H Ekberg

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Simultaneous inhibition of B7 and LFA-1 signaling prevents rejection of discordant neural xenografts in mice lacking CD40L
    Lena C Larsson
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Sweden
    Xenotransplantation 9:68-76. 2002
  2. ncbi request reprint Initial inhibition of tissue factor signalling reduces chronic vascular changes in isogenic rat aortic transplants
    C Osterholm
    Department of Nephrology and Transplantation, Lund University, University Hospital, , Sweden
    Am J Transplant 1:29-37. 2001
  3. ncbi request reprint Clinicians underestimate gastrointestinal symptoms and overestimate quality of life in renal transplant recipients: a multinational survey of nephrologists
    Henrik Ekberg
    Department of Nephrology and Transplantation, Malmo University Hospital, Lund University, Malmo, Sweden
    Transplantation 84:1052-4. 2007
  4. doi request reprint The challenge of achieving target drug concentrations in clinical trials: experience from the Symphony study
    Henrik Ekberg
    Department of Nephrology and Transplantation, University Hospital, Lund University, Malmo, Sweden
    Transplantation 87:1360-6. 2009
  5. pmc Challenges and considerations in diagnosing the kidney disease in deteriorating graft function
    Henrik Ekberg
    Department of Nephrology and Transplantation, Skane University Hospital, Lund University, Malmo, Sweden
    Transpl Int 25:1119-28. 2012
  6. doi request reprint Effect of different immunosuppressive regimens on the evolution of distinct metabolic parameters: evidence from the Symphony study
    Kathleen Claes
    Department of Nephrology and Renal Transplantation, University Hospital Gasthuisberg, Leuven, Belgium
    Nephrol Dial Transplant 27:850-7. 2012
  7. ncbi request reprint Cyclosporine sparing with mycophenolate mofetil, daclizumab and corticosteroids in renal allograft recipients: the CAESAR Study
    H Ekberg
    Lund University, Malmo, Sweden
    Am J Transplant 7:560-70. 2007
  8. ncbi request reprint Reduced exposure to calcineurin inhibitors in renal transplantation
    Henrik Ekberg
    Lund University, Malmo, Sweden
    N Engl J Med 357:2562-75. 2007
  9. ncbi request reprint The specific monocarboxylate transporter-1 (MCT-1) inhibitor, AR-C117977, induces donor-specific suppression, reducing acute and chronic allograft rejection in the rat
    Henrik Ekberg
    Department of Nephrology and Transplantation, Lund University, University Hospital, Malmo, Sweden
    Transplantation 84:1191-9. 2007
  10. ncbi request reprint Increased prevalence of gastrointestinal symptoms associated with impaired quality of life in renal transplant recipients
    Henrik Ekberg
    Department of Nephrology and Transplantation, Malmo University Hospital, Lund University, Malmo, Sweden
    Transplantation 83:282-9. 2007

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Simultaneous inhibition of B7 and LFA-1 signaling prevents rejection of discordant neural xenografts in mice lacking CD40L
    Lena C Larsson
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Sweden
    Xenotransplantation 9:68-76. 2002
    ..The treatment most likely reduced antigen presenting capacity and interfered with the costimulatory signaling needed for T cell activation to occur...
  2. ncbi request reprint Initial inhibition of tissue factor signalling reduces chronic vascular changes in isogenic rat aortic transplants
    C Osterholm
    Department of Nephrology and Transplantation, Lund University, University Hospital, , Sweden
    Am J Transplant 1:29-37. 2001
    ..We conclude that active site inhibited FVIIa (rFVIIai) given prior to and directly after implantation of aortic transplants significantly reduces intimal hyperplasia caused by nonimmunological factors in this model...
  3. ncbi request reprint Clinicians underestimate gastrointestinal symptoms and overestimate quality of life in renal transplant recipients: a multinational survey of nephrologists
    Henrik Ekberg
    Department of Nephrology and Transplantation, Malmo University Hospital, Lund University, Malmo, Sweden
    Transplantation 84:1052-4. 2007
    ..Improving patient-clinician communication could lead to more informed management, resulting in better HRQoL and increased graft survival...
  4. doi request reprint The challenge of achieving target drug concentrations in clinical trials: experience from the Symphony study
    Henrik Ekberg
    Department of Nephrology and Transplantation, University Hospital, Lund University, Malmo, Sweden
    Transplantation 87:1360-6. 2009
    ..The Symphony study compared four immunosuppressant regimens, defined by protocol-specified target drug concentrations. This subanalysis examines actual drug levels and the implications on the interpretation of results...
  5. pmc Challenges and considerations in diagnosing the kidney disease in deteriorating graft function
    Henrik Ekberg
    Department of Nephrology and Transplantation, Skane University Hospital, Lund University, Malmo, Sweden
    Transpl Int 25:1119-28. 2012
    ..Diagnosis requires a thorough clinical investigation, and in the majority of cases a specific cause can be identified...
  6. doi request reprint Effect of different immunosuppressive regimens on the evolution of distinct metabolic parameters: evidence from the Symphony study
    Kathleen Claes
    Department of Nephrology and Renal Transplantation, University Hospital Gasthuisberg, Leuven, Belgium
    Nephrol Dial Transplant 27:850-7. 2012
    ..The aim of this sub-analysis of the Symphony study was to assess the progression of the laboratory parameters associated with MS in the first year after transplantation...
  7. ncbi request reprint Cyclosporine sparing with mycophenolate mofetil, daclizumab and corticosteroids in renal allograft recipients: the CAESAR Study
    H Ekberg
    Lund University, Malmo, Sweden
    Am J Transplant 7:560-70. 2007
    ..4% and 27.5%, respectively; p < 0.05). In summary, a regimen of continuous low-dose CsA with MMF, CS and daclizumab induction is a clinically safe and effective immunosuppressive regimen in renal transplant recipients...
  8. ncbi request reprint Reduced exposure to calcineurin inhibitors in renal transplantation
    Henrik Ekberg
    Lund University, Malmo, Sweden
    N Engl J Med 357:2562-75. 2007
    ..Immunosuppressive regimens with the fewest possible toxic effects are desirable for transplant recipients. This study evaluated the efficacy and relative toxic effects of four immunosuppressive regimens...
  9. ncbi request reprint The specific monocarboxylate transporter-1 (MCT-1) inhibitor, AR-C117977, induces donor-specific suppression, reducing acute and chronic allograft rejection in the rat
    Henrik Ekberg
    Department of Nephrology and Transplantation, Lund University, University Hospital, Malmo, Sweden
    Transplantation 84:1191-9. 2007
    ..Here, we report the effects of AR-C117977, a potent MCT-1 inhibitor, on alloimmune responses in the rat...
  10. ncbi request reprint Increased prevalence of gastrointestinal symptoms associated with impaired quality of life in renal transplant recipients
    Henrik Ekberg
    Department of Nephrology and Transplantation, Malmo University Hospital, Lund University, Malmo, Sweden
    Transplantation 83:282-9. 2007
    ..Immunosuppressive therapies have been associated with gastrointestinal (GI) side effects, which may impair health-related quality of life (HRQoL)...
  11. doi request reprint Calcineurin inhibitor minimization in the Symphony study: observational results 3 years after transplantation
    H Ekberg
    Lund University, Malmo, Sweden
    Am J Transplant 9:1876-85. 2009
    ....
  12. ncbi request reprint No robust conclusions to be drawn from clinical trials in the absence of an adequate control group
    Henrik Ekberg
    Lund University, Malmo, Sweden
    Transpl Int 20:25-6. 2007
  13. doi request reprint Cyclosporine, tacrolimus and sirolimus retain their distinct toxicity profiles despite low doses in the Symphony study
    Henrik Ekberg
    Department of Nephrology and Transplantation, Lund University, University Hospital, Malmo, Sweden
    Nephrol Dial Transplant 25:2004-10. 2010
    ..This sub-analysis focuses on specific toxicities observed with the low-dose regimens...
  14. doi request reprint Relationship of tacrolimus exposure and mycophenolate mofetil dose with renal function after renal transplantation
    Henrik Ekberg
    Department of Nephrology and Transplantation, Skane University Hospital, Malmo, Sweden
    Transplantation 92:82-7. 2011
    ..Whether nephrotoxicity is an issue with tacrolimus at the currently used dosages remains an open question...
  15. ncbi request reprint Two doses of daclizumab in conjunction with low-dose cyclosporine, mycophenolate mofetil and steroids resulted in a low incidence of acute rejection after renal transplantation
    H Ekberg
    Department of Nephrology and Transplantation, University Hospital, Malmo, Sweden
    Scand J Immunol 58:670-7. 2003
    ..This CsA low-dose protocol, including two doses of daclizumab, MMF and CS, resulted in a reduction and delay of AR episodes and excellent graft function, graft survival and patient survival, despite an increase in DGF...
  16. ncbi request reprint Daclizumab prevents acute rejection and improves patient survival post transplantation: 1 year pooled analysis
    H Ekberg
    Department of Vascular and Renal Diseases, Lund University, University Hospital, Malmo, Sweden
    Transpl Int 13:151-9. 2000
    ..17.5 %). Therapy with daclizumab significantly reduces acute rejection in renal transplantation and improves patient survival without any increase in morbidity...
