Research Topics
| Anders GrubbSummaryAffiliation: Lund University Country: Sweden Publications
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Detail Information
Publications
Improved estimation of glomerular filtration rate (GFR) by comparison of eGFRcystatin C and eGFRcreatinineAnders Grubb
Department of Clinical Chemistry, Lund University Hospital, Lund, Sweden
Scand J Clin Lab Invest 72:73-7. 2012....- Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis developmentAlexandra Bäcklund
Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles vag 2, 171 77, Stockholm, Sweden
Arthritis Res Ther 13:R54. 2011..In particular, the cysteine proteases have been proposed to be detrimental to the arthritic process and even immunomodulatory. A natural inhibitor of cysteine proteases is cystatin C... - Cystatin C, a marker for successful aging and glomerular filtration rate, is not influenced by inflammationAnders Grubb
Department of Clinical Chemistry, Lund University Hospital, Lund, Sweden
Scand J Clin Lab Invest 71:145-9. 2011..The present work concerns the cystatin C levels and degree of inflammation in longitudinal studies of individual subjects without inflammation, who undergo elective surgery... 
Non-invasive estimation of glomerular filtration rate (GFR). The Lund model: Simultaneous use of cystatin C- and creatinine-based GFR-prediction equations, clinical data and an internal quality checkAnders Grubb
Department of Clinical Chemistry, University Hospital, Lund, Sweden
Scand J Clin Lab Invest 70:65-70. 2010..If the GFRs predicted agree for a patient, the creatinine value is reliably connected to a specific GFR and can be used to follow changes in GFR of that patient...
Fibrillogenic oligomers of human cystatin C are formed by propagated domain swappingMaria Wahlbom
Department of Clinical Chemistry, Lund University Hospital, S 221 85 Lund, Sweden
J Biol Chem 282:18318-26. 2007..Redox experiments using wild type and stabilized cystatin C strongly suggest that the oligomers, and thus probably the fibrils as well, are formed by propagated domain swapping rather than by assembly of domain-swapped cystatin C dimers...- Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for childrenAnders Grubb
Department of Clinical Chemistry, Competence Centre for Clinical Research, Department of Nephrology, University Hospital, Lund, Sweden
Clin Chem 51:1420-31. 2005..73 m(2))(-1). The present study analyzes whether these GFR prediction equations for adults and children might be replaced by simple prediction equations based on plasma concentrations of cystatin C... - A new tool for predicting the probability of chronic kidney disease from a specific value of estimated GFRJonas Bjork
Competence Centre for Clinical Research, Lund University Hospital, Lund, Sweden
Scand J Clin Lab Invest 70:327-33. 2010..To demonstrate how patients' probability of having chronic kidney disease (CKD) stage 3-5 (measured GFR <60 mL/min/1.73 m(2)) can be predicted from a specific value of estimated glomerular filtration rate (eGFR)... - Revised equations for estimating glomerular filtration rate based on the Lund-Malmö Study cohortJonas Bjork
Competence Centre for Clinical Research, Skane University Hospital, Lund, Sweden
Scand J Clin Lab Invest 71:232-9. 2011..73 m(2) by revising the Lund-Malmö (LM) equations, to elaborate on more complex forms to improve the LM and CKD-EPI equations further, and to assess benefits of adding lean body mass (LBM)... - Variability in diagnostic accuracy can be estimated using simple population weightingJonas Bjork
Competence Centre for Clinical Research, Lund University Hospital, Barngatan 2, SE 221 85 Lund, Sweden
J Clin Epidemiol 62:54-7. 2009..g., chronic, referrals, or screening) under investigation. Simple weighted averages calculated from a single study sample may be used to assess variability in accuracy in different types of populations... - Natriuretic peptides as indicators of cardiac remodeling in hypertensive patientsMartin Magnusson
Department of Cardiology, Malmo University Hospital, Lund University, Malmo, Sweden
