Jenny Karlsson

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. doi request reprint Activation of human telomerase reverse transcriptase through gene fusion in clear cell sarcoma of the kidney
    Jenny Karlsson
    Department of Clinical Genetics, BMC C13, Lund University, Lund SE 221 84, Sweden Electronic address
    Cancer Lett 357:498-501. 2015
  2. doi request reprint High-resolution genomic profiling of an adult Wilms' tumor: evidence for a pathogenesis distinct from corresponding pediatric tumors
    Jenny Karlsson
    Department of Clinical Genetics, BMC B13, University and Regional Laboratories, Lund University, 221 84 Lund, Sweden
    Virchows Arch 459:547-53. 2011
  3. doi request reprint SIX1 protein expression selectively identifies blastemal elements in Wilms tumor
    Daniel Sehic
    Department of Clinical Genetics, Lund University, University and Regional Laboratories, Lund, Sweden
    Pediatr Blood Cancer 59:62-8. 2012
  4. ncbi request reprint Multidrug-resistant neuroblastoma cells are responsive to arsenic trioxide at both normoxia and hypoxia
    Jenny Karlsson
    Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, University Hospital MAS, Malmo, Sweden
    Mol Cancer Ther 4:1128-35. 2005
  5. doi request reprint Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer
    Linda Holmquist Mengelbier
    Department of Clinical Genetics, Lund University, Biomedical Center C13, SE22184 Lund, Sweden
    Nat Commun 6:6125. 2015
  6. doi request reprint Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells
    Helen M Pettersson
    Center for Molecular Pathology, CREATE Health, Department of Laboratory Medicine, Lund University, University Hospital MAS, Entrance 78, SE 205 02 Malmo, Sweden
    Mol Cancer Ther 8:160-70. 2009
  7. ncbi request reprint Arsenic trioxide and neuroblastoma cytotoxicity
    Helen M Pettersson
    Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, University Hospital MAS, Malmo, Sweden
    J Bioenerg Biomembr 39:35-41. 2007
  8. pmc Deletions of 16q in Wilms tumors localize to blastemal-anaplastic cells and are associated with reduced expression of the IRXB renal tubulogenesis gene cluster
    Linda Holmquist Mengelbier
    Department of Clinical Genetics, University and Regional Laboratories, Lund University, Skane University Hospital, SE 221 85 Lund, Sweden
    Am J Pathol 177:2609-21. 2010
  9. pmc Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin
    Jenny Karlsson
    Department of Clinical Genetics, Lund University, University and Regional Laboratories, Lund, Sweden
    Genes Chromosomes Cancer 53:381-91. 2014
  10. doi request reprint Absence of Epstein-Barr and cytomegalovirus infection in neuroblastoma cells by standard detection methodologies
    Daniel Sehic
    Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden
    Pediatr Blood Cancer 60:E91-3. 2013

Collaborators

  • Ingrid Øra
  • David Gisselsson
  • Helen M Pettersson
  • Daniel Bexell
  • Daniel Sehic
  • Linda Holmquist Mengelbier
  • Bengt Sandstedt
  • David Lindgren
  • Anders Edsjö
  • Niklas Pal
  • Anna Börjesson
  • Thoas Fioretos
  • Tord Jonson
  • Adam Ameur
  • Markus Mayrhofer
  • Rogier Versteeg
  • Anders Isaksson
  • Torbjörn Backman
  • Anders Valind
  • Marianne Rissler
  • Noémie Braekeveldt
  • Henrik Lilljebjörn
  • Caroline Jansson
  • Hanna Göransson Kultima
  • Jurate Asmundsson
  • Ildiko Frigyesi
  • Johannes Bras
  • Margareth Isaksson
  • Attila Frigyesi
  • Filip Pattyn
  • Sven Påhlman
  • Frank Speleman
  • Helen Nilsson
  • Jo Vandesompele
  • Lloyd A Culp

