Dick Heinegard

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. pmc Early increase in serum-COMP is associated with joint damage progression over the first five years in patients with rheumatoid arthritis
    Maria L E Andersson
    R and D Center, Spenshult Hospital, Oskarström, Sweden
    BMC Musculoskelet Disord 14:229. 2013
  2. pmc Proteoglycans and more--from molecules to biology
    Dick Heinegard
    Department of Clinical Sciences, Section for Rheumatology, Molecular Skeletal Biology, Lund University, Lund, Sweden
    Int J Exp Pathol 90:575-86. 2009
  3. doi The role of the cartilage matrix in osteoarthritis
    Dick Heinegard
    Department of Clinical Sciences, Section of Rheumatology, Lund University, BMC Plan C12, SE 22184 Lund, Sweden
    Nat Rev Rheumatol 7:50-6. 2011
  4. pmc The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors
    Viveka Tillgren
    Department of Clinical Sciences, Lund, Section for Rheumatology, Molecular Skeletal Biology, Lund University, Biomedical Center Plan C12, Lund SE 221 84, Sweden
    J Biol Chem 284:28543-53. 2009
  5. doi Interactions of the complement system with molecules of extracellular matrix: relevance for joint diseases
    Kaisa E Happonen
    Department of Laboratory Medicine, Division of Medical Protein Chemistry, Wallenberg Laboratory, Skane University Hospital, Lund University, Sweden
    Immunobiology 217:1088-96. 2012
  6. ncbi COMP acts as a catalyst in collagen fibrillogenesis
    Krisztina Halász
    Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 282:31166-73. 2007
  7. ncbi Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry
    Patrik Onnerfjord
    Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, BMC C12, 221 84 Lund, Sweden
    J Biol Chem 279:26-33. 2004
  8. ncbi Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis
    Pilar Lorenzo
    Section for Connective Tissue Biology, Department of Cell and Molecular Biology, Lund University, BMC, Plan C12, SE 22184 Lund, Sweden
    Matrix Biol 23:381-91. 2004
  9. pmc Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation
    Andreas P Sjöberg
    Department of Laboratory Medicine, University Hospital Malmo, Lund University, Malmo, Sweden
    Mol Immunol 46:830-9. 2009
  10. pmc NC4 Domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H
    Nikolina Kalchishkova
    Department of Laboratory Medicine, Section of Medical Protein Chemistry, Lund University, S 205 02 Malmo, Sweden
    J Biol Chem 286:27915-26. 2011

Collaborators

Detail Information

Publications35

  1. pmc Early increase in serum-COMP is associated with joint damage progression over the first five years in patients with rheumatoid arthritis
    Maria L E Andersson
    R and D Center, Spenshult Hospital, Oskarström, Sweden
    BMC Musculoskelet Disord 14:229. 2013
    ....
  2. pmc Proteoglycans and more--from molecules to biology
    Dick Heinegard
    Department of Clinical Sciences, Section for Rheumatology, Molecular Skeletal Biology, Lund University, Lund, Sweden
    Int J Exp Pathol 90:575-86. 2009
    ..Those fragments released can be specifically detected employing antibodies specific to the cleavage site and used to diagnose and monitor e.g. joint disease at early stages...
  3. doi The role of the cartilage matrix in osteoarthritis
    Dick Heinegard
    Department of Clinical Sciences, Section of Rheumatology, Lund University, BMC Plan C12, SE 22184 Lund, Sweden
    Nat Rev Rheumatol 7:50-6. 2011
    ....
  4. pmc The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors
    Viveka Tillgren
    Department of Clinical Sciences, Lund, Section for Rheumatology, Molecular Skeletal Biology, Lund University, Biomedical Center Plan C12, Lund SE 221 84, Sweden
    J Biol Chem 284:28543-53. 2009
    ..These interactions may sequester growth factors, cytokines, and matrix metalloproteinases in the extracellular matrix as well as contribute to its organization...
  5. doi Interactions of the complement system with molecules of extracellular matrix: relevance for joint diseases
    Kaisa E Happonen
    Department of Laboratory Medicine, Division of Medical Protein Chemistry, Wallenberg Laboratory, Skane University Hospital, Lund University, Sweden
    Immunobiology 217:1088-96. 2012
    ..Future challenges are to target the complement inhibition specifically to the joints to minimize systemic complement blockade...
  6. ncbi COMP acts as a catalyst in collagen fibrillogenesis
    Krisztina Halász
    Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 282:31166-73. 2007
    ..Thus, COMP appears to catalyze the fibril formation by promoting early association of collagen molecules leading to increased rate of fibrillogenesis and more distinct organization of the fibrils...
  7. ncbi Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry
    Patrik Onnerfjord
    Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, BMC C12, 221 84 Lund, Sweden
    J Biol Chem 279:26-33. 2004
    ..We also identified an error in the published sequence of bovine fibromodulin, resulting in the replacement of Thr37 by Tyr37-Gly38, thus increasing its homology with its human counterpart...
  8. ncbi Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis
    Pilar Lorenzo
    Section for Connective Tissue Biology, Department of Cell and Molecular Biology, Lund University, BMC, Plan C12, SE 22184 Lund, Sweden
    Matrix Biol 23:381-91. 2004
    ..The early OA samples studied appear to represent two distinct groups of early lesions in different stages of the process of cartilage deterioration as shown by their differences in relative rates of synthesis and abundance of proteins...
  9. pmc Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation
    Andreas P Sjöberg
    Department of Laboratory Medicine, University Hospital Malmo, Lund University, Malmo, Sweden
    Mol Immunol 46:830-9. 2009
    ....
  10. pmc NC4 Domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H
    Nikolina Kalchishkova
    Department of Laboratory Medicine, Section of Medical Protein Chemistry, Lund University, S 205 02 Malmo, Sweden
    J Biol Chem 286:27915-26. 2011
    ....
  11. pmc PRELP protein inhibits the formation of the complement membrane attack complex
    Kaisa E Happonen
    Department of Laboratory Medicine, Division of Medical Protein Chemistry, Wallenberg Laboratory, Skane University Hospital, Lund University, S 20502 Lund, Sweden
    J Biol Chem 287:8092-100. 2012
    ..The net outcome of PRELP-mediated complement inhibition will highly depend on the local concentration of other complement modulating molecules as well as on the local concentration of available complement proteins...
  12. pmc Identification and characterization of the integrin alpha2beta1 binding motif in chondroadherin mediating cell attachment
    Lisbet Haglund
    Department of Clinical Sciences Lund, Lund University, BMC Plan C12, SE 22184 Lund, Sweden
    J Biol Chem 286:3925-34. 2011
    ..The peptides, particularly the more stable cyclic peptide, open new opportunities to modulate cell behavior in situations of tissue pathology...
  13. ncbi Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrix
    Kaisa E Happonen
    Department of Laboratory Medicine, Wallenberg Laboratory, University Hospital Malmo, Lund University, Malmo, Sweden
    J Immunol 182:1518-25. 2009
    ....
  14. doi Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis
    Kaisa E Happonen
    Lund University, Malmo, Sweden
    Arthritis Rheum 62:3574-83. 2010
    ..This study was undertaken to investigate the ability of COMP to regulate complement, a capacity that has previously been shown for some other cartilage proteins...
  15. ncbi Fragmentation of proteins in cartilage treated with interleukin-1: specific cleavage of type IX collagen by matrix metalloproteinase 13 releases the NC4 domain
    Mikael Danfelter
    Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 282:36933-41. 2007
    ..These data describe cleavage by an MMP-13 activity toward non-collagenous and triple helix domains. These potentially important degradation events precede the major loss of type II collagen...
  16. pmc The C-type lectin of the aggrecan G3 domain activates complement
    Camilla Melin Fürst
    Department of Laboratory Medicine, Division of Medical Protein Chemistry, Lund University, Malmo, Sweden
    PLoS ONE 8:e61407. 2013
    ..This was most apparent at the level of deposition of terminal complement components. Taken together our observations indicate aggrecan CLD as one factor involved in the sustained inflammation of the joint...
  17. pmc Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept
    Meliha Crnkic
    Department of Rheumatology, Lund University Hospital, Lund, Sweden
    Arthritis Res Ther 5:R181-5. 2003
    ..Serum COMP has potential as a useful marker for evaluating tissue effects of novel treatment modalities in rheumatoid arthritis...
  18. ncbi Fibronectin fragments cause release and degradation of collagen-binding molecules from equine explant cultures
    Anna Johnson
    Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, Lund, Sweden
    Osteoarthritis Cartilage 12:149-59. 2004
    ..In this study we investigated the fate of the collagen- and cell-binding molecules Cartilage oligomeric matrix protein (COMP) and chondroadherin...
