Research Topics
| L GreiffSummaryAffiliation: Lund University Country: Sweden Publications
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Publications
A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitisBen Wallwork
School of Biomolecular and Biomedical Science, Griffith University, and Princess Alexandria Hospital, Brisbane, Australia
Laryngoscope 116:189-93. 2006..To date, this effect has not been tested in a randomized, placebo-controlled study...
Effects of intranasal TNFalpha on granulocyte recruitment and activity in healthy subjects and patients with allergic rhinitisHenrik Widegren
Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, Lund, Sweden
Respir Res 9:15. 2008..The objective of the present study was to examine indices of granulocyte presence and activity in response to intranasal TNFalpha challenge...
Desloratadine reduces allergen challenge-induced mucinous secretion and plasma exudation in allergic rhinitisLennart Greiff
Department of Otorhinolaryngology, University Hospital, Lund, Sweden
Ann Allergy Asthma Immunol 89:413-8. 2002..The nasal output of fluid in allergic rhinitis is associated with luminal appearance of bioactive molecules emanating from the microcirculation as well as the secretory apparatus...
Absorption across the nasal airway mucosa in house dust mite perennial allergic rhinitisLennart Greiff
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Lund, Sweden
Clin Physiol Funct Imaging 22:55-7. 2002..We conclude that nasal airway absorption of the 1067 Da peptide desmopressin is unaffected in perennial house dust mite allergic rhinitis compared with healthy subjects...
Challenge-induced plasma exudation and mucinous secretion in human airwaysLennart Greiff
Department of Otorhinolaryngology, Lund University Hospital, Lund, Sweden
Clin Physiol Funct Imaging 25:241-5. 2005..Along with the acknowledged secretion of mucins, a practically non-depletable, pluripotent mucosal output of plasma emerges as an important component of the innate immunity of human airways...
Hypertonic saline increases secretory and exudative responsiveness of human nasal airway in vivoL Greiff
Dept of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Lund, Sweden
Eur Respir J 21:308-12. 2003..Through different mechanisms the HS exposure may also improve the recovery of soluble indices in human nasal airways. Whether or not the present findings are translatable to human bronchial airways remains to be examined...
Airway microvascular extravasation and luminal entry of plasmaLennart Greiff
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Lund Malmö, Sweden
Clin Physiol Funct Imaging 23:301-6. 2003....
Effects of a dual CCR3 and H1-antagonist on symptoms and eosinophilic inflammation in allergic rhinitisLennart Greiff
Department of ORL, Head and Neck Surgery, Lund University Hospital, Lund, Sweden
Respir Res 11:17. 2010..The CC-chemokine receptor-3 (CCR3) has emerged as a target molecule for pharmacological intervention in allergic inflammation...
Effects of rhinovirus-induced common colds on granulocyte activity in allergic rhinitisL Greiff
Department of Otorhinolaryngology, University Hospital, S 221 85 Lund, Sweden
J Infect 45:227-32. 2002..To explore the activities of mast cells, eosinophils, and neutrophils in patients with allergic rhinitis developing common colds and increased responsiveness to allergen following nasal rhinovirus inoculation...
Mucosal output of eotaxin in allergic rhinitis and its attenuation by topical glucocorticosteroid treatmentL Greiff
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Lund, Sweden
Clin Exp Allergy 31:1321-7. 2001..The number of subepithelial eosinophils and mucosal outputs of bulk plasma (alpha2-macroglobulin) and eosinophil cationic protein (ECP) are also examined...
Allergen-induced eosinophil cytolysis is a primary mechanism for granule protein release in human upper airwaysJ S Erjefält
Departments of Physiology and Neuroscience, Otolaryngology, and Clinical Pharmacology, University Hospital, Lund, Sweden
Am J Respir Crit Care Med 160:304-12. 1999..e., protein-laden extracellular granules) indicate that allergen-induced cytolysis is a primary and major mechanism for the release of eosinophil proteins in human allergic airway inflammation in vivo...