Detail Information

Publications11

  1. doi request reprint Activation of human telomerase reverse transcriptase through gene fusion in clear cell sarcoma of the kidney
    Jenny Karlsson
    Department of Clinical Genetics, BMC C13, Lund University, Lund SE 221 84, Sweden Electronic address
    Cancer Lett 357:498-501. 2015
    ..IRX2 was also expressed in human fetal kidney - the presumed tissue of origin for CCSK. We conclude that in addition to promoter mutations and epigenetic events, TERT can also be activated in tumors via formation of fusion transcripts. ..
  2. doi request reprint High-resolution genomic profiling of an adult Wilms' tumor: evidence for a pathogenesis distinct from corresponding pediatric tumors
    Jenny Karlsson
    Department of Clinical Genetics, BMC B13, University and Regional Laboratories, Lund University, 221 84 Lund, Sweden
    Virchows Arch 459:547-53. 2011
    ..Our results indicate that adult WT is a biological entity distinct from the corresponding pediatric tumor type...
  3. doi request reprint SIX1 protein expression selectively identifies blastemal elements in Wilms tumor
    Daniel Sehic
    Department of Clinical Genetics, Lund University, University and Regional Laboratories, Lund, Sweden
    Pediatr Blood Cancer 59:62-8. 2012
    ..However, there is currently no molecular marker for blastemal cells, and risk stratification for post-nephrectomy treatment is therefore often based on clinico-histological parameters alone...
  4. ncbi request reprint Multidrug-resistant neuroblastoma cells are responsive to arsenic trioxide at both normoxia and hypoxia
    Jenny Karlsson
    Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, University Hospital MAS, Malmo, Sweden
    Mol Cancer Ther 4:1128-35. 2005
    ..Together, our results support As(2)O(3) as a potential candidate drug as a complement to conventional treatments for high-risk neuroblastoma patients and perhaps also for patients with other multidrug-resistant solid tumors...
  5. doi request reprint Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer
    Linda Holmquist Mengelbier
    Department of Clinical Genetics, Lund University, Biomedical Center C13, SE22184 Lund, Sweden
    Nat Commun 6:6125. 2015
    ..Survival was 100% for patients lacking microdiversity. Thus, intratumoral genetic diversity is common in childhood cancers after chemotherapy and may be an important factor behind treatment failure. ..
  6. doi request reprint Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells
    Helen M Pettersson
    Center for Molecular Pathology, CREATE Health, Department of Laboratory Medicine, Lund University, University Hospital MAS, Entrance 78, SE 205 02 Malmo, Sweden
    Mol Cancer Ther 8:160-70. 2009
    ..In addition to cell death induction, antiangiogenic induction of differentiation may also be part of the in vivo effect of As2O3 on SCLC growth, as suggested by an increase in neuroendocrine markers in cultured cells...
  7. ncbi request reprint Arsenic trioxide and neuroblastoma cytotoxicity
    Helen M Pettersson
    Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, University Hospital MAS, Malmo, Sweden
    J Bioenerg Biomembr 39:35-41. 2007
    ..In this report we discuss the background to the use of arsenic trioxide in cancer therapy and the currently known mechanisms by which arsenic trioxide kills human neuroblastoma cells...
  8. pmc Deletions of 16q in Wilms tumors localize to blastemal-anaplastic cells and are associated with reduced expression of the IRXB renal tubulogenesis gene cluster
    Linda Holmquist Mengelbier
    Department of Clinical Genetics, University and Regional Laboratories, Lund University, Skane University Hospital, SE 221 85 Lund, Sweden
    Am J Pathol 177:2609-21. 2010
    ..A disturbed balance between tubular differentiation and self-renewal of anaplastic-blastic elements may thus be one mechanism linking 16q deletion to adverse outcome in Wilms tumor...
  9. pmc Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin
    Jenny Karlsson
    Department of Clinical Genetics, Lund University, University and Regional Laboratories, Lund, Sweden
    Genes Chromosomes Cancer 53:381-91. 2014
    ....
  10. doi request reprint Absence of Epstein-Barr and cytomegalovirus infection in neuroblastoma cells by standard detection methodologies
    Daniel Sehic
    Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden
    Pediatr Blood Cancer 60:E91-3. 2013
    ..These standard methods did not detect infection by EBV or HCMV in NB cells in any tumor, while occasional immune cells were positive for EBV RNA or HCMV protein in four cases...
  11. ncbi request reprint Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation
    Anders Edsjö
    Department of Laboratory Medicine, Molecular Medicine, Lund University, University Hospital MAS, S 20502 Malmo, Sweden
    Lab Invest 84:406-17. 2004
    ....