R Holmdahl

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice
    Alexei von Delwig
    Musculoskeletal Research Group, Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK
    Arthritis Res Ther 8:R93. 2006
  2. ncbi Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells
    Kutty Selva Nandakumar
    Section for Medical Inflammation Research, Lund University, Sweden
    Arthritis Res Ther 6:R544-50. 2004
  3. ncbi Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice
    Ann Sofie Hansson
    Department of Clinical Immunology, Goteborg University, Goteborg, Sweden
    Arthritis Res Ther 6:R484-91. 2004
  4. ncbi Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro
    Duncan E Crombie
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Arthritis Res Ther 7:R927-37. 2005
  5. ncbi Perforin deficiency attenuates collagen-induced arthritis
    Kristin Bauer
    Institute of Immunology, University of Rostock, Rostock, Germany
    Arthritis Res Ther 7:R877-84. 2005
  6. ncbi Dissection of the genetic complexity of arthritis using animal models
    Rikard Holmdahl
    Section for Medical Inflammation Research, Solvegatan 19, I11 BMC, Lund University, S 22184 Lund, Sweden
    J Autoimmun 21:99-103. 2003
  7. ncbi The molecular pathogenesis of collagen-induced arthritis in mice--a model for rheumatoid arthritis
    Rikard Holmdahl
    Section for Medical Inflammation Research, Solvegatan 19, I 11 BMC, Lund University, S 221 84 Lund, Sweden
    Ageing Res Rev 1:135-47. 2002
  8. ncbi Rheumatoid arthritis viewed using a headache paradigm
    R Holmdahl
    Medical Inflammation Research, Lund University, Lund, Sweden
    Arthritis Res 2:169-71. 2000
  9. ncbi Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis
    R Holmdahl
    Section of Medical Inflammation Research, Lund University, Sweden
    Immunol Rev 184:184-202. 2001
  10. ncbi Genetics of susceptibility to chronic experimental encephalomyelitis and arthritis
    R Holmdahl
    Section for Medical Inflammation Research CMB, Lund University Box 94 S 22100 Lund Sweden
    Curr Opin Immunol 10:710-7. 1998

Detail Information

Publications127 found, 100 shown here

  1. ncbi Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice
    Alexei von Delwig
    Musculoskeletal Research Group, Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK
    Arthritis Res Ther 8:R93. 2006
    ....
  2. ncbi Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells
    Kutty Selva Nandakumar
    Section for Medical Inflammation Research, Lund University, Sweden
    Arthritis Res Ther 6:R544-50. 2004
    ..However, a combined treatment with anti-CII monoclonal antibodies and CII-reactive T cells enhanced the progression of severe arthritis...
  3. ncbi Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice
    Ann Sofie Hansson
    Department of Clinical Immunology, Goteborg University, Goteborg, Sweden
    Arthritis Res Ther 6:R484-91. 2004
    ..In conclusion, MHC genes, as well as non-MHC genes, are important for MIRP induction, and IL-10 plays a major suppressive role in cartilage inflammation of the respiratory tract...
  4. ncbi Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro
    Duncan E Crombie
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Arthritis Res Ther 7:R927-37. 2005
    ..We conclude that antibodies to CII can have pathogenic effects that are independent of inflammatory mediators or Fc-binding...
  5. ncbi Perforin deficiency attenuates collagen-induced arthritis
    Kristin Bauer
    Institute of Immunology, University of Rostock, Rostock, Germany
    Arthritis Res Ther 7:R877-84. 2005
    ..Thus, pfp-mediated cytotoxicity is involved in the initiation of tissue damage in arthritis, but pfp-independent cytotoxic death pathways might also contribute to CIA...
  6. ncbi Dissection of the genetic complexity of arthritis using animal models
    Rikard Holmdahl
    Section for Medical Inflammation Research, Solvegatan 19, I11 BMC, Lund University, S 22184 Lund, Sweden
    J Autoimmun 21:99-103. 2003
    ..Both of these genes are associated with T cell activation and arthritis severity...
  7. ncbi The molecular pathogenesis of collagen-induced arthritis in mice--a model for rheumatoid arthritis
    Rikard Holmdahl
    Section for Medical Inflammation Research, Solvegatan 19, I 11 BMC, Lund University, S 221 84 Lund, Sweden
    Ageing Res Rev 1:135-47. 2002
    ..These provide useful tools for further investigations of the pathogenesis of CIA as well as for understanding the pathogenesis of rheumatoid arthritis...
  8. ncbi Rheumatoid arthritis viewed using a headache paradigm
    R Holmdahl
    Medical Inflammation Research, Lund University, Lund, Sweden
    Arthritis Res 2:169-71. 2000
    ..It is argued that this new model, as with other animal models, is unlikely to explain RA, but it will add to the tools available to reveal the complexity of RA...
  9. ncbi Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis
    R Holmdahl
    Section of Medical Inflammation Research, Lund University, Sweden
    Immunol Rev 184:184-202. 2001
    ..In addition, many of these loci are found in other autoimmune models in the rat as well as associated with arthritis in mice and humans...
  10. ncbi Genetics of susceptibility to chronic experimental encephalomyelitis and arthritis
    R Holmdahl
    Section for Medical Inflammation Research CMB, Lund University Box 94 S 22100 Lund Sweden
    Curr Opin Immunol 10:710-7. 1998
    ....
  11. ncbi Autoimmunity: Another pathway towards arthritis
    R Holmdahl
    Lund University, Section for Medical Inflammation Research, Solvegatan 19, 22362, Lund, Sweden
    Curr Biol 9:R528-30. 1999
    ..This new model will be useful for further analyses of the different pathways involved in rheumatoid arthritis...
  12. ncbi The structural basis of MHC control of collagen-induced arthritis; binding of the immunodominant type II collagen 256-270 glycopeptide to H-2Aq and H-2Ap molecules
    P Kjellen
    Department of Cell and Molecular Biology, Lund University, Sweden
    Eur J Immunol 28:755-67. 1998
    ....
  13. ncbi A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1)
    A S Hansson
    Section for Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University, 22362 Lund, Sweden
    J Clin Invest 104:589-98. 1999
    ..Taken together, these results represent a novel model for RP: matrilin-1-induced RP. Our findings also suggest that different cartilage proteins are involved in pathogenic models of RP and RA...
  14. ncbi Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritis
    A Corthay
    Department of Cell and Molecular Biology, Lund University, Sweden
    Eur J Immunol 28:2580-90. 1998
    ..We conclude that this glycopeptide is immunodominant in CIA and that posttranslational modifications of CII create new T cell determinants that generate a diverse TCR repertoire...
  15. ncbi Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes
    C Vingsbo
    Department of Cell and Molecular Biology, Lund University, Sweden
    Am J Pathol 149:1675-83. 1996
    ....
  16. ncbi The H2-Ab gene influences the severity of experimental allergic encephalomyelitis induced by proteolipoprotein peptide 103-116
    P Kjellen
    Section for Medical Inflammation Research, Lund University, Solvegatan 21, l11 BMC, S 223 62, Lund, Sweden
    J Neuroimmunol 120:25-33. 2001
    ....
  17. ncbi Identification of epistasis through a partial advanced intercross reveals three arthritis loci within the Cia5 QTL in mice
    M Johannesson
    Medical Inflammation Research, BMC I11, Lund University, Lund, Sweden
    Genes Immun 6:175-85. 2005
    ..The definition of genetic interactions was a prerequisite to dissect the Cia5 QTL and we suggest the partial advanced intercross strategy to be helpful also for dissecting other QTL controlling complex phenotypes...
  18. ncbi The novel small molecule drug Rabeximod is effective in reducing disease severity of mouse models of autoimmune disorders
    M Hultqvist
    Section for Medical Inflammation Research, I11 BMC, Lund University, Lund, Sweden
    Ann Rheum Dis 68:130-5. 2009
    ..In this study we aimed to evaluate Rabeximod as a treatment for autoimmune diseases, using animal models...
  19. ncbi Genetic control of tolerance to type II collagen and development of arthritis in an autologous collagen-induced arthritis model
    Johan Bäcklund
    Section of Medical Inflammation Research, Lund University, Lund, Sweden
    J Immunol 171:3493-9. 2003
    ..This finding is important for understanding CIA and perhaps also rheumatoid arthritis, as in both diseases MHC class II-restricted T cell recognition of the glycosylated CII peptide occurs...
  20. ncbi Influence of CD4 or CD8 deficiency on collagen-induced arthritis
    M Ehinger
    Department of Molecular Biophysics and Medical Inflammation Research Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden
    Immunology 103:291-300. 2001
    ....
  21. ncbi Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis
    K Bergsteinsdottir
    Section for Medical Inflammation Research, Lund University, Lund, Sweden
    J Immunol 164:1564-8. 2000
    ..Our results show that different phases of EAE are controlled by different sets of genes and that common genes are likely to be involved in different autoimmune diseases...
  22. ncbi B cell-deficient mice do not develop type II collagen-induced arthritis (CIA)
    L Svensson
    Section for Medical Inflammation Research, CMB, Lund University, Sweden
    Clin Exp Immunol 111:521-6. 1998
    ..We conclude that B cells play a crucial role in the development of CIA...
  23. ncbi Influence on spontaneous tissue inflammation by the major histocompatibility complex region in the nonobese diabetic mouse
    A K B Lindqvist
    Department of Cell and Molecular Biology, Section for Medical Inflammation Research, Lund University, Lund, Sweden
    Scand J Immunol 61:119-27. 2005
    ..Q compared to NOD. Consequently, we show that different haplotypes of MHC are instrumental in directing the specificity of the spontaneous autoimmune inflammation...
