Deniz Kirik

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Localized striatal delivery of GDNF as a treatment for Parkinson disease
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 22184 Lund, Sweden
    Nat Neurosci 7:105-10. 2004
  2. ncbi request reprint Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke
    Elin Gustafsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University of Lund, BMC A 11 SE 221 84 Lund, Sweden
    Eur J Neurosci 17:2667-78. 2003
  3. ncbi request reprint Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11 SE 221 84, Lund, Sweden
    Neurobiol Dis 14:542-56. 2003
  4. doi request reprint Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain
    Lachlan H Thompson
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Eur J Neurosci 30:625-38. 2009
  5. ncbi request reprint Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer
    Biljana Georgievska
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 221 84, Lund, Sweden
    Exp Neurol 177:461-74. 2002
  6. doi request reprint Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors
    Sanaz Gabery
    Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden
    Eur J Neurosci 36:2789-800. 2012
  7. ncbi request reprint Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections
    Lachlan Thompson
    Wallenberg Neuroscience Center, Department of Experimental Medical Research, Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, SE 221 84 Lund, Sweden
    J Neurosci 25:6467-77. 2005
  8. ncbi request reprint Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector
    Biljana Georgievska
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Sweden
    Neuroreport 13:75-82. 2002
  9. pmc Presynaptic dopaminergic compartment determines the susceptibility to L-DOPA-induced dyskinesia in rats
    Ayse Ulusoy
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, BMC D11, 22184 Lund, Sweden
    Proc Natl Acad Sci U S A 107:13159-64. 2010
  10. doi request reprint Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration
    Thomas Carlsson
    Department Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC D11, Lund, Sweden
    Brain 132:319-35. 2009

Detail Information

Publications74

  1. ncbi request reprint Localized striatal delivery of GDNF as a treatment for Parkinson disease
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 22184 Lund, Sweden
    Nat Neurosci 7:105-10. 2004
  2. ncbi request reprint Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke
    Elin Gustafsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University of Lund, BMC A 11 SE 221 84 Lund, Sweden
    Eur J Neurosci 17:2667-78. 2003
    ..Concomitantly, brain-derived neurotrophic factor potentiates the stroke-induced neurogenic response, at least at early stages...
  3. ncbi request reprint Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11 SE 221 84, Lund, Sweden
    Neurobiol Dis 14:542-56. 2003
    ..Our findings also underscore the need for quantitative assessment of long-term neuronal survival and behavioral changes to evaluate the therapeutic potential of factors such as GDNF...
  4. doi request reprint Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain
    Lachlan H Thompson
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Eur J Neurosci 30:625-38. 2009
    ..Results from testing of amphetamine-induced rotational behaviour suggest, moreover, that dopamine neurons implanted into the substantia nigra are also capable of integrating into the host circuitry at the functional level...
  5. ncbi request reprint Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer
    Biljana Georgievska
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 221 84, Lund, Sweden
    Exp Neurol 177:461-74. 2002
    ....
  6. doi request reprint Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors
    Sanaz Gabery
    Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden
    Eur J Neurosci 36:2789-800. 2012
    ....
  7. ncbi request reprint Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections
    Lachlan Thompson
    Wallenberg Neuroscience Center, Department of Experimental Medical Research, Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, SE 221 84 Lund, Sweden
    J Neurosci 25:6467-77. 2005
    ....
  8. ncbi request reprint Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector
    Biljana Georgievska
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Sweden
    Neuroreport 13:75-82. 2002
    ..Sprouting of the lesioned axons was observed along the nigrostriatal pathway, precisely corresponding to the areas containing anterogradely transported GDNF...
  9. pmc Presynaptic dopaminergic compartment determines the susceptibility to L-DOPA-induced dyskinesia in rats
    Ayse Ulusoy
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, BMC D11, 22184 Lund, Sweden
    Proc Natl Acad Sci U S A 107:13159-64. 2010
    ..Taken together, these data provide direct evidence that the status of the presynaptic, DA releasing compartment is a critical determinant of both the induction and maintenance of L-DOPA-induced dyskinesias...
  10. doi request reprint Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration
    Thomas Carlsson
    Department Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC D11, Lund, Sweden
    Brain 132:319-35. 2009
    ....
  11. ncbi request reprint Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector
    Biljana Georgievska
    Division of Neurobiology, Department of Physiological Sciences, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
    Hum Gene Ther 15:934-44. 2004
    ..Accordingly, TH protein expression returned to normal by 2-8 weeks after removal of doxycycline, indicating that GDNF-induced downregulation of TH is a reversible event...
