Christian H Lindh

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. doi request reprint Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations
    Christian H Lindh
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, 221 85 Lund, Sweden
    Chemosphere 88:1269-75. 2012
  2. pmc Dioxin-like activities in serum across European and Inuit populations
    Manhai Long
    Unit of Cellular and Molecular Toxicology, Department of Environmental and Occupational Medicine, Institute of Public Health, University of Aarhus, Vennelyst Boulevard 6, DK 8000 Aarhus C, Denmark
    Environ Health 5:14. 2006
  3. pmc Xenoestrogenic activity in blood of European and Inuit populations
    Eva C Bonefeld-Jorgensen
    Unit of Cellular and Molecular Toxicology, Department of Environmental and Occupational Medicine, Institute of Public Health, Vennelyst Boulevard 6, Build, 1260, University of Aarhus, DK 8000 Aarhus, Denmark
    Environ Health 5:12. 2006
  4. pmc Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and
    Bo A G Jonsson
    Department of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Environ Health 4:27. 2005
  5. pmc Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study
    Annemieke W J Opstal-van Winden
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    BMC Cancer 11:381. 2011
  6. doi request reprint Analysis of chlormequat in human urine as a biomarker of exposure using liquid chromatography triple quadrupole mass spectrometry
    Christian H Lindh
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 879:1551-6. 2011
  7. doi request reprint Analysis of ethylenethiourea as a biomarker in human urine using liquid chromatography/triple quadrupole mass spectrometry
    Christian H Lindh
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, SE 221 85 Lund, Sweden
    Rapid Commun Mass Spectrom 22:2573-9. 2008
  8. ncbi request reprint Analysis of 3,5-dichloroaniline as a biomarker of vinclozolin and iprodione in human urine using liquid chromatography/triple quadrupole mass spectrometry
    Christian H Lindh
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, SE 221 85 Lund, Sweden
    Rapid Commun Mass Spectrom 21:536-42. 2007
  9. doi request reprint Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland
    Linus Kvist
    Department of Clinical Sciences, Molecular Genetic Reproductive Medicine, Lund University, Malmo, Sweden
    Reprod Toxicol 34:644-50. 2012
  10. doi request reprint Methylhexahydrophthalic anhydride adducted albumin tryptic peptides in nasal lavage fluid
    Marina C Jeppsson
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, Lund, Sweden
    Inhal Toxicol 21:1013-20. 2009

Collaborators

Detail Information

Publications37

  1. doi request reprint Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations
    Christian H Lindh
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, 221 85 Lund, Sweden
    Chemosphere 88:1269-75. 2012
    ..For the other populations no strong determinants were found...
  2. pmc Dioxin-like activities in serum across European and Inuit populations
    Manhai Long
    Unit of Cellular and Molecular Toxicology, Department of Environmental and Occupational Medicine, Institute of Public Health, University of Aarhus, Vennelyst Boulevard 6, DK 8000 Aarhus C, Denmark
    Environ Health 5:14. 2006
    ....
  3. pmc Xenoestrogenic activity in blood of European and Inuit populations
    Eva C Bonefeld-Jorgensen
    Unit of Cellular and Molecular Toxicology, Department of Environmental and Occupational Medicine, Institute of Public Health, Vennelyst Boulevard 6, Build, 1260, University of Aarhus, DK 8000 Aarhus, Denmark
    Environ Health 5:12. 2006
    ....
  4. pmc Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and
    Bo A G Jonsson
    Department of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Environ Health 4:27. 2005
    ....
  5. pmc Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study
    Annemieke W J Opstal-van Winden
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    BMC Cancer 11:381. 2011
    ..We present for the first time pre-diagnostic serum protein profiles in relation to breast cancer, using the Prospect-EPIC (European Prospective Investigation into Cancer and nutrition) cohort...
  6. doi request reprint Analysis of chlormequat in human urine as a biomarker of exposure using liquid chromatography triple quadrupole mass spectrometry
    Christian H Lindh
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 879:1551-6. 2011
    ..The levels found in the population samples are several magnitudes lower than those found in the experimental exposure, which corresponds to an oral exposure of 50% of the ADI for CCC...