  24. ncbi Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats
    C Vingsbo-Lundberg
    Department of Cell and Molecular Biology, Lund University, Sweden
    Nat Genet 20:401-4. 1998
    ..These findings demonstrate for the first time that different phases of a chronic self-perpetuative disease which mimics RA are associated with distinct sets of genes...
  25. ncbi Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice
    M Johannesson
    Section for Medical Inflammation Research, Lund University, Lund, Sweden
    Genes Immun 6:575-83. 2005
    ..We conclude the QTL-chip strategy to be valuable in the selection of candidate genes to be prioritized for further investigation...
  26. ncbi IL-10-deficient B10.Q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type II collagen antibodies
    - Johansson AC
    Section for Medical Inflammation Research, University of Lund, Lund, Sweden
    J Immunol 167:3505-12. 2001
    ..These data emphasize the importance of studying IL-10 in a defined genetic context in vivo, to understand its role in a complex disease like arthritis...
  27. ncbi Identification and isolation of dominant susceptibility loci for pristane-induced arthritis
    Peter Olofsson
    Section for Medical Inflammation Research, Lund University, Lund, Sweden
    J Immunol 171:407-16. 2003
    ..These data highlight the usefulness of the statistical power obtained in a backcross of a complex disease like arthritis...
  28. ncbi Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1
    Peter Olofsson
    Section for Medical Inflammation Research, Lund University, S 22184 Lund, Sweden
    Genomics 83:765-71. 2004
    ..Therefore, the LEW/Mol should be regarded as a recombinant inbred strain...
  29. ncbi Role of glycopeptide-specific T cells in collagen-induced arthritis: an example how post-translational modification of proteins may be involved in autoimmune disease
    A Corthay
    Section for Medical Inflammation Research, Lund University, Sweden
    Ann Med 33:456-65. 2001
    ..These data open the possibility that outoimmune disease may be caused by the creation of new epitopes by posttranslational modification of proteins under circumstances such as trauma, inflammation or ageing...
  30. ncbi Finemapping of the arthritis QTL Pia7 reveals co-localization with Oia2 and the APLEC locus
    C Rintisch
    Department of Experimental Medical Science, Lund University, Sweden
    Genes Immun 11:239-45. 2010
    ..In conclusion, this study shows that the APLEC locus is a major locus regulating the severity of experimentally induced arthritis in rats...
  31. ncbi Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) mice
    A Corthay
    Department of Cell and Molecular Biology, Section for Medical Inflammation Research, Lund University, Solvegatan 19, 221 00 Lund, Sweden
    Int Immunol 11:1065-73. 1999
    ..We conclude that alphabeta T cells are necessary for CIA development and for an IgG response towards CII, whereas gammadelta T cells are neither necessary nor sufficient for development of CIA...
  32. ncbi Primed B cells present type-II collagen to T cells
    M Holmdahl
    Section for Medical Inflammation Research, Lund University, Lund, Sweden
    Scand J Immunol 55:382-9. 2002
    ..We further conclude that B cells have the potential to play an important role as APC in the development of CIA...
  33. ncbi Efficient promotion of collagen antibody induced arthritis (CAIA) using four monoclonal antibodies specific for the major epitopes recognized in both collagen induced arthritis and rheumatoid arthritis
    Kutty Selva Nandakumar
    Medical Inflammation Research, BMC I 11, Lund University, S 22184 Lund, Sweden
    J Immunol Methods 304:126-36. 2005
    ..Thus, this method is recommended as a new protocol for the induction of CAIA...
  34. ncbi Detection of arthritis-susceptibility loci, including Ncf1, and variable effects of the major histocompatibility complex region depending on genetic background in rats
    Carola Rintisch
    Lund University, Lund, and Karolinska Institute, Stockholm, Sweden
    Arthritis Rheum 60:419-27. 2009
    ....
  35. ncbi Positional cloning of Ncf1--a piece in the puzzle of arthritis genetics
    P Olofsson
    Section for Medical Inflammation Research, Lund University, , S-22184 Lund, Sweden
    Scand J Immunol 58:155-64. 2003
    ..In this review, we outline the methods used to identify Ncf1 as one single susceptibility gene in a complex puzzle of inherited factors that render susceptibility to a complex autoimmune disorder like arthritis...
  36. ncbi Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models
    A S Hansson
    Medical Inflammation Research, Biomedical Center, Lund University, Lund, Sweden
    Clin Exp Immunol 127:37-42. 2002
    ..We conclude that pristane-induced arthritis is a joint-specific model whereas collagen-induced arthritis affect joints as well as extra-articular cartilage. Furthermore, collagen immunization induces an antibody response to matrilin-1...
