolving marmoset MSMB genes are differently expressed in the male genital tractAke Lundwall
Lund University, Department of Laboratory Medicine, Division of Clinical Chemistry, University Hospital MAS, Malmo, Sweden
Reprod Biol Endocrinol 7:96. 2009..Here we have investigated the background for the species difference by analyzing the chromosomal organization and expression of MSMB in the common marmoset (Callithrix jacchus)... - Chemical characterization of the predominant proteins secreted by mouse seminal vesiclesA Lundwall
Lund University, Department of Laboratory Medicine, University Hospital, Malmo, Sweden
Eur J Biochem 249:39-44. 1997..As previously reported for other seminal-vesicle-secreted proteins, the semenoclotin transcripts are shown to be under androgen control... - Cloning of the semenogelin II gene of the rhesus monkey. Duplications of 360 bp extend the coding region in man, rhesus monkey and baboonM Ulvsback
Department of Clinical Chemistry, Lund University, Malmo University Hospital, Sweden
Eur J Biochem 245:25-31. 1997..However, another New World monkey, the cotton-top tamarin, carries only one semenogelin gene, but also has a gene that is similar to the mouse semenoclotin gene... - The cloning of a rapidly evolving seminal-vesicle-transcribed gene encoding the major clot-forming protein of mouse semenA Lundwall
Department of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
Eur J Biochem 235:424-30. 1996..It is highly charged at pH 7 and it has an isoelectric point of 10.68. The central part of the protein consists of tandem repeats that might serve as a substrate for transglutaminase... - New world, but not Old World, monkeys carry several genes encoding beta-microseminoproteinM Makinen
Department of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
Eur J Biochem 264:407-14. 1999..A phylogenetic analysis demonstrated that the genes probably arose in New World monkeys after the separation from Old World primates... - Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistryA Bjartell
Department of Urology, University Hospital, Malmo, Sweden
J Androl 17:17-26. 1996.... - The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNAA Lundwall
Department of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
Eur J Biochem 235:466-70. 1996..A comparison of the SgI gene and the SgII gene suggests that they evolved by the duplication of an approximately 8 kb DNA segment about 61 million years ago, probably by a mechanism involving recombination between L1 elements... - The cotton-top tamarin carries an extended semenogelin I gene but no semenogelin II geneA Lundwall
Department of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
Eur J Biochem 255:45-51. 1998..Approximately half of the primary structure consists of five nearly identical tandem repeats of 58 amino acid residues, that probably evolved relatively late... - Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminaseA Peter
Department of Laboratory Medicine, Lund University, University Hospital, Malmo, Sweden
Eur J Biochem 252:216-21. 1998..We also found that PSA was unable to release any semenogelin fragments during exposure of the high molecular-mass complexes of cross-linked semenogelin to active PSA... - Measurement of prostate-specific antigen and human glandular kallikrein 2 in different body fluidsJ Lovgren
Department of Laboratory Medicine, Lund University, University Hospital, Malmo, Sweden
J Androl 20:348-55. 1999..Furthermore, the concerted expression of PSA and hK2 in seminal plasma, amniotic fluid, and breast milk suggests that the two proteases might form a functional unit but not always as demonstrated by the sole presence of hK2 in saliva... - Semenogelin II gene is replaced by a truncated line 1 repeat in the cotton-top tamarinA Lundwall
Department of Laboratory Medicine, Lund University, University Hospital, Malmo, S 205 02 Malmo, Sweden
Biol Reprod 65:420-5. 2001..Thus, a mammalian ancestor probably carried a single gene that in the rodent lineage developed into the semenoclotin gene and in the primate lineage into a progenitor of the semenogelin genes... - Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related proteinH Lilja
Department of Clinical Chemistry, Lund University, Malmo General Hospital, Sweden
Proc Natl Acad Sci U S A 89:4559-63. 1992..The SgII structure is translated from an open reading frame in a polyadenylylated 2.4-kilobase transcript. The message is abundant in the seminal vesicles but rare in the epididymis... - Production and activation of recombinant hK2 with propeptide mutations resulting in high expression levelsJ Lovgren
Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
Eur J Biochem 266:1050-5. 1999.... - Ejaculates from the common marmoset (Callithrix jacchus) contain semenogelin and beta-microseminoprotein but not prostate-specific antigenCamilla Valtonen-Andre
Wallenberg Laboratory, Department of Laboratory Medicine, Lund University, University Hospital MAS, Malmo, Sweden
