Research Topics
| Sara EkSummaryAffiliation: Lund University Country: Sweden Publications
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Detail Information
Publications
Mantle cell lymphomas express a distinct genetic signature affecting lymphocyte trafficking and growth regulation as compared with subpopulations of normal human B cellsSara Ek
Department of Immunotechnology, Lund University, SE-220 07, Sweden
Cancer Res 62:4398-405. 2002..Furthermore, hierarchical cluster analysis revealed two subpopulations of MCLs, which indicates that despite the homogeneous and strong overexpression of cyclin D1, further subtyping might be possible...
The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylationSandra Sernbo
Department of Immunotechnology, Lund University, Lund, Sweden
BMC Cancer 11:405. 2011....- Transcriptional profiling and assessment of cell lines as in vitro models for mantle cell lymphomaSara Ek
Department of Immunotechnology, Lund University, P O Box 7031, SE 22007 Lund, Sweden
Leuk Res 29:205-13. 2005..Taken together, our data show that the cell lines are clearly derived from MCL tumours and expressed similar genetic and phenotypic signatures compared to primary tumours, which confirmed their usefulness as in vitro models... - From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignanciesSara Ek
Department of Immunotechnology, Lund University, SE 22007 Lund, Sweden
Mol Cell Proteomics 5:1072-81. 2006.... - Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphomaSara Ek
Department of Immunotechnology, CREATE Health, Biomedical Center, Lund University, and Department of Pathology, Lund University Hospital, Sweden
Blood 111:800-5. 2008.... 
Identification of molecular targets associated with transformed diffuse large B cell lymphoma using highly purified tumor cellsUlrika Andréasson
Department of Immunotechnology, Lund University, Lund, Sweden
Am J Hematol 84:803-8. 2009..Galectin-3 and NEK2 both identified a subgroup of DLBCL-tr, and the function of these protein markers also suggests a biological role in the transformation process...- Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samplesUlrika Andréasson
Department of Immunotechnology, Lund University, Sweden
Am J Hematol 85:418-25. 2010..The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treatment... - B cell lymphomas express CX3CR1 a non-B cell lineage adhesion moleculeUlrika Andréasson
Department of Immunotechnology, Lund University, CREATE Health, Lund University, BMC D13, 221 84, Lund, Sweden
Cancer Lett 259:138-45. 2008..CX3CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX3CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma... - SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignanciesElin Gustavsson
Department of Immunotechnology, Lund University, Lund, Sweden
Mol Cancer 9:187. 2010..SOX11 has been shown to prevent gliomagenesis in vivo but the causes and consequences of aberrant expression of SOX11 outside the CNS remain unexplained... - Mantle cell lymphomas acquire increased expression of CCL4, CCL5 and 4-1BB-L implicated in cell survivalSara Ek
Department of Immunotechnology, Lund University, Lund, Sweden
Int J Cancer 118:2092-7. 2006..Signaling through 4-1BB-L allows B cells to proliferate and the expression of its ligand, by the intra-tumoral mesh of follicular dendritic cells (FDC), could thus serve as a paracrine loop facilitating growth and survival of MCL cells... - Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphomaMichael Dictor
Department of Pathology, Lund University Hospital, Sweden
Haematologica 94:1563-8. 2009..We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1... - Functionally associated targets in mantle cell lymphoma as defined by DNA microarrays and RNA interferenceEva Ortega-Paino
Department of Immunotechnology, Lund University, Lund, Sweden
Blood 111:1617-24. 2008.... - Expanded clinical and experimental use of SOX11 - using a monoclonal antibodyLena Nordström
Department of Immunotechnology, Lund University, BMCD13, Lund, SE 221 84, Sweden
BMC Cancer 12:269. 2012.... - Knock-down of SOX11 induces autotaxin-dependent increase in proliferation in vitro and more aggressive tumors in vivoPaolo Conrotto
Department of Immunotechnology, Lund University, BMC D13, SE 221 84 Lund, Sweden
Mol Oncol 5:527-37. 2011.... - Increased expression of Ki-67 in mantle cell lymphoma is associated with de-regulation of several cell cycle regulatory components, as identified by global gene expression analysisSara Ek
Department of Immunotechnology, Lund University, Sweden
Haematologica 89:686-95. 2004..The generated signature was used to assign new MCL samples to the high proliferative group, validating the association between these genes and proliferation in MCL... - Surrogate antigens as targets for proteome-wide binder selectionElin Gustavsson
Department of Immunotechnology, Lund University, SE 221 84 Lund, Sweden
N Biotechnol 28:302-11. 2011..These binders were subsequently tested in western blot, immunohistochemistry and protein microarray application to demonstrate their functionality... - Molecular serum portraits in patients with primary breast cancer predict the development of distant metastasesAnders Carlsson
Department of Immunotechnology, CREATE Health, Lund University, BMC D13, SE 22184 Lund, Sweden
Proc Natl Acad Sci U S A 108:14252-7. 2011..Consequently, we present here a candidate serum biomarker signature able to classify patients with primary breast cancer according to their risk of developing distant recurrence, with an accuracy outperforming current procedures... - Profiling of internalizing tumor-associated antigens on breast and pancreatic cancer cells by reversed genomicsJohan Fransson
Department of Immunotechnology, Lund University, P.O. Box 7031, SE-220 07 Lund, Sweden
Cancer Lett 208:235-42. 2004..The ability of the selected antibodies to undergo receptor-mediated internalization was verified by confocal microscopy, thus proving our strategy to provide a unique set of human antibodies, potentially useful in immunotherapy... - Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cellsFalk Hertwig
Department of Immunotechnology, Lund University Hospital, and Department of Laboratory Medicine, Lund University, Lund, Sweden
Cancer Res 72:3381-92. 2012.... - High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphomaErik Björck
Department of Molecular Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
Blood 105:2908-15. 2005..CCNB1 expression had an independent prognostic value when included in a multivariate analysis together with the 5 parameters of the follicular lymphoma international prognostic index...