  37. ncbi The Y chromosome-linked "autoimmune accelerating" yaa gene suppresses collagen-induced arthritis
    L Jansson
    Department of Medical Inflammation Research, Lund University, Sweden
    Eur J Immunol 24:1213-7. 1994
    ..yaa mice a reduced number of T cells were found to produce interferon-gamma after in vitro stimulation with CII. Thus, although autoreactive B cells are important in both diseases they play different roles in murine lupus and in CIA...
  38. ncbi Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis
    Kutty Selva Nandakumar
    Medical Inflammation Research, Lund University, Lund 22184, Sweden
    Arthritis Res Ther 8:223. 2006
    ....
  39. ncbi IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis
    Ingrid Teige
    Section for Medical Inflammation Research, Department of Cell and Molecular Biology, University of Lund, Lund, Sweden
    J Immunol 170:4776-84. 2003
    ..We suggest that lack of endogenous IFN-beta in CNS leads to augmented microglia activation, resulting in a sustained inflammation, cytokine production, and tissue damage with consequent chronic neurological deficits...
  40. ncbi A comparative genetic analysis between collagen-induced arthritis and pristane-induced arthritis
    Peter Olofsson
    Section for Medical Inflammation Research, , I11 BMC, Lund University, S-22184 Lund, Sweden
    Arthritis Rheum 48:2332-42. 2003
    ..CONCLUSION: The underlying genetic control of CIA was found to have many, but not all, pathogenic mechanisms in common with PIA, despite the use of a cartilage-specific antigen (type II collagen) to induce CIA but not PIA...
  41. ncbi The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans
    Balik Dzhambazov
    Department of Cell and Molecular Biology, Section for Medical Inflammation Research, Lund University, Lund, Sweden
    Eur J Immunol 35:357-66. 2005
    ..We conclude that the chondrocyte determines the structures presented to the immune system and that these structures are different in normal versus arthritic states...
  42. ncbi Positional identification of Ncf1 as a gene that regulates arthritis severity in rats
    Peter Olofsson
    Section for Medical Inflammation Research and Department of Cell and Molecular Biology, Solvegatan 19, I11 BMC, Lund University, S 22184 Lund, Sweden
    Nat Genet 33:25-32. 2003
    ..Hence, Ncf1 is associated with a new autoimmune mechanism leading to severe destructive arthritis, notably similar to rheumatoid arthritis in humans...
  43. ncbi Pristane-induced arthritis in the rat
    Peter Olofsson
    Medical Inflammation Research, Lund, Sweden
    Methods Mol Med 136:255-68. 2007
    ..PIA can be diagnosed by biochemical analyzes in plasma that reflects systemic inflammation (alpha1-acid glycoprotein (AGP) and IL-6) and cartilage erosion (COMP)...
  44. ncbi Nature's choice of genes controlling chronic inflammation
    R Holmdahl
    Medical Inflammation Research, I11 BMC, Lund University, 22184 Lund, Sweden
    Ernst Schering Found Symp Proc 4:1-15. 2006
    ....
  45. ncbi Increased litter size and super-ovulation rate in congenic C57BL mice carrying a polymorphic fragment of NFR/N origin at the Fecq4 locus of chromosome 9
    Maria Liljander
    Lund Transgenic Core Facility, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Genet Res (Camb) 91:259-65. 2009
    ..Genes of the cytochrome P450 family (1, 11 and 19), such as Cyp19a1, are assumed to be particularly interesting, since they are known to exhibit female-associated reproductive phenotypes, affecting the ovulation rate, if mutated...
  46. ncbi Backcross and partial advanced intercross analysis of nonobese diabetic gene-mediated effects on collagen-induced arthritis reveals an interactive effect by two major loci
    Anna Karin B Lindqvist
    Medical Inflammation Research, Lund University, Lund, Sweden
    J Immunol 177:3952-9. 2006
    ..These data show that not only arthritis but also C5-dependent complement activity is dominantly suppressed, confirming that C5 is one of the major genes explaining the Cia2 effect...
  47. ncbi CD1-dependent regulation of chronic central nervous system inflammation in experimental autoimmune encephalomyelitis
    Anna Teige
    Section for Medical Inflammation Research, Lund University, I11 Biomedicinskt Centrum, S 221 84 Lund, Sweden
    J Immunol 172:186-94. 2004
    ....
  48. ncbi Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen
    Estelle Bajtner
    Medical Inflammation Research, Lund University, Lund, Sweden
    Arthritis Res Ther 7:R1148-57. 2005
    ..The development of chronic relapsing arthritis, initially induced by CII immunization, is associated with an arthritogenic antibody response to certain CII epitopes...
  49. ncbi Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene
    Malin Hultqvist
    Section for Medical Inflammation Research, Lund University, SE 22184 Lund, Sweden
    Proc Natl Acad Sci U S A 101:12646-51. 2004
    ....