Mol Reprod Dev 71:247-55. 2005..Thus, in this study we have shown that semen coagulum proteins are present in marmoset seminal plasma, but the lack of PSA precludes a similar liquefaction as of human semen... - Cystatin C is highly expressed in the human male reproductive systemThomas Jiborn
Department of Urology, Malmo University Hospital, Lund University, Sweden
J Androl 25:564-72. 2004..It is concluded that cystatin C is highly expressed and widely distributed throughout the male genital tract, suggesting that cystatin C is an important regulator for normal and pathological proteolysis in the male reproductive system... - Truncated semenogelin I binds zinc and is cleaved by prostate-specific antigenMagnus Jonsson
Laboratory Medicine, Section for Clinical Chemistry, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
J Androl 27:542-7. 2006..These findings imply that the studied characteristics do not depend on a well-defined tertiary structure, or that the deletion has no major effect on the structure responsible for these features... - The common marmoset (Callithrix jacchus) has two very similar semenogelin genes as the result of gene conversionCamilla Valtonen-Andre
University Hospital MAS, Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, S 205 02 Malmo, Sweden
Biol Reprod 76:604-10. 2007..Together, these studies shed new light on the evolution of semenogelins and the mechanisms that have generated the structural diversity of semen coagulum proteins... - The evolution of a genetic locus encoding small serine proteinase inhibitorsAdam Clauss
Department of Laboratory Medicine, Clinical Chemistry, Lund University, University Hospital MAS, Malmo, Sweden
Biochem Biophys Res Commun 333:383-9. 2005..The conservation of different WFDC domains varies considerably, and it is hypothesized that this reflects a dual role of WFDC inhibitors in natural immunity, which is directed both against microbes and proinflammatory cells... - Beta-microseminoprotein in serum correlates with the levels in seminal plasma of young, healthy malesCamilla Valtonen-Andre
Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
J Androl 29:330-7. 2008..This suggests that MSP in serum can be used as a marker of prostate secretion, despite the contribution from extra prostatic tissues... - The cotton-top tamarin (Saguinus oedipus) has five beta-microseminoprotein genes, two of which are pseudogenesCamilla Valtonen-Andre
Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, University Hospital MAS, Malmo, Sweden
DNA Cell Biol 27:45-54. 2008..The MSP genes described in this study probably arose by phylogenetically rather late duplication or retrotransposition, suggesting that they are confined to a limited number of New World monkeys... - Anti-thrombin is expressed in the benign prostatic epithelium and in prostate cancer and is capable of forming complexes with prostate-specific antigen and human glandular kallikrein 2Yue Cao
Department of Urology, University Hospital Malmo, Lund University, SE 205 02 Malmo, Sweden
Am J Pathol 161:2053-63. 2002..Anti-thrombin may act as a local anti-angiogenic factor, the effect of which is partially lost in poorly differentiated prostatic tumors... - Molecular cloning of complementary DNA encoding mouse seminal vesicle-secreted protein SVS I and demonstration of homology with copper amine oxidasesAke Lundwall
Department of Laboratory Medicine, Lund University, University Hospital MAS, S 205 02 Malmo, Sweden
Biol Reprod 69:1923-30. 2003..The species difference in size of SVS I is caused by tandem repeats of 18 amino acid residues in the central part of the molecule: The mouse has seven repeats, and the rat has 12 repeats... - Organization and evolution of the glandular kallikrein locus in Mus musculusA Yvonne Olsson
Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital MAS, Malmo, Sweden
Biochem Biophys Res Commun 299:305-11. 2002..Phylogenetic analyses show that classical GK genes emerged after the separation of the primate and rodent lineages, forming a subgroup within the newly extended GK family... - Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigenA Yvonne Olsson
Wallenberg Laboratory, Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, 4th Floor, University Hospital MAS, S 205 02 Malmo, Sweden
Genomics 84:147-56. 2004..This is highly interesting with respect to animal models of benign prostate hyperplasia and prostate adenocarcinoma--diseases that have been described only in humans and dogs... - Expression of prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) in ileum and other extraprostatic tissuesA Yvonne Olsson
Department of Laboratory Medicine, Lund University, University Hospital UMAS, S 205 02 Malmo, Sweden
Int J Cancer 113:290-7. 2005..Supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html... - Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigenMagnus Jonsson
Department of Laboratory Medicine, Section for Clinical Chemistry, Lund University, Malmo University Hospital, Malmo, SE 205 02, Sweden
