Affiliation: Lund University
- Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3Rebecka Hellsten
Division of Urological Cancers, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
Prostate 68:269-80. 2008..In this study we investigated the in vitro and in vivo effects of the fungal metabolite galiellalactone, a direct inhibitor of Stat3, on PCa cells...
- Galiellalactone inhibits stem cell-like ALDH-positive prostate cancer cellsRebecka Hellsten
Division of Urological Cancers, Department of Clinical Sciences, Lund University, Malmo, Sweden
PLoS ONE 6:e22118. 2011....
- Galiellalactone Is a Direct Inhibitor of the Transcription Factor STAT3 in Prostate Cancer CellsNicholas Don-Doncow
From the Division of Urological Cancers, Lund University, SE 205 02 Malmo, Sweden
J Biol Chem 289:15969-78. 2014..This further validates galiellalactone as a promising direct STAT3 inhibitor for treatment of castration-resistant prostate cancer. ..
- A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissueCamilla Valtonen-Andre
Lund University, Division of Clinical Chemistry, Department of Laboratory Medicine, University Hospital MAS, S 205 02 Malmo, Sweden
Biol Chem 388:289-95. 2007..Studies on human prostate cancer specimens showed immunohistochemical staining of both tumor and benign glandular cells. Our results suggest that PSMP is an important protein with significance in prostate cancer...