Research Topics
| D KirikSummaryAffiliation: Lund University Country: Sweden Publications
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Publications
Growth and functional efficacy of intrastriatal nigral transplants depend on the extent of nigrostriatal degenerationD Kirik
Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, 22184, Lund, Sweden
J Neurosci 21:2889-96. 2001..These data have implications for the optimal use of fetal nigral transplants in Parkinson patients in different stages of the disease...- Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectorsDeniz Kirik
Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 22184 Lund, Sweden
Trends Neurosci 26:386-92. 2003..Targeted overexpression of disease-causing genes by recombinant viral vectors provides a new and highly flexible approach for in vivo modeling of neurodegenerative diseases, not only in mice and rats but also in primates... 
Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's diseaseDeniz Kirik
Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, BMC A11, 221 84 Lund, Sweden
Proc Natl Acad Sci U S A 100:2884-9. 2003..This model offers new opportunities for the study of pathogenetic mechanisms and exploration of new therapeutic targets of particular relevance to human PD...- Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's diseaseD Kirik
Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 221 84 Lund, Sweden
Eur J Neurosci 13:1589-99. 2001.... - Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factorD Kirik
Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, 223 62 Lund, Sweden
Eur J Neurosci 12:3871-82. 2000.... - Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal systemD Kirik
Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, 223 62 Lund, Sweden
J Neurosci 20:4686-700. 2000..GDNF transgene expression was maintained at high levels throughout this period. These results provide evidence that rAAV is a highly efficient vector system for long-term expression of therapeutic proteins in the nigrostriatal system... - Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricleC Rosenblad
Department of Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Sweden
Eur J Neurosci 11:1554-66. 1999..The lower efficacy of NTN after IS, and particularly ICV, administration may be explained by the poor solubility and diffusion properties at neutral pH... - Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson modelA Bjorklund
Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Solvegatan 17, S 22362, Lund, Sweden
Brain Res 886:82-98. 2000.... - Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion modelC Rosenblad
Wallenberg Neuroscience Center, Department of Physiology, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
Exp Neurol 161:503-16. 2000..We conclude that functional recovery in the partial lesion model depends not only on preservation of the nigral cell bodies, but more critically on the ability of GDNF to promote significant reinnervation of the denervated striatum... - Continuous exposure to glial cell line-derived neurotrophic factor to mature dopaminergic transplants impairs the graft's ability to improve spontaneous motor behavior in parkinsonian ratsC Winkler
Department of Experimental Medical Science, Section of Neuroscience, CNS Disease Modeling Unit, Lund University, BMCA11, S-22184 Lund, Sweden
Neuroscience 141:521-31. 2006..Since rather low doses of glial cell line-derived neurotrophic factor at nanogram levels appear to saturate these effects, it may be critical to adjust GDNF levels using tightly regulated gene expression systems... - In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/arteminC Rosenblad
Wallenberg Neuroscience Center, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
Mol Cell Neurosci 15:199-214. 2000..We conclude that NBN/ART, similarly to GDNF, is a potent neuroprotective factor for the nigrostriatal DA neurons in vivo... - Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's diseaseM Lundblad
Department of Physiological Sciences, Wallenberg Neuroscience Centre, Neurobiology Division, Lund University, BMC A11, S-221 84 Lund, Sweden
Eur J Neurosci 15:120-32. 2002..Such deficits can be quantified using novel and relatively simple testing procedures, whereas rotometry cannot discriminate between dyskinetic and antiakinetic effects of antiparkinsonian treatments... 
