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Genomes and GenesSpecies | Henryk A DomanskiSummaryAffiliation: Lund University Country: Sweden Publications
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Publications
Fine-needle aspiration of neurilemoma (schwannoma). A clinicocytopathologic study of 116 patientsHenryk A Domanski
Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden
Diagn Cytopathol 34:403-12. 2006..Furthermore aspirates showing predominantly Antoni A features, nuclear pleomorphism, and/or myxoid changes can easily be confused with other types of benign or malignant soft-tissue tumors...
Low-grade fibromyxoid sarcoma is difficult to diagnose by fine needle aspiration cytology: a cytomorphological study of eight casesH A Domanski
Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden
Cytopathology 20:304-14. 2009..The diagnosis of LGFMS can be difficult to render from fine needle aspiration cytology (FNAC) alone because of morphological overlap with other spindle cell and myxoid lesions...- Fine-needle aspiration of soft tissue leiomyosarcoma: an analysis of the most common cytologic findings and the value of ancillary techniquesHenryk A Domanski
Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden
Diagn Cytopathol 34:597-604. 2006..Ancillary studies can confirm the diagnosis of LMS and help in the correct interpretation of predominant spindle-cell or epitheloid-cell smears resembling neurilemoma or carcinoma, respectively... - The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcomaIoannis Panagopoulos
Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
Genes Chromosomes Cancer 40:218-28. 2004..The results indicated that FUS/CREB3L2 is specifically associated with LGFMS and that RT-PCR or FISH analysis may be useful for the differential diagnosis... - Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion geneFredrik Mertens
Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
Lab Invest 85:408-15. 2005..Taken together, the results indicate that virtually all LGFMS are characterized by a chimeric FUS/CREB3L2 gene, and that rare cases may display a variant FUS/CREB3L1 fusion... - Heterogeneous genetic profiles in soft tissue myoepitheliomasKarolin H Hallor
Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
Mod Pathol 21:1311-9. 2008.... - Two genetic pathways, t(1;10) and amplification of 3p11-12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesionsKarolin H Hallor
Department of Clinical Genetics, University Hospital, Lund, Sweden
J Pathol 217:716-27. 2009..The identified genetic aberrations were not confined to MIFS; an identical t(1;10) was also found in a case of HFT and the amplicon in 3p was seen in an IMFH... 
Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroupsHammurabi Bartuma
Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
Mol Cancer 8:36. 2009....- Assessment of the clinical and molecular impact of different cytogenetic subgroups in a series of 272 lipomas with abnormal karyotypeHammurabi Bartuma
Department of Clinical Genetics, University Hospital, Lund, