Karin Jirstrom

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts
    Gustav Andersson
    Department of Clinical Sciences, Oncology and Pathology, Lund University, Skane University Hospital, Lund 221 85, Sweden
    BMC Urol 14:36. 2014
  2. ncbi request reprint HMG-CoA reductase expression in primary colorectal cancer correlates with favourable clinicopathological characteristics and an improved clinical outcome
    Erik Bengtsson
    Department of Clinical Sciences, Oncology and Pathology, Lund University, 221 85 Lund, Sweden
    Diagn Pathol 9:78. 2014
  3. pmc High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer
    A Gaber
    Department of Laboratory Medicine, Center for Molecular Pathology, Malmo University Hospital, Lund University, Malmo, Sweden
    Br J Cancer 100:1540-8. 2009
  4. pmc A cohort study of the prognostic and treatment predictive value of SATB2 expression in colorectal cancer
    J Eberhard
    Department of Clinical Sciences, Division of Oncology, Lund University, Skane University Hospital, 221 85 Lund, Sweden
    Br J Cancer 106:931-8. 2012
  5. pmc CD44 enhances invasion of basal-like breast cancer cells by upregulating serine protease and collagen-degrading enzymatic expression and activity
    Nicola Montgomery
    Centre for Cancer Research and Cell Biology, Queens University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland
    Breast Cancer Res 14:R84. 2012
  6. pmc Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer
    Patrick C O Leary
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland
    BMC Cancer 13:175. 2013
  7. pmc Modifying effect of gender on the prognostic value of clinicopathological factors and Ki67 expression in melanoma: a population-based cohort study
    Marie Fridberg
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, 221 85 Lund, Sweden
    Biol Sex Differ 3:16. 2012
  8. pmc The G protein-coupled estrogen receptor 1 (GPER/GPR30) does not predict survival in patients with ovarian cancer
    Zuzana Kolkova
    Department of Gynecology and Obstetrics, Department of Clinical Sciences, Lund University, Skåne University Hospital Lund, SE 221 85 Lund, Sweden
    J Ovarian Res 5:9. 2012
  9. pmc Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer
    Elton Rexhepaj
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Ireland
    Breast Cancer Res 10:R89. 2008
  10. pmc Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro
    Fiona Lanigan
    University College Dublin School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 12:R59. 2010

Detail Information

Publications85

  1. ncbi request reprint Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts
    Gustav Andersson
    Department of Clinical Sciences, Oncology and Pathology, Lund University, Skane University Hospital, Lund 221 85, Sweden
    BMC Urol 14:36. 2014
    ..In the present study, we examined the prognostic significance of ezrin expression in urothelial bladder cancer in a total number of 442 tumours from two independent patient cohorts...
  2. ncbi request reprint HMG-CoA reductase expression in primary colorectal cancer correlates with favourable clinicopathological characteristics and an improved clinical outcome
    Erik Bengtsson
    Department of Clinical Sciences, Oncology and Pathology, Lund University, 221 85 Lund, Sweden
    Diagn Pathol 9:78. 2014
    ..In this study, the expression, clinicopathological correlates and prognostic value of HMGCR expression in colorectal cancer was examined...
  3. pmc High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer
    A Gaber
    Department of Laboratory Medicine, Center for Molecular Pathology, Malmo University Hospital, Lund University, Malmo, Sweden
    Br J Cancer 100:1540-8. 2009
    ..85; 95% CI=1.43-5.66). In conclusion, high TATI expression is associated with liver metastasis and is an independent predictor of poor prognosis in patients with colorectal cancer...
  4. pmc A cohort study of the prognostic and treatment predictive value of SATB2 expression in colorectal cancer
    J Eberhard
    Department of Clinical Sciences, Division of Oncology, Lund University, Skane University Hospital, 221 85 Lund, Sweden
    Br J Cancer 106:931-8. 2012
    ..In this study, we validated the prognostic ability of SATB2 expression in a large, prospective CRC cohort...