  50. ncbi A transient post-translationally modified form of cartilage type II collagen is ignored by self-reactive T cells
    Hisakata Yamada
    Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University, Lund, Sweden
    J Immunol 173:4729-35. 2004
    ..Therefore, we conclude that the transient post-translationally modified form of cartilage CII does not induce T cell tolerance. This lack of T cell tolerance could increase the risk of developing autoimmune arthritis...
  51. ncbi Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis
    Hui Geng
    Department of Experimental Medical Sciences, BMC, Lund University, Lund, Sweden
    Arthritis Res Ther 10:R134. 2008
    ..The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. We have investigated the development of CIA in COMP-deficient mice...
  52. ncbi Antibodies to citrullinated proteins: molecular interactions and arthritogenicity
    Hüseyin Uysal
    Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden
    Immunol Rev 233:9-33. 2010
    ....
  53. ncbi Pristane, a non-antigenic adjuvant, induces MHC class II-restricted, arthritogenic T cells in the rat
    Jens Holmberg
    Medical Inflammation Research, Lund University, Lund, Sweden
    J Immunol 176:1172-9. 2006
    ..These data suggest that the in vivo administration of a non-antigenic adjuvant, like pristane, activates CD4+ alphabetaT cells that are MHC class II restricted and arthritogenic...
  54. ncbi Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2 fragments
    Maria Liljander
    Lund Transgenic Core Facility, BMC C13, Lund University, Lund, Sweden
    Arthritis Res Ther 10:R88. 2008
    ..The present study was performed to evaluate the role of the Cia40 locus in congenic B10.Q mice and to identify possible polymorphic candidate genes, which may also be relevant in the context of RA...
  55. ncbi Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis
    Johan Bäcklund
    Section of Medical Inflammation Research, BMC, Lund University, Lund, Sweden
    Eur J Immunol 32:3776-84. 2002
    ..Again, a strong vaccination potential of the glycopeptide was seen. Hence CII-glycopeptides may be the optimal choice of vaccination target in RA, since humans share the same epitope as the MMC mouse...
  56. ncbi Genetic linkage analysis of collagen-induced arthritis in the mouse
    J Jirholt
    Section for Medical Inflammation Research, CMB, Lund University, Sweden
    Eur J Immunol 28:3321-8. 1998
    ..A second putative locus was identified on chromosome 13 (lod 3.13). The present finding identifies new loci outside the MHC controlling CIA and provides evidence that mouse CIA is controlled by polymorphic genes...
  57. ncbi C4b-binding protein (C4BP) inhibits development of experimental arthritis in mice
    A M Blom
    Department of Laboratory Medicine, Division of Medical Protein Chemistry, Lund University, University Hospital Malmö entrance 46, The Wallenberg Laboratory floor 4, S 205 02 Malmo, Sweden
    Ann Rheum Dis 68:136-42. 2009
    ..To assess the human complement inhibitor C4b-binding protein (C4BP) for treatment of arthritis...
  58. ncbi Genetics of autoimmune diseases: a multistep process
    M Johannesson
    Medical Inflammation Research, Lund University, Sweden
    Curr Top Microbiol Immunol 305:259-76. 2006
    ..Here we will discuss the possibilities and difficulties of gene identification in animal models of autoimmune disorders...
  59. ncbi Identification of conformation-dependent epitopes and V gene selection in the B cell response to type II collagen in the DA rat
    P Wernhoff
    Section for Medical Inflammation Research, I 11 BMC, Lund University, 22184 Lund, Sweden
    Int Immunol 13:909-19. 2001
    ..However, the V genes used for recognition of the closely related collagen structures differed considerably between mouse and rat, indicating an influence of the species-specific variation in the V gene repertoire...
  60. ncbi Dissection of the genetic complexity of arthritis using animal models
    Rikard Holmdahl
    Medical Inflammation Research, BMC I11, Lund University, S 22184 Lund, Sweden
    Immunol Lett 103:86-91. 2006
    ..In this review I will argue for the usefulness of animal models as a tool to identify genes and pathways associated with disease. The examples to be discussed are genes controlling the oxidative burst pathways and MHC class II genes...
  61. ncbi Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules
    Balik Dzhambazov
    Medical Inflammation Research, Lund University, Lund, Sweden
    J Immunol 176:1525-33. 2006
    ..Thus, a complex between MHC class II molecules and a posttranslationally modified peptide offers a new possibility for treatment of chronically active autoimmune inflammation such as rheumatoid arthritis...
  62. ncbi IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis
    Lars Svensson
    Section for Medical Inflammation Research, I11 BMC, Lund University, SE 221 84 Lund, Sweden
    Eur J Immunol 32:2944-53. 2002
    ..We conclude that IL-4 plays different roles depending on the type of adjuvant used and the phase (acute or chronic) of the clinical disease...
