H Herwald

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Activation of the contact-phase system on bacterial surfaces--a clue to serious complications in infectious diseases
    H Herwald
    Department of Cell and Molecular Biology, Lund University, Sweden
    Nat Med 4:298-302. 1998
  2. ncbi Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of Pseudomonas aeruginosa
    Katarina Lundqvist
    Section for Dermatology, Department of Medical Microbiology, Dermatology and Infection, Lund University, Biomedical Center, Lund, Sweden
    Thromb Haemost 92:281-7. 2004
  3. pmc M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes
    Lisa I Påhlman
    Department of Clinical Sciences, Lund, Section for Clinical and Experimental Infection Medicine, Lund University, SE 22184 Lund, Sweden
    Microbiology 153:2458-64. 2007
  4. doi Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen
    Sonja Oehmcke
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
    Blood 114:444-51. 2009
  5. ncbi M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage
    Heiko Herwald
    Department of Cell and Molecular Biology, Lund University, Tornavagen 10, S 221 84 Lund, Sweden
    Cell 116:367-79. 2004
  6. ncbi Interactions between surface proteins of Streptococcus pyogenes and coagulation factors modulate clotting of human plasma
    H Herwald
    Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Lund, Sweden
    J Thromb Haemost 1:284-91. 2003
  7. ncbi Zinc-dependent conformational changes in domain D5 of high molecular mass kininogen modulate contact activation
    H Herwald
    Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Tornavagen 10, S 221 Lund, Sweden
    Eur J Biochem 268:396-404. 2001
  8. pmc Staphylococcus aureus induces release of bradykinin in human plasma
    E Mattsson
    Department of Cell and Molecular Biology, Lund University, Sweden
    Infect Immun 69:3877-82. 2001
  9. ncbi Streptococcal M protein: a multipotent and powerful inducer of inflammation
    Lisa I Påhlman
    Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Biomedicinskt Centrum B14, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden
    J Immunol 177:1221-8. 2006
  10. pmc Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response
    Fredrik Kahn
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, BMC, B14, Lund, Sweden
    PLoS Pathog 4:e1000149. 2008

Collaborators

Detail Information

Publications32

  1. ncbi Activation of the contact-phase system on bacterial surfaces--a clue to serious complications in infectious diseases
    H Herwald
    Department of Cell and Molecular Biology, Lund University, Sweden
    Nat Med 4:298-302. 1998
    ..Thus, the complex interplay of microbe surface proteins and host contact-phase factors may contribute to the symptoms of sepsis and septic shock...
  2. ncbi Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of Pseudomonas aeruginosa
    Katarina Lundqvist
    Section for Dermatology, Department of Medical Microbiology, Dermatology and Infection, Lund University, Biomedical Center, Lund, Sweden
    Thromb Haemost 92:281-7. 2004
    ..Our data suggest a possible link between bacterial presence and HBP-release in chronic ulcers. Thus, targeting HBP offers an interesting option for reduction of endothelial barrier dysfunction in chronic ulcers...
  3. pmc M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes
    Lisa I Påhlman
    Department of Clinical Sciences, Lund, Section for Clinical and Experimental Infection Medicine, Lund University, SE 22184 Lund, Sweden
    Microbiology 153:2458-64. 2007
    ..Taken together, the results imply an important role for M proteins in the induction of haemostatic disorders in invasive streptococcal infectious diseases...
  4. doi Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen
    Sonja Oehmcke
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
    Blood 114:444-51. 2009
    ..HKH20 inhibits activation of the contact system and protects mice with invasive S pyogenes infection from lung damage. In combination with clindamycin treatment, the peptide also significantly prolongs the survival of infected mice...
  5. ncbi M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage
    Heiko Herwald
    Department of Cell and Molecular Biology, Lund University, Tornavagen 10, S 221 84 Lund, Sweden
    Cell 116:367-79. 2004
    ..In addition, M protein/fibrinogen complexes were identified in tissue biopsies from a patient with necrotizing fasciitis and STSS, further underlining the pathogenic significance of such complexes in severe streptococcal infections...
  6. ncbi Interactions between surface proteins of Streptococcus pyogenes and coagulation factors modulate clotting of human plasma
    H Herwald
    Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Lund, Sweden
    J Thromb Haemost 1:284-91. 2003
    ..The results suggest that interactions between S. pyogenes and components of the coagulation system contribute to some of the symptoms seen in severe infections caused by this important human pathogen...
  7. ncbi Zinc-dependent conformational changes in domain D5 of high molecular mass kininogen modulate contact activation
    H Herwald
    Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Tornavagen 10, S 221 Lund, Sweden
    Eur J Biochem 268:396-404. 2001
    ..The present data emphasize the role of zinc and other metal ions in the regulation of contact activation...
  8. pmc Staphylococcus aureus induces release of bradykinin in human plasma
    E Mattsson
    Department of Cell and Molecular Biology, Lund University, Sweden
    Infect Immun 69:3877-82. 2001
    ..aureus sepsis. The data also suggest that the contact system could be used as a target in the treatment of S. aureus infections...
  9. ncbi Streptococcal M protein: a multipotent and powerful inducer of inflammation
    Lisa I Påhlman
    Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Biomedicinskt Centrum B14, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden
    J Immunol 177:1221-8. 2006
    ..The results show that M protein, in synergy with HBP, evokes an inflammatory response that may contribute to the profound pathophysiological consequences seen in severe streptococcal infections...
  10. pmc Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response
    Fredrik Kahn
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, BMC, B14, Lund, Sweden
    PLoS Pathog 4:e1000149. 2008
    ..The data add a novel aspect to bacterial pathogenesis where antibodies contribute to the severity of disease by promoting a pathologic inflammatory response...
  11. doi Activation of the human contact system on neutrophil extracellular traps
    Sonja Oehmcke
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
    J Innate Immun 1:225-30. 2009
    ..In addition, we present evidence that M1 protein, a streptococcal surface protein, in concert with human fibrinogen triggers polymorphonuclear neutrophils to form NETs...
  12. ncbi The antibacterial activity of peptides derived from human beta-2 glycoprotein I is inhibited by protein H and M1 protein from Streptococcus pyogenes
    Maria Nilsson
    Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
    Mol Microbiol 67:482-92. 2008
    ..Taken together, the data suggest that the interaction between the streptococcal proteins and beta(2)GPI or beta(2)GPI-derived peptides presents a novel mechanism to resist an antibacterial attack by beta(2)GPI-cleavage products...
  13. pmc Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis
    A M Olofsson
    Department of Cell and Molecular Biology, Lund University, S 22100 Lund, Sweden
    J Clin Invest 104:885-94. 1999
    ....
  14. doi M1 protein from streptococcus pyogenes induces nitric oxide-mediated vascular hyporesponsiveness to phenylephrine: involvement of toll-like receptor activation
    Thorgerdur Sigurdardottir
    Division of Anesthesiology and Intensive Care, Department of Clinical Sciences, Lund University, Lund, Sweden
    Shock 34:98-104. 2010
    ..M1 protein could contribute to the circulatory disturbances accompanying severe invasive streptococcal infections...
  15. ncbi Soluble M1 protein of Streptococcus pyogenes triggers potent T cell activation
    Lisa I Påhlman
    Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, Lund, Sweden
    Cell Microbiol 10:404-14. 2008
    ....
  16. ncbi Activation of human polymorphonuclear neutrophils by streptolysin O from Streptococcus pyogenes leads to the release of proinflammatory mediators
    Maria Nilsson
    Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, BMC, B14, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden
    Thromb Haemost 95:982-90. 2006
    ..The results of the present work therefore suggest that the interaction between SLO and PMNs evokes an exaggerated host response which may contribute to the pathogenesis of local and generalized S. pyogenes infections...
  17. doi Antimicrobial activity of fibrinogen and fibrinogen-derived peptides - a novel link between coagulation and innate immunity
    L I Påhlman
    Lisa I Påhlman, Department of Clinical Sciences, Lund, Division of Infection Medicine, BMC B14, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden, Tel 46 46 2220380, Fax 46 46 157756, E mail
    Thromb Haemost 109:930-9. 2013
    ....
  18. doi Induction of anti-β2 -glycoprotein I autoantibodies in mice by protein H of Streptococcus pyogenes
    G M A Van O S
    Department of Clinical Chemistry and Hematology, University Medical Center, CX, Utrecht, The Netherlands
    J Thromb Haemost 9:2447-56. 2011
    ..Only the latter conformation is recognized by patient antibodies. β(2) -GPI has been shown to interact with Streptococcus pyogenes...
  19. ncbi Superantigens from Staphylococcus aureus induce procoagulant activity and monocyte tissue factor expression in whole blood and mononuclear cells via IL-1 beta
    E Mattsson
    Department of Medical Microbiology, Dermatology, and Infection, Lund University Hospital, Lund, Sweden
    J Thromb Haemost 1:2569-76. 2003
    ..During severe sepsis and septic shock microthrombi and multiorgan dysfunction are observed as a result of bacterial interference with the host defense and coagulation systems...
  20. ncbi Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles
    Hans Tapper
    Department of Cell and Molecular Biology, Lund University, Sweden
    Blood 99:1785-93. 2002
    ..The ability of neutrophils to secrete HBP from secretory vesicles may be important for proinflammatory functions of this protein, such as the alteration of vascular permeability...
  21. ncbi The conversion of fibrinogen to fibrin at the surface of curliated Escherichia coli bacteria leads to the generation of proinflammatory fibrinopeptides
    Kristin Persson
    Department of Cell and Molecular Biology, Lund University, S 221 84 Lund, Sweden
    J Biol Chem 278:31884-90. 2003
    ..Our results therefore demonstrate that activation of the coagulation system at the bacterial surface contributes to the pathophysiology of bacterial infectious diseases...
  22. pmc Kinin receptor expression during Staphylococcus aureus infection
    Sara H Bengtson
    Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden
    Blood 108:2055-63. 2006
    ..The data of the present study implicate an important and previously unknown role for kinin receptor regulation in S aureus infections...
  23. doi Streptococcal M proteins and their role as virulence determinants
    Sonja Oehmcke
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, SE 22184 Lund, Sweden
    Clin Chim Acta 411:1172-80. 2010
    ..The present review article aims to present a state-of-the-art overview of the most important virulence mechanisms employed by M proteins to trigger disease...
  24. pmc Protein C inhibitor--a novel antimicrobial agent
    Erik Malmström
    Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, Lund, Sweden
    PLoS Pathog 5:e1000698. 2009
    ..pyogenes. Taken together, our data describe a new function for PCI in innate immunity...
  25. doi Heparin-binding protein: an early marker of circulatory failure in sepsis
    Adam Linder
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
    Clin Infect Dis 49:1044-50. 2009
    ..In this study, we investigated whether plasma levels of HBP could be used as an early diagnostic marker for severe sepsis with hypotension...
  26. ncbi Thrombin-activatable fibrinolysis inhibitor binds to Streptococcus pyogenes by interacting with collagen-like proteins A and B
    Lisa I Påhlman
    Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, SE 22184 Lund, Sweden
    J Biol Chem 282:24873-81. 2007
    ..These findings suggest an important role for TAFI in the modulation of host responses by streptococci...
  27. ncbi Contact activation by pathogenic bacteria: a virulence mechanism contributing to the pathophysiology of sepsis
    Heiko Herwald
    Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Lund, Sweden
    Scand J Infect Dis 35:604-7. 2003
    ..Several significant human pathogens have the ability to activate the contact system, and the potential significance of this mechanism in bacterial virulence, including its role in sepsis, is discussed in this review...
  28. ncbi The dual role of the contact system in bacterial infectious disease
    Inga Maria Frick
    Section for Clinical and Experimental Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
    Thromb Haemost 98:497-502. 2007
    ....
  29. pmc Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages
    Oliver Soehnlein
    Department of Physiology and Pharmacology and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    J Clin Invest 118:3491-502. 2008
    ..Thus, we attribute what may be a novel role for PMN granule proteins in regulating the immune response to bacterial infections...
  30. pmc Peptidoglycan from Staphylococcus aureus induces tissue factor expression and procoagulant activity in human monocytes
    Eva Mattsson
    Department of Medical Microbiology, Lund University, Lund, Sweden
    Infect Immun 70:3033-9. 2002
    ..This mechanism helps to explain the procoagulant activity, which plays such an important role in the pathogenicity of severe S. aureus infections...
  31. pmc Neutrophil secretion products pave the way for inflammatory monocytes
    Oliver Soehnlein
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Blood 112:1461-71. 2008
    ..This cellular cross-talk functionally results in enhanced cytokine levels and increased bacterial clearance, thus boosting the early immune response...
  32. ncbi Identification of two protein-binding and functional regions of curli, a surface organelle and virulence determinant of Escherichia coli
    Arne Olsen
    Section for Molecular Pathogenesis, Department of Cell and Molecular Biology, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 277:34568-72. 2002
    ..The results map important curli functions to the regions corresponding to the NNS24 and VDQ26 sequences...