Leif Groop

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Classifying diabetes according to the new WHO clinical stages
    E Lindholm
    Department of Endocrinology, University Hospital MAS, , Sweden
    Eur J Epidemiol 17:983-9. 2001
  2. ncbi request reprint Genes and type 2 diabetes mellitus
    Leif Groop
    Department of Clinical Sciences Diabetes and Endocrinology, Lund University, University Hospital Malmoe, 20502, Malmoe, Sweden
    Curr Diab Rep 8:192-7. 2008
  3. ncbi request reprint Insulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment
    Leif Groop
    Department of Endocrinology, Malmo University Hospital, Lund University, Malmo, Sweden
    Horm Res 64:45-50. 2005
  4. ncbi request reprint Latent autoimmune diabetes in adults (LADA)--more than a name
    L Groop
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, 20502, Malmo, Sweden
    Diabetologia 49:1996-8. 2006
  5. pmc New insights into impaired muscle glycogen synthesis
    Leif Groop
    Department of Clinical Sciences, Diabetes andEndocrinology Research Unit, Lund UniversityDiabetes Centre, Lund University, Malmoe, Sweden
    PLoS Med 5:e25. 2008
  6. ncbi request reprint A Central Role for GRB10 in Regulation of Islet Function in Man
    Inga Prokopenko
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, United Kingdom
    PLoS Genet 10:e1004235. 2014
  7. doi request reprint Genetics of diabetes--are we missing the genes or the disease?
    Leif Groop
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Skane, Malmo, Sweden Glostrup Research Institute, Glostrup University Hospital, Glostrup, Denmark Electronic address
    Mol Cell Endocrinol 382:726-39. 2014
  8. pmc High prevalence of type 2 diabetes in Iraqi and Swedish residents in a deprived Swedish neighbourhood--a population based study
    Louise Bennet
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    BMC Public Health 11:303. 2011
  9. pmc Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus
    Hemang Parikh
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden
    BMC Med Genomics 2:72. 2009
  10. ncbi request reprint Genetic basis of beta-cell dysfunction in man
    L Groop
    Department of Clinical Sciences Diabetes and Endocrinology, and Lund University Diabetes Centre, Lund University, University Hospital Malmoe, Sweden
    Diabetes Obes Metab 11:149-58. 2009

Collaborators

Detail Information

Publications166 found, 100 shown here

  1. ncbi request reprint Classifying diabetes according to the new WHO clinical stages
    E Lindholm
    Department of Endocrinology, University Hospital MAS, , Sweden
    Eur J Epidemiol 17:983-9. 2001
    ..However, because of the cross-sectional nature of these data, they need to be confirmed in a prospective study with defined cut-off limits for when insulin should be initiated...
  2. ncbi request reprint Genes and type 2 diabetes mellitus
    Leif Groop
    Department of Clinical Sciences Diabetes and Endocrinology, Lund University, University Hospital Malmoe, 20502, Malmoe, Sweden
    Curr Diab Rep 8:192-7. 2008
    ..In the future, the possibility of whole-genome DNA methylation studies may elucidate the extent of these epigenetic effects. This article reviews genes that have recently been determined to be associated with T2DM...
  3. ncbi request reprint Insulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment
    Leif Groop
    Department of Endocrinology, Malmo University Hospital, Lund University, Malmo, Sweden
    Horm Res 64:45-50. 2005
    ..This article discusses this and other potential long-term metabolic effects of GH, and raises a number of questions to be addressed by future research...
  4. ncbi request reprint Latent autoimmune diabetes in adults (LADA)--more than a name
    L Groop
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, 20502, Malmo, Sweden
    Diabetologia 49:1996-8. 2006
  5. pmc New insights into impaired muscle glycogen synthesis
    Leif Groop
    Department of Clinical Sciences, Diabetes andEndocrinology Research Unit, Lund UniversityDiabetes Centre, Lund University, Malmoe, Sweden
    PLoS Med 5:e25. 2008
  6. ncbi request reprint A Central Role for GRB10 in Regulation of Islet Function in Man
    Inga Prokopenko
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, United Kingdom
    PLoS Genet 10:e1004235. 2014
    ..The data also emphasize the need in genetic studies to consider whether risk alleles are inherited from the mother or the father. ..
  7. doi request reprint Genetics of diabetes--are we missing the genes or the disease?
    Leif Groop
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Skane, Malmo, Sweden Glostrup Research Institute, Glostrup University Hospital, Glostrup, Denmark Electronic address
    Mol Cell Endocrinol 382:726-39. 2014
    ....
  8. pmc High prevalence of type 2 diabetes in Iraqi and Swedish residents in a deprived Swedish neighbourhood--a population based study
    Louise Bennet
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    BMC Public Health 11:303. 2011
    ..An additional aim was to identify metabolic, lifestyle and socioeconomic risk factors associated with IFG/IGT and T2D in these residents...
  9. pmc Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus
    Hemang Parikh
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden
    BMC Med Genomics 2:72. 2009
    ....
  10. ncbi request reprint Genetic basis of beta-cell dysfunction in man
    L Groop
    Department of Clinical Sciences Diabetes and Endocrinology, and Lund University Diabetes Centre, Lund University, University Hospital Malmoe, Sweden
    Diabetes Obes Metab 11:149-58. 2009
    ..For the first time, we can anticipate with some confidence that the genetics of a complex disease like T2D really can be dissected...
  11. doi request reprint Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  12. ncbi request reprint Genetic and nongenetic regulation of CAPN10 mRNA expression in skeletal muscle
    Emma Carlsson
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmo University Hospital, S 205 02 Malmo, Sweden
    Diabetes 54:3015-20. 2005
    ..Glucose-tolerant but not glucose-intolerant individuals upregulate their CAPN10 mRNA levels in response to prolonged exposure to fat...
  13. doi request reprint Expression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin
    Maja Ahlzén
    Department of Clinical Sciences Malmo, Clinical Obesity, Entrance 72, Building 91, Floor 12, CRC, Lund University, Malmo University Hospital, S 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 370:49-52. 2008
    ..In conclusion, TCF7L2 mRNA levels in adipocytes are decreased by insulin and seem to increase in insulin resistant subjects and in HapA carriers...
  14. pmc Genetic prediction of future type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden
    PLoS Med 2:e345. 2005
    ..A number of common variants have been associated with T2D but our knowledge of their ability to predict T2D prospectively is limited...
  15. pmc Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality
    Eero Lindholm
    Department of Clinical Sciences, Clinical Research Center, University Hospital Malmö MAS, Lund University, Malmo, Sweden
    PLoS ONE 1:e64. 2006
    ..Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI)...
  16. pmc Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins
    Tina Rönn
    Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, CRC Malmö University Hospital, Lund University, Malmo, Sweden
    PLoS ONE 4:e4793. 2009
    ..Our aims were to investigate mechanisms regulating ATP5O expression in skeletal muscle and association with glucose metabolism, and the relationship between ATP5O single nucleotide polymorphisms (SNPs) and risk of T2D...
  17. pmc Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality
    Jenny Fredriksson
    Department of Clinical Sciences in Malmo, Clinical Research Centre, Lund University, Malmo, Sweden
    PLoS ONE 2:e285. 2007
    ....
  18. ncbi request reprint Interaction between the angiotensin-converting enzyme gene insertion/deletion polymorphism and obstructive sleep apnoea as a mechanism for hypertension
    Kristina Bengtsson Boström
    Department of Clinical Sciences, Diabetes and Endocrinology, Skaraborg Institute, Skovde, Sweden
    J Hypertens 25:779-83. 2007
    ..The aim of this study was to explore the interaction between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and OSA in the association with hypertension...
  19. pmc A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion
    Anna Jonsson
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, and Lund University Diabetes Centre, Malmo, Sweden
    Diabetes 58:2409-13. 2009
    ..Here we studied whether a common variant in KCNQ1 would influence BMI as well as insulin secretion and action and predict future type 2 diabetes in subjects from Sweden and Finland...
  20. ncbi request reprint The FOXC2 C-512T polymorphism is associated with obesity and dyslipidemia
    Emma Carlsson
    Department of Endocrinology, Lund University, University Hospital MAS, Wallenberglaboratory, S 205 02 Malmo, Sweden
    Obes Res 12:1738-43. 2004
    ..95 [1.30 to 2.68] vs. 1.60 [1.10 to 2.40] mM, p(adj) = 0.02) compared with obese carriers of the T/T genotype. Our data suggest that FOXC2 is a weak but consistent candidate gene for obesity and dyslipidemia...
  21. doi request reprint Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes
    Sofia A Andersson
    Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    Mol Cell Endocrinol 364:36-45. 2012
    ..Our data support that reduced expression of exocytotic genes contributes to impaired insulin secretion, and suggest decreased expression of these genes as part of T2D pathogenesis...
  22. doi request reprint The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes
    Anders H Olsson
    Lund University, Department of Clinical Sciences Malmo, Lund University Diabetes Centre, Scania University Hospital, Malmo, Sweden
    Mol Genet Metab 103:275-81. 2011
    ....
  23. pmc Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins
    Charlotte Ling
    Department of Endocrinology, Lund University, Wallenberg Laboratory, Malmo University Hospital, Malmo, Sweden
    J Clin Invest 114:1518-26. 2004
    ....
  24. doi request reprint Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes
    Johan Holmkvist
    Department of Clinical Sciences Diabetes and Endocrinology, CRC, Malmö University Hospital MAS, Lund University, Malmo, Sweden
    Diabetes 57:1738-44. 2008
    ....
  25. doi request reprint Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes
    Taman Mahdi
    Lund University Diabetes Centre, Lund University, 20502 Malmo, Sweden
    Cell Metab 16:625-33. 2012
    ..Moreover, the protein was increased in serum from T2D patients several years before the diagnosis, suggesting that SFRP4 could be a potential biomarker for islet dysfunction in T2D...
  26. doi request reprint Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes
    Camilla Cervin
    Department of Clinical Sciences Diabetes and Endocrinology, Clinical Research Center, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    Diabetes 57:1433-7. 2008
    ..One way to improve classification is to study whether LADA shares genetic features with type 1 and/or type 2 diabetes...
  27. doi request reprint Impact of exercise intensity and duration on insulin sensitivity in women with T2D
    Asa B Segerström
    Department of Health Sciences, Division of Physiotherapy, Lund University, Lund, Sweden
    Eur J Intern Med 21:404-8. 2010
    ..The aim of this study was to examine the effect of group exercise training on exercise capacity, insulin sensitivity and HbA1c in women with diabetes...
  28. pmc Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes
    Charlotte Ling
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Clinical Research Centre CRC, Malmo, Sweden
    PLoS ONE 4:e6558. 2009
    ..We also tested if polymorphisms in the CAPN10 gene are associated with gene expression and insulin secretion in vitro...
  29. pmc Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Diabetes and Endocrinology, and Lund University Diabetes Center, Lund University, Malmo, Sweden
    J Clin Invest 117:2155-63. 2007
    ..In conclusion, the increased risk of T2D conferred by variants in TCF7L2 involves the enteroinsular axis, enhanced expression of the gene in islets, and impaired insulin secretion...
  30. doi request reprint Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes
    Jalal Taneera
    Lund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skane University Hospital, Lund University, Malmo 20502, Sweden
    Mol Cell Endocrinol 375:35-42. 2013
    ..Our data provide a comprehensive expression pattern of cell cycle genes in human islets. More human studies are required to confirm and reproduce animal studies. ..
  31. pmc Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α- and β-cell function and insulin action in humans
    Anna Jonsson
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Malmo, Sweden
    Diabetes 62:2978-83. 2013
    ..Many of the genetic variants shown to be associated with type 2 diabetes or glycemic traits also exert pleiotropic in vivo and in vitro effects on islet function. ..
  32. ncbi request reprint Variation in the adiponutrin gene influences its expression and associates with obesity
    Lovisa E Johansson
    Department of Clinical Sciences Malmo, Clinical Obesity, Lund University, University Hospital MAS, S 205 02 Malmo, Sweden
    Diabetes 55:826-33. 2006
    ....
  33. ncbi request reprint Impaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes
    Xudong Huang
    Department of Endocrinology, Wallenberg Laboratory, Malmo, Sweden
    Diabetes 52:2411-8. 2003
    ..In humans, insulin-stimulated cathepsin L expression in skeletal muscle is impaired in diabetic but not in nondiabetic monozygotic twins, suggesting that the changes may be secondary to impaired glucose metabolism...
  34. doi request reprint Exercise capacity in relation to body fat distribution and muscle fibre distribution in elderly male subjects with impaired glucose tolerance, type 2 diabetes and matched controls
    Asa B Segerström
    Department of Health Sciences, Division of Physiotherapy, Lund University, Lund, Sweden
    Diabetes Res Clin Pract 94:57-63. 2011
    ..The aim of this study was to examine the impact of insulin sensitivity and muscle fibre composition to exercise capacity in individuals with type 2 diabetes (T2D), impaired glucose tolerance (IGT) and normal glucose tolerance (NGT)...
  35. doi request reprint Validation of a multi-marker model for the prediction of incident type 2 diabetes mellitus: combined results of the Inter99 and Botnia studies
    Valeria Lyssenko
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmo, Sweden
    Diab Vasc Dis Res 9:59-67. 2012
    ..To assess performance of a biomarker-based score that predicts the five-year risk of diabetes (Diabetes Risk Score, DRS) in an independent cohort that included 15-year follow-up...
  36. pmc Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients
    Martin Magnusson
    Department of Cardiology, Malmo University Hospital, Lund University, Lund, Sweden
    Cardiovasc Diabetol 9:2. 2010
    ....
  37. ncbi request reprint Dipping and variability of blood pressure and heart rate at night are heritable traits
    Cristiano Fava
    Department of Endocrinology, University Hospital MAS, Malmo, Sweden
    Am J Hypertens 18:1402-7. 2005
    ..The aim of this study was to determine whether these traits are heritable...
  38. pmc Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle
    Charlotte Ling
    Department of Clinical Sciences, Lund University, University Hospital MAS, Malmo, Sweden
    J Clin Invest 117:3427-35. 2007
    ....
  39. ncbi request reprint COX-2 and SCD, markers of inflammation and adipogenesis, are related to disease activity in Graves' ophthalmopathy
    Tereza Vondrichova
    Division of Diabetes and Endocrinology, Department of Clinical Sciences, Lund University, Malmo University Hospital, Malmo, Sweden
    Thyroid 17:511-7. 2007
    ..Inflammation and adipogenesis are two parallel processes with increased activity in severe Graves' ophthalmopathy...
  40. ncbi request reprint Variation in the calpain-10 gene is associated with elevated triglyceride levels and reduced adipose tissue messenger ribonucleic acid expression in obese Swedish subjects
    Emma Carlsson
    Department of Endocrinology, Lund University, Wallenberg Laboratory, Malmo University Hospital, S 205 02 Malmo, Sweden
    J Clin Endocrinol Metab 89:3601-5. 2004
    ....
  41. ncbi request reprint Growth hormone replacement therapy induces insulin resistance by activating the glucose-fatty acid cycle
    Margareta Bramnert
    Department of Endocrinology, University Hospital, S 205 02 Malmo, Sweden
    J Clin Endocrinol Metab 88:1455-63. 2003
    ..Also, a shift toward more insulin-resistant type II X fibers is seen in muscle. Glucose metabolism should be carefully monitored during long-term GH replacement therapy...
  42. ncbi request reprint Gastric bypass improves β-cell function and increases β-cell mass in a porcine model
    Andreas Lindqvist
    Department of Clinical Sciences, Lund University Diabetes Centre, Malmo, Sweden
    Diabetes 63:1665-71. 2014
    ..Our data from a pig model of RYGB emphasize the key role of improved β-cell function and β-cell mass to explain the improved glucose tolerance after RYGB as food intake and body weight remained identical. ..
  43. pmc Link between GIP and osteopontin in adipose tissue and insulin resistance
    Emma Ahlqvist
    Department of Clinical Sciences, Diabetes, and Endocrinology, University Hospital Malmo, Lund University, Malmo, Sweden
    Diabetes 62:2088-94. 2013
    ..Carriers of the GIPR rs10423928 A allele showed protective properties via reduced GIP effects. Identification of this unprecedented link between GIP and OPN in adipose tissue might open new avenues for therapeutic interventions...
  44. pmc A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue
    Tina Rönn
    Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, CRC, Malmo, Sweden
    PLoS Genet 9:e1003572. 2013
    ..In conclusion, exercise induces genome-wide changes in DNA methylation in human adipose tissue, potentially affecting adipocyte metabolism. ..
  45. doi request reprint Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance
    Lovisa E Johansson
    Department of Clinical Sciences Malmo, Clinical Obesity, Lund University Diabetes Centre, Lund University, Malmo, Sweden
    Am J Clin Nutr 96:196-207. 2012
    ..Differential gene expression in adipose tissue during diet-induced weight loss followed by a weight stability period is poorly characterized. Markers of these processes may provide a deeper understanding of underlying mechanisms...
  46. doi request reprint A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets
    Jalal Taneera
    Lund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital Malmö, Lund University, Malmo 20502, Sweden
    Cell Metab 16:122-34. 2012
    ..The data present a global map of genes associated with islet dysfunction and demonstrate the value of systems genetics for the identification of genes potentially involved in T2D...
  47. doi request reprint Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort
    Emily Sonestedt
    Department of Clinical Sciences, Malmo, Lund University, Clinical Research Centre, Building 60 floor 13, Skane University Hospital, Malmo, Entrance 72, Malmo SE 205 02, Sweden
    J Clin Endocrinol Metab 97:E810-8. 2012
    ..Glucose-dependent insulinotropic polypeptide is secreted after food consumption and gipr knockout mice fed a high-fat diet are protected against obesity and disturbances in glucose homeostasis...
  48. ncbi request reprint Haplotype construction of the FRDA gene and evaluation of its role in type II diabetes
    Johan Holmkvist
    Department of Clinical Sciences Diabetes and Endocrinology, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    Eur J Hum Genet 13:849-55. 2005
    ..01) as well as in the case-controls (P=0.03). In conclusions, this study excludes a role of genetic variation within the X25 gene, but instead suggests that genetic variation downstream the X25 gene, may increase risk for T2D...
  49. ncbi request reprint Contribution of insulin-stimulated glucose uptake and basal hepatic insulin sensitivity to surrogate measures of insulin sensitivity
    Devjit Tripathy
    Department of Endocrinology, University Hospital MAS, Lund University, Malmo, S 20502 Sweden
    Diabetes Care 27:2204-10. 2004
    ..The goal of this study was to evaluate the performance of surrogate measures of insulin sensitivity and insulin secretion...
  50. doi request reprint Upper body muscle strength and endurance in relation to peak exercise capacity during cycling in healthy sedentary male subjects
    Asa B Segerström
    Department of Health Sciences, Division of Physiotherapy, Lund University, Lund, Sweden
    J Strength Cond Res 25:1413-7. 2011
    ..Resistance training of the arms, chest, and trunk may help improve cycling performance...
  51. pmc Variants in the FFAR1 gene are associated with beta cell function
    Martins Kalis
    Department of Clinical Sciences, Cellular Autoimmunity Unit, Lund University, Malmo University Hospital, Malmo, Sweden
    PLoS ONE 2:e1090. 2007
    ..We therefore investigated whether variations at the FFAR1 locus are associated with T2D and beta cell function...
  52. doi request reprint Differences in effects of insulin glargine or pioglitazone added to oral anti-diabetic therapy in patients with type 2 diabetes: what to add--insulin glargine or pioglitazone?
    Mozhgan Dorkhan
    Department of Clinical Sciences, Division of Diabetes and Endocrinology, Lund University, Malmo University Hospital, Malmo S 20502, Sweden
    Diabetes Res Clin Pract 82:340-5. 2008
    ..While metformin is the first line treatment in type 2 diabetes, the best way to escalate therapy is not always clear, particularly whether to add one or two oral agents or to introduce insulin...
  53. pmc Plasma copeptin and the risk of diabetes mellitus
    Sofia Enhörning
    Department of Clinical Sciences, Lund University, Clinical Research Center, Entrance 72, Bldg 91, Floor 12, Malmo University Hospital, SE 20502 Malmo, Sweden
    Circulation 121:2102-8. 2010
    ..Animal studies suggest that the arginine vasopressin system may play a role in glucose metabolism, but data from humans are limited...
  54. doi request reprint Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans
    Andreas Lindqvist
    Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, SE 205 02 Malmo, Sweden
    J Clin Endocrinol Metab 98:E856-61. 2013
    ..Most studies aiming to explain the underlying mechanisms are limited to data obtained after a postsurgical recovery period, making assessment of confounding influences from, for example, weight loss and altered nutrient intake difficult...
  55. pmc Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes
    Marloes Dekker Nitert
    Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Scania University Hospital, Malmo, Sweden
    Diabetes 61:3322-32. 2012
    ..In addition, both expression and methylation of several genes, i.e., ADIPOR1, BDKRB2, and TRIB1, changed after exercise. These findings provide new insights into how genetic background and environment can alter the human epigenome...
  56. ncbi request reprint A combination of human leukocyte antigen DQB1*02 and the tumor necrosis factor alpha promoter G308A polymorphism predisposes to an insulin-deficient phenotype in patients with type 2 diabetes
    Haiyan Li
    Diabetes and Endocrine Research Laboratory, Department of Endocrinology, Lund University, S 20502 Malmo, Sweden
    J Clin Endocrinol Metab 88:2767-74. 2003
    ..However, we could show an association between TNF alpha(308) polymorphism and the phenotype of common type 2 diabetes...
  57. ncbi request reprint Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people
    Jose C Florez
    Department of Endocrinology, University Hospital MAS, Lund University, Malmo, Sweden
    Diabetes 54:1884-91. 2005
    ....
  58. ncbi request reprint Thyrostimulin (a TSH-like Hormone) expression in orbital and thyroid tissue
    Mikael Lantz
    Division of Diabetes and Endocrinology, Department of Clinical Sciences, Lund University, Malmo University Hospital, Malmo, Sweden
    Thyroid 17:113-8. 2007
    ..To investigate gene expression of thyrostimulin in orbital and thyroid tissue from patients with and without Graves' disease...
  59. ncbi request reprint Variants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels
    Marju Orho-Melander
    Department of Endocrinology, Wallenberg Laboratory, Lund University, Malmo, Sweden
    Diabetes 51:2658-64. 2002
    ....
  60. ncbi request reprint Role of the FOXC2 -512C>T polymorphism in type 2 diabetes: possible association with the dysmetabolic syndrome
    E Carlsson
    Department of Endocrinology, Lund University, University Hospital MAS, Malmo, Sweden
    Int J Obes (Lond) 29:268-74. 2005
    ..Here, we addressed the potential role for FOXC2 as a candidate gene for type 2 diabetes and associated phenotypes...
  61. ncbi request reprint Parallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes
    D Tripathy
    Wallenberg Laboratory, Department of Endocrinology, Lund University, Sweden
    Diabetologia 47:782-93. 2004
    ..The aim of the study was to evaluate the relationship between insulin sensitivity, beta cell function and glucose tolerance, and its dependence on variants in the newly identified Type 2 diabetes susceptibility gene, calpain-10 ( CAPN10)...
  62. pmc Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo
    Anders H Olsson
    Department of Clinical Sciences, Lund University, Scania University Hospital, Malmo, Sweden
    Eur J Endocrinol 164:765-71. 2011
    ..Mitochondrial ATP production is important in the regulation of glucose-stimulated insulin secretion. Genetic factors may modulate the capacity of the β-cells to secrete insulin and thereby contribute to the risk of type 2 diabetes...
  63. doi request reprint A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes
    Thomas Koeck
    Department of Clinical Sciences, Lund University Diabetes Centre, CRC, Scania University Hospital, 205 02 Malmo, Sweden
    Cell Metab 13:80-91. 2011
    ..Consequently, nutrient-stimulated ATP generation was reduced, leading to perturbed insulin secretion. We conclude that a deficiency in TFB1M and impaired mitochondrial function contribute to the pathogenesis of T2D...
  64. pmc Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations
    Marju Orho-Melander
    Department of Clinical Sciences, University Hospital Malmo, Clinical Research Center, Lund University, Malmo, Sweden
    Diabetes 57:3112-21. 2008
    ....