Can overexpression of parkin provide a novel strategy for neuroprotection in Parkinson's disease?Ayse Ulusoy
Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, BMC D11, 22184, Lund University, Lund, Sweden
Exp Neurol 212:258-60. 2008....- Seizure suppression by GDNF gene therapy in animal models of epilepsyIrene Kanter-Schlifke
Experimental Epilepsy Group, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
Mol Ther 15:1106-13. 2007.... - Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrainAndisheh Eslamboli
Department of Experimental Psychology, Downing Street, Cambridge, UK
Brain 130:799-815. 2007.... - Targeted in utero delivery of a retroviral vector for gene transfer in the rodent brainSimon R W Stott
CNS Disease Modelling Unit, Section of Neuroscience, Department of Experimental Medical Science, Lund University, Sweden
Eur J Neurosci 24:1897-906. 2006..5. Delivery into later embryos resulted in a reduction in neuronal profiles with a reciprocal increase in glial cells... - Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpressionMatthew Maingay
Department of Experimental Medical Science, Section of Neuroscience, CNS Disease Modeling Unit, Lund University, Wallenberg Neuroscience Center, BMCA11, S 22184 Lund, Sweden
Neurobiol Dis 23:522-32. 2006.... - An investigation of the problem of two-layered immunohistochemical staining in paraformaldehyde fixed sectionsEduardo M Torres
Cardiff University, School of Biosciences, Museum Avenue, Cardiff CF10 3US, United Kingdom
J Neurosci Methods 158:64-74. 2006..The present investigation contributes to the development of new fixation protocols, optimised for use in both immunohistochemical methods and morphometric analyses... - Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesiaThomas Carlsson
Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, 221 84, Lund, Sweden
Neurobiol Dis 21:657-68. 2006..The results indicate that graft-induced dyskinesias in PD patients may be linked to single, small graft deposits that provide an uneven, patchy reinnervation of the putamen... - Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mousePerrine Barraud
Wallenberg Neuroscience Center, BMC A11, Section of Neurobiology, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, University, SE-221 84 Lund, Sweden
Eur J Neurosci 22:1555-69. 2005..Thus, not all Sox1-GFP cells possess the same capacity for neuronal differentiation in vivo... - Restoration of the striatal dopamine synthesis for Parkinson's disease: viral vector-mediated enzyme replacement strategyThomas Carlsson
CNS Disease Modeling Unit, Department of Experimental Medical Science, Lund University, BMC A11, 221 84 Lund, Sweden
Curr Gene Ther 7:109-20. 2007.... - Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian ratsManolo Carta
Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
Brain 130:1819-33. 2007.... - Brain area, age and viral vector-specific glial cell-line-derived neurotrophic factor expression and transport in ratIrene Kanter Schlifke
Experimental Epilepsy Group, Section for Neuroscience, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A 11, Lund University, Lund, Sweden
Neuroreport 18:845-50. 2007.... - In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathwayDwain K Irvin
Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A 11, SE 22184 Lund, Sweden
Neurobiol Dis 30:343-52. 2008..Noggin transduction did not result in the generation of new neurons, but interestingly, greatly increased the number of oligodendrocytes generated from newborn cells... - Is alpha-synuclein the culprit of the Parkinsonian neurodegeneration?Deniz Kirik
Exp Neurol 209:3-4. 2008 - In vivo gene delivery for development of mammalian models for Parkinson's diseaseAyse Ulusoy
CNS Disease Modeling Unit, Section of Neuroscience, Department of Experimental Medical Science, Lund University, Lund, Sweden
Exp Neurol 209:89-100. 2008.... - Murine models of acute neuronopathic Gaucher diseaseIda Berglin Enquist
Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine and the Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC A12, 221 84 Lund, Sweden
Proc Natl Acad Sci U S A 104:17483-8. 2007..These findings also demonstrate that normal microglial cells cannot rescue this neurodegenerative disease. These mouse models have significant implications for the development of therapy for patients with neuronopathic GD... - Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brainLachlan H Thompson
Division of Neurobiology, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, S 22184 Lund, Sweden
Exp Neurol 213:220-8. 2008.... - Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's diseaseThomas Carlsson
CNS Disease Modeling Unit, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
J Neurosci 27:8011-22. 2007..We conclude that serotonin neurons in the grafts are likely to have a detrimental effect on L-DOPA-induced dyskinesias in cases in which the grafts contain no or few dopamine neurons... - Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memoryLiselijn A B Wisman
Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden
J Neurosci 28:7797-807. 2008..Thus, further analyses of cholinergic alterations may prove useful in better understanding the cognitive symptoms in Parkinson's disease... - The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing diseaseNathalie Breysse
Central Nervous System Disease Modeling Unit, Section for Neuroscience, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
J Neurosci 27:5849-56. 2007.... - Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projectionsLachlan Thompson
Wallenberg Neuroscience Center, Department of Experimental Medical Research, Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, SE 221 84 Lund, Sweden
J Neurosci 25:6467-77. 2005.... - Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising resultsDeniz Kirik
Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11 22466, Lund, Sweden
Brain 128:1478-9. 2005 - Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in ratsAndreas Arvidsson
Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11 SE 221 84, Lund, Sweden
Neurobiol Dis 14:542-56. 2003..Our findings also underscore the need for quantitative assessment of long-term neuronal survival and behavioral changes to evaluate the therapeutic potential of factors such as GDNF... - Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus)Andisheh Eslamboli