  63. ncbi Tissue transglutaminase enhances collagen type II-induced arthritis and modifies the immunodominant T-cell epitope CII260-270
    Balik Dzhambazov
    Department of Medical Biochemistry and Biophysics, Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden
    Eur J Immunol 39:2412-23. 2009
    ..Moreover, we conclude that both processes, deamidation and cross-linking, are involved in the tTG-catalyzed reactions, and in vivo administration of tTG enhances arthritis severity and joint destruction in mice...
  64. ncbi The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis
    Patrik Wernhoff
    Lund University, Lund, Sweden
    Arthritis Rheum 48:3584-96. 2003
    ..To investigate the genetic regulation of rheumatoid factor (RF) in a rat model of rheumatoid arthritis, in order to gain understanding of the enigmatic role of RF in the disease...
  65. ncbi Intrinsic tolerance in autologous collagen-induced arthritis is generated by CD152-dependent CD4+ suppressor cells
    Alexandra P Treschow
    Section for Medical Inflammation Research, University of Lund, Sweden
    J Immunol 174:6742-50. 2005
    ....
  66. ncbi Reversal of tolerance induced by transplantation of skin expressing the immunodominant T cell epitope of rat type II collagen entitles development of collagen-induced arthritis but not graft rejection
    Johan Bäcklund
    Section of Medical Inflammation Research, BMC, Lund University, Lund, Sweden
    Eur J Immunol 32:1773-83. 2002
    ..Strikingly, despite the regained T cell response, development of arthritis was not accompanied by graft rejection, showing that these immune-mediated inflammatory responses involve different mechanisms...
  67. ncbi Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation
    Kutty Selva Nandakumar
    Lund University, Lund, Sweden
    Arthritis Rheum 58:184-96. 2008
    ....
  68. ncbi Stromal cells and osteoclasts are responsible for exacerbated collagen-induced arthritis in interferon-beta-deficient mice
    Alexandra P Treschow
    Section for Medical Inflammation Research, University of Lund, Lund, Sweden
    Arthritis Rheum 52:3739-48. 2005
    ..Clinical trials using interferon-beta (IFNbeta) in the treatment of rheumatoid arthritis have shown conflicting results. We undertook this study to understand the mechanisms of IFNbeta in arthritis at a physiologic level...
  69. ncbi Genetic heterogeneity of autoimmune disorders in the nonobese diabetic mouse
    A C M Johansson
    Section for Medical Inflammation Research, Department of Cell and Molecular Biology, University of Lund, Sweden
    Scand J Immunol 57:203-13. 2003
    ..However, based on various gene-segregation experiments, it seems that only a few loci are shared and that each disorder is influenced also by a unique set of genes...
  70. ncbi Genetic control of collagen-induced arthritis in a cross with NOD and C57BL/10 mice is dependent on gene regions encoding complement factor 5 and FcgammaRIIb and is not associated with loci controlling diabetes
    A C Johansson
    Section for Medical Inflammation Research, Department of Cell and Molecular Biology, University of Lund, Lund, Sweden
    Eur J Immunol 31:1847-56. 2001
    ..The genetic control of arthritis is unique in comparison to diabetes, since none of these loci have been identified in analysis of diabetes susceptibility...
  71. ncbi The occurrence of autoantibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis
    A S Hansson
    Medical Inflammation Research, Lund University, Sweden
    Arthritis Rheum 44:2402-12. 2001
    ..We investigated the response to matrilin 1 and other cartilage proteins in sera from patients with RP, 4 additional groups of patients with other major connective tissue diseases, and healthy control subjects...
  72. ncbi Primer: comparative genetics of animal models of arthritis--a tool to resolve complexity
    Rikard Holmdahl
    Medical Inflammation Research, Lund University, Lund, Sweden
    Nat Clin Pract Rheumatol 3:104-11. 2007
    ....
  73. ncbi Fragmentation of two quantitative trait loci controlling collagen-induced arthritis reveals a new set of interacting subloci
    Emma Ahlqvist
    Medical Inflammation Research, Lund University, Lund 22184, Sweden
    J Immunol 178:3084-90. 2007
    ..Our results indicate that F(2) crosses do not reveal the full complexity of identified QTLs, and that detection is more dependent on the genetic context of a QTL than the potential effect of the underlying gene...
  74. ncbi Endoglycosidase treatment abrogates IgG arthritogenicity: importance of IgG glycosylation in arthritis
    Kutty Selva Nandakumar
    Medical Inflammation Research, Lund University, Lund, Sweden
    Eur J Immunol 37:2973-82. 2007
    ..Hence, the asparagine-linked glycan on IgG plays a crucial role in the development of arthritis...
  75. ncbi Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species
    Kyra A Gelderman
    Section of Medical Inflammation Research, Lund University, Lund, Sweden
    J Clin Invest 117:3020-8. 2007
    ..In conclusion, macrophage-derived ROS play a role in T cell selection, maturation, and differentiation, and also a suppressive role in T cell activation, and thereby mediate protection against autoimmune diseases like arthritis...
