Research Topics
Species | H HerwaldSummaryAffiliation: Lund University Country: Sweden Publications
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Detail Information
Publications
Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of Pseudomonas aeruginosaKatarina Lundqvist
Section for Dermatology, Department of Medical Microbiology, Dermatology and Infection, Lund University, Biomedical Center, Lund, Sweden
Thromb Haemost 92:281-7. 2004..Our data suggest a possible link between bacterial presence and HBP-release in chronic ulcers. Thus, targeting HBP offers an interesting option for reduction of endothelial barrier dysfunction in chronic ulcers...
M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytesLisa I Påhlman
Department of Clinical Sciences, Lund, Section for Clinical and Experimental Infection Medicine, Lund University, SE 22184 Lund, Sweden
Microbiology 153:2458-64. 2007..Taken together, the results imply an important role for M proteins in the induction of haemostatic disorders in invasive streptococcal infectious diseases...
Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogenSonja Oehmcke
Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
Blood 114:444-51. 2009..HKH20 inhibits activation of the contact system and protects mice with invasive S pyogenes infection from lung damage. In combination with clindamycin treatment, the peptide also significantly prolongs the survival of infected mice...- Activation of the contact-phase system on bacterial surfaces--a clue to serious complications in infectious diseasesH Herwald
Department of Cell and Molecular Biology, Lund University, Sweden
Nat Med 4:298-302. 1998..Thus, the complex interplay of microbe surface proteins and host contact-phase factors may contribute to the symptoms of sepsis and septic shock... - Zinc-dependent conformational changes in domain D5 of high molecular mass kininogen modulate contact activationH Herwald
Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Tornavagen 10, S 221 Lund, Sweden
Eur J Biochem 268:396-404. 2001..The present data emphasize the role of zinc and other metal ions in the regulation of contact activation... - M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakageHeiko Herwald
Department of Cell and Molecular Biology, Lund University, Tornavagen 10, S 221 84 Lund, Sweden
Cell 116:367-79. 2004..In addition, M protein/fibrinogen complexes were identified in tissue biopsies from a patient with necrotizing fasciitis and STSS, further underlining the pathogenic significance of such complexes in severe streptococcal infections... - Interactions between surface proteins of Streptococcus pyogenes and coagulation factors modulate clotting of human plasmaH Herwald
Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Lund, Sweden
J Thromb Haemost 1:284-91. 2003..The results suggest that interactions between S. pyogenes and components of the coagulation system contribute to some of the symptoms seen in severe infections caused by this important human pathogen... - Staphylococcus aureus induces release of bradykinin in human plasmaE Mattsson
Department of Cell and Molecular Biology, Lund University, Sweden
Infect Immun 69:3877-82. 2001..aureus sepsis. The data also suggest that the contact system could be used as a target in the treatment of S. aureus infections... - Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory responseFredrik Kahn
Department of Clinical Sciences, Division of Infection Medicine, Lund University, BMC, B14, Lund, Sweden
PLoS Pathog 4:e1000149. 2008..The data add a novel aspect to bacterial pathogenesis where antibodies contribute to the severity of disease by promoting a pathologic inflammatory response... - Streptococcal M protein: a multipotent and powerful inducer of inflammationLisa I Påhlman
Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Biomedicinskt Centrum B14, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden
J Immunol 177:1221-8. 2006..The results show that M protein, in synergy with HBP, evokes an inflammatory response that may contribute to the profound pathophysiological consequences seen in severe streptococcal infections... - Activation of the human contact system on neutrophil extracellular trapsSonja Oehmcke
Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
J Innate Immun 1:225-30. 2009..In addition, we present evidence that M1 protein, a streptococcal surface protein, in concert with human fibrinogen triggers polymorphonuclear neutrophils to form NETs... - The antibacterial activity of peptides derived from human beta-2 glycoprotein I is inhibited by protein H and M1 protein from Streptococcus pyogenesMaria Nilsson
Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
Mol Microbiol 67:482-92. 2008..Taken together, the data suggest that the interaction between the streptococcal proteins and beta(2)GPI or beta(2)GPI-derived peptides presents a novel mechanism to resist an antibacterial attack by beta(2)GPI-cleavage products... - Soluble M1 protein of Streptococcus pyogenes triggers potent T cell activationLisa I Påhlman
Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, Lund, Sweden
Cell Microbiol 10:404-14. 2008.... - M1 protein from streptococcus pyogenes induces nitric oxide-mediated vascular hyporesponsiveness to phenylephrine: involvement of toll-like receptor activationThorgerdur Sigurdardottir
Division of Anesthesiology and Intensive Care, Department of Clinical Sciences, Lund University, Lund, Sweden
Shock 34:98-104. 2010..M1 protein could contribute to the circulatory disturbances accompanying severe invasive streptococcal infections... - Activation of human polymorphonuclear neutrophils by streptolysin O from Streptococcus pyogenes leads to the release of proinflammatory mediatorsMaria Nilsson
Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, BMC, B14, Lund University, , SE-221 84 Lund, Sweden
Thromb Haemost 95:982-90. 2006..The results of the present work therefore suggest that the interaction between SLO and PMNs evokes an exaggerated host response which may contribute to the pathogenesis of local and generalized S. pyogenes infections... - Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosisA M Olofsson
Department of Cell and Molecular Biology, Lund University, S 22100 Lund, Sweden
J Clin Invest 104:885-94. 1999.... - Induction of anti-β2 -glycoprotein I autoantibodies in mice by protein H of Streptococcus pyogenesG M A Van O S
Department of Clinical Chemistry and Hematology, University Medical Center, CX, Utrecht, The Netherlands
J Thromb Haemost 9:2447-56. 2011..Only the latter conformation is recognized by patient antibodies. β(2) -GPI has been shown to interact with Streptococcus pyogenes... - Superantigens from Staphylococcus aureus induce procoagulant activity and monocyte tissue factor expression in whole blood and mononuclear cells via IL-1 betaE Mattsson
Department of Medical Microbiology, Dermatology, and Infection, Lund University Hospital, Lund, Sweden
J Thromb Haemost 1:2569-76. 2003..During severe sepsis and septic shock microthrombi and multiorgan dysfunction are observed as a result of bacterial interference with the host defense and coagulation systems... - The conversion of fibrinogen to fibrin at the surface of curliated Escherichia coli bacteria leads to the generation of proinflammatory fibrinopeptidesKristin Persson
Department of Cell and Molecular Biology, Lund University, S-221 84 Lund, Sweden
J Biol Chem 278:31884-90. 2003..Our results therefore demonstrate that activation of the coagulation system at the bacterial surface contributes to the pathophysiology of bacterial infectious diseases... - Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesiclesHans Tapper
Department of Cell and Molecular Biology, Lund University, Sweden
Blood 99:1785-93. 2002..The ability of neutrophils to secrete HBP from secretory vesicles may be important for proinflammatory functions of this protein, such as the alteration of vascular permeability... - Streptococcal M proteins and their role as virulence determinantsSonja Oehmcke
Department of Clinical Sciences, Division of Infection Medicine, Lund University, SE 22184 Lund, Sweden
Clin Chim Acta 411:1172-80. 2010..The present review article aims to present a state-of-the-art overview of the most important virulence mechanisms employed by M proteins to trigger disease... - Protein C inhibitor--a novel antimicrobial agentErik Malmström
Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, Lund, Sweden
PLoS Pathog 5:e1000698. 2009..pyogenes. Taken together, our data describe a new function for PCI in innate immunity... - Contact activation by pathogenic bacteria: a virulence mechanism contributing to the pathophysiology of sepsisHeiko Herwald
Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Lund, Sweden
Scand J Infect Dis 35:604-7. 2003..Several significant human pathogens have the ability to activate the contact system, and the potential significance of this mechanism in bacterial virulence, including its role in sepsis, is discussed in this review... - Heparin-binding protein: an early marker of circulatory failure in sepsisAdam Linder
Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
Clin Infect Dis 49:1044-50. 2009..In this study, we investigated whether plasma levels of HBP could be used as an early diagnostic marker for severe sepsis with hypotension... - Thrombin-activatable fibrinolysis inhibitor binds to Streptococcus pyogenes by interacting with collagen-like proteins A and BLisa I Påhlman
Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, SE 22184 Lund, Sweden
J Biol Chem 282:24873-81. 2007..These findings suggest an important role for TAFI in the modulation of host responses by streptococci... - Kinin receptor expression during Staphylococcus aureus infectionSara H Bengtson
Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden
Blood 108:2055-63. 2006..The data of the present study implicate an important and previously unknown role for kinin receptor regulation in S aureus infections... - The dual role of the contact system in bacterial infectious diseaseInga Maria Frick
Section for Clinical and Experimental Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
Thromb Haemost 98:497-502. 2007.... - Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophagesOliver Soehnlein
Department of Physiology and Pharmacology and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
J Clin Invest 118:3491-502. 2008..Thus, we attribute what may be a novel role for PMN granule proteins in regulating the immune response to bacterial infections... - Neutrophil secretion products pave the way for inflammatory monocytesOliver Soehnlein
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
Blood 112:1461-71. 2008..This cellular cross-talk functionally results in enhanced cytokine levels and increased bacterial clearance, thus boosting the early immune response... - Identification of two protein-binding and functional regions of curli, a surface organelle and virulence determinant of Escherichia coliArne Olsen
Section for Molecular Pathogenesis, Department of Cell and Molecular Biology, Lund University, SE 221 84 Lund, Sweden
J Biol Chem 277:34568-72. 2002..The results map important curli functions to the regions corresponding to the NNS24 and VDQ26 sequences... - Peptidoglycan from Staphylococcus aureus induces tissue factor expression and procoagulant activity in human monocytesEva Mattsson
Department of Medical Microbiology, Lund University, Lund, Sweden
Infect Immun 70:3033-9. 2002..This mechanism helps to explain the procoagulant activity, which plays such an important role in the pathogenicity of severe S. aureus infections...