  12. ncbi request reprint Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse
    Perrine Barraud
    Wallenberg Neuroscience Center, BMC A11, Section of Neurobiology, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, University, SE 221 84 Lund, Sweden
    Eur J Neurosci 22:1555-69. 2005
    ..Thus, not all Sox1-GFP cells possess the same capacity for neuronal differentiation in vivo...
  13. ncbi request reprint Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors
    Thomas Carlsson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
    Brain 128:559-69. 2005
    ..These findings form a strong basis for replacing, or supplementing, conventional systemic L-DOPA therapy by continuous intrastriatal DOPA using in vivo gene transfer in the treatment of patients with advanced Parkinson's disease...
  14. doi request reprint Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
    Ana Munoz
    Department of Experimental Medical Science, Neurobiology Unit, Wallenberg Neuroscience Center, University of Lund, Lund, Sweden
    Brain 131:3380-94. 2008
    ..Our results support the importance of a clinical investigation of the effect of 5-HT(1A) and 5-HT(1B) agonists, particularly in combination, in dyskinetic l-DOPA-treated Parkinson's disease patients...
  15. pmc Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, BMC A11, 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 100:2884-9. 2003
    ..This model offers new opportunities for the study of pathogenetic mechanisms and exploration of new therapeutic targets of particular relevance to human PD...
  16. doi request reprint Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats
    Tomas Bjorklund
    Department of Experimental Medical Science, Lund University, Brain Repair and Imaging in Neural Systems, Lund, Sweden
    J Neurochem 111:355-67. 2009
    ..Importantly, the BH4 synthesis from ectopic GCH1 expression was saturable, yielding optimal TH enzyme functionality between GCH1 : TH ratios of 1 : 3 and 1 : 7...
  17. ncbi request reprint Applications of lentiviral vectors for biology and gene therapy of neurological disorders
    Cecilia Lundberg
    Department of Experimental Medical Science, Lund University, BMC D11, 22184, Lund, Sweden
    Curr Gene Ther 8:461-73. 2008
    ..Moreover, the potential of these vectors in the development of gene therapy to treat neurological disorders is considerable, which is supported by the fact that clinical trials using rLVs are underway...
  18. ncbi request reprint Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression
    Matthew Maingay
    Department of Experimental Medical Science, Section of Neuroscience, CNS Disease Modeling Unit, Lund University, Wallenberg Neuroscience Center, BMCA11, S 22184 Lund, Sweden
    Neurobiol Dis 23:522-32. 2006
    ....
  19. pmc Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectors
    Hélène Hall
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, Lund, Sweden
    PLoS ONE 8:e64844. 2013
    ....
  20. pmc The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease
    Shane Grealish
    Wallenberg Neuroscience Centre, Lund University, Lund, Sweden
    Brain 133:482-95. 2010
    ..Furthermore, the results have interesting implications for current efforts in this field to generate well-characterized and standardized preparations of transplantable dopamine neuronal progenitors from stem cells...
  21. pmc Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease
    Tomas Bjorklund
    Brain Repair and Imaging in Neural Systems, 22184 Lund, Sweden
    Brain 133:496-511. 2010
    ..Taken together these results show that vector-mediated continuous 3,4-dihydroxyphenylalanine delivery has the potential to provide significant symptomatic relief even in advanced stages of Parkinson's disease...
  22. doi request reprint Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Mov Disord 25:S174-9. 2010
    ....
  23. ncbi request reprint Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor
    Biljana Georgievska
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, 22184, Lund, Sweden
    Eur J Neurosci 20:3121-30. 2004
    ....
  24. doi request reprint Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease
    Ayse Ulusoy
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Prog Brain Res 184:89-111. 2010
    ....
  25. ncbi request reprint Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
    Thomas Carlsson
    CNS Disease Modeling Unit, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    J Neurosci 27:8011-22. 2007
    ..We conclude that serotonin neurons in the grafts are likely to have a detrimental effect on L-DOPA-induced dyskinesias in cases in which the grafts contain no or few dopamine neurons...
  26. doi request reprint Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain
    Lachlan H Thompson
    Division of Neurobiology, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, S 22184 Lund, Sweden
    Exp Neurol 213:220-8. 2008
    ....