  76. ncbi Cartilage oligomeric matrix protein induction of chronic arthritis in mice
    Stefan Carlsen
    Lund University, Lund, Sweden
    Arthritis Rheum 58:2000-11. 2008
    ..To develop a new mouse model for arthritis using cartilage oligomeric matrix protein (COMP) and to study the role of major histocompatibility complex (MHC) and Ncf1 genes in COMP-induced arthritis (COMPIA)...
  77. ncbi Ncf1-associated reduced oxidative burst promotes IL-33R+ T cell-mediated adjuvant-free arthritis in mice
    Kristin Hagenow
    Medical Inflammation Research, Lund University and Karolinska Institute, Stockholm, Sweden
    J Immunol 183:874-81. 2009
    ..These results demonstrate that the insufficient production of ROS promotes the breakdown of immune tolerance and development of autoimmune and adjuvant-free arthritis through an IL-5- and IL33R-dependent T cell activation pathway...
  78. ncbi Arthritis induced with cartilage-specific antibodiesis IL-4-dependent
    Kutty Selva Nandakumar
    Medical Inflammation Research, Lund University, Sweden
    Eur J Immunol 36:1608-18. 2006
    ..IL-1R- and IL-1RTNFR-deficient mice were completely resistant to CAIA. Thus, IL-4 promotes an antibody-mediated and TNF-alpha/IL-1beta-dependent inflammation in vivo...
  79. ncbi Identification of genetic regions of importance for reproductive performance in female mice
    Maria Liljander
    Lund Transgenic Core Facility, Lund University, Sweden
    Genetics 173:901-9. 2006
    ..It is well known that reproductive performance is polygenically controlled, and the identification of the major loci in this complex process opens the possibility of investigating the natural genetic control of reproduction...
  80. ncbi A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity
    Lina M Olsson
    Medical Inflammation Research, Lund University, BMC I11, 221 84, Lund, Sweden
    Arthritis Res Ther 9:R98. 2007
    ....
  81. ncbi Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice
    Malin Hultqvist
    Section for Medical Inflammation Research, Lund University, Lund, Sweden
    J Immunol 179:1431-7. 2007
    ..This is important as we, for the first time, can follow the effect of ROS on molecular mechanisms where T cells are responsible for either protection or promotion of arthritis depending on the level of oxygen species produced...
  82. ncbi Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes
    Therese Lindvall
    Department of Experimental Medical Science, Unit for Medical Inflammation Research, BMC l11, Lund Unviersity, S 221 84 Lund, Sweden
    Arthritis Res Ther 11:R10. 2009
    ..The aim of the present study was to investigate whether genes within Eae39, in addition to EAE, control development of collagen-induced arthritis (CIA)...
  83. ncbi Comment on "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease"
    Thomas Blom
    Department of Medical Inflammation Research, Lund University, , Lund 22184, Sweden
    Science 299:1845; author reply 1845. 2003
  84. ncbi Two-loci interaction confirms arthritis-regulating quantitative trait locus on rat chromosome 6
    Peter Olofsson
    Section for Medical Inflammation Research, Lund University, S 22184 Lund, Sweden
    Genomics 82:652-9. 2003
    ..As the introduction of Pia4 heterozygosity results in a lower level of arthritis severity we regard this as an additive interaction with a severity threshold-lowering effect...
  85. ncbi Oligoclonal IgG bands synthesized in the central nervous system are present in rats with experimental autoimmune encephalomyelitis
    B Rostrom
    Section for Medical Inflammation Research, Lund University, Lund, Sweden
    Acta Neurol Scand 109:106-12. 2004
    ..Oligoclonal bands (OBs) in electrophoresis of cerebrospinal fluid (CSF) are present in multiple sclerosis and here is investigated whether these also occur in experimental autoimmune encephalomyelitis (EAE)...
  86. ncbi Enhancement of collagen-induced arthritis in female mice by estrogen receptor blockage
    L Jansson
    Section for Medical Inflammation Research, Lund University, Sweden
    Arthritis Rheum 44:2168-75. 2001
    ..CONCLUSION: These findings show that estrogen-induced suppression of CIA is mediated via the nuclear ERs and is operating at physiologic, possibly even subphysiologic, levels of estrogens...
  87. ncbi Limited polymorphism in the first domain of the rat MHC class II RT1-D molecule
    M Vestberg
    Section for Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University, Box 94, S-221 00 Lund, Sweden
    Immunogenetics 48:344-9. 1998
  88. ncbi Identification of new loci controlling collagen-induced arthritis in mouse using a partial advanced intercross and congenic strains
    M Popovic
    Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden
    Scand J Immunol 68:405-13. 2008
    ..Both Tcr loci were within CIA loci making them candidate susceptibility genes. The results demonstrate the importance of breaking up genetic regions in smaller fragments to identify the underlying complex set of loci...