  19. pmc The C-terminal peptide of chondroadherin modulates cellular activity by selectively binding to heparan sulfate chains
    Lisbet Haglund
    Department of Clinical Sciences, Lund, Section of Rheumatology, Molecular Skeletal Biology, Biomedical Center C12, Lund University, SE 22184 Lund, Sweden
    J Biol Chem 288:995-1008. 2013
    ....
  20. ncbi The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q
    Andreas Sjöberg
    Department of Laboratory Medicine, University Hospital Malmo, BMC, Lund University, Sweden
    J Biol Chem 280:32301-8. 2005
    ..Taken together our observations indicate fibromodulin as one factor involved in the sustained inflammation of the joint...
  21. ncbi Altered osteoclast development and function in osteopontin deficient mice
    Ahnders Franzén
    Department of Experimental Medical Science, Lund University, BMC C12, SE 22184, Lund, Sweden
    J Orthop Res 26:721-8. 2008
    ..This quantitative study demonstrates a bone phenotype in the osteopontin null mice of all ages. The data provides further evidence for a role of osteopontin in osteoclast activity...
  22. ncbi The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells
    Andreas P Sjöberg
    Department of Laboratory Medicine, University Hospital Malmo, Lund University, S 205 02 Malmo, Sweden
    J Biol Chem 282:10894-900. 2007
    ..The variations in binding affinity of the two alleles indicate that complement activation and local inflammation in response to different targets will differ between His/His and Tyr/Tyr homozygotes...
  23. ncbi Extracellular matrix in disc degeneration
    Haoyu Feng
    Department of Experimental Medical Sciences, Lund University, BMC Plan C12, SE 221 84 Lund, Sweden
    J Bone Joint Surg Am 88:25-9. 2006
    ..An early event in disease is degradation of aggrecan by the members of the ADAMTS (a disintegrin-like and metalloprotease with thrombospondin motifs) family and degradation of molecules important in maintaining the collagen network...
  24. pmc Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-α treatment
    Kaisa E Happonen
    Department of Laboratory Medicine Malmö, Section of Medical Protein Chemistry, Lund University, Wallenberg Laboratory Floor 4, SE 205 02 Malmo, Sweden
    Arthritis Res Ther 14:R15. 2012
    ..We now set out to elaborate on the information provided by this marker in a variety of diseases and larger patient cohorts...
  25. ncbi Comment on "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease"
    Thomas Blom
    Department of Medical Inflammation Research, Lund University, Solvegatan 19, Lund 22184, Sweden
    Science 299:1845; author reply 1845. 2003
  26. pmc Quantitative proteomic analysis of eight cartilaginous tissues reveals characteristic differences as well as similarities between subgroups
    Patrik Onnerfjord
    Department of Clinical Sciences Lund, Lund University, BMC C12, 221 84 Lund, Sweden
    J Biol Chem 287:18913-24. 2012
    ..g. asporin, CILP, and COMP, indicating cross-linking. Distinct differences in protein patterns may relate to different tissue mechanical properties, and to the intriguing tropism in different patterns of joint pathology...
  27. doi Extracellular matrix alterations and acute inflammation; developing in parallel during early induction of pulmonary fibrosis
    Kristina Rydell-Törmänen
    Section of Rheumatology, Department of Clinical Science, Lund University, Lund, Sweden
    Lab Invest 92:917-25. 2012
    ..A transient neutrophilia is detected and increased number of macrophages likely represents a clearance process of said neutrophils. The study suggests fibrosis initiation and acute inflammation to occur in parallel in this model...
  28. ncbi Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulfate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase-13
    Terrence F Heathfield
    Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, SE 22184 Lund, Sweden
    J Biol Chem 279:6286-95. 2004
    ....
  29. doi COMP-C3b complexes in rheumatoid arthritis with severe extraarticular manifestations
    Kaisa E Happonen
    From the Department of Laboratory Medicine, Section of Medical Protein Chemistry, and the Department of Clinical Sciences, Section of Rheumatology, Lund University, Malmö the Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden the Oslo University Hospital Rikshospitalet, and University of Oslo, Oslo the Research Laboratory Nordland Hospital, and University of Tromsø, Tromsø, Norway
    J Rheumatol 40:2001-5. 2013
    ..To investigate biomarker patterns in rheumatoid arthritis (RA) with extraarticular manifestations...
  30. pmc The skeletal phenotype of chondroadherin deficient mice
    Lovisa Hessle
    Sections of Molecular Skeletal Biology and Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
    PLoS ONE 8:e63080. 2013
    ..The skeletal phenotype points at a role for chondroadherin in both bone and cartilage homeostasis, however, without leading to altered longitudinal growth...
  31. pmc Recent developments and future research in the bone and joint decade 2000-2010
    Dick Heinegard
    Department of Cell and Molecular Biology, University of Lund, Lund, Sweden
    Bull World Health Organ 81:686-8. 2003
  32. pmc Purification, crystallization and preliminary X-ray diffraction analysis of human chondroadherin
    Anna Pramhed
    Department of Molecular Biophysics, Centre for Chemistry and Chemical Engineering, Lund University, S 221 00 Lund, Sweden
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:516-9. 2008
    ..2, and are most likely to contain four molecules in the asymmetric unit. The crystals diffracted to at least 2.3 A using synchrotron radiation, but structure determination using molecular replacement has so far been unsuccessful...
  33. ncbi Rheumatoid arthritis and the complement system
    Marcin Okroj
    Lund University, Department of Laboratory Medicine, University Hospital Malmo, Malmo, Sweden
    Ann Med 39:517-30. 2007
    ..Success of complement inhibition in the experimental models described so far encourages novel therapeutic approaches to the treatment of human RA...
  34. ncbi The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor
    Eva Bengtsson
    Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 277:15061-8. 2002
    ..Based on the location of PRELP and its interaction with perlecan heparan sulfate chains and collagen, we propose a function of PRELP as a molecule anchoring basement membranes to the underlying connective tissue...
  35. ncbi Altered vascular remodeling in osteopontin-deficient atherosclerotic mice
    Asa Ström
    Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, Lund, Sweden
    J Vasc Res 41:314-22. 2004
    ..Osteopontin (OPN) is a cell-binding phosphoprotein with proposed functions in atherosclerosis. The aim of this study was to examine how OPN deficiency affects the atherosclerotic process...