Tord A Hjalt

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells
    Lars M Ittner
    Research Laboratory for Calcium Metabolism, Orthopedic University Hospital Balgrist, CH-8008 Zurich, Switzerland
    J Biol 4:11. 2005
  2. ncbi Novel forms of Paired-like homeodomain transcription factor 2 (PITX2): generation by alternative translation initiation and mRNA splicing
    Pankaj Lamba
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    BMC Mol Biol 9:31. 2008
  3. ncbi Current molecular understanding of Axenfeld-Rieger syndrome
    Tord A Hjalt
    Lund University, Department of Experimental Medical Research, BMC B12, Tornavagen 10, SE 22184 Lund, Sweden
    Expert Rev Mol Med 7:1-17. 2005
  4. ncbi PITX2 gain-of-function induced defects in mouse forelimb development
    Johan Holmberg
    Department of Experimental Medical Science, Division for Cell and Matrix Biology, Lund University, Lund, Sweden
    BMC Dev Biol 8:25. 2008
  5. ncbi PITX2 gain-of-function in Rieger syndrome eye model
    Johan Holmberg
    Lund University, Department of Cell and Molecular Biology, Section for Cell and Developmental Biology, BMC B12, Tornavagen 10, SE 22184 Lund, Sweden
    Am J Pathol 165:1633-41. 2004
  6. ncbi Differential regulation of gene expression by PITX2 isoforms
    Carol J Cox
    Department of Biological Science, The University of Tulsa, Oklahoma 74104 3189, USA
    J Biol Chem 277:25001-10. 2002
  7. ncbi PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5
    Mrudula Ganga
    Department of Biological Science, The University of Tulsa, Tulsa, Oklahoma 74104 3189, USA
    J Biol Chem 278:22437-45. 2003
  8. ncbi PITX genes are required for cell survival and Lhx3 activation
    Michael A Charles
    4301 MSRB III, 1500 West Medical Center Drive, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Mol Endocrinol 19:1893-903. 2005
  9. ncbi Pituitary homeobox 2 regulates adrenal4 binding protein/steroidogenic factor-1 gene transcription in the pituitary gonadotrope through interaction with the intronic enhancer
    Yuichi Shima
    Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Japan
    Mol Endocrinol 22:1633-46. 2008

Collaborators

  • Johan Holmberg
  • Chia Yang Liu
  • Peter Leander
  • Pankaj Lamba
  • J Drouin
  • Philip Gage
  • Lukas Sommer
  • B A Amendt
  • Carol J Cox
  • Yuichi Shima
  • Michael A Charles
  • Lars M Ittner
  • Mrudula Ganga
  • Lisa Morton
  • Herbert M Espinoza
  • Ken ichirou Morohashi
  • Ken-Ichirou Morohashi
  • Mohamad Zubair
  • Chikako Yokoyama
  • Tomoko Komatsu
  • Sanae Oka
  • Taro Tachibana
  • Fabian Ille
  • Per Leveen
  • Sally A Camper
  • Thomas Kunz
  • Ueli Suter
  • Stefan Karlsson
  • Kerstin Schwerdtfeger
  • Heiko Wurdak
  • Farhad Hafezi
  • Walter Born
  • Hoonkyo Suh
  • Youngsook Lee
  • Kimberly Chappell
  • Elena V Semina
  • Bryan McWilliams

Detail Information

Publications9

  1. ncbi Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells
    Lars M Ittner
    Research Laboratory for Calcium Metabolism, Orthopedic University Hospital Balgrist, CH-8008 Zurich, Switzerland
    J Biol 4:11. 2005
    ..The similarity to developmental eye disorders in humans suggests that defective TGFbeta signal modulation in ocular NC derivatives contributes to the pathophysiology of these diseases...
  2. ncbi Novel forms of Paired-like homeodomain transcription factor 2 (PITX2): generation by alternative translation initiation and mRNA splicing
    Pankaj Lamba
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    BMC Mol Biol 9:31. 2008
    ..The proteins derived from these mRNAs contain identical homeodomain and carboxyl termini. Differences in the amino-termini of the proteins may confer functional differences in some contexts...
  3. ncbi Current molecular understanding of Axenfeld-Rieger syndrome
    Tord A Hjalt
    Lund University, Department of Experimental Medical Research, BMC B12, Tornavagen 10, SE 22184 Lund, Sweden
    Expert Rev Mol Med 7:1-17. 2005
    ..In experimental animal models and in cell culture experiments using PITX2, abundant evidence indicates that a narrow window of expression level of this gene is vital for its correct function...
  4. ncbi PITX2 gain-of-function induced defects in mouse forelimb development
    Johan Holmberg
    Department of Experimental Medical Science, Division for Cell and Matrix Biology, Lund University, Lund, Sweden
    BMC Dev Biol 8:25. 2008
    ..Pitx2 is expressed in the majority of premature presumptive forelimb musculature at embryonic day 12.5 and then maintained throughout embryogenesis to adult skeletal muscle...
  5. ncbi PITX2 gain-of-function in Rieger syndrome eye model
    Johan Holmberg
    Lund University, Department of Cell and Molecular Biology, Section for Cell and Developmental Biology, BMC B12, Tornavagen 10, SE 22184 Lund, Sweden
    Am J Pathol 165:1633-41. 2004
    ..These findings indicate a novel pathogenetic mechanism in which excess corneal and iridal PITX2A cause glaucoma and anterior defects that closely resemble Axenfeld-Rieger syndrome...
  6. ncbi Differential regulation of gene expression by PITX2 isoforms
    Carol J Cox
    Department of Biological Science, The University of Tulsa, Oklahoma 74104 3189, USA
    J Biol Chem 277:25001-10. 2002
    ..PITX2 isoform activities are both promoter- and cell-specific, and our data reveal new mechanisms for PITX2-regulated gene expression...
  7. ncbi PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5
    Mrudula Ganga
    Department of Biological Science, The University of Tulsa, Tulsa, Oklahoma 74104 3189, USA
    J Biol Chem 278:22437-45. 2003
    ..We provide a new mechanism for the regulation of heart development by PITX2 isoforms through the regulation of ANF and PLOD1 gene expression and Nkx2.5 transcriptional activity...
  8. ncbi PITX genes are required for cell survival and Lhx3 activation
    Michael A Charles
    4301 MSRB III, 1500 West Medical Center Drive, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Mol Endocrinol 19:1893-903. 2005
    ..Thus, the combined dosage of these PITX family members is vital for pituitary development, and their persistent coexpression in the adult pituitary suggests a continued role in maintenance of pituitary function...
  9. ncbi Pituitary homeobox 2 regulates adrenal4 binding protein/steroidogenic factor-1 gene transcription in the pituitary gonadotrope through interaction with the intronic enhancer
    Yuichi Shima
    Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Japan
    Mol Endocrinol 22:1633-46. 2008
    ....