  7. doi request reprint Analysis of ethylenethiourea as a biomarker in human urine using liquid chromatography/triple quadrupole mass spectrometry
    Christian H Lindh
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, SE 221 85 Lund, Sweden
    Rapid Commun Mass Spectrom 22:2573-9. 2008
    ..5% ETU. Two healthy volunteers received 8.9 microg/kg body weight (b.w.) Ridomil Gold in a single oral dose followed by urine sampling for 104 h post-exposure. The elimination half-life of ETU was estimated to 17-23 h...
  8. ncbi request reprint Analysis of 3,5-dichloroaniline as a biomarker of vinclozolin and iprodione in human urine using liquid chromatography/triple quadrupole mass spectrometry
    Christian H Lindh
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, SE 221 85 Lund, Sweden
    Rapid Commun Mass Spectrom 21:536-42. 2007
    ..Two healthy volunteers received 200 microg single oral doses of each pesticide followed by urine sampling during 72-120 h post-exposure. Between 78-107% of the dose was recovered as 3,5-DCA in the urine after exposure...
  9. doi request reprint Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland
    Linus Kvist
    Department of Clinical Sciences, Molecular Genetic Reproductive Medicine, Lund University, Malmo, Sweden
    Reprod Toxicol 34:644-50. 2012
    ..002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men...
  10. doi request reprint Methylhexahydrophthalic anhydride adducted albumin tryptic peptides in nasal lavage fluid
    Marina C Jeppsson
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, Lund, Sweden
    Inhal Toxicol 21:1013-20. 2009
    ..The results also show a correlation between adducted peptides and albumin in nasal lavage. Furthermore, there may be a difference in the potential to induce hyperresponsiveness between adducts bound to different amino acids...
  11. ncbi request reprint Correlations between air levels of hexahydrophthalic anhydride (HHPA) and HHPA-adducted albumin tryptic peptides in nasal lavage fluid from experimentally exposed volunteers
    Monica H Kristiansson
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, SE 221 85 Lund, Sweden
    Rapid Commun Mass Spectrom 18:1592-8. 2004
    ..It was possible to detect exposures below 10 microg/m3 with the method. Thus, these adducted peptides may be used as biomarkers of exposure, which may better estimate the risk than previous biomarkers developed for OAAs...
  12. ncbi request reprint Biological monitoring of exposure to toluene diisocyanate
    Carl Johan Sennbro
    Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden
    Scand J Work Environ Health 30:371-8. 2004
    ..In this study, 2,4- and 2,6-toluenediamine in hydrolyzed urine and plasma were evaluated as biomarkers of exposure to 2,4- and 2,6-TDI, respectively...
  13. ncbi request reprint Determination of isocyanates in air using 1-(2-methoxyphenyl)piperazine-impregnated filters: long-term sampling performance and field comparison with impingers with dibutylamine
    Carl J Sennbro
    Department of Occupational and Environmental Medicine, University Hospital, SE 221 85 Lund, Sweden
    Ann Occup Hyg 48:415-24. 2004
    ..For long-term monitoring the 2MP method can be applied for TDI but, since the method underestimates the concentrations, a correction factor is needed which needs to be corroborated further...
  14. doi request reprint Strategy for identification and detection of multiple oxidative modifications within proteins applied on persulfate-oxidized hemoglobin and human serum albumin
    Harriet Mortstedt
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund, Lund University, SE 221 85 Lund, Sweden
    Rapid Commun Mass Spectrom 25:327-40. 2011
    ..For peptides containing oxidized tryptophan the oxidation degree increased after exposure. Some of these oxidized peptides may be suitable as biomarkers; however, further evaluation is required...
  15. ncbi request reprint Fetal exposure to perfluorinated compounds and attention deficit hyperactivity disorder in childhood
    Amanda Ode
    Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    PLoS ONE 9:e95891. 2014
    ..The association between exposure to perfluorinated compounds (PFCs) and attention deficit hyperactivity disorder (ADHD) diagnosis has been sparsely investigated in humans and the findings are inconsistent...
  16. doi request reprint Determinants of maternal and fetal exposure and temporal trends of perfluorinated compounds
    Amanda Ode
    Division of Occupational and Environmental Medicine, Lund University, 221 85, Lund, Sweden
    Environ Sci Pollut Res Int 20:7970-8. 2013
    ..Our results demonstrate that maternal country of origin, parity, and gestational age might be associated with PFC exposure...