  27. pmc Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons
    Ayse Ulusoy
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Mol Ther 17:1574-84. 2009
    ..Our results have implications for both mechanistic and therapeutic studies utilizing long-term shRNA-mediated gene silencing in the nigrostriatal projection system...
  28. ncbi request reprint Targeted in utero delivery of a retroviral vector for gene transfer in the rodent brain
    Simon R W Stott
    CNS Disease Modelling Unit, Section of Neuroscience, Department of Experimental Medical Science, Lund University, Sweden
    Eur J Neurosci 24:1897-906. 2006
    ..5. Delivery into later embryos resulted in a reduction in neuronal profiles with a reciprocal increase in glial cells...
  29. ncbi request reprint The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease
    Nathalie Breysse
    Central Nervous System Disease Modeling Unit, Section for Neuroscience, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    J Neurosci 27:5849-56. 2007
    ....
  30. ncbi request reprint Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes
    Natalija Popovic
    Section for Neuronal Survival, Division of Neurobiology, Department of Physiological Sciences, Wallenberg Neuroscience Center, Lund University, BMC A10, Sweden
    Exp Neurol 193:65-74. 2005
    ..Further studies are, however, needed to investigate if GDNF given at earlier time points is beneficial...
  31. ncbi request reprint Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 22184 Lund, Sweden
    Trends Neurosci 26:386-92. 2003
    ..Targeted overexpression of disease-causing genes by recombinant viral vectors provides a new and highly flexible approach for in vivo modeling of neurodegenerative diseases, not only in mice and rats but also in primates...
  32. doi request reprint Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Prog Brain Res 172:465-78. 2008
    ..Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication...
  33. ncbi request reprint L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson's disease: relation to motor and cellular parameters of nigrostriatal function
    Christian Winkler
    Department of Physiological Sciences, Neurobiology Division, Wallenberg Neuroscience Center, Lund University, BMC A11, S 221 84, Lund, Sweden
    Neurobiol Dis 10:165-86. 2002
    ....
  34. ncbi request reprint Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia
    Thomas Carlsson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, 221 84, Lund, Sweden
    Neurobiol Dis 21:657-68. 2006
    ..The results indicate that graft-induced dyskinesias in PD patients may be linked to single, small graft deposits that provide an uneven, patchy reinnervation of the putamen...
  35. doi request reprint Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model
    Ana Munoz
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Exp Neurol 219:298-307. 2009
    ....
  36. ncbi request reprint Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system
    Biljana Georgievska
    Department of Physiological Sciences, Division of Neurobiology, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
    J Neurosci 24:6437-45. 2004
    ..This compensatory mechanism is proposed to maintain long-term DA neuron function within the normal range...
  37. doi request reprint Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits
    Sofia Hult
    Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden
    Cell Metab 13:428-39. 2011
    ....
  38. ncbi request reprint Viral vector mediated overexpression of human alpha-synuclein in the nigrostriatal dopaminergic neurons: a new model for Parkinson's disease
    Matthew Maingay
    Division of Neurobiology, Wallenberg Neurocenter, Lund University, Sweden
    CNS Spectr 10:235-44. 2005
    ....
  39. pmc Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease
    Erik Cederfjäll
    Brain Repair and Imaging in Neural Systems B R A I N S Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Sci Rep 3:2157. 2013
    ..In the TH-GCH1 group, GCH1 expression was robust but TH was not detectable. Moreover, TH-GCH1 treatment did not result in functional improvement in non-human primates. ..
  40. ncbi request reprint Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts
    Andreas Toft Sørensen
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A 11, Lund University, Lund, Sweden
    Eur J Neurosci 21:2793-9. 2005
    ..Our findings define specific electrophysiological characteristics of transplanted fetal dopaminergic neurons, and we provide the first direct evidence of functional synaptic integration of these neurons into host neural circuitries...
  41. ncbi request reprint Brain area, age and viral vector-specific glial cell-line-derived neurotrophic factor expression and transport in rat
    Irene Kanter-Schlifke
    Experimental Epilepsy Group, Section for Neuroscience, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A 11, Lund University, Lund, Sweden
    Neuroreport 18:845-50. 2007
    ....
  42. ncbi request reprint Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11 22466, Lund, Sweden
    Brain 128:1478-9. 2005
  43. doi request reprint Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology
    Ayse Ulusoy
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Eur J Neurosci 32:409-22. 2010
    ..Taken together these data suggest that C-terminal truncated alphasyn can interact with and exacerbate the formation of pathological accumulations containing alphasynFL in vivo...
