D Erlinge

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Rapid endovascular catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction. The CHILL-MI trial: a randomized controlled study of the use of central venous cathete
    David Erlinge
    Department of Cardiology, Lund University, Lund, Sweden Electronic address
    J Am Coll Cardiol 63:1857-65. 2014
  2. ncbi request reprint Clopidogrel metaboliser status based on point-of-care CYP2C19 genetic testing in patients with coronary artery disease
    David Erlinge
    David Erlinge, Dept of Cardiology, Lund University, Skane University Hospital, Lund 221 85 Lund, Sweden, Tel 46 46172597, Fax 46 46157857, E mail
    Thromb Haemost 111:943-50. 2014
  3. pmc The P2Y 13 Met-158-Thr polymorphism, which is in linkage disequilibrium with the P2Y 12 locus, is not associated with acute myocardial infarction
    Stefan Amisten
    Department of Cardiology, Lund University Hospital, Lund, Sweden
    PLoS ONE 3:e1462. 2008
  4. doi request reprint Prasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: the GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients
    David Erlinge
    Department of Cardiology, Lund University, Lund, Sweden
    J Am Coll Cardiol 62:577-83. 2013
  5. doi request reprint A pooled analysis of the effect of endovascular cooling on infarct size in patients with ST-elevation myocardial infarction
    David Erlinge
    Department of Cardiology, Lund University, Skane University Hospital, Lund, Sweden
    EuroIntervention 8:1435-40. 2013
  6. doi request reprint Reduction in platelet reactivity with prasugrel 5 mg in low-body-weight patients is noninferior to prasugrel 10 mg in higher-body-weight patients: results from the FEATHER trial
    David Erlinge
    Department of Cardiology, Lund University, Lund, Sweden
    J Am Coll Cardiol 60:2032-40. 2012
  7. pmc Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y₁₂ receptor-mediated platelet aggregation
    Carl Högberg
    Department of Cardiology, Lund University, Lund, Sweden
    Thromb Haemost 108:119-32. 2012
  8. pmc Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y(1) and the P2Y (12) receptor and is correlated with protein expression of P2Y (12)
    Oscar O Braun
    Department of Cardiology, Lund University Hospital, 221 85, Lund, Sweden
    Purinergic Signal 3:195-201. 2007
  9. pmc Cardiovascular magnetic resonance of the myocardium at risk in acute reperfused myocardial infarction: comparison of T2-weighted imaging versus the circumferential endocardial extent of late gadolinium enhancement with transmural projection
    Joey F A Ubachs
    Department of Clinical Physiology, Lund University and Skåne University Hospital, Lund, Sweden
    J Cardiovasc Magn Reson 12:18. 2010
  10. pmc Rapid short-duration hypothermia with cold saline and endovascular cooling before reperfusion reduces microvascular obstruction and myocardial infarct size
    Matthias Götberg
    Department of Cardiology, Lund University Hospital, 221 85, Lund, Sweden
    BMC Cardiovasc Disord 8:7. 2008

Detail Information

Publications28

  1. ncbi request reprint Rapid endovascular catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction. The CHILL-MI trial: a randomized controlled study of the use of central venous cathete
    David Erlinge
    Department of Cardiology, Lund University, Lund, Sweden Electronic address
    J Am Coll Cardiol 63:1857-65. 2014
    ..The aim of this study was to confirm the cardioprotective effects of hypothermia using a combination of cold saline and endovascular cooling...
  2. ncbi request reprint Clopidogrel metaboliser status based on point-of-care CYP2C19 genetic testing in patients with coronary artery disease
    David Erlinge
    David Erlinge, Dept of Cardiology, Lund University, Skane University Hospital, Lund 221 85 Lund, Sweden, Tel 46 46172597, Fax 46 46157857, E mail
    Thromb Haemost 111:943-50. 2014
    ....
  3. pmc The P2Y 13 Met-158-Thr polymorphism, which is in linkage disequilibrium with the P2Y 12 locus, is not associated with acute myocardial infarction
    Stefan Amisten
    Department of Cardiology, Lund University Hospital, Lund, Sweden
    PLoS ONE 3:e1462. 2008
    ....
  4. doi request reprint Prasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: the GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients
    David Erlinge
    Department of Cardiology, Lund University, Lund, Sweden
    J Am Coll Cardiol 62:577-83. 2013
    ..This study assessed pharmacodynamic (PD) response to the reduced prasugrel maintenance dose of 5 mg in very elderly (VE) patients (≥75 years of age)...
  5. doi request reprint A pooled analysis of the effect of endovascular cooling on infarct size in patients with ST-elevation myocardial infarction
    David Erlinge
    Department of Cardiology, Lund University, Skane University Hospital, Lund, Sweden
    EuroIntervention 8:1435-40. 2013
    ..Recent results from a randomised feasibility study suggest rapid induction of hypothermia in primary PCI results in a significant reduction in infarct size (IS)...