Blood Press 18:196-203. 2009..This study was performed to evaluate the relationship between three different natriuretic peptides and left ventricular mass, function and diameter, and kidney function in patients with hypertension... - Lack of the cysteine protease inhibitor cystatin C promotes atherosclerosis in apolipoprotein E-deficient miceEva Bengtsson
Department of Clinical Sciences, Malmo University Hospital, Lund University, Sweden
Arterioscler Thromb Vasc Biol 25:2151-6. 2005..It is present in the normal artery wall but severely reduced in human atherosclerotic lesions... - High throughput testing of drug library substances and monoclonal antibodies for capacity to reduce formation of cystatin C dimers to identify candidates for treatment of hereditary cystatin C amyloid angiopathyGustav Ostner
Department of Clinical Chemistry, Lund University Hospital, Lund, Sweden
Scand J Clin Lab Invest 71:676-82. 2011.... - Elevated infection parameters and infection symptoms predict an acute coronary eventErkki Pesonen
Department of Pediatric Cardiology, University Hospital, Lund, Sweden
Ther Adv Cardiovasc Dis 2:419-24. 2008..The etiology and significance of flu-like symptoms often appearing before myocardial infarction should be clarified... - Prevention of domain swapping inhibits dimerization and amyloid fibril formation of cystatin C: use of engineered disulfide bridges, antibodies, and carboxymethylpapain to stabilize the monomeric form of cystatin CMaria Nilsson
Department of Clinical Chemistry, University Hospital, S-22185 Lund, Sweden
J Biol Chem 279:24236-45. 2004..It was observed that catalytic amounts of both the monoclonal antibody and carboxymethylpapain could suppress dimerization... - Different elimination patterns of beta-trace protein, beta2-microglobulin and cystatin C in haemodialysis, haemodiafiltration and haemofiltrationVeronica Lindström
Department of Clinical Chemistry, Lund University Hospital, Lund, Sweden
Scand J Clin Lab Invest 68:685-91. 2008..In this study, we used beta(2)-microglobulin, cystatin C and beta-trace protein, which differ in molecular mass and charge, to characterize the elimination patterns of three different dialysis modalities... - New antimicrobial cystatin C-based peptide active against gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus and multiresistant coagulase-negative staphylococciAftab Jasir
Department of Clinical Chemistry, University Hospital, Lund, Sweden
APMIS 111:1004-10. 2003..aureus (MRSA) and multiantibiotic-resistant coagulase-negative staphylococci (CNS), suggesting that its mechanism of action differs from those of most currently used antibiotics... - Glomerular filtration rate dependence of sieving of albumin and some neutral proteins in rat kidneysUlla Lund
Department of Nephrology, University Hospital, S-221 85 Lund, Sweden
Am J Physiol Renal Physiol 284:F1226-34. 2003..Furthermore, the glomerular small-pore radius assessed from endogenous (neutral) protein sieving data was found to be smaller than previously determined using dextran or Ficoll as test molecules... - Lowered levels of serum albumin and HDL-cholesterol in children with a recent mild infectionElhadi H Aburawi
Division of Pediatric Cardiology, Lund University Hospital, Lund
Ann Med 38:154-60. 2006..Infections are associated with atherogenic changes in serum.AIM. To elucidate effects of recent infections on risk factors for coronary heart disease in children... - First certified reference material for cystatin C in human serum ERM-DA471/IFCCAnders Grubb
Department of Clinical Chemistry, University Hospital, Lund, Sweden
Clin Chem Lab Med 48:1619-21. 2010..The certified cystatin C mass concentration in ERM-DA471/IFCC, if reconstituted according to the specified procedure, is 5.48 mg/L, the expanded uncertainty (k=2) being 0.15 mg/L... - Serum cystatin C reflects glomerular endotheliosis in normal, hypertensive and pre-eclamptic pregnanciesHelena Strevens
Department of Obstetrics and Gynaecology, University Hospital, University of Lund, S-221 85 Lund, Sweden
BJOG 110:825-30. 2003..It may be of value in the monitoring of pregnancies complicated by pre-eclampsia... - Cysteine proteases in Langerhans cells limits presentation of cartilage derived type II collagen for autoreactive T cellsMeirav Holmdahl
Department of Clinical Chemistry, Lund University, Sweden
Int Immunol 16:717-26. 2004....