Department of Experimental Psychology, Downing Street, University of Cambridge, CB2 3EB, Cambridge, UK
Exp Neurol 184:536-48. 2003..Therefore, our study provides evidence for the behavioural and anatomical efficacy of GDNF delivered via an rAAV vector as a possible treatment for Parkinson's disease... - Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following strokeElin Gustafsson
Section of Restorative Neurology, Wallenberg Neuroscience Center, University of Lund, BMC A 11 SE 221 84 Lund, Sweden
Eur J Neurosci 17:2667-78. 2003..Concomitantly, brain-derived neurotrophic factor potentiates the stroke-induced neurogenic response, at least at early stages... - Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine systemCarl Rosenblad
NsGene A S, Ballerup, Denmark
Eur J Neurosci 17:260-70. 2003.... - Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transferBiljana Georgievska
Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 221 84, Lund, Sweden
Exp Neurol 177:461-74. 2002.... - L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson's disease: relation to motor and cellular parameters of nigrostriatal functionChristian Winkler
Department of Physiological Sciences, Neurobiology Division, Wallenberg Neuroscience Center, Lund University, BMC A11, S-221 84, Lund, Sweden
Neurobiol Dis 10:165-86. 2002.... - Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vectorBiljana Georgievska
Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Sweden
Neuroreport 13:75-82. 2002..Sprouting of the lesioned axons was observed along the nigrostriatal pathway, precisely corresponding to the areas containing anterogradely transported GDNF... - Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal systemDeniz Kirik
Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, 221 84, Lund, Sweden
J Neurosci 22:2780-91. 2002..Targeted overexpression of alpha-synuclein in the nigrostriatal system may provide a new animal model of Parkinson's disease that reproduces some of the cardinal pathological, neurochemical, and behavioral features of the human disease... - Localized striatal delivery of GDNF as a treatment for Parkinson diseaseDeniz Kirik
Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 22184 Lund, Sweden
Nat Neurosci 7:105-10. 2004 - Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine systemBiljana Georgievska
Department of Physiological Sciences, Division of Neurobiology, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
J Neurosci 24:6437-45. 2004..This compensatory mechanism is proposed to maintain long-term DA neuron function within the normal range... - Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factorBiljana Georgievska
Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, 22184, Lund, Sweden
Eur J Neurosci 20:3121-30. 2004.... - Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal graftsAndreas Toft Sørensen
Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A 11, Lund University, Lund, Sweden
Eur J Neurosci 21:2793-9. 2005..Our findings define specific electrophysiological characteristics of transplanted fetal dopaminergic neurons, and we provide the first direct evidence of functional synaptic integration of these neurons into host neural circuitries... - Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changesNatalija Popovic
Section for Neuronal Survival, Division of Neurobiology, Department of Physiological Sciences, Wallenberg Neuroscience Center, Lund University, BMC A10, Sweden
Exp Neurol 193:65-74. 2005..Further studies are, however, needed to investigate if GDNF given at earlier time points is beneficial... - Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transferDeniz Kirik
Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, BMC A11, S-221 84, Lund, Sweden
Proc Natl Acad Sci U S A 99:4708-13. 2002.... - Viral vector mediated overexpression of human alpha-synuclein in the nigrostriatal dopaminergic neurons: a new model for Parkinson's diseaseMatthew Maingay
Division of Neurobiology, Wallenberg Neurocenter, Lund University, Sweden
CNS Spectr 10:235-44. 2005.... - Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's diseaseAndisheh Eslamboli
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 25:769-77. 2005..We conclude that when delivered continuously, a low level of GDNF in the striatum (approximately threefold above baseline) is sufficient to provide optimal functional outcome... - Cell transplantation in Parkinson's disease: how can we make it work?Christian Winkler
Department of Neurology, Hannover Medical School, 30625 Hannover, Germany
Trends Neurosci 28:86-92. 2005.... - Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectorsThomas Carlsson
Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
Brain 128:559-69. 2005..These findings form a strong basis for replacing, or supplementing, conventional systemic L-DOPA therapy by continuous intrastriatal DOPA using in vivo gene transfer in the treatment of patients with advanced Parkinson's disease... - Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vectorBiljana Georgievska
Division of Neurobiology, Department of Physiological Sciences, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
Hum Gene Ther 15:934-44. 2004..Accordingly, TH protein expression returned to normal by 2-8 weeks after removal of doxycycline, indicating that GDNF-induced downregulation of TH is a reversible event... - Imaging in cell-based therapy for neurodegenerative diseasesDeniz Kirik
Section for Neuroscience, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Disease Modeling Group, Lund University, BMC A11, 22184, Lund, Sweden
Eur J Nucl Med Mol Imaging 32:S417-34. 2005..The ultimate goal will be to use the combination of multiple imaging modalities for complete functional monitoring of the repair processes in the central nervous system... - Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusionJens M Nygren
Hematopoietic Stem Cell Laboratory, Lund University, BMC B10, Klinikgatan 26, 221 84 Lund, Sweden
Nat Cell Biol 10:584-92. 2008..Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation... - Neuronal replacement from endogenous precursors in the adult brain after strokeAndreas Arvidsson
Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
Nat Med 8:963-70. 2002..If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans...