Research Topics
Genomes and GenesSpecies | Oskar HanssonSummaryAffiliation: Lund University Country: Sweden Publications
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Detail Information
Publications
Evaluation of plasma Aβ as predictor of Alzheimer's disease in older individuals without dementia: a population-based studyOskar Hansson
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
J Alzheimers Dis 28:231-8. 2012..However, plasma Aβ(40) may possibly be regarded as a moderate risk marker comparable to other risk markers for AD such as first-degree family history of dementia...- Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementiaPeder Buchhave
Neuropsychiatric Clinic, Skane University Hospital, Malmo, Sweden
Arch Gen Psychiatry 69:98-106. 2012..Early detection of prodromal Alzheimer disease (AD) is important because new disease-modifying therapies are most likely to be effective when initiated during the early stages of disease... 
Combined rCBF and CSF biomarkers predict progression from mild cognitive impairment to Alzheimer's diseaseOskar Hansson
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
Neurobiol Aging 30:165-73. 2009..In conclusion, the combination of rCBF and CSF biomarkers improves the risk assessment of progression to AD in patients with MCI...- Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairmentOskar Hansson
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
Neurobiol Aging 31:357-67. 2010..In conclusion, the results show that CSF biomarkers are better predictors of progression to AD than plasma Abeta isoforms... 
Comparison of brief cognitive tests and CSF biomarkers in predicting Alzheimer's disease in mild cognitive impairment: six-year follow-up studySebastian Palmqvist
Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmo, Sweden
PLoS ONE 7:e38639. 2012..In this study, we compared brief cognitive tests and cerebrospinal fluid (CSF) biomarkers in predicting conversion from mild cognitive impairment (MCI) to AD...- Prediction of Alzheimer's disease using the CSF Abeta42/Abeta40 ratio in patients with mild cognitive impairmentOskar Hansson
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
Dement Geriatr Cogn Disord 23:316-20. 2007..05). In conclusion, the data provide further support for the view that amyloid precursor protein metabolism is disturbed in early sporadic AD and points to the usefulness of the Abeta42/Abeta40 ratio as a predictive biomarker for AD... - Cube copying test in combination with rCBF or CSF A beta 42 predicts development of Alzheimer's diseasePeder Buchhave
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Lund, Sweden
Dement Geriatr Cogn Disord 25:544-52. 2008..The aim was to identify subjects with incipient Alzheimer's disease (AD) among patients with mild cognitive impairment (MCI) using brief cognitive tests... - Evaluation of CSF biomarkers as predictors of Alzheimer's disease: a clinical follow-up study of 4.7 yearsJoakim Hertze
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
J Alzheimers Dis 21:1119-28. 2010..However, the specificities and positive predictive values are still too low to be able to diagnose AD before the patients fulfill the clinical criteria... - Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensityKajsa Sämgård
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Lund, Sweden
Int J Geriatr Psychiatry 25:403-10. 2010.... - Correlation of longitudinal cerebrospinal fluid biomarkers with cognitive decline in healthy older adultsErik Stomrud
Clinical Memory Research Unit, Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
Arch Neurol 67:217-23. 2010..Abnormal cerebrospinal fluid (CSF) biomarker levels predict development of Alzheimer disease with good accuracy and are thought to precede cognitive deterioration... - Slowing of EEG correlates with CSF biomarkers and reduced cognitive speed in elderly with normal cognition over 4 yearsErik Stomrud
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, S 205 02 Malmo, Sweden
Neurobiol Aging 31:215-23. 2010..The changes precede cognitive decline and should be visible already in preclinical stages. We therefore aimed to investigate their relationship in cognitively healthy individuals... - Longitudinal study of CSF biomarkers in patients with Alzheimer's diseasePeder Buchhave
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Lund, Sweden
PLoS ONE 4:e6294. 2009..However, previous studies on longitudinal changes of tau and Abeta42 in individual patients with AD and elderly controls report somewhat inconsistent results... - CSF biomarkers correlate with cerebral blood flow on SPECT in healthy elderlyErik Stomrud
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
Dement Geriatr Cogn Disord 33:156-63. 2012..The aim of this study was therefore to investigate CSF biomarkers, regional cerebral blood flow (rCBF) and cognitive performance in cognitively healthy older individuals... - Soluble TNF receptors are associated with Aβ metabolism and conversion to dementia in subjects with mild cognitive impairmentPeder Buchhave
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden Neuropsychiatric Clinic, Malmo University Hospital, Sweden
Neurobiol Aging 31:1877-84. 2010..Moreover, amyloid-induced toxicity has been shown to be dependent on TNFR-signaling. However, it is still unclear whether TNFRs are involved in the early stages of dementia... - Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up studyOskar Hansson
Clinical Memory Research Unit, Department of Clinical Sciences Malm, Lund University, Sweden
Lancet Neurol 5:228-34. 2006..8). INTERPRETATION: Concentrations of T-tau, P-tau181, and Abeta42 in CSF are strongly associated with future development of Alzheimer's disease in patients with MCI... - Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderlyErik Stomrud
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, University Hospital MAS, Malmo, Sweden
Dement Geriatr Cogn Disord 24:118-24. 2007..To investigate whether cerebrospinal fluid (CSF) biomarkers can predict cognitive decline in healthy, elderly individuals as they have been shown to do in cognitively impaired patient samples... - CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's diseaseKarin Westin
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
PLoS ONE 7:e30525. 2012..Moreover, CCR2-related signaling pathways might be new therapeutic targets for therapies aiming at slowing down the disease progression rate of AD... - Predicting long-term cognitive outcome with new regression models in donepezil-treated Alzheimer patients in a naturalistic settingCarina Wattmo
Clinical Memory Research Unit, Department of Clinical Sciences, Malmo, Lund University, Malmo, Sweden
Dement Geriatr Cogn Disord 26:203-11. 2008.... - Elevated plasma levels of soluble CD40 in incipient Alzheimer's diseasePeder Buchhave
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
Neurosci Lett 450:56-9. 2009..28, p<0.01) and sAPP-beta (r(s)=0.23, p<0.05) in cerebrospinal fluid. In conclusion, CD40-signalling might play a role in the pathogenesis of early AD... - Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's diseaseMaria Björkqvist
Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
PLoS ONE 7:e29868. 2012..Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies... - Differences in survival between patients with dementia with Lewy bodies and patients with Alzheimer's disease--measured from a fixed cognitive levelKajsa Stubendorff
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
Dement Geriatr Cogn Disord 32:408-16. 2011..Since anamnestic and retrospective information about disease duration are unreliable variables, we measured survival from a fixed cognitive level... - CSF Mg and Ca as diagnostic markers for dementia with Lewy bodiesFredrik Bostrom
Clinical Memory Research Unit, Department of Clinical Sciences, University Hospital MAS Malmö, Sweden
Neurobiol Aging 30:1265-71. 2009..Furthermore, determination of CSF-Mg and CSF-Ca concentration may be a valuable tool in distinguishing DLB from AD... - Practical suggestions on how to differentiate dementia with Lewy bodies from Alzheimer's disease with common cognitive testsSebastian Palmqvist
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, University Hospital MAS, Malmo, Sweden
Int J Geriatr Psychiatry 24:1405-12. 2009..The aim of this study was to suggest practical interpretations of the Mini-Mental State Examination (MMSE), clock drawing, and cube-copying to identify DLB and differentiate it from AD... - The usefulness of cube copying for evaluating treatment of Alzheimer's diseaseSebastian Palmqvist
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, University Hospital MAS, Malmo, Sweden
Am J Alzheimers Dis Other Demen 23:439-46. 2008..Cube copying measures visuospatial ability, which is often impaired in Alzheimer's disease (AD). Cube copying was examined as an evaluation of cholinesterase inhibitor (ChEI) treatment in AD... - Low CSF Levels of Both α-Synuclein and the α-Synuclein Cleaving Enzyme Neurosin in Patients with SynucleinopathyMalin Wennström
Lund University, Department of Clinical Sciences Malmo, Molecular Memory Research Unit, The Wallenberg Laboratory at Skåne University Hospital, Malmo, Sweden
PLoS ONE 8:e53250. 2013.... - Proinflammatory cytokines are elevated in serum of patients with multiple system atrophyEli Kaufman
Department of Clinical Sciences, Section for Psychiatry, Lund University, Lund, Sweden
PLoS ONE 8:e62354. 2013..Despite several lines of evidence from preclinical and post-mortem studies suggesting that inflammation is involved in Multiple System Atrophy (MSA), no previous studies have measured peripheral indices of inflammation in MSA patients... - A Quick Test of cognitive speed is sensitive in detecting early treatment response in Alzheimer's diseaseSebastian Palmqvist
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, S 205 02 Malmo, Sweden
Alzheimers Res Ther 2:29. 2010..In this study, A Quick Test of cognitive speed (AQT) was compared with the mini-mental state examination (MMSE) in the evaluation of treatment outcome in AD... - Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's diseaseErik Stomrud
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University SUS, 205 02 Malmo, Sweden
Alzheimers Res Ther 2:20. 2010.... - No diagnostic value of plasma clusterin in Alzheimer's diseaseEdina Silajdzic
Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
PLoS ONE 7:e50237. 2012..There was a slight, but significant, increase in plasma clusterin in patients with depression compared to all other groups tested, which may warrant further investigation... - Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serumDaniel Lindqvist
Department of Clinical Sciences, Section for Psychiatry, Lund University, Lund, Sweden
PLoS ONE 7:e47387. 2012..The main objective of this study was to investigate associations between pro-inflammatory substances and non-motor symptoms in patients with PD... - Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progressionOskar Hansson
Section for Neuronal Survival, Wallenberg Neuroscience Center, BMC A10, Department of Physiological Sciences, Lund University, Sweden
Brain Res 970:47-57. 2003..Interestingly, the polyglutamine protein affected the potential rescuing agent, because in older R6/2-Hsp70 mice a large proportion of the Hsp70 protein was sequestrated in nuclear inclusions...