Biochem J 387:447-53. 2005..The system is self-regulating, and PSA is maintained in an active state by its substrate... - The evolution of the glandular kallikrein locus: identification of orthologs and pseudogenes in the cotton-top tamarinA Yvonne Olsson
Wallenberg Laboratories Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Entr 46, 4th fl University Hospital UMAS, S 205 02 Malmo, Sweden
Gene 343:347-55. 2004..KLK15 appeared to be functional, thus, we predict that it generates a protease with specificity similar to that of the human ortholog... - Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissuesAke Lundwall
Department of Laboratory Medicine, Lund University, University Hospital MAS, S 205 02 Malmo, Sweden
Mol Hum Reprod 8:805-10. 2002..The staining of skeletal muscle cells and a few scattered cells in the central nervous system suggests that semenogelin expression is not restricted to epithelial cells... - The semenogelins: proteins with functions beyond reproduction?M Jonsson
Department of Laboratory Medicine, Section for Clinical Chemistry, Lund University, Malmo University Hospital, 205 02, Malmo, Sweden
Cell Mol Life Sci 63:2886-8. 2006..However, more recent results indicate that it is time to put the semenogelins in a broader physiological perspective that goes beyond reproduction and fertility... - A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic proteinAdam Clauss
Wallenberg Laboratory, Department of Laboratory Medicine, University Hospital MAS, Lund University, S 205 02 Malmo, Sweden
Biochem J 368:233-42. 2002.... - A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissueCamilla Valtonen-Andre
Lund University, Division of Clinical Chemistry, Department of Laboratory Medicine, University Hospital MAS, S 205 02 Malmo, Sweden
Biol Chem 388:289-95. 2007..Studies on human prostate cancer specimens showed immunohistochemical staining of both tumor and benign glandular cells. Our results suggest that PSMP is an important protein with significance in prostate cancer... - A frequent allele codes for a truncated variant of semenogelin I, the major protein component of human semen coagulumAke Lundwall
Department of Laboratory Medicine, Lund University, University Hospital, Malmo, Sweden
Mol Hum Reprod 9:345-50. 2003.... - Testicular cancer and molecular geneticsA Giwercman
Fertility Centre, Department of Urology and Department of Clinical Chemistry, , Lund University, Malm, Sweden
Andrologia 37:224-5. 2005 - Immunohistochemical detection of cysteine-rich secretory protein 3 in tissue and in serum from men with cancer or benign enlargement of the prostate glandAnders Bjartell
Department of Urology, Malmo University Hospital, Lund University, Malmo, Sweden
Prostate 66:591-603. 2006..The current aims were to investigate diagnostic use of tissue expression and immunodetection in serum of CRISP-3 for detection or monitoring of PCa... - Expression of protein C inhibitor (PCI) in benign and malignant prostatic tissuesYue Cao
Department of Urology, University Hospital Malmo, Lund University, Lund, Sweden
Prostate 57:196-204. 2003..Previous studies have localized PCI in the male genital tract. Here we have performed a detailed investigation of PCI expression in the prostatic tissues, metastases, and cell lines... - Characterization and localization of cysteine-rich secretory protein 3 (CRISP-3) in the human male reproductive tractLene Udby
Granulocyte Research Laboratory 9322, Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
J Androl 26:333-42. 2005..Examination of seminal plasma from vasectomized males indicates that organs downstream of the epididymis are probably the major sources of seminal plasma CRISP-3... - Characterization of semenogelin proteins in the human retinaVera L Bonilha
Department of Ophthalmic Research, The Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
Exp Eye Res 83:120-7. 2006..Our data support the expression of semenogelin I and II in the human retina in several different compartments. Further studies towards addressing the function of these proteins in the retina are in progress... - beta-Microseminoprotein binds CRISP-3 in human seminal plasmaLene Udby
Granulocyte Research Laboratory, Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Denmark
Biochem Biophys Res Commun 333:555-61. 2005..Structural similarity with an MSP-binding protein from blood plasma suggests that CRISP-3 binds MSP through its aminoterminal SCP-domain... - Semenogelins in the human retina: Differences in distribution and content between AMD and normal donor tissuesVera L Bonilha
Department of Ophthalmology, The Cole Eye Institute, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Exp Eye Res 86:150-6. 2008..We find the distribution of SgI in the AMD retinas substantially lower than observed in normal retina. SgI localization to photoreceptors and the RPE suggests a possible function related to the ability of these cells to sequester zinc...