Sassan Hafizi

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases
    Sassan Hafizi
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Cytokine Growth Factor Rev 17:295-304. 2006
  2. ncbi The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases
    Sassan Hafizi
    Department of Laboratory Medicine, Section for Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Int J Biochem Cell Biol 37:2344-56. 2005
  3. ncbi Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, Wallenberg Laboratory, University Hospital Malmo, Sweden
    FEBS J 273:5231-44. 2006
  4. ncbi Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer
    Danuta Martuszewska
    Department of Laboratory Medicine, Section for Clinical Chemistry, Lund University, University Hospital Malmo, Malmo, Sweden
    PLoS ONE 4:e4350. 2009
  5. ncbi Individual domains of Tensin2 exhibit distinct subcellular localisations and migratory effects
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Int J Biochem Cell Biol 42:52-61. 2010
  6. ncbi Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival
    Anna Gustafsson
    Lund University, Department of Laboratory Medicine, Sections for Clinical Chemistry, University Hospital Malmo, Malmo SE 205 02, Sweden
    Clin Cancer Res 15:4742-9. 2009
  7. ncbi Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 399:396-401. 2010
  8. ncbi Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts
    Jonas Stenhoff
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, Malmo SE 205 02, Sweden
    Biochem Biophys Res Commun 319:871-8. 2004
  9. ncbi Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin
    Sassan Hafizi
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 299:793-800. 2002
  10. ncbi C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration
    Sassan Hafizi
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, Malmo, Sweden
    FASEB J 19:971-3. 2005

Collaborators

Detail Information

Publications11

  1. ncbi Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases
    Sassan Hafizi
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Cytokine Growth Factor Rev 17:295-304. 2006
    ..In this way, we hope to gain a greater understanding of the mechanisms that set each of them apart, and that relay their associated functions...
  2. ncbi The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases
    Sassan Hafizi
    Department of Laboratory Medicine, Section for Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Int J Biochem Cell Biol 37:2344-56. 2005
    ..This novel insight into the signalling interactions of Axl and Sky may shed further light on their suspected roles in tumourigenesis, inflammation as well as other cell proliferative diseases...
  3. ncbi Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, Wallenberg Laboratory, University Hospital Malmo, Sweden
    FEBS J 273:5231-44. 2006
    ..Further knowledge of this exquisite ligand-receptor system and the circumstances of its activation should provide the basis for development of novel therapies for the above diseases...
  4. ncbi Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer
    Danuta Martuszewska
    Department of Laboratory Medicine, Section for Clinical Chemistry, Lund University, University Hospital Malmo, Malmo, Sweden
    PLoS ONE 4:e4350. 2009
    ..Here, we have for the first time evaluated the significance of all four Tensins in a study of human renal cell carcinoma (RCC), as well as probed the biological function of Tensin3...
  5. ncbi Individual domains of Tensin2 exhibit distinct subcellular localisations and migratory effects
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Int J Biochem Cell Biol 42:52-61. 2010
    ..In conclusion, our results indicate that differential proteolytic cleavage of Tensin2 can liberate domains with discrete localisations and functions, which has implications for the role of Tensins in cancer cell survival and motility...
  6. ncbi Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival
    Anna Gustafsson
    Lund University, Department of Laboratory Medicine, Sections for Clinical Chemistry, University Hospital Malmo, Malmo SE 205 02, Sweden
    Clin Cancer Res 15:4742-9. 2009
    ..Overexpression of the receptor tyrosine kinase Axl is implicated in several cancers. Therefore, we conducted this study to determine the expression of Axl and its ligand Gas6 in various renal cell carcinoma (RCC) types and in oncocytoma...
  7. ncbi Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 399:396-401. 2010
    ..In summary, we provide evidence that Tensin2, in addition to regulating cytoskeletal dynamics, influences phosphoinositide-Akt signalling through its PTPase domain...
  8. ncbi Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts
    Jonas Stenhoff
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, Malmo SE 205 02, Sweden
    Biochem Biophys Res Commun 319:871-8. 2004
    ..These findings implicate vitamin K-dependent biochemical reactions in growth processes in development and in disease...
  9. ncbi Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin
    Sassan Hafizi
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 299:793-800. 2002
    ..In summary, we have identified a novel multi-domain intracellular protein that interacts with Axl and which may furthermore be involved in other signal transduction pathways...
  10. ncbi C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration
    Sassan Hafizi
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, Malmo, Sweden
    FASEB J 19:971-3. 2005
    ..However, the particular domain organization of C1-TEN may enable it to regulate RTK and other signaling complexes that are linked to Akt/PKB signaling in a unique manner...
  11. ncbi Analysis of Gas6 in human platelets and plasma
    Istvan Balogh
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malm, Sweden
    Arterioscler Thromb Vasc Biol 25:1280-6. 2005
    ..These findings open up new directions regarding the role of Gas6 in normal and pathophysiological situations such as inflammation, autoimmune disease, thrombosis and arteriosclerosis...