  5. pmc CD44 enhances invasion of basal-like breast cancer cells by upregulating serine protease and collagen-degrading enzymatic expression and activity
    Nicola Montgomery
    Centre for Cancer Research and Cell Biology, Queens University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland
    Breast Cancer Res 14:R84. 2012
    ..The purpose of this study was to establish the relation of CD44 to BL-BCa and to characterize how HA/CD44 signaling promotes a protease-dependent invasion of breast cancer (BrCa) cells...
  6. pmc Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer
    Patrick C O Leary
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland
    BMC Cancer 13:175. 2013
    ....
  7. pmc Modifying effect of gender on the prognostic value of clinicopathological factors and Ki67 expression in melanoma: a population-based cohort study
    Marie Fridberg
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, 221 85 Lund, Sweden
    Biol Sex Differ 3:16. 2012
    ..abstract:..
  8. pmc The G protein-coupled estrogen receptor 1 (GPER/GPR30) does not predict survival in patients with ovarian cancer
    Zuzana Kolkova
    Department of Gynecology and Obstetrics, Department of Clinical Sciences, Lund University, Skåne University Hospital Lund, SE 221 85 Lund, Sweden
    J Ovarian Res 5:9. 2012
    ..abstract:..
  9. pmc Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer
    Elton Rexhepaj
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Ireland
    Breast Cancer Res 10:R89. 2008
    ..In the present article we describe the development of a novel approach for automatically quantifying oestrogen receptor (ER) and progesterone receptor (PR) protein expression assessed by IHC in primary breast cancer...
  10. pmc Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro
    Fiona Lanigan
    University College Dublin School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 12:R59. 2010
    ..However, the clinical implications of Msx2 expression in breast cancer are unclear. The aims of this study were to investigate the potential clinical value of Msx2 as a breast cancer biomarker and to clarify its functional role in vitro...
  11. pmc Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer
    Donal J Brennan
    Dept of Obstetrics and Gynaecology, National Maternity Hospital, Holles Street, Dublin 2, Ireland
    BMC Cancer 10:125. 2010
    ..In the present study, the prognostic value of HMG-CoAR expression was examined in tumours from a cohort of patients with primary epithelial ovarian cancer...
  12. pmc Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer
    Elton Rexhepaj
    UCD Conway Institute, University College Dublin, Belfield, Ireland
    BMC Cancer 10:639. 2010
    ..Here, we validate survivin CNR in a separate and extended cohort. Furthermore, we present new data suggesting that a low CNR may predict outcome in tamoxifen-treated patients...
  13. pmc Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarray
    Elin Möllerström
    Department of Oncology, Institute of Clinical Sciences, Blå stråket 2, University of Gothenburg, SE 413 45 Goteborg, Sweden
    BMC Cancer 10:296. 2010
    ..The aim of this study was to characterize the expression of the corresponding proteins in breast carcinoma and to determine their correlation with clinical outcome...
  14. pmc Long-term survival of women with basal-like ductal carcinoma in situ of the breast: a population-based cohort study
    Wenjing Zhou
    Department of Surgical Science, Uppsala University, Uppsala, SE 75105, Sweden
    BMC Cancer 10:653. 2010
    ..However, the prognosis of basal-like ductal carcinoma in situ (DCIS) is still unknown. Our aim was to study the prognosis of basal-like DCIS in a large population-based cohort...
  15. pmc Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 13:R12. 2011
    ..Here, the predictive value of HMG-CoAR expression in relation to tamoxifen response was examined...
  16. pmc Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival
    Björn Nodin
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, and Skåne Regional Laboratories, Malmo, Sweden
    J Ovarian Res 3:14. 2010
    ..Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear...
  17. doi request reprint Nuclear expression of the RNA-binding protein RBM3 is associated with an improved clinical outcome in breast cancer
    Annika Jögi
    Department of Laboratory Medicine, Center for Molecular Pathology, Malmo University Hospital, Lund University, Malmo, Sweden
    Mod Pathol 22:1564-74. 2009
    ..49, 95% CI: 0.30-0.79, P=0.004). These data strongly indicate that nuclear RBM3 is an independent favorable prognostic factor in breast cancer, and seems to have a specific role in ER-positive tumors...
  18. ncbi request reprint High progesterone receptor expression correlates to the effect of adjuvant tamoxifen in premenopausal breast cancer patients
    Maria Stendahl
    Department of Laboratory Medicine, Division of Pathology, Malmo University Hospital, Lund University, Malmo, Sweden
    Clin Cancer Res 12:4614-8. 2006
    ..In this study, we aimed to assess whether a further subclassification of hormone receptor status could enhance the treatment predictive value...
  19. doi request reprint Low expression of SHP-2 is associated with less favorable prostate cancer outcomes
    Helena Tassidis
    Department of Laboratory Medicine, Division of Tumor Biology, Lund University, Lund, Sweden
    Tumour Biol 34:637-42. 2013
    ..005 and p = 0.018, respectively). The loss of cytoplasmic SHP-2 expression is associated with increased growth and prostatic cancer progression...
  20. ncbi request reprint Molecular and genetic diversity in the metastatic process of melanoma
    Katja Harbst
    Department of Oncology, Clinical Sciences, Lund University, Sweden CREATE Health Strategic Centre for Clinical Cancer Research, Lund University, Sweden
    J Pathol 233:39-50. 2014
    ....
  21. doi request reprint Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer
    Helena Tassidis
    Department of Tumor Biology, Lund University, Malmo University Hospital, Malmo, Sweden
    Int J Cancer 126:2296-307. 2010
    ....
  22. pmc Associations of beta-catenin alterations and MSI screening status with expression of key cell cycle regulating proteins and survival from colorectal cancer
    Sakarias Wangefjord
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, Lund, Sweden
    Diagn Pathol 8:10. 2013
    ..In this paper, we studied the associations between beta-catenin overexpression and MSI status with survival from CRC, and with expression of p21, p27, cyclin D1 and p53, in a large, prospective cohort study...
  23. ncbi request reprint Cyclin E overexpression obstructs infiltrative behavior in breast cancer: a novel role reflected in the growth pattern of medullary breast cancers
    Pontus Berglund
    Division of Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    Cancer Res 65:9727-34. 2005
    ....
  24. pmc Molecular correlates and prognostic significance of SATB1 expression in colorectal cancer
    Björn Nodin
    Department of Clinical Sciences, Pathology, Lund University, Skane University Hospital, Lund, SE, 221 85, Sweden
    Diagn Pathol 7:115. 2012
    ..e. beta-catenin overexpression, microsatellite instability (MSI) screening status, and SATB2 expression...
  25. pmc Prognostic impact of tumour-specific HMG-CoA reductase expression in primary breast cancer
    Signe Borgquist
    Center for Molecular Pathology, Department of Laboratory Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Breast Cancer Res 10:R79. 2008
    ..In the present study, we examined the prognostic value of HMG-CoAR expression in a large cohort of primary breast cancer patients with long-term follow up...
  26. doi request reprint Detecting EGFR alterations in clinical specimens-pitfalls and necessities
    Sofi Isaksson
    Department of Clinical Sciences, Division of Oncology, Lund University, Medicon Village, SE 223 81, Lund, Sweden
    Virchows Arch 463:755-64. 2013
    ....
  27. doi request reprint Anthropometric factors and ovarian cancer risk in the Malmö Diet and Cancer Study
    Jenny Brändstedt
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, Malmo, Sweden
    Cancer Epidemiol 35:432-7. 2011
    ..To examine the associations of measured anthropometric factors, including general and central adiposity, with epithelial ovarian cancer (EOC) risk in the Malmö Diet and Cancer Study...
  28. pmc Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer
    Karolina Boman
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, Lund 221 85, Sweden
    BMC Urol 13:17. 2013
    ..g. breast, ovarian, colorectal, prostate cancer and malignant melanoma. The aim of this study was to examine the prognostic impact of RBM3 expression in urinary bladder cancer...
