Research Topics
Genomes and Genes
| Dick HeinegardSummaryAffiliation: Lund University Country: Sweden Publications
| Collaborators
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Detail Information
Publications
The role of the cartilage matrix in osteoarthritisDick Heinegard
Department of Clinical Sciences, Section of Rheumatology, Lund University, BMC Plan C12, SE 22184 Lund, Sweden
Nat Rev Rheumatol 7:50-6. 2011....
Proteoglycans and more--from molecules to biologyDick Heinegard
Department of Clinical Sciences, Section for Rheumatology, Molecular Skeletal Biology, Lund University, Lund, Sweden
Int J Exp Pathol 90:575-86. 2009..Those fragments released can be specifically detected employing antibodies specific to the cleavage site and used to diagnose and monitor e.g. joint disease at early stages...- The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factorsViveka Tillgren
Department of Clinical Sciences, Lund, Section for Rheumatology, Molecular Skeletal Biology, Lund University, Biomedical Center Plan C12, Lund SE 221 84, Sweden
J Biol Chem 284:28543-53. 2009..These interactions may sequester growth factors, cytokines, and matrix metalloproteinases in the extracellular matrix as well as contribute to its organization... 
COMP acts as a catalyst in collagen fibrillogenesisKrisztina Halász
Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
J Biol Chem 282:31166-73. 2007..Thus, COMP appears to catalyze the fibril formation by promoting early association of collagen molecules leading to increased rate of fibrillogenesis and more distinct organization of the fibrils...- Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activationAndreas P Sjöberg
Department of Laboratory Medicine, University Hospital Malmo, Lund University, Malmo, Sweden
Mol Immunol 46:830-9. 2009.... - PRELP protein inhibits the formation of the complement membrane attack complexKaisa E Happonen
Department of Laboratory Medicine, Division of Medical Protein Chemistry, Wallenberg Laboratory, Skane University Hospital, Lund University, S 20502 Lund, Sweden
J Biol Chem 287:8092-100. 2012..The net outcome of PRELP-mediated complement inhibition will highly depend on the local concentration of other complement modulating molecules as well as on the local concentration of available complement proteins... - NC4 Domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor HNikolina Kalchishkova
Department of Laboratory Medicine, Section of Medical Protein Chemistry, Lund University, S 205 02 Malmo, Sweden
J Biol Chem 286:27915-26. 2011.... - Fragmentation of proteins in cartilage treated with interleukin-1: specific cleavage of type IX collagen by matrix metalloproteinase 13 releases the NC4 domainMikael Danfelter
Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
J Biol Chem 282:36933-41. 2007..These data describe cleavage by an MMP-13 activity toward non-collagenous and triple helix domains. These potentially important degradation events precede the major loss of type II collagen... - Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrixKaisa E Happonen
Department of Laboratory Medicine, Wallenberg Laboratory, University Hospital Malmo, Lund University, Malmo, Sweden
J Immunol 182:1518-25. 2009.... - Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritisKaisa E Happonen
Lund University, Malmo, Sweden
Arthritis Rheum 62:3574-83. 2010..This study was undertaken to investigate the ability of COMP to regulate complement, a capacity that has previously been shown for some other cartilage proteins... - Identification and characterization of the integrin alpha2beta1 binding motif in chondroadherin mediating cell attachmentLisbet Haglund
Department of Clinical Sciences Lund, Lund University, BMC Plan C12, SE 22184 Lund, Sweden
J Biol Chem 286:3925-34. 2011..The peptides, particularly the more stable cyclic peptide, open new opportunities to modulate cell behavior in situations of tissue pathology... - The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1qAndreas Sjöberg
Department of Laboratory Medicine, University Hospital Malmo, BMC, Lund University, Sweden
J Biol Chem 280:32301-8. 2005..Taken together our observations indicate fibromodulin as one factor involved in the sustained inflammation of the joint... - The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cellsAndreas P Sjöberg
Department of Laboratory Medicine, University Hospital Malmo, Lund University, S 205 02 Malmo, Sweden
J Biol Chem 282:10894-900. 2007..The variations in binding affinity of the two alleles indicate that complement activation and local inflammation in response to different targets will differ between His/His and Tyr/Tyr homozygotes... - Altered osteoclast development and function in osteopontin deficient miceAhnders Franzén
Department of Experimental Medical Science, Lund University, BMC C12, SE 22184, Lund, Sweden
J Orthop Res 26:721-8. 2008..This quantitative study demonstrates a bone phenotype in the osteopontin null mice of all ages. The data provides further evidence for a role of osteopontin in osteoclast activity... - Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-α treatmentKaisa E Happonen
Department of Laboratory Medicine Malmö, Section of Medical Protein Chemistry, Lund University, Wallenberg Laboratory Floor 4, SE 205 02 Malmo, Sweden
Arthritis Res Ther 14:R15. 2012..We now set out to elaborate on the information provided by this marker in a variety of diseases and larger patient cohorts... - Quantitative proteomic analysis of eight cartilaginous tissues reveals characteristic differences as well as similarities between subgroupsPatrik Onnerfjord
Department of Clinical Sciences Lund, Lund University, BMC C12, 221 84 Lund, Sweden
J Biol Chem 287:18913-24. 2012..g. asporin, CILP, and COMP, indicating cross-linking. Distinct differences in protein patterns may relate to different tissue mechanical properties, and to the intriguing tropism in different patterns of joint pathology... - Extracellular matrix alterations and acute inflammation; developing in parallel during early induction of pulmonary fibrosisKristina Rydell-Törmänen
Section of Rheumatology, Department of Clinical Science, Lund University, Lund, Sweden
Lab Invest 92:917-25. 2012..A transient neutrophilia is detected and increased number of macrophages likely represents a clearance process of said neutrophils. The study suggests fibrosis initiation and acute inflammation to occur in parallel in this model... - Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulfate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase-13Terrence F Heathfield
Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, SE 22184 Lund, Sweden
J Biol Chem 279:6286-95. 2004.... - Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritisPilar Lorenzo
Section for Connective Tissue Biology, Department of Cell and Molecular Biology, Lund University, BMC, Plan C12, SE-22184 Lund, Sweden
Matrix Biol 23:381-91. 2004..The early OA samples studied appear to represent two distinct groups of early lesions in different stages of the process of cartilage deterioration as shown by their differences in relative rates of synthesis and abundance of proteins... - Interactions of the complement system with molecules of extracellular matrix: relevance for joint diseasesKaisa E Happonen
Department of Laboratory Medicine, Division of Medical Protein Chemistry, Wallenberg Laboratory, Skane University Hospital, Lund University, Sweden
Immunobiology 217:1088-96. 2012..Future challenges are to target the complement inhibition specifically to the joints to minimize systemic complement blockade... - Fibronectin fragments cause release and degradation of collagen-binding molecules from equine explant culturesAnna Johnson
Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, Lund, Sweden
Osteoarthritis Cartilage 12:149-59. 2004..The responses to both fragments were elicited within 24h. CONCLUSIONS: We suggest that the events described here may be early, critical stages in cartilage destruction preceding collagen destruction... - Recent developments and future research in the bone and joint decade 2000-2010Dick Heinegard
Department of Cell and Molecular Biology, University of Lund, Lund, Sweden
Bull World Health Organ 81:686-8. 2003 - Purification, crystallization and preliminary X-ray diffraction analysis of human chondroadherinAnna Pramhed
Department of Molecular Biophysics, Centre for Chemistry and Chemical Engineering, Lund University, S 221 00 Lund, Sweden
Acta Crystallogr Sect F Struct Biol Cryst Commun 64:516-9. 2008..2, and are most likely to contain four molecules in the asymmetric unit. The crystals diffracted to at least 2.3 A using synchrotron radiation, but structure determination using molecular replacement has so far been unsuccessful... - Rheumatoid arthritis and the complement systemMarcin Okroj
Lund University, Department of Laboratory Medicine, University Hospital Malmo, Malmo, Sweden
Ann Med 39:517-30. 2007..Success of complement inhibition in the experimental models described so far encourages novel therapeutic approaches to the treatment of human RA... - The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchorEva Bengtsson
Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, SE 221 84 Lund, Sweden
J Biol Chem 277:15061-8. 2002..Based on the location of PRELP and its interaction with perlecan heparan sulfate chains and collagen, we propose a function of PRELP as a molecule anchoring basement membranes to the underlying connective tissue... - Extracellular matrix in disc degenerationHaoyu Feng
Department of Experimental Medical Sciences, Lund University, BMC-plan C12, SE-221 84 Lund, Sweden
J Bone Joint Surg Am 88:25-9. 2006..An early event in disease is degradation of aggrecan by the members of the ADAMTS (a disintegrin-like and metalloprotease with thrombospondin motifs) family and degradation of molecules important in maintaining the collagen network... - Altered vascular remodeling in osteopontin-deficient atherosclerotic miceAsa Ström
Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, Lund, Sweden
J Vasc Res 41:314-22. 2004..Osteopontin (OPN) is a cell-binding phosphoprotein with proposed functions in atherosclerosis. The aim of this study was to examine how OPN deficiency affects the atherosclerotic process... - Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometryPatrik Onnerfjord
Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, BMC C12, 221 84 Lund, Sweden
J Biol Chem 279:26-33. 2004..We also identified an error in the published sequence of bovine fibromodulin, resulting in the replacement of Thr37 by Tyr37-Gly38, thus increasing its homology with its human counterpart... - Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanerceptMeliha Crnkic
Department of Rheumatology, Lund University Hospital, Lund, Sweden
Arthritis Res Ther 5:R181-5. 2003..Serum COMP has potential as a useful marker for evaluating tissue effects of novel treatment modalities in rheumatoid arthritis...