  17. doi request reprint Screening method using selected reaction monitoring for targeted proteomics studies of nasal lavage fluid
    Harriet Mortstedt
    Department of Laboratory Medicine, Lund, Division of Occupational and Environmental Medicine, Lund University, SE 221 85 Lund, Sweden
    J Proteome Res 12:234-47. 2013
    ..In conclusion, a high throughput screening method for relative quantification of 244 NLF proteins was developed. The method should be of general use in any proteomic study of the upper airways...
  18. doi request reprint Identification of covalent binding sites of phthalic anhydride in human hemoglobin
    Marina C Jeppsson
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, SE 221 85 Lund, Sweden
    Chem Res Toxicol 21:2156-63. 2008
    ..It was also found that PA differs in its binding site as compared to hexahydrophthalic anhydride. The result of this study suggests several interesting applications of biological monitoring...
  19. doi request reprint Time-dependent proteomic iTRAQ analysis of nasal lavage of hairdressers challenged by persulfate
    Monica H Kåredal
    Department of Laboratory Medicine, Lund University, SE 221 85 Lund, Sweden
    J Proteome Res 9:5620-8. 2010
    ..Our results suggest there may be differences between the mechanisms responsible for the rhinitis in the symptomatic and atopic group...
  20. ncbi request reprint A survey of airborne isocyanate exposure in 13 Swedish polyurethane industries
    Carl J Sennbro
    Department of Occupational and Environmental Medicine, University Hospital, SE 221 85 Lund, Sweden
    Ann Occup Hyg 48:405-14. 2004
    ..Isocyanic acid, which could not be sampled by the 2MP method used for personal monitoring, was found by short-term stationary monitoring in levels up to 38 p.p.b. in the flame lamination plants...
  21. ncbi request reprint N-nitrosamines in the southern Swedish rubber industries - exposure, health effects, and immunologic markers
    Lena S Jönsson
    Division of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Scand J Work Environ Health 35:203-11. 2009
    ..The aim of this study was twofold: (i) to evaluate the air levels of N-nitrosamines in the Swedish rubber industry and (ii) to estimate the risk of symptoms and changed levels of immunologic markers in relation to these levels...
  22. ncbi request reprint Underestimation of toluene diisocyanate concentration using long-term sampling with 1-(2-methoxyphenyl) piperazine impregnated filters
    Christian Mattsson
    Department of Occupational and Environmental Medicine, University Hospital, SE 21133 Lund, Sweden
    Int J Hyg Environ Health 211:458-62. 2008
    ..For a 4-h sampling, the air levels were calculated to underestimate the exposure for 2,4-TDI by a factor of 1.4 and for 2,6-TDI by a of factor 1.3. The calculated underestimation was lower than earlier reported...
  23. doi request reprint Identification of covalent binding sites of ethyl 2-cyanoacrylate, methyl methacrylate and 2-hydroxyethyl methacrylate in human hemoglobin using LC/MS/MS techniques
    Marina C Jeppsson
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, SE 221 85 Lund, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 878:2474-82. 2010
    ..The adducted peptides were possible to measure using LC/MS/MS in selected reaction monitoring mode. These peptides may be used for biological monitoring of exposure to ECA, MMA and HEMA...
  24. ncbi request reprint Analysis of phenoxyacetic acid herbicides as biomarkers in human urine using liquid chromatography/triple quadrupole mass spectrometry
    Christian H Lindh
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, Lund, Sweden
    Rapid Commun Mass Spectrom 22:143-50. 2008
    ..After exposure, between 90 and 101% of the dose was recovered in the urine. In the female subject, 23%, and in the male subject 17%, of MCPA was excreted as HMCPA...
  25. ncbi request reprint Evaluation of an immunoaffinity extraction column for enrichment of adducts between human serum albumin and hexahydrophthalic anhydride in plasma
    Gunvor A Johannesson
    Department of Laboratory Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Biomed Chromatogr 22:327-32. 2008
    ..15-1.2 nmol conjugate. The evaluation showed that the IAE column had adequate affinity towards the HHPA adducts and that the adducts could be extracted with good recovery and precision from a large volume of plasma...