Immediate effect of topical budesonide on allergen challenge-induced nasal mucosal fluid levels of granulocyte-macrophage colony-stimulating factor and interleukin-5M Linden
Experimental Medicine, AstraZeneca R and D, Lund, Sweden
Am J Respir Crit Care Med 162:1705-8. 2000..These data demonstrate that GM-CSF and IL-5 are induced in a nonsymptomatic, late phase response to nasal allergen challenge, and that this cytokine response is prevented by single dose budesonide pretreatment...
Allergen-induced biphasic plasma exudation responses in guinea pig large airwaysI Erjefalt
Department of Pharmacology, Astra Draco AB, Lund, Sweden
Am Rev Respir Dis 148:695-701. 1993..01).(abstract truncated at 250 words)..
Steroid-sensitive indices of airway inflammation in children with seasonal allergic rhinitisPeter Meyer
Department of Pediatrics, University Hospital, Lund, Sweden
Pediatr Allergy Immunol 14:60-5. 2003..The seasonal increase in ECP and the trend for an increase in eotaxin were absent in the glucocorticosteroid-treated subjects...
Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitisLena Uller
Department of Experimental Medical Science, Lund University, Lund, Sweden
Respir Res 11:54. 2010....
Blockade of CTLA-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation toleranceL Alenmyr
Department of Clinical and Experimental Pharmacology, Lund University Hospital, Lund, Sweden
Scand J Immunol 62:437-44. 2005..Our findings also show that once inhalation tolerance is established it may not be disrupted by blockade of CTLA-4...
Circulating eosinophils in asthma, allergic rhinitis, and atopic dermatitis lack morphological signs of degranulationM Malm-Erjefalt
Clinical and Experimental Pharmacology, Department of Laboratory Medicine, Lund University Hospital, University of Lund, Sweden
Clin Exp Allergy 35:1334-40. 2005..If degranulation occurs in the circulation, this could contribute to widespread systemic effects and provide an important marker of disease...
The effect of intranasal budesonide spray on mucosal blood flow measured with laser Doppler flowmetryA Cervin
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Lund, S-221 85 Lund, Sweden
Rhinology 39:13-6. 2001..9 +/- 7.1% measured from baseline values. CONCLUSION: A single dose of intranasal budesonide aqueous nasal spray has no acute effects on nasal septal mucosal blood flow...
Degranulation patterns of eosinophil granulocytes as determinants of eosinophil driven diseaseJ S Erjefält
Department of Physiological Sciences, Lund University Hospital, 221 84 Lund, Sweden
Thorax 56:341-4. 2001..However, because of a lack of appropriate methods, little is known about degranulation of eosinophils in common eosinophilic diseases...
Nasal neutrophil activity and mucinous secretory responsiveness in COPDUlf Nihlen
Departments of Respiratory Medicine and Allergology, University Hospital, Lund, Sweden
Clin Physiol Funct Imaging 23:138-42. 2003..Furthermore, when associated with nasal symptoms, COPD may be associated with an increased nasal secretory responsiveness...
Effects of loratadine on red wine-induced symptoms and signs of rhinitisMorgan Andersson
Department of Otorhinolaryngology, University Hospital, Lund, Sweden
Acta Otolaryngol 123:1087-93. 2003..The aim of this study was to examine whether nasal symptoms produced by red wine are reproducible, associated with mucinous secretion or plasma exudation and affected by antihistamine treatment...
Secretoneurin is released into human airways by topical histamine but not capsaicinM Korsgren
Department of Clinical Pharmacology, University Hospital, Lund, Sweden
Allergy 60:459-63. 2005..The present observations support the possibility that secretoneurin is involved in histamine-dependent responses of the human airway mucosa...
Eosinophil degranulation status in allergic rhinitis: observations before and during seasonal allergen exposureC A Ahlstrom-Emanuelsson
Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, 221 84 Lund, Sweden
Eur Respir J 24:750-7. 2004....
Effects of topical platelet activating factor on the guinea-pig tracheobronchial mucosa in vivoL Greiff
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Lund, Sweden
Acta Physiol Scand 160:387-91. 1997..We suggest that endogenous PAF may participate in first line respiratory defence reactions by causing lumenal entry of bulk plasma without harming the epithelium...
Effects of TNFalpha on the human nasal mucosa in vivoHenrik Widegren
Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, Lund, Sweden
Respir Med 101:1982-7. 2007..Increased nasal mucosal output of TNFalpha has been demonstrated in allergic rhinitis, but the effect of TNFalpha on the human nasal mucosa has not been examined in vivo...
Incidence and remission of self-reported allergic rhinitis symptoms in adultsU Nihlen
Department of Respiratory Medicine and Allergology, University Hospital, Lund, Sweden
Allergy 61:1299-304. 2006..A few studies have examined the incidence and remission of allergic rhinitis (AR) in the same general population...
Onset of action of a topical antihistamine as assessed by histamine challenge-induced plasma exudation responsesMagnus Korsgren
Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
Ann Allergy Asthma Immunol 96:345-8. 2006..Although usually administered orally, antihistamines are available also for topical use in allergic rhinitis. Information on onset of action of these drugs is incomplete...
Effects of experimental changes in nasal airway pressure on mucosal output of plasmaSøren Berg
Department of Otorhinolaryngology, University Hospital, Lund, Sweden
Clin Physiol Funct Imaging 23:155-8. 2003..We conclude that extravasated plasma may be moved across the epithelium by a hydrostatic pressure-operated epithelial mechanism...
Topical treatment with aqueous solutions of rofleponide palmitate and budesonide in a pollen-season model of allergic rhinitisC Ahlstrom-Emanuelsson
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Lund, Sweden
Clin Exp Allergy 34:731-5. 2004..Thus, the rofleponide palmitate pro-drug is designed to provide topical exposure of the mucosa to the inactive lipophilic drug, which would be locally metabolized to the more hydrophilic and readily cleared drug rofleponide...
TRPV1-mediated itch in seasonal allergic rhinitisL Alenmyr
Department of Clinical Chemistry and Pharmacology, Lund University Hospital, Lund, Sweden
Allergy 64:807-10. 2009..Patients with allergic rhinitis may be abnormally sensitive to stimulation of the ion channel transient receptor potential vanilloid-1 (TRPV1)...
Nasal retention of budesonide and fluticasone in man: formation of airway mucosal budesonide-esters in vivoH Petersen
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Reykjavik, Iceland
Br J Clin Pharmacol 51:159-63. 2001..It is suggested that the formation of budesonide-esters and their subsequent release of budesonide contributes to an extended retention of budesonide in the airway mucosa...
Effects of topical formoterol alone and in combination with budesonide in a pollen season model of allergic rhinitisCecilia Ahlström Emanuelsson
Department of Otorhinolaryngology, Lund University Hospital, SE 221 85 Lund, Sweden
Respir Med 101:1106-12. 2007..While available data suggest no or only marginal effects of beta(2)-agonists on symptoms of allergic rhinitis, little is known about whether these drugs may add to the efficacy of anti-rhinitis drugs...
Effects of Clara cell 10 (CC10) protein on symptoms and signs of allergic rhinitisHenrik Widegren
Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, Lund, Sweden
Ann Allergy Asthma Immunol 102:51-6. 2009..Reduced levels of CC10 are associated with allergic rhinitis and asthma. In experimental models, treatment with the CC10 protein may reduce features of airway inflammation...
Nasal treatment with a microemulsion reduces allergen challenge-induced symptoms and signs of allergic rhinitisMorgan Andersson
Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, Lund Malm, Sweden
Acta Otolaryngol 128:666-9. 2008..We hypothesize that the mechanism of action involves modification of the allergen-mucosa interaction. The present observation suggests a novel principle for prevention in allergic rhinitis...
Wine produced by ecological methods produces relatively little nasal blockage in wine-sensitive subjectsMorgan Andersson
Department of Otorhinolaryngology Head and Neck Surgery, Lund University Hospital, Lund, Sweden
Acta Otolaryngol 129:1232-6. 2009..Subjects with self-reported nasal symptoms following consumption of red wine may respond with less nasal blockage to a wine produced with ecological methods than to wine not labelled as ecologically produced...
Obstructive airways diseases, smoking and use of inhaled corticosteroids in southern Sweden in 1992 and 2000R Montnémery
Department of Health Sciences, Division of Geriatric Medicine, Lund University, Lund, Sweden
Int J Tuberc Lung Dis 10:490-8. 2006..To examine the prevalence of obstructive pulmonary diseases, respiratory symptoms, smoking habits and pulmonary medication in an adult population, and to compare the results with a study performed in the same geographical area in 1992...
Diversity of immunoglobulin E-encoding transcripts in sinus mucosa of subjects diagnosed with non-allergic fungal eosinophilic sinusitisM Levin
Department of Immunotechnology, Lund University, Lund, Sweden
Clin Exp Allergy 41:811-20. 2011..In other cases, such signs can be absent despite elevated levels of IgE-positive cells in sinus tissue and the presence of IgE and eosinophils in the sinus mucous...
Specific nasal symptoms and symptom-provoking factors may predict increased risk of developing COPDUlf Nihlen
Respiratory Medicine and Allergology, Lund University Hospital, Lund, Sweden
Clin Physiol Funct Imaging 28:240-50. 2008..This supports the possibility of nasal co-morbidity in COPD...
Clinical efficacy and pharmacokinetic profiles of intranasal and oral cetirizine in a repeated allergen challenge model of allergic rhinitisMagnus Korsgren
Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
Ann Allergy Asthma Immunol 98:316-21. 2007..Intranasal and oral antihistamines are effective in treating allergic rhinitis. Studies comparing these routes of administration of an antihistamine regarding efficacy and pharmacokinetic profile are lacking...
Natural allergen exposure does not diminish the sensitivity of cytokine production to glucocorticosteroids in blood cells of seasonal allergic asthma and rhinitis patientsSusanne Larsson
Department of Respiratory Medicine, Lund University Hospital, Sweden
Respir Med 96:927-33. 2002..In conclusion, natural allergen exposure did not reduce the sensitivity of GM-CSF production to GCS inhibition in blood cells of seasonal allergic asthma and rhinitis patients...
Neural expression and increased lavage fluid levels of secretoneurin in seasonal allergic rhinitisMagnus Korsgren
Department of Clinical Pharmacology, University Hospital, SE 221 85 Lund, Sweden
Am J Respir Crit Care Med 167:1504-8. 2003..These data favor a role of secretoneurin in the local traffic of immune cells in human airway mucosa...
Establishing a model of seasonal allergic rhinitis and demonstrating dose-response to a topical glucocorticosteroidCecilia Ahlström-Emanuelsson
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Lund, Sweden
Ann Allergy Asthma Immunol 89:159-65. 2002..In a preliminary study, involving 7 days' challenge with allergen, promising symptom consistency was obtained and dose-response to a glucocorticosteroid could, in part, be demonstrated...
Loss of size-selectivity at histamine-induced exudation of plasma proteins in atopic nasal airwaysLennart Greiff
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Lund, Sweden
Clin Physiol Funct Imaging 22:28-31. 2002..Inferentially, the full immunological capacity of plasma proteins may readily be made available at the surface of human intact airway mucosa...
Immunomodulatory nanoparticles as adjuvants and allergen-delivery system to human dendritic cells: Implications for specific immunotherapySissela Broos
Department of Immunotechnology, Lund University, Lund, Sweden
Vaccine 28:5075-85. 2010..Thus, gamma-PGA NPs are promising as sophisticated adjuvants and allergen-delivery systems in allergen-specific immunotherapy...
Nasal septal perforations during treatment with topical nasal glucocorticosteroids are generally not associated with contact allergy to steroidsAnders Cervin
Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, Lund, Sweden
ORL J Otorhinolaryngol Relat Spec 65:103-5. 2003..Contact allergy to steroids has been suggested as a possible aetiological factor in patients who develop perforations during topical steroid use...
Augmented Phl p 5-specific Th2 response after exposure of dendritic cells to allergen in complex with specific IgE compared to IgG1 and IgG4Kristina Lundberg
Department of Immunotechnology, Lund University, Lund, Sweden
Clin Immunol 128:358-65. 2008....
Microvascular response in guinea pig skin to histamine challenge with and without application of skin windowVladimir Evilevitch
Departments of Clinical Physiology and Radiation Physics, , S-205 02 Malm, Sweden
Clin Physiol Funct Imaging 24:266-9. 2004..This difference should be considered when performing and interpreting studies of the microvascular reaction in the skin...
Occurrence of apoptosis, secondary necrosis, and cytolysis in eosinophilic nasal polypsLena Uller
Department of Physiological Sciences, BMC F10, Lund University, 221 84 Lund, Sweden
Am J Respir Crit Care Med 170:742-7. 2004....
Nasal indices of eosinophilic and exudative inflammation in bakery-workersTorgeir Storaas
Department of Otolaryngology Head and Neck Surgery, Haukeland University Hospital, Bergen, Norway
Clin Physiol Funct Imaging 27:23-9. 2007....
Bronchial responsiveness in bakery workers: relation to airway symptoms, IgE sensitization, nasal indices of inflammation, flour dust exposure and smokingTorgeir Storaas
Department of Otolaryngology, Head and Neck Surgery, Haukeland University Hospital, N 5021 Bergen, Norway
Clin Physiol Funct Imaging 27:327-34. 2007....
Acute exudative inflammation and nasally exhaled nitric oxide are two independent phenomenaAnders Cervin
School of Biomolecular and Biomedical Sciences, Griffith University Brisbane, Australia
ORL J Otorhinolaryngol Relat Spec 64:26-31. 2002..The aim of the present study was to investigate a possible relationship between nasal NO concentrations and acutely induced exudative inflammation of the nasal mucosa...
Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of conceptJorg D Leuppi
Pneumology, Department of Internal Medicine, University Hospital, Petersgraben 4, Basel CH 4031, Switzerland
Pulm Pharmacol Ther 18:83-8. 2005..There are no predictors known that can identify COPD patients who will respond to treatment with ICS...
A common idiotype in IgE and its relation to recognition of the grass pollen allergen Phl p 2Helena Persson
Department of Immunotechnology, Lund University, BMC D13, SE 221 84 Lund, Sweden
Mol Immunol 45:2715-20. 2008..Such a restriction may contribute to the limited molecular diversity observed in some IgE populations...
Modulation of the inflammatory response to histamine by terbutaline and sodium nitroprusside in guinea-pig skinVladimir Evilevitch
, Lund University, Sweden
Clin Physiol Funct Imaging 25:340-3. 2005..We found no indication of a pro-inflammatory effect of SNP when combined with histamine. Rather, the lack of additive effect may suggest an anti-inflammatory effect of SNP on the response to histamine...
Genomic and functional delineation of dendritic cells and memory T cells derived from grass pollen-allergic patients and healthy individualsMalin Lindstedt
Department of Immunotechnology, Lund University, PO Box 7031, S-220 07 Lund, Sweden
Int Immunol 17:401-9. 2005..The panel of differentially expressed genes in the allergic group will form the basis for an increased understanding of the molecular mechanisms in allergy...