  17. ncbi request reprint Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice
    Matthias Corbascio
    Department of Nephrology and Transplantation, University Hospital, Lund University, Malmo, Sweden
    Transplantation 74:35-41. 2002
    ..To overcome CD40L-independent immune responses, we used anti-lymphocyte function-associated antigen monoclonal antibody (LFA)-1, which has previously been shown to inhibit CD8+ immune responses...
  18. ncbi request reprint Activation of donor-specific CTL in a tolerant recipient of cardiac allograft
    E Petersson
    The Wallenberg Laboratory, Lund University, Lund, Sweden
    Cell Immunol 189:19-24. 1998
    ..Despite donor-specific CTL activation in vivo the recipients failed to reject their established grafts, implying an ongoing presence of suppression...
  19. ncbi request reprint CTLA4ig induces long-term graft survival of allogeneic skin grafts and totally inhibits T-cell proliferation in LFA-1-deficient mice
    Helene Malm
    Department of Nephrology and Transplantation, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    Transplantation 73:293-7. 2002
    ..The purpose of this study was to define the effect of combined blockade of the LFA-1 and B7 costimulation pathways on the alloimmune response in mice...
  20. doi request reprint Costimulation blockade in transplantation of nerve allografts: long-term effects
    Martin Kvist
    Department of Clinical Sciences Hand Surgery, Malmo University Hospital, Malmo, Sweden
    J Peripher Nerv Syst 13:200-7. 2008
    ..We conclude that rejection is suppressed by costimulation blockade. Treatment improves recovery of target muscle and myelination after nerve allografting...
  21. ncbi request reprint Combined costimulation blockade prevents rejection of allogeneic islets in mice
    H Malm
    Department of Nephrology and Transplantation, Malmo University Hospital, Lund University, Malmo, Sweden
    Scand J Immunol 64:398-403. 2006
    ..In conclusion, a short induction treatment with anti-CD40L and CTLA4Ig totally prevents rejection and preserves the allogeneic islets transplanted to mice. The addition of anti-LFA-1 did not confer any benefit...
  22. ncbi request reprint CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely
    Matthias Corbascio
    Department of Nephrology and Transplantation, Lund University, University Hospital, Malmo, Sweden
    Transpl Immunol 10:55-61. 2002
    ..In conclusion, these results indicate a synergistic effect of combining anti-LFA-1 with CTLA4Ig in inhibiting lymphocyte proliferation and prolonging the survival of fully MHC-mismatched allografts...
  23. doi request reprint Operational tolerance in nonvascularized transplant models induced by AR-C117977, a monocarboxylate transporter inhibitor
    Clara Pahlman
    Department of Nephrology and Transplantation, University Hospital, Malmo, Sweden
    Transplantation 86:1135-8. 2008
    ..Islet allograft survival was moderately prolonged with CsA or AR-C117977. AR-C117977 is an efficient immunosuppressive drug in stringent rodent transplant models and further studies are warranted...
  24. ncbi request reprint Induction of operational tolerance to discordant dopaminergic porcine xenografts
    Lena C Larsson
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Sweden
    Transplantation 75:1448-54. 2003
    ..Lymphocyte function antigen (LFA)-1 is an important costimulatory molecule for CD8+ T cells, and we hypothesize that blockade with anti-LFA-1 may enhance the efficacy of CTLA4Ig and anti-CD40L therapy...
  25. ncbi request reprint Costimulation blockade-induced cardiac allograft tolerance: inhibition of T cell expansion and accumulation of intragraft cD4(+)Foxp3(+) T cells
    Cecilia Oderup
    Section for Immunology, Lund University, Lund, Sweden
    Transplantation 82:1493-500. 2006
    ....
  26. ncbi request reprint Kidneys from marginal donors: views of patients on informed consent
    Marie Omnell Persson
    Department of Nephrology and Transplantation, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Nephrol Dial Transplant 17:1497-502. 2002
    ..The aim of this study was to investigate the views of patients on the information they received about kidneys from marginal donors and their reaction to being asked to make a decision on this issue...
  27. pmc Fundamental and distinct roles of P-selectin and LFA-1 in ischemia/reperfusion-induced leukocyte-endothelium interactions in the mouse colon
    Amjid Ali Riaz
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    Ann Surg 236:777-84; discussion 784. 2002
    ..To study the adhesive mechanisms underlying ischemia/reperfusion (I/R)-induced leukocyte-endothelium interactions in the colon...
  28. ncbi request reprint Tailoring of minimal immunosuppression long term
    H Ekberg
    Department of Nephrology and Transplantation, University Hospital, Malmo, Sweden
    Transplant Proc 35:755-7. 2003
  29. pmc Major liver resection for hilar cholangiocarcinoma
    S Bengmark
    Department of Surgery, Lund University, Sweden
    Ann Surg 207:120-5. 1988
    ..The importance of a free resection margin indicates that surgery should be aggressive and include liver resection...
