Lotta Gustafsson

Summary

Affiliation: Lund University
Location: Lund, Sweden
Publications:
Micro- and macromechanical effects on the wound bed by negative pressure wound therapy using gauze and foam. Ann Plast Surg. 2010

Mitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion. Mol Vis. 2010

Proteasome inhibition and changes in proteasome structure caused by HAMLET in tumor cells. PLoS One. 2009

HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death. Int J Cancer. 2009

Protein kinase C in porcine retinal arteries and neuroretina following retinal ischemia-reperfusion. Mol Vis. 2009

Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways. BMC Cardiovasc Disord. 2008

Topical negative pressure therapy of a sternotomy wound increases sternal fluid content but does not affect internal thoracic artery blood flow: assessment using magnetic resonance imaging. J Thorac Cardiovasc Surg. 2008

Pressure transduction to the thoracic cavity during topical negative pressure therapy of a sternotomy wound. Int Wound J. 2008

Increased endothelin ETA and ETB receptor contraction in the left internal mammary artery from patients with hypertension. J Hum Hypertens. 2008

PKC and MAPK signalling pathways regulate vascular endothelin receptor expression. Eur J Pharmacol. 2008

Endothelin receptor-mediated vasodilatation: Effects of organ culture. Eur J Pharmacol. 2008

Histone Deacetylase Inhibitors Promote the Tumoricidal Effect of HAMLET. Cancer Res. 2007

Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells). Int J Cancer. 2007

Hemodynamic effects of vacuum-assisted closure therapy in cardiac surgery: assessment using magnetic resonance imaging. J Thorac Cardiovasc Surg. 2007

Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4. Cell Microbiol. 2007

Sternal Stability at Different Negative Pressures DuringVacuum-Assisted Closure Therapy. Ann Thorac Surg. 2006

Effect of vacuum-assisted closure on blood flow in the peristernal thoracic wall after internal mammary artery harvesting. Eur J Cardiothorac Surg. 2006

HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53. Apoptosis. 2006

Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid. New Engl J Med. 2004

Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Res. 2004

Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells). Protein Sci. 2003

HAMLET interacts with histones and chromatin in tumor cell nuclei. J Biol Chem. 2003

Kinetics of the superficial perfusion and temperature in connection with photodynamic therapy of basal cell carcinomas using esterified and non-esterified 5-aminolaevulinic acid. Br J Dermatol. 2003

Uptake and intracellular transportation of a bacterial surface protein in lymphoid cells. Mol Microbiol. 2002


Photodynamic therapy and diagnostic measurements of basal carcinomas using esterified and non-esterified -aminolevulinic acid. J. Porphyrins Phtalocyanines 2001

Can misfolded proteins be beneficial? The HAMLET case. Ann Med. 2008

Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells). Adv Exp Med Biol. 2008

Apoptosis and tumor cell death in response to HAMLET (Human alpha-lactalbumin made lethal to tumor cells). Bioactive components of milk. 2006

HAMLET kills tumor cells by apoptosis: Structure, cellular mechanisms and therapy. Nutrition. 2005

HAMLET; a novel tool to identify apoptotic pathways in tumor cells. Applications of Apoptosis to Cancer Treatment. 2005

HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects. Adv Cancer Res. 2003

Publications

  1. ncbi request reprint Uptake and intracellular transportation of a bacterial surface protein in lymphoid cells
    Inga Maria Frick
    Department of Cell and Molecular Biology, Lund University, BMC, B14, Tornavagen 10, S 221 84 Lund, Sweden
    Mol Microbiol 44:917-34. 2002
  2. ncbi request reprint Endothelin receptor-mediated vasodilatation: effects of organ culture
    David Nilsson
    Department of Medicine, Lund University Hospital, Lund, Sweden
    Eur J Pharmacol 579:233-40. 2008
  3. ncbi request reprint PKC and MAPK signalling pathways regulate vascular endothelin receptor expression
    David Nilsson
    Department of Medicine, Lund University Hospital, Lund, Sweden
    Eur J Pharmacol 580:190-200. 2008
  4. ncbi request reprint Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET
    Patrick Brest
    Institute of Laboratory Medicine, Section of Microbiology, Immunology, and Glycobiology, Lund University, Lund, Sweden
    Cancer Res 67:11327-34. 2007
  5. doi request reprint Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells)
    Oskar Hallgren
    Department for Experimental Medical Sciences, Section for Lungbiology, Lund, Sweden
    Adv Exp Med Biol 606:217-40. 2008
  6. doi request reprint Topical negative pressure therapy of a sternotomy wound increases sternal fluid content but does not affect internal thoracic artery blood flow: assessment using magnetic resonance imaging
    Rainer Petzina
    Department of Medicine, Lund University Hospital, Lund, Sweden
    J Thorac Cardiovasc Surg 135:1007-13. 2008
  7. pmc Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways
    David Nilsson
    Department of Medicine, Lund University Hospital, Sweden
    BMC Cardiovasc Disord 8:21. 2008
  8. doi request reprint Pressure transduction to the thoracic cavity during topical negative pressure therapy of a sternotomy wound
    Christian Torbrand
    Department of Medicine, Lund University Hospital, Lund, Sweden
    Int Wound J 5:579-84. 2008
  9. doi request reprint Can misfolded proteins be beneficial? The HAMLET case
    Jenny Pettersson-Kastberg
    Department of Microbiology, Immunology and Glycobiology MIG, Institute of Laboratory Medicine, Lund University, Solvegatan 23, Lund, Sweden
    Ann Med 41:162-76. 2009
  10. doi request reprint HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death
    Sonja Aits
    Institute of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden
    Int J Cancer 124:1008-19. 2009