  29. doi request reprint HMG-CoA reductase expression in breast cancer is associated with a less aggressive phenotype and influenced by anthropometric factors
    Signe Borgquist
    Department of Laboratory Medicine, Center for Molecular Pathology, Malmo University Hospital, Malmo, Sweden
    Int J Cancer 123:1146-53. 2008
    ..Moreover, estrogen related life-style and anthropometric factors might indeed regulate HMG-CoAR expression...
  30. pmc Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: an analysis of 215 cases from the Malmö Diet and Cancer Study
    Liv Jonsson
    Department of Clinical Sciences, Pathology, Lund University, Skane University Hospital, 221 85 Lund, Sweden
    J Transl Med 9:114. 2011
    ..In this study, the prognostic value of immunohistochemical RBM3 expression was assessed in incident cases of malignant melanoma from a prospective population-based cohort study...
  31. pmc Increased serum levels of tumour-associated trypsin inhibitor independently predict a poor prognosis in colorectal cancer patients
    Alexander Gaber
    Department of Laboratory Medicine, Lund University, Skane University Hospital, Center for Molecular Pathology, Malmo, Sweden
    BMC Cancer 10:498. 2010
    ..We further assessed the prognostic value of carcino-embryonic antigen in serum (s-CEA) and the interrelationship between s-TATI and TATI in tissue (t-TATI)...
  32. ncbi request reprint A non-functional retinoblastoma tumor suppressor (RB) pathway in premenopausal breast cancer is associated with resistance to tamoxifen
    Sophie Lehn
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, Malmo, Sweden
    Cell Cycle 10:956-62. 2011
    ....
  33. doi request reprint Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial
    Olöf Bjarnadottir
    Department of Oncology, Skane University Hospital, Clinical Sciences, Lund University, SE 221 85, Lund, Sweden
    Breast Cancer Res Treat 138:499-508. 2013
    ..Future studies are needed to evaluate HMGCR as a predictive marker for the selection of breast cancer patients who may benefit from statin treatment...
  34. pmc High MCM3 expression is an independent biomarker of poor prognosis and correlates with reduced RBM3 expression in a prospective cohort of malignant melanoma
    Björn Nodin
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, 221 85, Lund, Sweden
    Diagn Pathol 7:82. 2012
    ..The aim of the present study was to examine the associations of MCM3 expression with clinical outcome and RBM3 expression in a prospective, population-based cohort of melanoma...
  35. pmc Stromal expression of β-arrestin-1 predicts clinical outcome and tamoxifen response in breast cancer
    Katja Lundgren
    Department of Laboratory Medicine, Center for Molecular Pathology, Lund University, Malmo University Hospital, Malmo, Sweden
    J Mol Diagn 13:340-51. 2011
    ..Furthermore, CCND1 amplification was inversely correlated with tumor cell expression of β-arrestin-1, indicating ARRB1 gene deletion in CCND1-amplified breast cancers...
  36. ncbi request reprint Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression
    Goran Landberg
    Division of Pathology, Department of Laboratory Medicine, U MAS, Lund University, Malmo, Sweden
    Breast Cancer Res Treat 89:313-6. 2005
    ..A strong association was found between cytoplasmic cyclin I staining and VEGF (p = 0.001) as well as the VEGF receptor KDR (p = 0.001), suggesting a link between cyclin I and angiogenesis...
  37. pmc Down-regulation of the oncogene cyclin D1 increases migratory capacity in breast cancer and is linked to unfavorable prognostic features
    Sophie Lehn
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, UMAS, Sweden
    Am J Pathol 177:2886-97. 2010
    ..This novel function of cyclin D1 illustrates the interplay between tumor proliferation and migration and may explain the attenuation of malignant behavior in breast cancers with high cyclin D1 levels...
  38. ncbi request reprint Adverse effect of adjuvant tamoxifen in premenopausal breast cancer with cyclin D1 gene amplification
    Karin Jirstrom
    Division of Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    Cancer Res 65:8009-16. 2005
    ....
  39. ncbi request reprint Hypoxia inducible factor-1alpha is a prognostic marker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response
    Asa Kronblad
    Division of Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, S Malmö, Sweden
    Int J Cancer 118:2609-16. 2006
    ....