  6. doi request reprint Reduction in platelet reactivity with prasugrel 5 mg in low-body-weight patients is noninferior to prasugrel 10 mg in higher-body-weight patients: results from the FEATHER trial
    David Erlinge
    Department of Cardiology, Lund University, Lund, Sweden
    J Am Coll Cardiol 60:2032-40. 2012
    ....
  7. pmc Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y₁₂ receptor-mediated platelet aggregation
    Carl Högberg
    Department of Cardiology, Lund University, Lund, Sweden
    Thromb Haemost 108:119-32. 2012
    ..It could be an endogenous antithrombotic factor modulating the strong platelet aggregatory effects of ADP in a manner similar to the use of clopidogrel, prasugrel or ticagrelor in the treatment of ischaemic heart disease...
  8. pmc Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y(1) and the P2Y (12) receptor and is correlated with protein expression of P2Y (12)
    Oscar O Braun
    Department of Cardiology, Lund University Hospital, 221 85, Lund, Sweden
    Purinergic Signal 3:195-201. 2007
    ..To achieve additional ADP inhibition in platelets, antagonists directed at the P2Y(1) receptor could be more promising than the development of more potent P2Y(12) receptor antagonists...
  9. pmc Cardiovascular magnetic resonance of the myocardium at risk in acute reperfused myocardial infarction: comparison of T2-weighted imaging versus the circumferential endocardial extent of late gadolinium enhancement with transmural projection
    Joey F A Ubachs
    Department of Clinical Physiology, Lund University and Skåne University Hospital, Lund, Sweden
    J Cardiovasc Magn Reson 12:18. 2010
    ..Hence, we sought to assess the ability of endocardial extent of infarction by LGE CMR to predict MaR as compared to T2-weighted imaging...
  10. pmc Rapid short-duration hypothermia with cold saline and endovascular cooling before reperfusion reduces microvascular obstruction and myocardial infarct size
    Matthias Götberg
    Department of Cardiology, Lund University Hospital, 221 85, Lund, Sweden
    BMC Cardiovasc Disord 8:7. 2008
    ..The aim of this study was to evaluate the combination of a rapid intravenous infusion of cold saline and endovascular hypothermia in a closed chest pig infarct model...
  11. pmc Mild hypothermia reduces cardiac post-ischemic reactive hyperemia
    Goran K Olivecrona
    Department of Cardiology, Lund University, Lund, Sweden
    BMC Cardiovasc Disord 7:5. 2007
    ..Reperfusion results in a massive increase in blood flow, reactive hyperemia, which may contribute to reperfusion damage. We postulated that hypothermia could attenuate the post-ischemic reactive hyperemia...
  12. pmc Treatment with the C5a receptor antagonist ADC-1004 reduces myocardial infarction in a porcine ischemia-reperfusion model
    Jesper Van der Pals
    Department of Cardiology, Skane University Hospital, Lund, Sweden
    BMC Cardiovasc Disord 10:45. 2010
    ..We investigated if treatment with ADC-1004, according to a clinically applicable protocol, would reduce infarct size and microvascular obstruction in a large animal myocardial infarct model...
  13. pmc Apyrase treatment of myocardial infarction according to a clinically applicable protocol fails to reduce myocardial injury in a porcine model
    Jesper Van der Pals
    Department of Cardiology, Lund University Hospital, Lund, Sweden
    BMC Cardiovasc Disord 10:1. 2010
    ..We therefore investigated if treatment with the ectonucleotidase apyrase, according to a clinically applicable protocol, would reduce IS and microvascular obstruction (MO) in a large animal model...
  14. pmc Mild hypothermia does not attenuate platelet aggregation and may even increase ADP-stimulated platelet aggregation after clopidogrel treatment
    Carl Högberg
    Department of Cardiology, Lund University, Lund, Sweden
    Thromb J 7:2. 2009
    ..We wanted to examine the effects of clopidogrel on platelet aggregation during hypothermia...
  15. doi request reprint Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo
    David Erlinge
    Department of Cardiology, Lund University, Lund, Sweden
    J Am Coll Cardiol 52:1968-77. 2008
    ..We evaluated the prevalence and mechanism of poor responsiveness to clopidogrel and prasugrel in coronary artery disease patients with and without diabetes...
  16. pmc P2 receptors in cardiovascular regulation and disease
    David Erlinge
    Department of Cardiology, Lund University Hospital, 22185, Lund, Sweden
    Purinergic Signal 4:1-20. 2008
    ..The extracellular nucleotides and their cardiovascular P2 receptors are now entering the phase of clinical development...
  17. ncbi request reprint Extracellular ATP: a growth factor for vascular smooth muscle cells
    D Erlinge
    Department of Internal Medicine, Lund University Hospital, Sweden
    Gen Pharmacol 31:1-8. 1998
    ....