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Uptake and intracellular transportation of a bacterial surface protein in lymphoid cells
    Inga Maria Frick
    Department of Cell and Molecular Biology, Lund University, BMC, B14, Tornavagen 10, S 221 84 Lund, Sweden
    Mol Microbiol 44:917-34. 2002
    ..Finally, the uptake and intracellular transportation of protein H was found to result in a cytostatic effect on B and T lymphocytes...
  2. ncbi request reprint Endothelin receptor-mediated vasodilatation: effects of organ culture
    David Nilsson
    Department of Medicine, Lund University Hospital, Lund, Sweden
    Eur J Pharmacol 579:233-40. 2008
    ..Down-regulation of endothelial endothelin ET(B) receptors may in part explain the increased endothelin ET(B) receptor-mediated vasoconstriction frequently studied in organ culture...
  3. ncbi request reprint PKC and MAPK signalling pathways regulate vascular endothelin receptor expression
    David Nilsson
    Department of Medicine, Lund University Hospital, Lund, Sweden
    Eur J Pharmacol 580:190-200. 2008
    ..Inhibiting these intracellular signal transduction pathways may provide a future therapeutic target for hindering the development of vascular endothelin receptor changes in cardiovascular disease...
  4. ncbi request reprint Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET
    Patrick Brest
    Institute of Laboratory Medicine, Section of Microbiology, Immunology, and Glycobiology, Lund University, Lund, Sweden
    Cancer Res 67:11327-34. 2007
    ..The results suggest that the synergy of HDIs and HAMLET is based on different but converging death pathways, both involving chromatin alterations. We speculate that HAMLET and HDIs might be combined to promote tumor cell death in vivo...
  5. doi request reprint Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells)
    Oskar Hallgren
    Department for Experimental Medical Sciences, Section for Lungbiology, Lund, Sweden
    Adv Exp Med Biol 606:217-40. 2008
    ..This complexity might underlie the rapid death response of tumor cells and the broad antitumor activity of HAMLET...
  6. doi request reprint Topical negative pressure therapy of a sternotomy wound increases sternal fluid content but does not affect internal thoracic artery blood flow: assessment using magnetic resonance imaging
    Rainer Petzina
    Department of Medicine, Lund University Hospital, Lund, Sweden
    J Thorac Cardiovasc Surg 135:1007-13. 2008
    ..No study has yet been performed to examine the effect of topical negative pressure on the blood and fluid content in the sternal bone marrow, which is a crucial component in osteitis...
  7. pmc Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways
    David Nilsson
    Department of Medicine, Lund University Hospital, Sweden
    BMC Cardiovasc Disord 8:21. 2008
    ..We hypothesize that mitogen-activated kinases (MAPK) and protein kinase C (PKC) are involved in the regulation of endothelin ETB receptors in human internal mammary arteries...
  8. doi request reprint Pressure transduction to the thoracic cavity during topical negative pressure therapy of a sternotomy wound
    Christian Torbrand
    Department of Medicine, Lund University Hospital, Lund, Sweden
    Int Wound J 5:579-84. 2008
    ....
  9. doi request reprint Can misfolded proteins be beneficial? The HAMLET case
    Jenny Pettersson-Kastberg
    Department of Microbiology, Immunology and Glycobiology MIG, Institute of Laboratory Medicine, Lund University, Solvegatan 23, Lund, Sweden
    Ann Med 41:162-76. 2009
    ....
  10. doi request reprint HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death
    Sonja Aits
    Institute of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden
    Int J Cancer 124:1008-19. 2009
    ..The results show that HAMLET triggers macroautophagy in tumor cells and suggest that macroautophagy contributes to HAMLET-induced tumor cell death...
  11. pmc Protein kinase C in porcine retinal arteries and neuroretina following retinal ischemia-reperfusion
    Bodil Gesslein
    Department of Ophthalmology, Lund University, Sweden
    Mol Vis 15:737-46. 2009
    ..The retinal blood vessels are key organs in circulatory failure, and this study was therefore designed to examine the retinal vasculature separately from the neuroretina...
  12. ncbi request reprint Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells)
    Ann Kristin Mossberg
    Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden
    Int J Cancer 121:1352-9. 2007
    ..The results suggest that HAMLET exerts a direct and selective effect on bladder cancer tissue in vivo and that local HAMLET administration might be of value in the future treatment of bladder cancers...
  13. ncbi request reprint Hemodynamic effects of vacuum-assisted closure therapy in cardiac surgery: assessment using magnetic resonance imaging
    Rainer Petzina
    Department of Medicine, Lund University Hospital, Lund, Sweden
    J Thorac Cardiovasc Surg 133:1154-62. 2007
    ....
  14. ncbi request reprint HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects
    Catharina Svanborg
    Institute of Laboratory Medicine, Department of Microbiology, Immunology and Glycobiology, Lund University, 221 00 Lund, Sweden
    Adv Cancer Res 88:1-29. 2003
    ..This mechanism may contribute to the protective effect of breastfeeding against childhood tumors. We propose that HAMLET should be explored as a novel approach to tumor therapy...
  15. ncbi request reprint Kinetics of the superficial perfusion and temperature in connection with photodynamic therapy of basal cell carcinomas using esterified and non-esterified 5-aminolaevulinic acid
    S Palsson
    Department of Physics, Lund Institute of Technology, Lund University Medical Laser Centre, PO Box 118, SE 221 00 Lund, Sweden
    Br J Dermatol 148:1179-88. 2003
    ..The skin is an important target and serves as a good model for monitoring and evaluating the interaction of light with biological tissue...
  16. ncbi request reprint HAMLET interacts with histones and chromatin in tumor cell nuclei
    Caroline Duringer
    Institute of Laboratory Medicine, Section for Microbiology, Immunology and Glycobiology, Lund University, Solvegatan 23, 223 62 Lund, Sweden
    J Biol Chem 278:42131-5. 2003
    ..We conclude that HAMLET interacts with histones and chromatin in tumor cell nuclei and propose that this interaction locks the cells into the death pathway by irreversibly disrupting chromatin organization...
  17. pmc Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells)
    Malin Svensson
    Department of Microbiology, Immunology and Glycobiology MIG, Institute of Laboratory Medicine, Lund University, Lund, Sweden
    Protein Sci 12:2794-804. 2003
    ..This suggests that the lipid cofactor stabilizes the altered fold without interfering with the Ca(2+)site...
  18. ncbi request reprint Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival
    Walter Fischer
    Institute of Laboratory Medicine, Department of Microbiology, Immunology and Glycobiology, University of Lund, Solvegatan 23, 223 62 Lund, Sweden
    Cancer Res 64:2105-12. 2004
    ..The results identify HAMLET as a new candidate in cancer therapy and suggest that HAMLET should be additionally explored as a novel approach to controlling GBM progression...
  19. ncbi request reprint Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid
    Lotta Gustafsson
    Institute of Laboratory Medicine, Department of Microbiology, Immunology, and Glycobiology, University of Lund, Lund, Sweden
    N Engl J Med 350:2663-72. 2004
    ....
  20. ncbi request reprint HAMLET kills tumor cells by apoptosis: structure, cellular mechanisms, and therapy
    Lotta Gustafsson
    Institute of Laboratory Medicine, Department of Microbiology, Immunology and Glycobiology, Lund University, Sweden
    J Nutr 135:1299-303. 2005
    ..HAMLET thus shows great promise as a new therapeutic with the advantage of selectivity for tumor cells and lack of toxicity...
  21. ncbi request reprint HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53
    O Hallgren
    Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden
    Apoptosis 11:221-33. 2006
    ..The use of other cell death pathways allows HAMLET to successfully circumvent fundamental anti-apoptotic strategies that are present in many tumor cells...
  22. ncbi request reprint Effect of vacuum-assisted closure on blood flow in the peristernal thoracic wall after internal mammary artery harvesting
    Rainer Petzina
    Department of Medicine, Lund University Hospital, Lund, Sweden
    Eur J Cardiothorac Surg 30:85-9. 2006
    ..The aim was to examine the effects of VAC negative pressure on peristernal soft tissue blood flow after internal mammary artery harvesting...
  23. ncbi request reprint Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4
    Hans Fischer
    Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Solvegatan 23, S 22362 Lund, Sweden
    Cell Microbiol 9:1239-51. 2007
    ..The results show that ceramide activates TLR4 signalling and suggest that this mechanism might allow pathogens to elicit mucosal TLR4 responses by perturbing sphingolipid receptors for virulence ligands like P fimbriae...
  24. pmc Mitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion
    Bodil Gesslein
    Department of Ophthalmology, Lund University, Lund, Sweden
    Mol Vis 16:392-407. 2010
    ..The aim of the present study was to examine changes in the expression of intracellular signal-transduction pathways, specifically mitogen-activated protein kinases, following retinal ischemia-reperfusion...