  30. ncbi request reprint The use of pretransplant erythropoietin to normalize hemoglobin levels has no deleterious effects on renal transplantation outcome
    T Linde
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Transplantation 71:79-82. 2001
    ..CONCLUSIONS: EPO treatment aimed at reaching a normal Hb in renal transplant recipients reduces the postoperative requirement for blood transfusions and has no deleterious effects on kidney graft function...
  31. pmc The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensalic nature of these viruses
    A Antonsson
    Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    J Virol 74:11636-41. 2000
    ..These results demonstrate that normal human skin harbors an array of papillomaviruses, most of them previously unknown...
  32. ncbi request reprint Immunomodulation by costimulation blockade inhibits rejection of nerve allografts
    Martin Kvist
    Department of Clinical Sciences Hand Surgery, Malmo University Hospital, Malmo, Sweden
    J Peripher Nerv Syst 12:83-90. 2007
    ..We conclude that costimulation blockade inhibits the immune response in nerve allografts without deterring early axonal outgrowth...
  33. ncbi request reprint Serum cystatin C is a more sensitive and more accurate marker of glomerular filtration rate than enzymatic measurements of creatinine in renal transplantation
    Anders Christensson
    Department of Nephrology and Transplantation, Malmo University Hospital, Malmo, Sweden
    Nephron Physiol 94:p19-27. 2003
    ....
  34. ncbi request reprint Rapid elimination by glomerular filtration of free prostate specific antigen and human kallikrein 2 after renal transplantation
    Laila Bruun
    Department of Nephrology and Transplantation, Lund University, University Hospital, Malmo, Sweden
    J Urol 171:1432-5. 2004
    ..We studied glomerular filtration dependent elimination of fPSA and hK2 in patients with renal insufficiency undergoing successful renal transplantation...
  35. ncbi request reprint [Potential for organ donation in Sweden. Analysis of five-year registration of all ICU deaths in southern Sweden]
    Nils H Persson
    Kliniken för njurmedicin och transplantation, Universitetssjukhuset MAS, Malmo, Sweden
    Lakartidningen 102:638-41. 2005
    ..Corresponding registration, as part of the computerised system for quality assurance for intensive care (PASIVA), may become a national and complete quality assurance for organ donation in Sweden...
  36. doi request reprint Calcineurin inhibitor sparing in renal transplantation
    Henrik Ekberg
    Transplantation 86:761-7. 2008
    ..Research aiming to achieve the "best" balance of efficacy and toxicity of available immunosuppressive regimens continues...
  37. ncbi request reprint Minimization of immunosuppressive therapy after renal transplantation: results of a randomized controlled trial
    Yves Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Transplant 5:87-95. 2005
    ..A longer follow-up will be needed to confirm the expected advantages for the long-term outcome and to assess the long-term safety of this minimization of immunosuppressive therapy...
  38. ncbi request reprint Anti-LFA-1 improves pig islet xenograft function in diabetic mice when long-term acceptance is induced by CTLA4Ig/anti-CD40L
    Makiko Kumagai-Braesch
    Department of Transplantation Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Transplantation 83:1259-67. 2007
    ..The purpose of this study was to test whether this costimulation blockade also can induce acceptance of adult pig islets transplanted to C57BL/6 mice with streptozotocin-induced diabetes...
  39. ncbi request reprint Estimated and measured donor creatinine clearance are poor predictors of long-term renal graft function and survival
    Eva Pokorna
    Transplant Center, Institute of Clinical and Experimental Medicine, Prague, Czech Republic
    Am J Transplant 2:373-80. 2002
    ....
  40. doi request reprint Costimulation blockade induces tolerance to HESC transplanted to the testis and induces regulatory T-cells to HESC transplanted into the heart
    Karl Henrik Grinnemo
    Department of Molecular Medicine and Surgery, Division of Cardiothoracic Surgery and Anaesthesiology, Karolinska University Hospital, S 171 76, Stockholm, Sweden
    Stem Cells 26:1850-7. 2008
    ..HESC specific regulatory T-cells developed to HESC transplanted to the heart and the success of transplantation was similar to that seen in SCID mice...
  41. doi request reprint Association of four DNA polymorphisms with acute rejection after kidney transplantation
    Josep Grinyo
    Department of Nephrology, Hospital de Bellvitge, University of Barcelona, Barcelona, Spain
    Transpl Int 21:879-91. 2008
    ..Variation in genes of immune response and pharmacodynamic/pharmacokinetic relevance may be important in understanding acute rejection after renal transplant...