  40. pmc High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression
    Liv Jonsson
    Department of Clinical Sciences, Pathology, Lund University, Skane University Hospital, 221 85 Lund, Sweden
    Diagn Pathol 6:91. 2011
    ..The aim of this study was to examine the prognostic impact of immunohistochemical RBM3 expression in prostate cancer...
  41. doi request reprint Anthropometric factors in relation to different tumor biological subgroups of postmenopausal breast cancer
    Signe Borgquist
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, University Hospital MAS, S 205 02 Malmo, Sweden
    Int J Cancer 124:402-11. 2009
    ..Furthermore, obesity was associated with tumors expressing several markers corresponding with low malignancy...
  42. pmc The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation
    Sandra Sernbo
    Department of Immunotechnology, Lund University, Lund, Sweden
    BMC Cancer 11:405. 2011
    ....
  43. doi request reprint Epidermal growth factor receptor and vascular endothelial growth factor receptor 2 are specific biomarkers in triple-negative breast cancer. Results from a controlled randomized trial with long-term follow-up
    Lisa Rydén
    Department of Surgery, Institution of Clinical Sciences, Lund University Hospital, SE 221 85, Lund, Sweden
    Breast Cancer Res Treat 120:491-8. 2010
    ..High VEGFR2 expression, EGFR expression, and EGFR gene copy number were significantly correlated to TNB, supporting their role as putative candidate biomarkers for selection of targeted therapy in TNB...
  44. pmc Validation of podocalyxin-like protein as a biomarker of poor prognosis in colorectal cancer
    Anna Larsson
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, 221 85, Lund, Sweden
    BMC Cancer 12:282. 2012
    ..The aim of this study was to validate these results in two additional independent patient cohorts and to examine the correlation between PODXL mRNA and protein levels in a subset of tumours...
  45. pmc Effects of radiation therapy on tissue and serum concentrations of tumour associated trypsin inhibitor and their prognostic significance in rectal cancer patients
    Alexander Gaber
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, Lund, Sweden
    Radiat Oncol 6:100. 2011
    ..In this study, we investigated the effects of neoadjuvant radiotherapy (RT) on concentrations of t-TATI and s-TATI in patients with rectal cancer...
  46. ncbi request reprint Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients
    Caroline Holm
    Division of Pathology, Department of Laboratory Medicine, Lund University, Malmo, Sweden
    J Natl Cancer Inst 98:671-80. 2006
    ..Here we studied associations between Pak1 expression and subcellular localization in tumor cells and tamoxifen resistance...
  47. doi request reprint Evaluation of the prognostic significance of MSMB and CRISP3 in prostate cancer using automated image analysis
    Anna Dahlman
    Department of Clinical Sciences, Division of Urological Cancers, Lund University, Skane University Hospital, Malmo, Sweden
    Mod Pathol 24:708-19. 2011
    ....
  48. doi request reprint p27Kip1 is a predictive factor for tamoxifen treatment response but not a prognostic marker in premenopausal breast cancer patients
    Maria Stendahl
    Center for Molecular Pathology, Lund University, Malmo University Hospital, Malmo, Sweden
    Int J Cancer 127:2851-8. 2010
    ..034). Our study suggests that p27 downregulation is associated with tamoxifen resistance in premenopausal breast cancer but is not linked to impaired prognosis...
  49. pmc Downregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration
    Sofie Nilsson
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, Malmo, Sweden
    PLoS ONE 7:e36051. 2012
    ....
  50. doi request reprint Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer
    Karolina Helczynska
    Center for Molecular Pathology, Department of Laboratory Medicine, University Hospital MAS, Malmo, Sweden
    Cancer Res 68:9212-20. 2008
    ..At prolonged hypoxia, HIF-2alpha remained accumulated, whereas HIF-1alpha protein levels decreased, in agreement with the oxygen level and time-dependent induction of HIFs recently reported in neuroblastoma...
  51. pmc RBM3-Regulated Genes Promote DNA Integrity and Affect Clinical Outcome in Epithelial Ovarian Cancer
    Osa Ehlén
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, Malmo, Sweden
    Transl Oncol 4:212-21. 2011
    ..Furthermore, it is demonstrated that Chk1, Chk2, and MCM3 are poor prognostic markers in EOC...
  52. doi request reprint Cysteinyl leukotriene receptor expression pattern affects migration of breast cancer cells and survival of breast cancer patients
    Cecilia Magnusson
    Division of Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, SE 205 02 Malmo, Sweden
    Int J Cancer 129:9-22. 2011
    ..Our data indicate that low CysLT(1)R together with high CysLT(2)R expression levels might be useful parameters in prognostication and treatment stratification of breast cancer patients...
  53. ncbi request reprint Associations of Anthropometric Factors with KRAS and BRAF Mutation Status of Primary Colorectal Cancer in Men and Women: A Cohort Study
    Jenny Brändstedt
    Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Skane University Hospital, Lund, Sweden Department of Surgery, Skane University Hospital, Malmo, Sweden
    PLoS ONE 9:e98964. 2014
    ..The results from this prospective cohort study further support an influence of sex and lifestyle factors on different pathways of colorectal carcinogenesis, defined by KRAS and BRAF mutation status of the tumours. ..
  54. doi request reprint Erythropoietin receptor expression and correlation to tamoxifen response and prognosis in breast cancer
    Anna Maria Larsson
    Center for Molecular Pathology, Department of Laboratory Medicine, University Hospital MAS, Malmo, Sweden
    Clin Cancer Res 15:5552-9. 2009
    ..In an attempt to understand these clinical data, we analyzed EPO and EPOR expression in breast cancer and evaluated EPOR as a putative prognostic and predictive marker in breast cancer patients treated with tamoxifen...
  55. doi request reprint Plasma folate concentrations are positively associated with risk of estrogen receptor beta negative breast cancer in a Swedish nested case control study
    Ulrika Ericson
    Department of Clinical Sciences, Nutrition Epidemiology, Lund University, Malmo, Sweden
    J Nutr 140:1661-8. 2010
    ..The study contributes knowledge concerning folate's multifaceted role in cancer development. If replicated in other populations, the observations may have implications for public health, particularly regarding folic acid fortification...
  56. doi request reprint Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response
    Sophie Lehn
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, 205 02 Malmo, Sweden
    BMC Cancer 14:119. 2014
    ....
  57. pmc Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer
    Asa Ehlén
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, Malmo, Sweden
    J Transl Med 8:78. 2010
    ..The aim of this study was to examine the prognostic value of RBM3 mRNA and protein expression in epithelial ovarian cancer (EOC) and the cisplatin response upon RBM3 depletion in a cisplatin-sensitive ovarian cancer cell line...
  58. pmc Influence of anthropometric factors on tumour biological characteristics of colorectal cancer in men and women: a cohort study
    Jenny Brändstedt
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, Lund, Sweden
    J Transl Med 11:293. 2013
    ....
  59. pmc The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients
    Catharina Medrek
    Center for Molecular Pathology, Skane University Hospital, Lund University, Malmo, Sweden
    BMC Cancer 12:306. 2012
    ..We also analyzed the prognostic value of the localization of CD163(+) and CD68(+) myeloid cells in human breast cancer...
  60. ncbi request reprint Breast tumours following combined hormone replacement therapy express favourable prognostic factors
    Signe Borgquist
    Department of Laboratory Medicine, Division of Pathology, Malmo University Hospital, Lund University, SE 20502 Malmo, Sweden
    Int J Cancer 120:2202-7. 2007
    ..We conclude that the use of CHRT is associated with an increased incidence of breast tumours with comparatively favourable prognostic factors...
  61. ncbi request reprint Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatellite-instability
    Jenny Brändstedt
    Department of Clinical Sciences, Lund, Oncology and Pathology, Lund University, Skane University Hospital, Lund, Sweden
    BMC Cancer 14:371. 2014
    ..The aim of this molecular pathological epidemiology study was therefore to evaluate the associations between HRT and OC use and risk of specific CRC subgroups, overall and by tumour site...
