Sara Ek

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Mantle cell lymphomas express a distinct genetic signature affecting lymphocyte trafficking and growth regulation as compared with subpopulations of normal human B cells
    Sara Ek
    Department of Immunotechnology, Lund University, SE 220 07, Sweden
    Cancer Res 62:4398-405. 2002
  2. pmc Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro
    Sandra Sernbo
    Department of Immunotechnology, CREATE Health, Lund University, Lund, Sweden
    PLoS ONE 8:e70596. 2013
  3. ncbi request reprint From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies
    Sara Ek
    Department of Immunotechnology, Lund University, SE 22007 Lund, Sweden
    Mol Cell Proteomics 5:1072-81. 2006
  4. pmc The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation
    Sandra Sernbo
    Department of Immunotechnology, Lund University, Lund, Sweden
    BMC Cancer 11:405. 2011
  5. ncbi request reprint Transcriptional profiling and assessment of cell lines as in vitro models for mantle cell lymphoma
    Sara Ek
    Department of Immunotechnology, Lund University, P O Box 7031, SE 22007 Lund, Sweden
    Leuk Res 29:205-13. 2005
  6. ncbi request reprint Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma
    Sara Ek
    Department of Immunotechnology, CREATE Health, Biomedical Center, Lund University, and Department of Pathology, Lund University Hospital, Sweden
    Blood 111:800-5. 2008
  7. doi request reprint Identification of molecular targets associated with transformed diffuse large B cell lymphoma using highly purified tumor cells
    Ulrika Andréasson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Am J Hematol 84:803-8. 2009
  8. ncbi request reprint Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples
    Ulrika Andréasson
    Department of Immunotechnology, Lund University, Sweden
    Am J Hematol 85:418-25. 2010
  9. ncbi request reprint B cell lymphomas express CX3CR1 a non-B cell lineage adhesion molecule
    Ulrika Andréasson
    Department of Immunotechnology, Lund University, CREATE Health, Lund University, BMC D13, 221 84, Lund, Sweden
    Cancer Lett 259:138-45. 2008
  10. ncbi request reprint Mantle cell lymphomas acquire increased expression of CCL4, CCL5 and 4-1BB-L implicated in cell survival
    Sara Ek
    Department of Immunotechnology, Lund University, Lund, Sweden
    Int J Cancer 118:2092-7. 2006

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Mantle cell lymphomas express a distinct genetic signature affecting lymphocyte trafficking and growth regulation as compared with subpopulations of normal human B cells
    Sara Ek
    Department of Immunotechnology, Lund University, SE 220 07, Sweden
    Cancer Res 62:4398-405. 2002
    ..Furthermore, hierarchical cluster analysis revealed two subpopulations of MCLs, which indicates that despite the homogeneous and strong overexpression of cyclin D1, further subtyping might be possible...
  2. pmc Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro
    Sandra Sernbo
    Department of Immunotechnology, CREATE Health, Lund University, Lund, Sweden
    PLoS ONE 8:e70596. 2013
    ..This is supported by functional data, indicating that T-STAR regulation is of importance both for breast cancer biology and clinical outcome but future studies are needed to determine a potential role in patient stratification. ..
  3. ncbi request reprint From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies
    Sara Ek
    Department of Immunotechnology, Lund University, SE 22007 Lund, Sweden
    Mol Cell Proteomics 5:1072-81. 2006
    ....
  4. pmc The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation
    Sandra Sernbo
    Department of Immunotechnology, Lund University, Lund, Sweden
    BMC Cancer 11:405. 2011
    ....
  5. ncbi request reprint Transcriptional profiling and assessment of cell lines as in vitro models for mantle cell lymphoma
    Sara Ek
    Department of Immunotechnology, Lund University, P O Box 7031, SE 22007 Lund, Sweden
    Leuk Res 29:205-13. 2005
    ..Taken together, our data show that the cell lines are clearly derived from MCL tumours and expressed similar genetic and phenotypic signatures compared to primary tumours, which confirmed their usefulness as in vitro models...
  6. ncbi request reprint Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma
    Sara Ek
    Department of Immunotechnology, CREATE Health, Biomedical Center, Lund University, and Department of Pathology, Lund University Hospital, Sweden
    Blood 111:800-5. 2008
    ....
  7. doi request reprint Identification of molecular targets associated with transformed diffuse large B cell lymphoma using highly purified tumor cells
    Ulrika Andréasson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Am J Hematol 84:803-8. 2009
    ..Galectin-3 and NEK2 both identified a subgroup of DLBCL-tr, and the function of these protein markers also suggests a biological role in the transformation process...
  8. ncbi request reprint Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples
    Ulrika Andréasson
    Department of Immunotechnology, Lund University, Sweden
    Am J Hematol 85:418-25. 2010
    ..The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treatment...
  9. ncbi request reprint B cell lymphomas express CX3CR1 a non-B cell lineage adhesion molecule
    Ulrika Andréasson
    Department of Immunotechnology, Lund University, CREATE Health, Lund University, BMC D13, 221 84, Lund, Sweden
    Cancer Lett 259:138-45. 2008
    ..CX3CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX3CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma...