  65. pmc Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
    Valeriya Lyssenko
    Department of Clinical Sciences in Malmoe, Unit of Diabetes and Endocrinology, Lund University Diabetes Centre, University Hospital, Malmoe, Sweden
    Nat Genet 41:82-8. 2009
    ..In view of these results, blocking the melatonin ligand-receptor system could be a therapeutic avenue in T2D...
  66. pmc Pleiotropic effects of GIP on islet function involve osteopontin
    Valeriya Lyssenko
    Diabetes and Endocrinology, Department of Clinical Sciences, University Hospital Malmo, Lund University, Malmo, Sweden
    Diabetes 60:2424-33. 2011
    ..Here we explored mechanisms that could explain the protective effects of GIP on islet function...
  67. doi request reprint Relation between cycling exercise capacity, fiber-type composition, and lower extremity muscle strength and muscle endurance
    Asa B Segerström
    Department of Health Sciences, Division of Physiotherapy, Lund University, Lund, Sweden
    J Strength Cond Res 25:16-22. 2011
    ..The performance of sedentary subjects in a maximal incremental cycle test is highly affected by knee muscle strength and endurance. Fiber-type composition also contributes but to a smaller extent...
  68. ncbi request reprint Fat feeding impairs glycogen synthase activity in mice without effects on its gene expression
    Xudong Huang
    Wallenberg Laboratory, Department of Endocrinology, University of Lund, Malmo, Sweden
    Metabolism 52:535-9. 2003
    ..We conclude that (1) fat feeding results in similar elevation of plasma insulin levels and impairs GS activity in C57BL/6J and NMRI mice, and (2) the changes in GS activity do not involve effects on gene expression...
  69. ncbi request reprint Polymorphism in the beta(1)-adrenergic receptor gene and hypertension
    K Bengtsson
    Department of Endocrinology, Malmo University Hospital, Lund University, Sweden
    Circulation 104:187-90. 2001
    ..4+/-9.9 versus 76.0+/-10.1 mm Hg; P=0.003) and higher heart rates (68.3+/-11.0 versus 65.1+/-9.4 bpm; P=0.02) than siblings carrying 1 or 2 copies of the Gly389 allele. The Ser49Gly polymorphism was not associated with hypertension...
  70. ncbi request reprint Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus
    N Shaat
    Department of Endocrinology, Lund University, Wallenberg Laboratory, University Hospital MAS, Malmo, Sweden
    Diabetologia 47:878-84. 2004
    ....
  71. ncbi request reprint Common variants in HNF-1 alpha and risk of type 2 diabetes
    J Holmkvist
    Department of Clinical Sciences, Diabetes and Endocrinology, Clinical Research Center, Malmo University Hospital, Lund University, S 205 02, Malmo, Sweden
    Diabetologia 49:2882-91. 2006
    ....
  72. pmc Association between LTA, TNF and AGER polymorphisms and late diabetic complications
    Eero Lindholm
    Department of Clinical Sciences, University Hospital MAS, Lund University, Lund, Sweden
    PLoS ONE 3:e2546. 2008
    ..The aim of our study was therefore to explore whether polymorphisms (TNF -308 G-->A, LTA T60N C-->A and AGER -374 T-->A) in these genes alone or together (as haplotypes) increased the risk for diabetic complications...
  73. pmc Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes
    Anders H Rosengren
    Lund University Diabetes Centre, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    Diabetes 61:1726-33. 2012
    ..Our results underscore the importance of defects in β-cell exocytosis in T2D and demonstrate the potential of cellular phenotypic characterization in the elucidation of complex genetic disorders...
  74. ncbi request reprint Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: skaraborg hypertension and diabetes project
    Carl J Ostgren
    Department of Community Medicine, Malmo University Hospital, Malmo, Sweden
    J Hypertens 21:1657-62. 2003
    ..This study explored whether the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPARgamma) is associated with blood pressure in subjects with type 2 diabetes...
  75. doi request reprint Gene expression in Graves' ophthalmopathy and arm lymphedema: similarities and differences
    Tereza Planck
    Department of Endocrinology, Skane University Hospital, CRC, Malmo, Sweden
    Thyroid 21:663-74. 2011
    ..Graves' ophthalmopathy (GO) and lymphedema share some pathogenetic mechanisms, such as edema, inflammation, and adipogenesis. The aim of this study was to examine similarities and differences between chronic GO and chronic lymphedema...
  76. ncbi request reprint Heritability of ambulatory and office blood pressure phenotypes in Swedish families
    Cristiano Fava
    Department of Endocrinology, University Hospital MAS, Malmo, Sweden
    J Hypertens 22:1717-21. 2004
    ..The aim of this study was to estimate the heritability of 24-h ambulatory blood pressure and office blood pressure phenotypes in Swedish families...
  77. ncbi request reprint Calpain 10 and type 2 diabetes: are we getting closer to an explanation?
    Martin Ridderstrale
    Department of Clinical Sciences, Lund University, Wallenberg Laboratory, University Hospital MAS, S 205 02 Malmo, Sweden
    Curr Opin Clin Nutr Metab Care 8:361-6. 2005
    ..In this paper we give a general background on the genetic studies performed on CAPN10 to date, and review the most recent studies on the functional role of calpain 10...
  78. ncbi request reprint Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes
    Valeriya Lyssenko
    Department of Endocrinology, Wallenberg Laboratory, University Hospital MAS, 20502 Malmo, Sweden
    Diabetes 54:166-74. 2005
    ..In conclusion, a marked deterioration in beta-cell function precedes the onset of type 2 diabetes. These individuals can be identified early by knowledge of FPG, BMI, and family history of diabetes...
  79. ncbi request reprint Down-regulation of insulin receptor substrates (IRS)-1 and IRS-2 and Src homologous and collagen-like protein Shc gene expression by insulin in skeletal muscle is not associated with insulin resistance or type 2 diabetes
    Xudong Huang
    Wallenberg Laboratory, Department of Endocrinology, University of Lund, 20502 Malmo, Sweden
    J Clin Endocrinol Metab 87:255-9. 2002
    ....
  80. ncbi request reprint Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes
    H Li
    Diabetes and Endocrine Research Laboratory, Department of Endocrinology, Lund University, S 20502 Malmo, Sweden
    J Clin Endocrinol Metab 86:574-82. 2001
    ..The findings support a possible genetic interaction between type 1 and type 2 diabetes mediated by the HLA locus...
  81. ncbi request reprint Insulin-regulated mitochondrial gene expression is associated with glucose flux in human skeletal muscle
    X Huang
    Department of Endocrinology, University of Lund, Malmo, Sweden
    Diabetes 48:1508-14. 1999
    ....
  82. ncbi request reprint FOXC2 mRNA Expression and a 5' untranslated region polymorphism of the gene are associated with insulin resistance
    Martin Ridderstrale
    Department of Endocrinology, Lund University, Wallenberg Laboratory, University Hospital Malmo, S 205 02 Malmo, Sweden
    Diabetes 51:3554-60. 2002
    ..03 vs. P = 0.7). Our data suggest that increased FOXC2 expression may protect against insulin resistance in human subjects and that genetic variability in the gene may influence features associated with the metabolic syndrome...
  83. doi request reprint Genetic dissection of type 2 diabetes
    Martin Ridderstrale
    Department of Clinical Sciences Clinical Obesity, Lund University, University Hospital Malmoe, 20502 Malmoe, Sweden
    Mol Cell Endocrinol 297:10-7. 2009
    ..Nevertheless, today we are able for the first time to anticipate that the genetics of a complex disease like T2D really can be dissected...
  84. doi request reprint Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle
    T Rönn
    Department of Clinical Sciences, CRC Malmö University Hospital, Lund University, 205 02, Malmo, Sweden
    Diabetologia 51:1159-68. 2008
    ....
  85. ncbi request reprint Characterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) gene
    C Cervin
    Department of Endocrinology, Wallenberg Laboratory, Malmo University Hospital, Sweden
    Diabetologia 45:1703-8. 2002
    ..In this study we have examined the in vivo and in vitro effects of a mutation (L107I) outside the DNA binding and dimerization domains in the N terminal part of the HNF1 alpha gene...
  86. ncbi request reprint Glutamic acid decarboxylase antibody positivity is associated with an impaired insulin response to glucose and arginine in nondiabetic patients with autoimmune thyroiditis
    A L Lethagen
    Department of Endocrinology, University of Lund, S 205 02 Malmo, Sweden
    J Clin Endocrinol Metab 87:1177-83. 2002
    ..9 +/- 101.5 mU/liter, P = 0.035). In conclusion, GADab were associated with a decreased insulin secretion capacity in nondiabetic subjects with thyroiditis, which suggests that GADab positivity could be a marker of subclinical insulitis...
  87. pmc Effect of pioglitazone versus insulin glargine on cardiac size, function, and measures of fluid retention in patients with type 2 diabetes
    Mozhgan Dorkhan
    Department of Clinical Sciences, Division of Diabetes and Endocrinology, Lund University, Malmo University Hospital, Malmo, Sweden
    Cardiovasc Diabetol 8:15. 2009
    ..The present study evaluated the effect of pioglitazone or insulin glargine on cardiac function and size as well as on surrogate markers of fluid retention such as weight, haemoglobin and natriuretic peptides...
  88. ncbi request reprint Treatment with a thiazolidinedione increases eye protrusion in a subgroup of patients with type 2 diabetes
    Mozhgan Dorkhan
    Department of Clinical Sciences, Division of Diabetes and Endocrinology, Lund University, Malmo University Hospital, Sweden
    Clin Endocrinol (Oxf) 65:35-9. 2006
    ..Changes in eye protrusion in patients treated with pioglitazone...