  62. pmc Cyclin D1 expression in colorectal cancer is a favorable prognostic factor in men but not in women in a prospective, population-based cohort study
    Sakarias Wangefjord
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, 221 85 Lund, Sweden
    Biol Sex Differ 2:10. 2011
    ..abstract:..
  63. pmc PKCalpha expression is a marker for breast cancer aggressiveness
    Gry Kalstad Lønne
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Mol Cancer 9:76. 2010
    ..Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes...
  64. ncbi request reprint Expression and prognostic significance of the polymeric immunoglobulin receptor in esophageal and gastric adenocarcinoma
    Richard Fristedt
    Department of Clinical Sciences, Oncology and Pathology, Lund University, Skane University Hospital, 221 85 Lund, Sweden
    J Transl Med 12:83. 2014
    ..In the present study, we examined the expression, clinicopathological correlates and prognostic significance of PIGR expression in an extended cohort of adenocarcinoma of the upper gastrointestinal tract...
  65. ncbi request reprint Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression
    Willem Jan Keune
    Authors Affiliations The CRUK Inositide Laboratory Breakthrough Breast Cancer Research Unit Leukaemia Biology, Inositide Group Cancer Research UK Manchester Institute, The University of Manchester, Manchester Applied Bioinformatics of Cancer, University of Edinburgh Cancer Research UK Centre, Edinburgh, United Kingdom and Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital Malmö, Malmo, Sweden
    Cancer Res 73:6913-25. 2013
    ..Decreased CDH1 expression and enhancement of TGF-β-induced EMT by reduced PIP4K2B expression might, in part, explain the association between low PIP4K2B expression and poor patient survival...
  66. pmc Gender, anthropometric factors and risk of colorectal cancer with particular reference to tumour location and TNM stage: a cohort study
    Jenny Brändstedt
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, Lund, SE 221 85, Sweden
    Biol Sex Differ 3:23. 2012
    ..abstract:..
  67. pmc Tumors with nonfunctional retinoblastoma protein are killed by reduced γ-tubulin levels
    Asa Ehlén
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, SE 205 02 Malmo, Sweden
    J Biol Chem 287:17241-7. 2012
    ..Thus, the RB1/γ-tubulin signal network can be considered as a new target for cancer treatment...
  68. pmc Isolation and characterization of progenitor-like cells from human renal proximal tubules
    David Lindgren
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, SUS Malmö, Malmo, Sweden
    Am J Pathol 178:828-37. 2011
    ....
  69. doi request reprint Chondroitin sulfate expression predicts poor outcome in breast cancer
    Katrin J Svensson
    Department of Clinical Sciences, Section of Oncology, Lund University, SE 221 85, Lund, Sweden
    Int J Oncol 39:1421-8. 2011
    ....
  70. doi request reprint Histological specificity of alterations and expression of KIT and KITLG in non-small cell lung carcinoma
    Annette Salomonsson
    Division of Oncology, Department of Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 52:1088-96. 2013
    ....
  71. pmc Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro
    Sandra Sernbo
    Department of Immunotechnology, CREATE Health, Lund University, Lund, Sweden
    PLoS ONE 8:e70596. 2013
    ..This is supported by functional data, indicating that T-STAR regulation is of importance both for breast cancer biology and clinical outcome but future studies are needed to determine a potential role in patient stratification. ..
  72. doi request reprint Molecular evolution of specific human antibody against MUC1 mucin results in improved recognition of the antigen on tumor cells
    Jonas Persson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Tumour Biol 30:221-31. 2009
    ..Molecular evolution and specific fine-tuning thus have the potential to improve the performance of antibody specificities targeting tumor-associated epitopes on MUC1 mucin...
  73. doi request reprint Protein expression profiling of formalin-fixed paraffin-embedded tissue using recombinant antibody microarrays
    Frida Pauly
    Department of Immunotechnology, Lund University, Medicon Village, Lund, Sweden
    J Proteome Res 12:5943-53. 2013
    ..Thus, we have added FFPE samples to the list of sample formats available for high-throughput analysis by affinity proteomics, paving the way for the next generation of biomarker-driven discovery projects. ..