  26. ncbi request reprint Development, validation and characterization of an analytical method for the quantification of hydrolysable urinary metabolites and plasma protein adducts of 2,4- and 2,6-toluene diisocyanate, 1,5-naphthalene diisocyanate and 4,4'-methylenediphenyl diisoc
    Carl Johan Sennbro
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, Lund, Sweden
    Biomarkers 8:204-17. 2003
    ..74-0.90. The methods presented here will be valuable for the development of biological monitoring methods for diisocyanates...
  27. ncbi request reprint Characterization of adducts formed between human serum albumin and the butadiene metabolite epoxybutanediol
    Christian H Lindh
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Rapid Commun Mass Spectrom 19:2488-96. 2005
    ..Eight of the adducted peptides could be detected in tryptic digests of the 1:0.1 HSA/EBD conjugate...
  28. doi request reprint High-throughput method for the analysis of ethylenethiourea with direct injection of hydrolysed urine using online on-column extraction liquid chromatography and triple quadrupole mass spectrometry
    Eva Ekman
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Faculty of Medicine, Lund University, SE 221 85 Lund, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 934:53-9. 2013
    ..The results show an estimated half-life of ETU between 34 and 72h. Although the experiment is limited to two individuals, the data provide valuable and new information regarding the toxicokinetics of ETU after dermal exposure. ..
  29. doi request reprint N-nitrosamines are associated with shorter telomere length
    Huiqi Li
    Section of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Scand J Work Environ Health 37:316-24. 2011
    ..Aiming to examine the relationship between DNA-damaging agents and average telomere length in peripheral blood, we conducted a cross-sectional study among 157 workers working in the rubber industry in Sweden...
  30. ncbi request reprint Biomarkers of exposure in Monday morning urine samples as a long-term measure of exposure to aromatic diisocyanates
    Håkan Tinnerberg
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, Lund University, S 221 85, Lund, Sweden
    Int Arch Occup Environ Health 87:365-72. 2014
    ....
  31. ncbi request reprint Determination of hexahydrophthalic anhydride adducts to human serum albumin
    Monica H Kristiansson
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, SE 221 85 Lund, Sweden
    Biomarkers 8:343-59. 2003
    ..This knowledge generates the possibility of developing methods for the biological monitoring of HHPA exposure by analysing tryptic peptides including these binding sites...
  32. pmc A nested case-control study of intrauterine exposure to persistent organochlorine pollutants and the risk of hypospadias
    Anna Rignell-Hydbom
    Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    PLoS ONE 7:e44767. 2012
    ..The aim of this case-control study was to investigate the association between fetal exposure to persistent organochlorine pollutants (POP) and the risk for hypospadias...
  33. doi request reprint Time trends between 1987 and 2007 for perfluoroalkyl acids in plasma from Swedish women
    Anna Axmon
    Department of Occupational and Environmental Medicine, Lund University, SE 221 85 Lund, Sweden Electronic address
    Chemosphere 102:61-7. 2014
    ..73 ng mL(-1), 0.28 ng mL(-1), and 0.24 ng mL(-1), respectively, during the last study period...
  34. ncbi request reprint Exposure-response relationships for hexahydrophthalic and methylhexahydrophthalic anhydrides with total plasma protein adducts as biomarkers
    Seema Rosqvist
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, Lund, Sweden
    Scand J Work Environ Health 29:297-303. 2003
    ....
  35. doi request reprint Chronic exposure to cadmium and arsenic strongly influences concentrations of 8-oxo-7,8-dihydro-2'-deoxyguanosine in urine
    Karin S Engström
    Section of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, 221 85 Lund, Sweden
    Free Radic Biol Med 48:1211-7. 2010
    ..0026, p=0.004), and plasma Ft (beta=0.20, p< 0.001). A joint effect was seen for urinary Cd and As, but whether this effect was additive or multiplicative was difficult to discern...
  36. ncbi request reprint Mass spectrometric characterization of human hemoglobin adducts formed in vitro by hexahydrophthalic anhydride
    Monica H Kristiansson
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, SE 221 85 Lund, Sweden
    Chem Res Toxicol 15:562-9. 2002
    ..These results will constitute a basis for studies on structure-activity relationships as well as for development of methods for biological monitoring of acid anhydrides...
  37. ncbi request reprint Human biological monitoring of suspected endocrine-disrupting compounds
    Moosa Faniband
    Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Asian J Androl 16:5-16. 2014
    ..The aspects discussed are origin to exposure, metabolism, matrices to analyse, analytical determination methods, determinants, and time trends...