  89. ncbi The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes
    J Jirholt
    Section for Medical Inflammation Research, CMB, Lund University, S-223 63 Lund, Sweden
    Arthritis Res 3:87-97. 2001
    ..Animal models are therefore valuable tools for identifying genes and determining their pathogenic role in the disease. This is probably the fastest route towards unravelling the pathogenesisis of RA and developing new therapies...
  90. ncbi Estrogen-mediated immunosuppression in autoimmune diseases
    L Jansson
    Section for Medical Inflammation Research, CMB, Lund University, Sweden
    Inflamm Res 47:290-301. 1998
    ..In addition, the mechanisms of estrogen and anti-estrogens are discussed in relation to their possible use as future therapeutic anti-inflammatory agents...
  91. ncbi Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis
    Hüseyin Uysal
    Center for Molecular Protein Science, Biomedical Center I11, Lund University, 221 00 Lund, Sweden
    J Exp Med 206:449-62. 2009
    ..Based on these findings, we propose that autoimmunity to CII, leading to the production of antibodies specific for both native and citrullinated CII, is an important pathogenic factor in the development of RA...
  92. ncbi A comparative analysis of B cell-mediated myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis pathogenesis in B cell-deficient mice reveals an effect on demyelination
    Lars Svensson
    Medical Inflammation Research, Lund University, Lund, Sweden
    Eur J Immunol 32:1939-46. 2002
    ..The contribution of B cells to pathogenesis appears to be mainly through demyelination rather than through inflammation...
  93. ncbi Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations
    Jenny Karlsson
    Department for Cell and Molecular Biology, Section for Medical Inflammation Research, University of Lund, Sweden
    J Immunol 170:1019-26. 2003
    ..The identification of subphenotypes that are linked to the same loci as disease traits could be most useful in the search for candidate genes and biological pathways involved in the pathological process...
  94. ncbi Genetic links between the acute-phase response and arthritis development in rats
    Peter Olofsson
    Lund University, Sweden
    Arthritis Rheum 46:259-68. 2002
    ..We investigated the genetic control of the acute-phase protein response in pristane-induced arthritis (PIA), which is a chronic erosive arthritis model in rats...
  95. ncbi A genetic basis for shared autoimmunity in mouse models
    Asa Andersson
    Medical Inflammation Research, Lund University, Lund, Sweden
    Autoimmunity 38:209-17. 2005
    ..Here, we will discuss some aspects of shared autoimmunity in mouse models from a genetic point of view...
  96. ncbi Both common and unique susceptibility genes in different rat strains with pristane-induced arthritis
    Shemin Lu
    Section for Medical Inflammation Research, Biomedical Center, Lund University, Lund, Sweden
    Eur J Hum Genet 10:475-83. 2002
    ..These findings provide clues to how genetic factors by themselves, and in interaction with each other, regulate the development of a disease, which displays many similarities to RA...
  97. ncbi Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB
    Kutty Selva Nandakumar
    Medical Inflammation Research, Biomedical Center, Lund University, Lund, Sweden
    Eur J Immunol 33:2269-77. 2003
    ..These results demonstrate that single IgG anti-CII mAb can induce erosive arthritis and that IgG anti-CII Ab mediate arthritis by engagement of FcgammaR...
  98. ncbi Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes
    Kutty Selva Nandakumar
    Section for Medical Inflammation Research, I 11 BMC, Lund University, 22184 Lund, Sweden
    Am J Pathol 163:1827-37. 2003
    ..We conclude that CAIA is an acute arthritis triggered by antibody binding and neutrophils bypassing immune activation but with many characteristics in common with collagen-induced arthritis...
  99. ncbi Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis
    Johan Bäcklund
    Section of Medical Inflammation Research, Solvegatan 19, I11 BMC, Lund University, SE 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 99:9960-5. 2002
    ..Thus, RA T cells predominantly recognize the immunodominant CII peptide in its glycosylated form and may explain why previously it has been difficult to detect T cell responses to CII in RA patients...
  100. ncbi Chronicity of pristane-induced arthritis in rats is controlled by genes on chromosome 14
    Lena Wester
    Institute for Immunology, University of Rostock, Rostock, Germany
    J Autoimmun 21:305-13. 2003
    ..We conclude that the active relapsing chronic arthritis is under a unique genetic control that is different from the control of acute arthritis and postulate that the liver plays an important role in this regulation...
  101. ncbi Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats
    Lena Wester
    Institute für Immunologie, Universitat Rostock, Rostock, Germany
    Arthritis Res Ther 5:R361-72. 2003
    ..All genes have functions that are potentially important for arthritis, and nine of the genes are located within genomic regions previously associated with autoimmune disease...