  74. doi request reprint G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients
    Stefan Broselid
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Clin Cancer Res 19:1681-92. 2013
    ....
  75. pmc Podocalyxin-like protein expression in primary colorectal cancer and synchronous lymph node metastases
    Anna H Larsson
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, SE 221 85 Lund, Sweden
    Diagn Pathol 8:109. 2013
    ..In this study, we compared PODXL expression in primary CRC and synchronous lymph node metastases. We further analyzed whether its expression changed in rectal tumours after neoadjuvant radiation therapy...
  76. doi request reprint Sushi domain-containing protein 4 (SUSD4) inhibits complement by disrupting the formation of the classical C3 convertase
    Emelie Holmquist
    Department of Laboratory Medicine, Division of Medical Protein Chemistry, Lund University, Malmo, Sweden
    FASEB J 27:2355-66. 2013
    ..Overall, our results show that SUSD4 is a novel complement inhibitor with restricted expression...
  77. pmc Clinicopathological correlates and prognostic significance of KRAS mutation status in a pooled prospective cohort of epithelial ovarian cancer
    Björn Nodin
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, Lund, Sweden
    Diagn Pathol 8:106. 2013
    ..Here, we investigated the occurrence, clinicopathological correlates and prognostic significance of specific KRAS mutations in tumours from 153 epithelial ovarian cancer (EOC) cases from a pooled, prospective cohort...
  78. pmc Molecular profiling reveals low- and high-grade forms of primary melanoma
    Katja Harbst
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Clin Cancer Res 18:4026-36. 2012
    ..This raises the possibility that a molecular structure exists even in the early stages of melanoma and that molecular determinants could underlie histophenotype and eventual patient outcome...
  79. doi request reprint Wnt5a induces a tolerogenic phenotype of macrophages in sepsis and breast cancer patients
    Caroline Bergenfelz
    Center for Molecular Pathology, Skane University Hospital, Lund University, 20502 Malmo, Sweden
    J Immunol 188:5448-58. 2012
    ..In conclusion, our data point out Wnt5a as a potential target for an efficient therapeutic modality in severe human diseases as diverse as sepsis and malignancy...
  80. pmc Discovery of dachshund 2 protein as a novel biomarker of poor prognosis in epithelial ovarian cancer
    Björn Nodin
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, 221 85 Lund, Sweden
    J Ovarian Res 5:6. 2012
    ..abstract:..
  81. ncbi request reprint ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis
    Sofie Svensson
    Division of Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Oncogene 24:4370-9. 2005
    ..Finally, patients with oestrogen receptor positive and ERK1/2 phosphorylated tumours also had an impaired tamoxifen response...
  82. pmc Expression of the global regulator SATB1 is an independent factor of poor prognosis in high grade epithelial ovarian cancer
    Björn Nodin
    Department of Clinical Sciences, Division of Pathology, Lund University, Lund, SE 221 85, Sweden
    J Ovarian Res 5:24. 2012
    ..abstract:..
  83. ncbi request reprint CCR4 mediates CCL17 (TARC)-induced migration of human colon cancer cells via RhoA/Rho-kinase signaling
    Amr A Al-haidari
    Department of Clinical Sciences, Malmo, Section of Surgery, Skane University Hospital, Lund University, 20502, Malmo, Sweden
    Int J Colorectal Dis 28:1479-87. 2013
    ..CCR4 has been implicated in hematologic malignancies and recently also in solid tumors. Herein, we hypothesized that CCR4 might be expressed and support migration of colon cancer cells...
  84. ncbi request reprint Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma
    Sara Ek
    Department of Immunotechnology, CREATE Health, Biomedical Center, Lund University, and Department of Pathology, Lund University Hospital, Sweden
    Blood 111:800-5. 2008
    ....
  85. pmc Diet and body constitution in relation to subgroups of breast cancer defined by tumour grade, proliferation and key cell cycle regulators
    Signe Borgquist
    Division of Pathology, Department of Laboratory Medicine, Malmo University Hospital, S 205 02 Malmo, Sweden
    Breast Cancer Res 9:R11. 2007
    ....