  44. pmc Design of a single AAV vector for coexpression of TH and GCH1 to establish continuous DOPA synthesis in a rat model of Parkinson's disease
    Erik Cederfjäll
    Brain Repair and Imaging in Neural Systems B R A I N S Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Mol Ther 20:1315-26. 2012
    ..This is a favorable starting point for continued translation toward a therapeutic application, although future studies need to carefully review target region, vector spread and dilution with this approach...
  45. doi request reprint Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons
    Ayse Ulusoy
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, BMC D11, Lund, Sweden
    Neurobiol Dis 47:367-77. 2012
    ....
  46. ncbi request reprint Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, 221 84, Lund, Sweden
    J Neurosci 22:2780-91. 2002
    ..Targeted overexpression of alpha-synuclein in the nigrostriatal system may provide a new animal model of Parkinson's disease that reproduces some of the cardinal pathological, neurochemical, and behavioral features of the human disease...
  47. ncbi request reprint Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Brain 130:1819-33. 2007
    ....
  48. doi request reprint Key factors determining the efficacy of gene therapy for continuous DOPA delivery in the Parkinsonian brain
    Erik Cederfjäll
    Brain Repair and Imaging in Neural Systems B R A I N S Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Neurobiol Dis 48:222-7. 2012
    ....
  49. doi request reprint Gene therapy for dopamine replacement
    Tomas Bjorklund
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Prog Brain Res 184:221-35. 2010
    ....
  50. ncbi request reprint Restoration of the striatal dopamine synthesis for Parkinson's disease: viral vector-mediated enzyme replacement strategy
    Thomas Carlsson
    CNS Disease Modeling Unit, Department of Experimental Medical Science, Lund University, BMC A11, 221 84 Lund, Sweden
    Curr Gene Ther 7:109-20. 2007
    ....
  51. ncbi request reprint In vivo gene delivery for development of mammalian models for Parkinson's disease
    Ayse Ulusoy
    CNS Disease Modeling Unit, Section of Neuroscience, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Exp Neurol 209:89-100. 2008
    ....
  52. doi request reprint Involvement of the serotonin system in L-dopa-induced dyskinesias
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Parkinsonism Relat Disord 14:S154-8. 2008
    ..These findings make the serotonin system an intriguing target for anti-dyskinetic therapies...
  53. ncbi request reprint Development of advanced therapies based on viral vector-mediated overexpression of therapeutic molecules and knockdown of disease-related genes for Parkinson's disease
    Ayse Ulusoy
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    Ther Deliv 2:37-50. 2011
    ..Gene therapy is now becoming a reality in the clinics and developments in the next decade will help uncover the true potential of this approach for not only the treatment of PD patients, but also many other neurological disorders...
  54. doi request reprint In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway
    Dwain K Irvin
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A 11, SE 22184 Lund, Sweden
    Neurobiol Dis 30:343-52. 2008
    ..Noggin transduction did not result in the generation of new neurons, but interestingly, greatly increased the number of oligodendrocytes generated from newborn cells...
  55. doi request reprint Changes in key hypothalamic neuropeptide populations in Huntington disease revealed by neuropathological analyses
    Sanaz Gabery
    Department of Experimental Medical Sciences, Lund University, Sweden
    Acta Neuropathol 120:777-88. 2010
    ..They may be important in the development of psychiatric symptoms and metabolic disturbances in HD, and may provide potential targets for therapeutic interventions...
  56. doi request reprint Gene therapy for dopamine replacement in Parkinson's disease
    Anders Bjorklund
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Sci Transl Med 1:2ps2. 2009
    ..Now, a team of French and UK researchers reports promising results in a nonhuman primate model of PD, paving the way for clinical trials of this enzyme-replacement approach...
  57. ncbi request reprint Seizure suppression by GDNF gene therapy in animal models of epilepsy
    Irene Kanter-Schlifke
    Experimental Epilepsy Group, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    Mol Ther 15:1106-13. 2007
    ....
  58. doi request reprint Scientific rationale for the development of gene therapy strategies for Parkinson's disease
    Tomas Bjorklund
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Biochim Biophys Acta 1792:703-13. 2009
    ....
  59. pmc Murine models of acute neuronopathic Gaucher disease
    Ida Berglin Enquist
    Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine and the Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC A12, 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 104:17483-8. 2007
    ..These findings also demonstrate that normal microglial cells cannot rescue this neurodegenerative disease. These mouse models have significant implications for the development of therapy for patients with neuronopathic GD...