  10. ncbi request reprint Mantle cell lymphomas acquire increased expression of CCL4, CCL5 and 4-1BB-L implicated in cell survival
    Sara Ek
    Department of Immunotechnology, Lund University, Lund, Sweden
    Int J Cancer 118:2092-7. 2006
    ..Signaling through 4-1BB-L allows B cells to proliferate and the expression of its ligand, by the intra-tumoral mesh of follicular dendritic cells (FDC), could thus serve as a paracrine loop facilitating growth and survival of MCL cells...
  11. pmc SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies
    Elin Gustavsson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Mol Cancer 9:187. 2010
    ..SOX11 has been shown to prevent gliomagenesis in vivo but the causes and consequences of aberrant expression of SOX11 outside the CNS remain unexplained...
  12. pmc Expanded clinical and experimental use of SOX11 - using a monoclonal antibody
    Lena Nordström
    Department of Immunotechnology, Lund University, BMCD13, Lund, SE 221 84, Sweden
    BMC Cancer 12:269. 2012
    ....
  13. pmc Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma
    Michael Dictor
    Department of Pathology, Lund University Hospital, Sweden
    Haematologica 94:1563-8. 2009
    ..We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1...
  14. ncbi request reprint Functionally associated targets in mantle cell lymphoma as defined by DNA microarrays and RNA interference
    Eva Ortega-Paino
    Department of Immunotechnology, Lund University, Lund, Sweden
    Blood 111:1617-24. 2008
    ....
  15. doi request reprint Protein expression profiling of formalin-fixed paraffin-embedded tissue using recombinant antibody microarrays
    Frida Pauly
    Department of Immunotechnology, Lund University, Medicon Village, Lund, Sweden
    J Proteome Res 12:5943-53. 2013
    ..Thus, we have added FFPE samples to the list of sample formats available for high-throughput analysis by affinity proteomics, paving the way for the next generation of biomarker-driven discovery projects. ..
  16. doi request reprint Knock-down of SOX11 induces autotaxin-dependent increase in proliferation in vitro and more aggressive tumors in vivo
    Paolo Conrotto
    Department of Immunotechnology, Lund University, BMC D13, SE 221 84 Lund, Sweden
    Mol Oncol 5:527-37. 2011
    ....
  17. doi request reprint Surrogate antigens as targets for proteome-wide binder selection
    Elin Gustavsson
    Department of Immunotechnology, Lund University, SE 221 84 Lund, Sweden
    N Biotechnol 28:302-11. 2011
    ..These binders were subsequently tested in western blot, immunohistochemistry and protein microarray application to demonstrate their functionality...
  18. pmc Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases
    Anders Carlsson
    Department of Immunotechnology, CREATE Health, Lund University, BMC D13, SE 22184 Lund, Sweden
    Proc Natl Acad Sci U S A 108:14252-7. 2011
    ..Consequently, we present here a candidate serum biomarker signature able to classify patients with primary breast cancer according to their risk of developing distant recurrence, with an accuracy outperforming current procedures...
  19. ncbi request reprint Increased expression of Ki-67 in mantle cell lymphoma is associated with de-regulation of several cell cycle regulatory components, as identified by global gene expression analysis
    Sara Ek
    Department of Immunotechnology, Lund University, Sweden
    Haematologica 89:686-95. 2004
    ..Furthermore, primary and relapsed tumors were compared to identify the possible growth advantages possessed by cells which persist after therapy and which might evolve into a tumor relapse...
  20. ncbi request reprint SOX11 and TP53 add prognostic information to MIPI in a homogenously treated cohort of mantle cell lymphoma - a Nordic Lymphoma Group study
    Lena Nordström
    Department of Immunotechnology, CREATE Health, Lund University, Lund, Sweden
    Br J Haematol 166:98-108. 2014
    ..Based on these findings, we propose that TP53 and SOX11 should routinely be assessed and that a combined TP53/MIPI score may be used to guide treatment decisions. ..
  21. ncbi request reprint Profiling of internalizing tumor-associated antigens on breast and pancreatic cancer cells by reversed genomics
    Johan Fransson
    Department of Immunotechnology, Lund University, P O Box 7031, SE 220 07 Lund, Sweden
    Cancer Lett 208:235-42. 2004
    ..The ability of the selected antibodies to undergo receptor-mediated internalization was verified by confocal microscopy, thus proving our strategy to provide a unique set of human antibodies, potentially useful in immunotherapy...
  22. pmc Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells
    Falk Hertwig
    Department of Immunotechnology, Lund University Hospital, and Department of Laboratory Medicine, Lund University, Lund, Sweden
    Cancer Res 72:3381-92. 2012
    ....
  23. ncbi request reprint High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma
    Erik Björck
    Department of Molecular Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Blood 105:2908-15. 2005
    ..CCNB1 expression had an independent prognostic value when included in a multivariate analysis together with the 5 parameters of the follicular lymphoma international prognostic index...