David Gisselsson

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. pmc Intratumour diversity of chromosome copy numbers in neuroblastoma mediated by on-going chromosome loss from a polyploid state
    Gisela Lundberg
    Department of Clinical Genetics, Lund University, Skåne University and Regional Laboratories, Lund, Sweden
    PLoS ONE 8:e59268. 2013
  2. pmc Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification
    Gisela Lundberg
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    PLoS ONE 3:e3099. 2008
  3. pmc A del(X)(p11) carrying SRY sequences in an infant with ambiguous genitalia
    M Ellaithi
    Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
    BMC Pediatr 6:11. 2006
  4. pmc A case of Cornelia de Lange syndrome from Sudan
    Mona Ellaithi
    The Orchids Organization for Children with Special Needs, Khartoum, Sudan
    BMC Pediatr 7:6. 2007
  5. pmc Distinct evolutionary mechanisms for genomic imbalances in high-risk and low-risk neuroblastomas
    David Gisselsson
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    J Carcinog 6:15. 2007
  6. pmc When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses
    David Gisselsson
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    PLoS ONE 3:e1871. 2008
  7. doi request reprint Classification of chromosome segregation errors in cancer
    David Gisselsson
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Chromosoma 117:511-9. 2008
  8. doi request reprint High-resolution molecular cytogenetic analysis of Wilms tumors highlights diagnostic difficulties among small round cell kidney tumors
    Ylva Stewénius
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 47:845-52. 2008
  9. pmc Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity
    Ylva Stewénius
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Proc Natl Acad Sci U S A 102:5541-6. 2005
  10. ncbi request reprint Dissecting karyotypic patterns in renal cell carcinoma: an analysis of the accumulated cytogenetic data
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 153:1-9. 2004

Detail Information

Publications55

  1. pmc Intratumour diversity of chromosome copy numbers in neuroblastoma mediated by on-going chromosome loss from a polyploid state
    Gisela Lundberg
    Department of Clinical Genetics, Lund University, Skåne University and Regional Laboratories, Lund, Sweden
    PLoS ONE 8:e59268. 2013
    ..We conclude that aneuploid NBs typically show extensive intratumour chromosome copy number diversity, and that this phenomenon is most likely explained by continuous loss of chromosomes from a polyploid state...
  2. pmc Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification
    Gisela Lundberg
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    PLoS ONE 3:e3099. 2008
    ..Because DMs lack centromeric sequences it has been unclear how NB cells retain and amplify extrachromosomal MYCN copies during tumour development...
  3. pmc A del(X)(p11) carrying SRY sequences in an infant with ambiguous genitalia
    M Ellaithi
    Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
    BMC Pediatr 6:11. 2006
    ..This finding was confirmed by cytogenetic, fluorescent in situ hybridization (FISH) and polymerase chain reaction (PCR)...
  4. pmc A case of Cornelia de Lange syndrome from Sudan
    Mona Ellaithi
    The Orchids Organization for Children with Special Needs, Khartoum, Sudan
    BMC Pediatr 7:6. 2007
    ....
  5. pmc Distinct evolutionary mechanisms for genomic imbalances in high-risk and low-risk neuroblastomas
    David Gisselsson
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    J Carcinog 6:15. 2007
    ..Little is known about the temporal sequence in which these imbalances occur during the carcinogenic process...
  6. pmc When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses
    David Gisselsson
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    PLoS ONE 3:e1871. 2008
    ..Such multipolar mitoses have been proposed to generate genetic diversity and thereby contribute to clonal evolution. However, this notion has been little validated experimentally...
  7. doi request reprint Classification of chromosome segregation errors in cancer
    David Gisselsson
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Chromosoma 117:511-9. 2008
    ..Any morphology-based classification of chromosome segregation errors in cancer must therefore be taken as provisional, anticipating a satisfactory integration of morphology and molecular biology...
  8. doi request reprint High-resolution molecular cytogenetic analysis of Wilms tumors highlights diagnostic difficulties among small round cell kidney tumors
    Ylva Stewénius
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 47:845-52. 2008
    ..The fact that no recurrent translocations were found in the WTs of this study argues against the presence of a frequent pathognomonic translocation in this disease entity...
  9. pmc Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity
    Ylva Stewénius
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Proc Natl Acad Sci U S A 102:5541-6. 2005
    ..Bridging of telomere-deficient chromosomes could thus be a major mutational mechanism in colorectal cancer, whereas mitotic multipolarity appears to be a secondary phenomenon that rarely, if ever, contributes to clonal evolution...
  10. ncbi request reprint Dissecting karyotypic patterns in renal cell carcinoma: an analysis of the accumulated cytogenetic data
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 153:1-9. 2004
    ..The analyses also revealed three possible cytogenetic subtypes of the papillary tumors, one characterized by the presence of +10, a second by +17 and +3q, and a third by +16, +20, and +12...
  11. ncbi request reprint A model for karyotypic evolution in testicular germ cell tumors
    Attila Frigyesi
    Center for Mathematical Sciences, Mathematical Statistics, Lund University, Lund, Sweden
    Genes Chromosomes Cancer 40:172-8. 2004
    ..The results suggest that whole-chromosome changes originate from a multipolar cell division of a tetraploid cell, whereas imbalances caused by structural changes accumulate in a stepwise manner...
  12. ncbi request reprint Wilms tumors develop through two distinct karyotypic pathways
    Mattias Hoglund
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 150:9-15. 2004
    ..We also show that these pathways are well separated and do not share a common set of late imbalances...
  13. doi request reprint Alternative lengthening of telomeres--an enhanced chromosomal instability in aggressive non-MYCN amplified and telomere elongated neuroblastomas
    Gisela Lundberg
    Department of Clinical Genetics, Lund University, University and Regional Laboratories, Skane University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 50:250-62. 2011
    ..Thus, telomere-dependent chromosomal instability is highly prevalent in NB, and may contribute to the complexity of genomic alterations as well as therapy resistance in the absence of MYCN amplification and in this tumor type...
  14. doi request reprint Cytogenetic and single nucleotide polymorphism array findings in soft tissue tumors in infants
    Charles Walther
    Department of Clinical Genetics, University and Regional Laboratories, Skane University Hospital, Lund University, Lund, Sweden Department of Pathology, University and Regional Laboratories, Skane University Hospital, Lund, Sweden Electronic address
    Cancer Genet 206:299-303. 2013
    ..The present series suggests that the addition of array-based technologies is valuable for detecting underlying pathogenetic mechanisms...
  15. pmc Deletions of 16q in Wilms tumors localize to blastemal-anaplastic cells and are associated with reduced expression of the IRXB renal tubulogenesis gene cluster
    Linda Holmquist Mengelbier
    Department of Clinical Genetics, University and Regional Laboratories, Lund University, Skane University Hospital, SE 221 85 Lund, Sweden
    Am J Pathol 177:2609-21. 2010
    ..A disturbed balance between tubular differentiation and self-renewal of anaplastic-blastic elements may thus be one mechanism linking 16q deletion to adverse outcome in Wilms tumor...
  16. pmc Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis
    David Gisselsson
    Department of Clinical Genetics, Lund University, University and Regional Laboratories, University Hospital, SE 221 85 Lund, Sweden
    Proc Natl Acad Sci U S A 107:20489-93. 2010
    ....
  17. ncbi request reprint Statistical dissection of cytogenetic patterns in lung cancer reveals multiple modes of karyotypic evolution independent of histological classification
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 154:99-109. 2004
    ..No marked differences between the karyotypic profiles were found among morphologic subtypes, suggesting that lung cancer morphology is independent of the particular cytogenetic pathway operating in the tumor cells...
  18. ncbi request reprint Distinct mitotic segregation errors mediate chromosomal instability in aggressive urothelial cancers
    Yuesheng Jin
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Clin Cancer Res 13:1703-12. 2007
    ..The aim of this study was to evaluate whether disturbances of mitotic segregation contribute to CIN in UC, if these processes have any effect on the course of disease, and how deregulation of these mechanisms affects tumor cell growth...
  19. ncbi request reprint Ovarian carcinoma develops through multiple modes of chromosomal evolution
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Res 63:3378-85. 2003
    ..This process was linked to the presence of imbalances characteristic for the 6q-/1q- pathway. The transition to Phase III involved triploidization and was also linked to the presence of the 6q-/1q- pathway...
  20. ncbi request reprint Coping with complexity. multivariate analysis of tumor karyotypes
    Mattias Hoglund
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Cancer Genet Cytogenet 135:103-9. 2002
    ..By applying these methods on the chromosomal changes presently known, distinct subgroups have been identified among breast, kidney, bladder, colon, and brain tumors...
  21. ncbi request reprint Defective chromosome segregation and telomere dysfunction in aggressive Wilms' tumors
    Ylva Stewénius
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Clin Cancer Res 13:6593-602. 2007
    ..As an alternative to cytogenetic classification, we therefore have evaluated whether the rate of telomere-dependent chromosomal instability could influence the clinical course in WT patients...
  22. doi request reprint Genetic bottlenecks and the hazardous game of population reduction in cell line based research
    David Gisselsson
    Department of Clinical Genetics, Lund University, University and Regional Laboratories, Lund, Sweden
    Exp Cell Res 316:3379-86. 2010
    ..Genetic bottlenecks should therefore be considered a potential caveat in all studies involving sub-cloning, transfection and other conditions leading to a temporary reduction in cell number...
  23. ncbi request reprint Statistical behavior of complex cancer karyotypes
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Genes Chromosomes Cancer 42:327-41. 2005
    ..The change in karyotypic orderliness at the transition from Phase I to Phase II/III was also shown by a drastic difference in karyotypic entropy...
  24. pmc Euploidy in somatic cells from R6/2 transgenic Huntington's disease mice
    Asa Petersen
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
    BMC Cell Biol 6:34. 2005
    ..Aneuploidy is normally a feature closely connected to neoplastic disease. To further explore this unexpected aspect of HD, we studied cultures derived from 6- and 12-week-old R6/2 fibroblasts, skeletal muscle cells, and liver cells...
  25. pmc Whole chromosome gain does not in itself confer cancer-like chromosomal instability
    Anders Valind
    Department of Clinical Genetics, Lund University, University and Regional Laboratories, Biomedical Center B13, Lund SE22184, Sweden
    Proc Natl Acad Sci U S A 110:21119-23. 2013
    ....
  26. ncbi request reprint Statistical analyses of karyotypic complexity in head and neck squamous cell carcinoma
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 150:1-8. 2004
    ..Two major cytogenetic pathways, one dominated by gains and another by losses, were identified by means of principal component analysis. These were initiated by +7 and by any of the aberrations 1p-, 3p-, or 7q-, respectively...
  27. ncbi request reprint Mitotic instability associated with late genomic changes in bone and soft tissue tumours
    David Gisselsson
    Department of Clinical Genetics, University Hospital, Lund SE 221 85, Sweden
    Cancer Lett 206:69-76. 2004
    ....
  28. ncbi request reprint Ewing tumours and synovial sarcomas have critical features of karyotype evolution in common with epithelial tumours
    Mattias Hoglund
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Int J Cancer 116:401-6. 2005
    ....
  29. pmc snoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor Prognosis
    Kristoffer von Stedingk
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skane University Hospital, Malmo, Sweden
    Transl Oncol 6:447-57. 2013
    ..Together, these results underscore the prognostic value of snoRNP complex expression in NB and suggest a role for snoRNPs in telomere maintenance and genomic stability. ..
  30. ncbi request reprint Power law distribution of chromosome aberrations in cancer
    Attila Frigyesi
    Centre for Mathematical Sciences, Mathematical Statistics, Lund University, SE 221 85 Lund, Sweden
    Cancer Res 63:7094-7. 2003
    ..Because almost identical power law distributions are seen in breast, colorectal, and renal cell carcinomas we suggest that the obtained distributions are consequences of a common mechanism operating in malignant epithelial tumors...
  31. doi request reprint SIX1 protein expression selectively identifies blastemal elements in Wilms tumor
    Daniel Sehic
    Department of Clinical Genetics, Lund University, University and Regional Laboratories, Lund, Sweden
    Pediatr Blood Cancer 59:62-8. 2012
    ..However, there is currently no molecular marker for blastemal cells, and risk stratification for post-nephrectomy treatment is therefore often based on clinico-histological parameters alone...
  32. ncbi request reprint Dissecting karyotypic patterns in malignant melanomas: temporal clustering of losses and gains in melanoma karyotypic evolution
    Mattias Hoglund
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Int J Cancer 108:57-65. 2004
    ....
  33. ncbi request reprint Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Res 62:5939-46. 2002
    ..We also show that the adenoma-carcinoma transition in the 1p- pathway is strongly linked to karyoytypic evolution, whereas the +7 pathway is not, and that the cytogenetic pathways are separated at both early and late stages...
  34. pmc Elevated tolerance to aneuploidy in cancer cells: estimating the fitness effects of chromosome number alterations by in silico modelling of somatic genome evolution
    Anders Valind
    Department of Clinical Genetics, Lund University and Skåne Regional and University Laboratories, Lund, Sweden
    PLoS ONE 8:e70445. 2013
    ..In conclusion, our findings indicate that not only an elevated chromosomal mis-segregation rate, but also a generalised tolerance to novel chromosomal imbalances contribute to the genomic landscape of human tumours. ..
  35. ncbi request reprint Concurrent gain of 17q and the MYC oncogene in a medullomyoblastoma
    Eva Lindberg
    Department of Pathology, University Hospital, Lund, Sweden
    Neuropathology 27:556-60. 2007
    ..Our findings support the notion that MMB and classical medulloblastoma arise through similar genetic mechanisms and that the two main tissue components in MMB are clonally related...
  36. doi request reprint Biphasic, hyperdiploid breast tumors in children: a distinct entity?
    Charles Walther
    Department of Clinical Genetics, University and Regional Laboratories, Skane University Hospital, Lund University, Lund, Sweden
    J Pediatr Hematol Oncol 35:64-8. 2013
    ..However, the distinction between the 2 lesions is important to make, especially since the latter can be malignant and consequently the prognoses differ...
  37. ncbi request reprint A novel fusion gene, SS18L1/SSX1, in synovial sarcoma
    Clelia Tiziana Storlazzi
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 37:195-200. 2003
    ..Thus, the existence of genetic heterogeneity has to be taken into account when RT-PCR is used for the diagnosis of synovial sarcoma...
  38. ncbi request reprint Connecting mitotic instability and chromosome aberrations in cancer--can telomeres bridge the gap?
    David Gisselsson
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Semin Cancer Biol 15:13-23. 2005
    ..Even though many common cancers, such as breast, colorectal, and renal cell carcinomas adhere to this simple power-law dynamics, the underlying molecular mechanisms remain elusive...
  39. doi request reprint Absence of Epstein-Barr and cytomegalovirus infection in neuroblastoma cells by standard detection methodologies
    Daniel Sehic
    Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden
    Pediatr Blood Cancer 60:E91-3. 2013
    ..These standard methods did not detect infection by EBV or HCMV in NB cells in any tumor, while occasional immune cells were positive for EBV RNA or HCMV protein in four cases...
  40. ncbi request reprint Interphase chromosomal abnormalities and mitotic missegregation of hypomethylated sequences in ICF syndrome cells
    David Gisselsson
    Department of Clinical Genetics, University Hospital, 22185 Lund, Sweden
    Chromosoma 114:118-26. 2005
    ..This can help explain why specific types of 1qh and 16qh rearrangements are not present at high frequencies in ICF lymphoid cells despite diverse 1qh and 16qh aberrations continuously being generated...
  41. ncbi request reprint Multivariate analysis of chromosomal imbalances in breast cancer delineates cytogenetic pathways and reveals complex relationships among imbalances
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Res 62:2675-80. 2002
    ..Although the cytogenetic pathways are well separated at earlier stages, they later converge and include a common set of late imbalances...
  42. ncbi request reprint Cytogenetic aberrations and their prognostic impact in chondrosarcoma
    Nils Mandahl
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 33:188-200. 2002
    ..Only -13q was an independent prognostic factor for metastasis, regardless of tumor grade or size...
  43. pmc Bone marrow multipotent mesenchymal stroma cells act as pericyte-like migratory vehicles in experimental gliomas
    Daniel Bexell
    The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden
    Mol Ther 17:183-90. 2009
    ..v. injections. Intratumorally grafted pericyte-like MSCs might represent a particularly well-suited vector system for delivering molecules to affect tumor angiogenesis and for targeting cancer stem cells within the perivascular niche...
  44. doi request reprint Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice
    Helena Agerstam
    Department of Clinical Genetics, University and Regional Laboratories, Skane University Hospital, Lund University, Lund, Sweden
    Blood 116:2103-11. 2010
    ..The established in vivo EMS model should provide a valuable tool for future studies of this disorder...
  45. pmc HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells
    Alexander Pietras
    Department of Laboratory Medicine, Center for Molecular Pathology, CREATE Health, University Hospital MAS, Lund University, Malmo, Sweden
    Proc Natl Acad Sci U S A 106:16805-10. 2009
    ..Because low differentiation is associated with poor outcome and angiogenesis is crucial for tumor growth, HIF-2alpha is an attractive target for neuroblastoma therapy...
  46. ncbi request reprint Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma
    David Gisselsson
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 33:133-40. 2002
    ..These findings indicate that gain of sequences from the short arm of chromosome 12 could be a possible genetic pathway in the development of aggressive osteosarcoma...
  47. pmc Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma
    Johan Rebetz
    The Rausing Laboratory, Division of Neurosurgery, Lund University Hospital, Lund, Sweden
    PLoS ONE 3:e1936. 2008
    ....
  48. doi request reprint Intratumor diversity and clonal evolution in cancer--a skeptical standpoint
    David Gisselsson
    Departments of Clinical Genetics and Pathology, Lund University, Lund, Sweden
    Adv Cancer Res 112:1-9. 2011
    ....
  49. ncbi request reprint Evaluation of CITED1, SIX1, and CD56 protein expression for identification of blastemal elements in wilms tumor
    Daniel Sehic
    From the Department of Clinical Genetics, Lund University, Lund, Sweden and
    Am J Clin Pathol 141:828-33. 2014
    ..In the present study, we assessed the usefulness of protein markers for the detection of WT blastema...
  50. ncbi request reprint Confined trisomy 8 mosaicism of meiotic origin: a rare cause of aneuploidy in childhood cancer
    Anders Valind
    Department of Clinical Genetics, Lund University, University and Regional Laboratories, Lund, Sweden
    Genes Chromosomes Cancer 53:634-8. 2014
    ..This case provides proof of principle for the hypothesis that tumor genotypes may in rare cases reflect meiotic rather than mitotic events, also in patients lacking syndromic features. © 2014 Wiley Periodicals, Inc. ..
  51. ncbi request reprint Chromosome instability in cancer: how, when, and why?
    David Gisselsson
    Department of Clinical Genetics, University Hospital SE 221 85 Lund, Sweden
    Adv Cancer Res 87:1-29. 2003
    ..Also, overexpression of telomerase appears to play a crucial role for moderating the rate of chromosomal evolution...
  52. doi request reprint Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin
    Jenny Karlsson
    Department of Clinical Genetics, Lund University, University and Regional Laboratories, Lund, Sweden
    Genes Chromosomes Cancer 53:381-91. 2014
    ....
  53. ncbi request reprint Telomere-mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma
    David Gisselsson
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Genes Chromosomes Cancer 42:22-33. 2005
    ..That the model did not produce any of the whole-chromosome gains observed in OC indicates that these changes develop through a different mechanism...
  54. ncbi request reprint Mitotic instability in cancer: is there method in the madness?
    David Gisselsson
    Department of Clinical Genetics University Hospital SE 221 85 Lund, Sweden
    Cell Cycle 4:1007-10. 2005
    ..The telomere-dependent instability can be partly counteracted by expression of telomerase during tumor progression, but genomic stabilisation is rarely, if ever, complete...
  55. ncbi request reprint [Sudanese cytogeneticists--vision of a new kind of assistance]
    Therese Nilsson
    Avdelningen för klinisk genetik, Universitetssjukhuset i Lund
    Lakartidningen 101:702-5. 2004