Oskar Hansson

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease
    Ann Brinkmalm
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, S 431 80 Molndal, Sweden
    Mol Neurodegener 9:53. 2014
  2. pmc Dysphagia in Lewy body dementia - a clinical observational study of swallowing function by videofluoroscopic examination
    Elisabet Londos
    Clinical Memory Research Unit, Dept of Clinical Sciences Malmö, Lund University, Sweden
    BMC Neurol 13:140. 2013
  3. pmc Changes in cerebrospinal fluid and blood plasma levels of IGF-II and its binding proteins in Alzheimer's disease: an observational study
    Joakim Hertze
    Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmo, Sweden
    BMC Neurol 14:64. 2014
  4. pmc Factors associated with fear of falling in people with Parkinson's disease
    Beata Lindholm
    Department of Health Sciences, Lund University, Box 157, Lund SE 221 00, Sweden
    BMC Neurol 14:19. 2014
  5. ncbi request reprint NG2 cells, a new trail for Alzheimer's disease mechanisms?
    Henrietta M Nielsen
    Department of Clinical Sciences Malmo, Molecular Memory Research Unit, Lund University, The Wallenberg Laboratory 2nd floor, Inga Marie Nilssons gata, entrance 53, Skane University Hospital, Malmo, 205 02, Sweden
    Acta Neuropathol Commun 1:7. 2013
  6. pmc Longitudinal study of CSF biomarkers in patients with Alzheimer's disease
    Peder Buchhave
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Lund, Sweden
    PLoS ONE 4:e6294. 2009
  7. pmc CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease
    Karin Westin
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    PLoS ONE 7:e30525. 2012
  8. pmc Fluid biomarkers in Alzheimer's disease - current concepts
    Christoffer Rosén
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg Mölndal, S 431 80, Molndal, Sweden
    Mol Neurodegener 8:20. 2013
  9. ncbi request reprint Evaluation of plasma Aβ as predictor of Alzheimer's disease in older individuals without dementia: a population-based study
    Oskar Hansson
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
    J Alzheimers Dis 28:231-8. 2012
  10. ncbi request reprint Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment
    Oskar Hansson
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
    Neurobiol Aging 31:357-67. 2010

Collaborators

Detail Information

Publications44

  1. ncbi request reprint SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease
    Ann Brinkmalm
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, S 431 80 Molndal, Sweden
    Mol Neurodegener 9:53. 2014
    ....
  2. pmc Dysphagia in Lewy body dementia - a clinical observational study of swallowing function by videofluoroscopic examination
    Elisabet Londos
    Clinical Memory Research Unit, Dept of Clinical Sciences Malmö, Lund University, Sweden
    BMC Neurol 13:140. 2013
    ..The aim of this study was therefore to investigate the prevalence, and define the actual swallowing dysfunction according to a videofluoroscopic swallowing examination (VFSE) in patients with DLB and PDD...
  3. pmc Changes in cerebrospinal fluid and blood plasma levels of IGF-II and its binding proteins in Alzheimer's disease: an observational study
    Joakim Hertze
    Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmo, Sweden
    BMC Neurol 14:64. 2014
    ..In this study we explored changes in the IGF-related system in patients with Alzheimer's disease (AD), including changes in IGF-II levels...
  4. pmc Factors associated with fear of falling in people with Parkinson's disease
    Beata Lindholm
    Department of Health Sciences, Lund University, Box 157, Lund SE 221 00, Sweden
    BMC Neurol 14:19. 2014
    ..This study aimed to comprehensibly investigate potential contributing factors to fear of falling (FOF) among people with idiopathic Parkinson's disease (PD)...
  5. ncbi request reprint NG2 cells, a new trail for Alzheimer's disease mechanisms?
    Henrietta M Nielsen
    Department of Clinical Sciences Malmo, Molecular Memory Research Unit, Lund University, The Wallenberg Laboratory 2nd floor, Inga Marie Nilssons gata, entrance 53, Skane University Hospital, Malmo, 205 02, Sweden
    Acta Neuropathol Commun 1:7. 2013
    ..Here we describe alterations in the human NG2 cell population in response to pathological changes characteristic of Alzheimer's disease (AD)...
  6. pmc Longitudinal study of CSF biomarkers in patients with Alzheimer's disease
    Peder Buchhave
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Lund, Sweden
    PLoS ONE 4:e6294. 2009
    ..However, previous studies on longitudinal changes of tau and Abeta42 in individual patients with AD and elderly controls report somewhat inconsistent results...
  7. pmc CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease
    Karin Westin
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    PLoS ONE 7:e30525. 2012
    ..Moreover, CCR2-related signaling pathways might be new therapeutic targets for therapies aiming at slowing down the disease progression rate of AD...
  8. pmc Fluid biomarkers in Alzheimer's disease - current concepts
    Christoffer Rosén
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg Mölndal, S 431 80, Molndal, Sweden
    Mol Neurodegener 8:20. 2013
    ..But before drawing any major conclusions, these results need to be verified in independent studies. ..
  9. ncbi request reprint Evaluation of plasma Aβ as predictor of Alzheimer's disease in older individuals without dementia: a population-based study
    Oskar Hansson
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
    J Alzheimers Dis 28:231-8. 2012
    ..However, plasma Aβ(40) may possibly be regarded as a moderate risk marker comparable to other risk markers for AD such as first-degree family history of dementia...
  10. ncbi request reprint Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment
    Oskar Hansson
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
    Neurobiol Aging 31:357-67. 2010
    ..In conclusion, the results show that CSF biomarkers are better predictors of progression to AD than plasma Abeta isoforms...
  11. ncbi request reprint Combined rCBF and CSF biomarkers predict progression from mild cognitive impairment to Alzheimer's disease
    Oskar Hansson
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
    Neurobiol Aging 30:165-73. 2009
    ..In conclusion, the combination of rCBF and CSF biomarkers improves the risk assessment of progression to AD in patients with MCI...
  12. ncbi request reprint Prediction of Alzheimer's disease using the CSF Abeta42/Abeta40 ratio in patients with mild cognitive impairment
    Oskar Hansson
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    Dement Geriatr Cogn Disord 23:316-20. 2007
    ..05). In conclusion, the data provide further support for the view that amyloid precursor protein metabolism is disturbed in early sporadic AD and points to the usefulness of the Abeta42/Abeta40 ratio as a predictive biomarker for AD...
  13. ncbi request reprint Cerebrospinal fluid total tau is associated with shorter survival in dementia with Lewy bodies
    Fredrik Bostrom
    Department of Clinical Sciences, University Hospital MAS, Malmo, Sweden
    Dement Geriatr Cogn Disord 28:314-9. 2009
    ..05), but not among the AD patients or controls. Gender, age, MMSE score, Abeta42 concentration and phosphorylated tau, and CSF trace element concentrations did not influence survival in the obtained models...
  14. pmc Comparison of brief cognitive tests and CSF biomarkers in predicting Alzheimer's disease in mild cognitive impairment: six-year follow-up study
    Sebastian Palmqvist
    Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmo, Sweden
    PLoS ONE 7:e38639. 2012
    ..In this study, we compared brief cognitive tests and cerebrospinal fluid (CSF) biomarkers in predicting conversion from mild cognitive impairment (MCI) to AD...
  15. ncbi request reprint Cube copying test in combination with rCBF or CSF A beta 42 predicts development of Alzheimer's disease
    Peder Buchhave
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Lund, Sweden
    Dement Geriatr Cogn Disord 25:544-52. 2008
    ..The aim was to identify subjects with incipient Alzheimer's disease (AD) among patients with mild cognitive impairment (MCI) using brief cognitive tests...
  16. ncbi request reprint Evaluation of CSF biomarkers as predictors of Alzheimer's disease: a clinical follow-up study of 4.7 years
    Joakim Hertze
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    J Alzheimers Dis 21:1119-28. 2010
    ..However, the specificities and positive predictive values are still too low to be able to diagnose AD before the patients fulfill the clinical criteria...
  17. ncbi request reprint Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensity
    Kajsa Sämgård
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Lund, Sweden
    Int J Geriatr Psychiatry 25:403-10. 2010
    ....
  18. ncbi request reprint Slowing of EEG correlates with CSF biomarkers and reduced cognitive speed in elderly with normal cognition over 4 years
    Erik Stomrud
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, S 205 02 Malmo, Sweden
    Neurobiol Aging 31:215-23. 2010
    ..The changes precede cognitive decline and should be visible already in preclinical stages. We therefore aimed to investigate their relationship in cognitively healthy individuals...
  19. ncbi request reprint Correlation of longitudinal cerebrospinal fluid biomarkers with cognitive decline in healthy older adults
    Erik Stomrud
    Clinical Memory Research Unit, Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
    Arch Neurol 67:217-23. 2010
    ..Abnormal cerebrospinal fluid (CSF) biomarker levels predict development of Alzheimer disease with good accuracy and are thought to precede cognitive deterioration...
  20. ncbi request reprint Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia
    Peder Buchhave
    Neuropsychiatric Clinic, Skane University Hospital, Malmo, Sweden
    Arch Gen Psychiatry 69:98-106. 2012
    ..Early detection of prodromal Alzheimer disease (AD) is important because new disease-modifying therapies are most likely to be effective when initiated during the early stages of disease...
  21. ncbi request reprint CSF biomarkers correlate with cerebral blood flow on SPECT in healthy elderly
    Erik Stomrud
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    Dement Geriatr Cogn Disord 33:156-63. 2012
    ..The aim of this study was therefore to investigate CSF biomarkers, regional cerebral blood flow (rCBF) and cognitive performance in cognitively healthy older individuals...
  22. ncbi request reprint Soluble TNF receptors are associated with Aβ metabolism and conversion to dementia in subjects with mild cognitive impairment
    Peder Buchhave
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden Neuropsychiatric Clinic, Malmo University Hospital, Sweden
    Neurobiol Aging 31:1877-84. 2010
    ..Moreover, amyloid-induced toxicity has been shown to be dependent on TNFR-signaling. However, it is still unclear whether TNFRs are involved in the early stages of dementia...
  23. ncbi request reprint Cerebrospinal fluid inflammatory markers in Parkinson's disease--associations with depression, fatigue, and cognitive impairment
    Daniel Lindqvist
    Department of Clinical Sciences, Section for Psychiatry, Lund University, Lund, Sweden Psychiatry Skåne, Lund, Sweden Electronic address
    Brain Behav Immun 33:183-9. 2013
    ..032). Our results indicate that non-motor features of PD such as depression, fatigue, and cognitive impairment are associated with higher CSF levels of inflammatory markers. ..
  24. ncbi request reprint Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
    Oskar Hansson
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
    Lancet Neurol 5:228-34. 2006
    ..Here, we assess the association between CSF biomarkers and incipient Alzheimer's in patients with mild cognitive impairment (MCI)...
  25. ncbi request reprint Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly
    Erik Stomrud
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, University Hospital MAS, Malmo, Sweden
    Dement Geriatr Cogn Disord 24:118-24. 2007
    ..To investigate whether cerebrospinal fluid (CSF) biomarkers can predict cognitive decline in healthy, elderly individuals as they have been shown to do in cognitively impaired patient samples...
  26. ncbi request reprint Elevated plasma levels of soluble CD40 in incipient Alzheimer's disease
    Peder Buchhave
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
    Neurosci Lett 450:56-9. 2009
    ..28, p<0.01) and sAPP-beta (r(s)=0.23, p<0.05) in cerebrospinal fluid. In conclusion, CD40-signalling might play a role in the pathogenesis of early AD...
  27. ncbi request reprint Differences in survival between patients with dementia with Lewy bodies and patients with Alzheimer's disease--measured from a fixed cognitive level
    Kajsa Stubendorff
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    Dement Geriatr Cogn Disord 32:408-16. 2011
    ..Since anamnestic and retrospective information about disease duration are unreliable variables, we measured survival from a fixed cognitive level...
  28. pmc Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy
    Malin Wennström
    Lund University, Department of Clinical Sciences Malmo, Molecular Memory Research Unit, The Wallenberg Laboratory at Skåne University Hospital, Malmo, Sweden
    PLoS ONE 8:e53250. 2013
    ....
  29. ncbi request reprint Predicting long-term cognitive outcome with new regression models in donepezil-treated Alzheimer patients in a naturalistic setting
    Carina Wattmo
    Clinical Memory Research Unit, Department of Clinical Sciences, Malmo, Lund University, Malmo, Sweden
    Dement Geriatr Cogn Disord 26:203-11. 2008
    ....
  30. ncbi request reprint Correlations of CSF tau and amyloid levels with Alzheimer pathology in neuropathologically verified dementia with Lewy bodies
    Hans Brunnström
    Department of Pathology, Lund University and Regional Laboratories Region Skåne, Lund, Sweden
    Int J Geriatr Psychiatry 28:738-44. 2013
    ..The aim of this study was to investigate correlations between CSF biomarker levels and histopathological findings, with a focus on concomitant Alzheimer pathology, in neuropathologically verified DLB cases...
  31. pmc Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease
    Maria Björkqvist
    Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    PLoS ONE 7:e29868. 2012
    ..Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies...
  32. ncbi request reprint Practical suggestions on how to differentiate dementia with Lewy bodies from Alzheimer's disease with common cognitive tests
    Sebastian Palmqvist
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, University Hospital MAS, Malmo, Sweden
    Int J Geriatr Psychiatry 24:1405-12. 2009
    ..The aim of this study was to suggest practical interpretations of the Mini-Mental State Examination (MMSE), clock drawing, and cube-copying to identify DLB and differentiate it from AD...
  33. ncbi request reprint CSF Mg and Ca as diagnostic markers for dementia with Lewy bodies
    Fredrik Bostrom
    Clinical Memory Research Unit, Department of Clinical Sciences, University Hospital MAS Malmö, Sweden
    Neurobiol Aging 30:1265-71. 2009
    ..Furthermore, determination of CSF-Mg and CSF-Ca concentration may be a valuable tool in distinguishing DLB from AD...
  34. pmc Proinflammatory cytokines are elevated in serum of patients with multiple system atrophy
    Eli Kaufman
    Department of Clinical Sciences, Section for Psychiatry, Lund University, Lund, Sweden
    PLoS ONE 8:e62354. 2013
    ..Despite several lines of evidence from preclinical and post-mortem studies suggesting that inflammation is involved in Multiple System Atrophy (MSA), no previous studies have measured peripheral indices of inflammation in MSA patients...
  35. pmc No diagnostic value of plasma clusterin in Alzheimer's disease
    Edina Silajdzic
    Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    PLoS ONE 7:e50237. 2012
    ..There was a slight, but significant, increase in plasma clusterin in patients with depression compared to all other groups tested, which may warrant further investigation...
  36. ncbi request reprint The usefulness of cube copying for evaluating treatment of Alzheimer's disease
    Sebastian Palmqvist
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, University Hospital MAS, Malmo, Sweden
    Am J Alzheimers Dis Other Demen 23:439-46. 2008
    ..Cube copying measures visuospatial ability, which is often impaired in Alzheimer's disease (AD). Cube copying was examined as an evaluation of cholinesterase inhibitor (ChEI) treatment in AD...
  37. pmc A Quick Test of cognitive speed is sensitive in detecting early treatment response in Alzheimer's disease
    Sebastian Palmqvist
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, S 205 02 Malmo, Sweden
    Alzheimers Res Ther 2:29. 2010
    ..In this study, A Quick Test of cognitive speed (AQT) was compared with the mini-mental state examination (MMSE) in the evaluation of treatment outcome in AD...
  38. pmc Tau pathology and parietal white matter lesions have independent but synergistic effects on early development of Alzheimer's disease
    Joakim Hertze
    Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden Memory Clinic, Skane University Hospital, Malmo, Lund, Sweden
    Dement Geriatr Cogn Dis Extra 3:113-22. 2013
    ..This study investigates the relationship between WMLs, hyperphosphorylated tau (P-tau) in cerebrospinal fluid (CSF) and apolipoprotein E (APOE) ε4 genotype in prodromal Alzheimer's disease (AD)...
  39. pmc Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's disease
    Erik Stomrud
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University SUS, 205 02 Malmo, Sweden
    Alzheimers Res Ther 2:20. 2010
    ....
  40. ncbi request reprint Altered chemokine levels in the cerebrospinal fluid and plasma of suicide attempters
    Shorena Janelidze
    Psychoimmunology Unit, Section for Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden
    Psychoneuroendocrinology 38:853-62. 2013
    ..These results warrant future studies on the detailed neurobiological functions of chemokines in psychiatric patients...
  41. pmc Assessment of global and regional diffusion changes along white matter tracts in parkinsonian disorders by MR tractography
    Yulia Surova
    Department of Clinical Sciences, Neurology, Lund University, Lund, Sweden
    PLoS ONE 8:e66022. 2013
    ..Furthermore, the use of DTT in selected white matter tracts for differential diagnosis was assessed...
  42. pmc Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum
    Daniel Lindqvist
    Department of Clinical Sciences, Section for Psychiatry, Lund University, Lund, Sweden
    PLoS ONE 7:e47387. 2012
    ..The main objective of this study was to investigate associations between pro-inflammatory substances and non-motor symptoms in patients with PD...
  43. ncbi request reprint Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression
    Oskar Hansson
    Section for Neuronal Survival, Wallenberg Neuroscience Center, BMC A10, Department of Physiological Sciences, Lund University, Sweden
    Brain Res 970:47-57. 2003
    ..Interestingly, the polyglutamine protein affected the potential rescuing agent, because in older R6/2-Hsp70 mice a large proportion of the Hsp70 protein was sequestrated in nuclear inclusions...