  18. ncbi request reprint [Cardiovascular treatment potentials. P2 receptors important for future drugs]
    D Erlinge
    Medicinkliniken, Universitetssjukhuset i Lund
    Lakartidningen 96:2586-9. 1999
    ..The development of selective antagonists for other P2 receptor subtypes will lead to better understanding of cardiovascular disease processes and yield new therapeutic options...
  19. ncbi request reprint Characterization of contractile P2 receptors in human coronary arteries by use of the stable pyrimidines uridine 5'-O-thiodiphosphate and uridine 5'-O-3-thiotriphosphate
    M Malmsjo
    Department of Medicine, Lund University Hospital, Sweden
    J Pharmacol Exp Ther 293:755-60. 2000
    ..Antagonists of P2Y(2) and P2X receptors may be useful in the treatment of coronary vasospastic disorders...
  20. ncbi request reprint Transcriptional down-regulation of the platelet ADP receptor P2Y(12) and clusterin in patients with systemic lupus erythematosus
    L Wang
    Department of Cardiology, Lund University Hospital, S 221 85 Lund, Sweden
    J Thromb Haemost 2:1436-42. 2004
    ..These findings could help to achieve a better understanding of the platelet function in SLE and serve as a guide for further research and drug use...
  21. doi request reprint Succinate independently stimulates full platelet activation via cAMP and phosphoinositide 3-kinase-β signaling
    C Högberg
    Department of Cardiology, Lund University Hospital, Lund, Sweden
    J Thromb Haemost 9:361-72. 2011
    ..The citric cycle intermediate succinate has recently been identified as a ligand for the G-protein-coupled receptor (GPCR) SUCNR1. We have previously found that this receptor is one of the most highly expressed GPCRs in human platelets...
  22. pmc Tyrphostin inhibition of ATP-stimulated DNA synthesis, cell proliferation and fos-protein expression in vascular smooth muscle cells
    D Erlinge
    Department of Internal Medicine, Lund University Hospital, Sweden
    Br J Pharmacol 118:1028-34. 1996
    ..This indicates that the mitogenic effect of ATP on vascular smooth muscle cells is dependent on tyrosine kinases in contrast to the contractile effect of ATP in blood vessels...
  23. ncbi request reprint P2X receptors counteract the vasodilatory effects of endothelium derived hyperpolarising factor
    M Malmsjo
    Division of Experimental Vascular Research, Department of Internal Medicine, Lund University Hospital, Lund, Sweden
    Eur J Pharmacol 390:173-80. 2000
    ..In conclusion, both EDHF and NO-mediated dilatation can be induced by activation of P2Y(1) and P2Y(2)/P2Y(4) receptors. P2X receptor stimulation of smooth muscle cells selectively counteracts the dilatory effect of EDHF...
  24. ncbi request reprint P2Y receptor-induced EDHF vasodilatation is of primary importance for the regulation of perfusion pressure in the peripheral circulation of the rat
    M Malmsjø
    Division of Experimental Vascular Research, Department of Internal Medicine, Lund University Hospital, BMC A13, SE 221 84 Lund, Sweden
    Acta Physiol Scand 174:301-9. 2002
    ..In conclusion, extracellular nucleotides stimulate dilatation by activating P2Y(1) and P2Y(2)/P2Y(4) receptors, but not P2Y(6) receptors. The dilatory responses are mediated primarily by EDHF in the peripheral vascular bed...
  25. doi request reprint ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice
    S Amisten
    Department of Cardiology, Lund University, Skane University Hospital, Lund, Sweden
    Diabetologia 53:1927-34. 2010
    ..To investigate the effects of extracellular purines on insulin secretion from mouse pancreatic islets...
  26. doi request reprint Translational platelet research in patients with coronary artery disease: what are the major knowledge gaps?
    Paul A Gurbel
    Sinai Center for Thrombosis Research, Cardiac Catheterization Laboratory, 2401 W Belvedere Ave, Baltimore, MD 21215, USA
    Thromb Haemost 108:12-20. 2012
    ..Therefore, futher studies are needed to delineate the role of platelet function testing across the spectrum of symptomatic coronary artery disease...
  27. pmc The stable pyrimidines UDPbetaS and UTPgammaS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery
    M Malmsjo
    Division of Experimental Vascular Research, Department of Medicine, Lund University Hospital, Lund, Sweden
    Br J Pharmacol 131:51-6. 2000
    ..The P2X response was relatively weak, and there was no P2Y(1) response. Stimulation of P2Y(1) and P2Y(2)/P2Y(4) receptors elicited relaxation, while P2Y(6) did not contribute...
  28. ncbi request reprint Quantification of ADP and ATP receptor expression in human platelets
    L Wang
    Department of Cardiology, Lund University Hospital, Lund, Sweden
    J Thromb Haemost 1:330-6. 2003
    ..Furthermore, the method could be used to study platelet expression for any gene in human materials...