  89. ncbi request reprint Uromodulin gene variant is associated with type 2 diabetic nephropathy
    Tarunveer S Ahluwalia
    Department of Endocrinology and Lund University Diabetes Centre, University Hospital, Skåne, Malmo, Sweden
    J Hypertens 29:1731-4. 2011
    ..In the present study we examined the association of the common variant of the uromodulin (UMOD) gene with type 2 diabetic nephropathy and kidney function...
  90. ncbi request reprint Cosegregation of MIDD and MODY in a pedigree: functional and clinical consequences
    Camilla Cervin
    Department of Endocrinology, Malmo University Hospital, S 205 02 Malmo, Sweden
    Diabetes 53:1894-9. 2004
    ..The mutated protein showed normal nuclear targeting but increased DNA binding. These data demonstrate that several genetic factors might contribute to diabetes risk, even in families with mtDNA and HNF1alpha mutations...
  91. doi request reprint Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
    Anders H Rosengren
    Lund University Diabetes Centre, Malmo, SE 20502 Malmo, Sweden
    Science 327:217-20. 2010
    ..Human pancreatic islets from risk allele carriers exhibited reduced granule docking and secreted less insulin in response to glucose; both effects were counteracted by pharmacological alpha(2A)AR antagonists...
  92. doi request reprint Assessment of exercise capacity in women with type 2 diabetes
    Asa B Segerström
    Division of Physiotherapy, Department of Health Sciences, Lund University, Lund, Sweden
    Clin Physiol Funct Imaging 28:294-8. 2008
    ..The combined group training increased maximal work rate but not VO2peak. This is likely to reflect peripheral adaptation to exercise and/or improved mechanical efficiency...
  93. ncbi request reprint Genetics of the metabolic syndrome
    L Groop
    Department of Endocrinology, University Hospital MAS, Lund University, Malmo, Sweden
    Br J Nutr 83:S39-48. 2000
    ..appear to increase the risk of the metabolic syndrome. In addition, novel genes may be identified by genome-wide searches...
  94. ncbi request reprint Impaired insulin-stimulated expression of the glycogen synthase gene in skeletal muscle of type 2 diabetic patients is acquired rather than inherited
    X Huang
    Department of Endocrinology, University of Lund, Malmo, Sweden
    J Clin Endocrinol Metab 85:1584-90. 2000
    ..We conclude that 1) insulin stimulates GYS1 mRNA expression; and 2) impaired stimulation of GYS1 gene expression by insulin in patients with type 2 diabetes is acquired and most likely is secondary to chronic hyperglycemia...
  95. doi request reprint Unique splicing pattern of the TCF7L2 gene in human pancreatic islets
    P Osmark
    Department of Clinical Sciences, CRC Malmö University Hospital, Lund University, Malmo, Sweden
    Diabetologia 52:850-4. 2009
    ..Here, the detailed TCF7L2 splicing pattern in five human tissues is described and dependence on risk genotype explored...
  96. ncbi request reprint Elevated plasma levels of Nt-proBNP in patients with type 2 diabetes without overt cardiovascular disease
    Martin Magnusson
    Department of Cardiology, University Hospital MAS, Lund University, Sweden
    Diabetes Care 27:1929-35. 2004
    ....
  97. ncbi request reprint Overexpression of immediate early genes in active Graves' ophthalmopathy
    Mikael Lantz
    Department of Endocrinology, Malmo University Hospital, S 205 02 Malmo, Sweden
    J Clin Endocrinol Metab 90:4784-91. 2005
    ..In Graves' ophthalmopathy a major problem is an increase in the intraorbital adipose tissue volume...
  98. ncbi request reprint Importance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test: results with the Botnia clamp
    Devjit Tripathy
    Department of Endocrinology, University Hospital MAS, Lund University, Sweden
    Diabetes Care 26:1395-401. 2003
    ..This test was then applied to nondiabetic subjects with (FH+) and without (FH-) a first-degree family history of diabetes...
  99. doi request reprint Genome-wide association study for type 2 diabetes: clinical applications
    Valeriya Lyssenko
    Department of Clinical Sciences Diabetes and Endocrinology and Lund University Diabetes Centre, Lund University, University Hospital Malmo, Malmo, Sweden
    Curr Opin Lipidol 20:87-91. 2009
    ..The purpose of this review is to provide insights into recent advances in genetics of type 2 diabetes...
  100. ncbi request reprint A genome wide scan for early onset primary hypertension in Scandinavians
    Fredrik von Wowern
    Department of Endocrinology, Malmo University Hospital, SE 205 02, Malmo, Sweden
    Hum Mol Genet 12:2077-81. 2003
    ..Our data suggest a hypertension susceptibility locus on chromosome 14 around 41 cM. The locus on chromosome 2 is also promising as it has been implicated in hypertension and blood pressure regulation in earlier genome scans...
  101. ncbi request reprint [MODY--an autosomal dominant type of diabetes. Diagnosis via genetic testing results in better treatment]
    Ella Karlsson
    Universitetssjukhuset MAS, Malmo
    Lakartidningen 104:2600-2. 2007