  60. doi request reprint Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory
    Liselijn A B Wisman
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden
    J Neurosci 28:7797-807. 2008
    ..Thus, further analyses of cholinergic alterations may prove useful in better understanding the cognitive symptoms in Parkinson's disease...
  61. pmc Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis
    Charlotte Soneson
    Centre for Mathematical Sciences, Lund University, Sweden
    Neurobiol Dis 40:531-43. 2010
    ..In conclusion, our study shows, for the first time, that alterations in grey matter contents in the hypothalamic region occur at least a decade before clinical diagnosis in HD using MRI...
  62. ncbi request reprint Imaging in cell-based therapy for neurodegenerative diseases
    Deniz Kirik
    Section for Neuroscience, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Disease Modeling Group, Lund University, BMC A11, 22184, Lund, Sweden
    Eur J Nucl Med Mol Imaging 32:S417-34. 2005
    ..The ultimate goal will be to use the combination of multiple imaging modalities for complete functional monitoring of the repair processes in the central nervous system...
  63. doi request reprint Development of NMR spectroscopic methods for dynamic detection of acetylcholine synthesis by choline acetyltransferase in hippocampal tissue
    Hélène Hall
    Brain Repair and Imaging in Neural Systems B R A I N S, BMC D11, Department of Experimental Medical Science, Lund University, Lund, Sweden
    J Neurochem 124:336-46. 2013
    ..This method may be adapted to assess the state of the cholinergic system in the brain in vivo in a non-invasive manner using NMR spectroscopic techniques...
  64. doi request reprint Is alpha-synuclein the culprit of the Parkinsonian neurodegeneration?
    Deniz Kirik
    Exp Neurol 209:3-4. 2008
  65. ncbi request reprint Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease
    Andisheh Eslamboli
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:769-77. 2005
    ..We conclude that when delivered continuously, a low level of GDNF in the striatum (approximately threefold above baseline) is sufficient to provide optimal functional outcome...
  66. ncbi request reprint Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain
    Andisheh Eslamboli
    Department of Experimental Psychology, Downing Street, Cambridge, UK
    Brain 130:799-815. 2007
    ....
  67. ncbi request reprint Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system
    Carl Rosenblad
    NsGene A S, Ballerup, Denmark
    Eur J Neurosci 17:260-70. 2003
    ....
  68. doi request reprint Can overexpression of parkin provide a novel strategy for neuroprotection in Parkinson's disease?
    Ayse Ulusoy
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, BMC D11, 22184, Lund University, Lund, Sweden
    Exp Neurol 212:258-60. 2008
    ....
  69. ncbi request reprint Cell transplantation in Parkinson's disease: how can we make it work?
    Christian Winkler
    Department of Neurology, Hannover Medical School, 30625 Hannover, Germany
    Trends Neurosci 28:86-92. 2005
    ....
  70. pmc Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, BMC A11, S 221 84, Lund, Sweden
    Proc Natl Acad Sci U S A 99:4708-13. 2002
    ....
  71. ncbi request reprint Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus)
    Andisheh Eslamboli
    Department of Experimental Psychology, Downing Street, University of Cambridge, CB2 3EB, Cambridge, UK
    Exp Neurol 184:536-48. 2003
    ..Therefore, our study provides evidence for the behavioural and anatomical efficacy of GDNF delivered via an rAAV vector as a possible treatment for Parkinson's disease...
  72. ncbi request reprint An investigation of the problem of two-layered immunohistochemical staining in paraformaldehyde fixed sections
    Eduardo M Torres
    Cardiff University, School of Biosciences, Museum Avenue, Cardiff CF10 3US, United Kingdom
    J Neurosci Methods 158:64-74. 2006
    ..The present investigation contributes to the development of new fixation protocols, optimised for use in both immunohistochemical methods and morphometric analyses...
  73. ncbi request reprint Neuronal replacement from endogenous precursors in the adult brain after stroke
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    Nat Med 8:963-70. 2002
    ..If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans...
  74. doi request reprint Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion
    Jens M Nygren
    Hematopoietic Stem Cell Laboratory, Lund University, BMC B10, Klinikgatan 26, 221 84 Lund, Sweden
    Nat Cell Biol 10:584-92. 2008
    ..Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation...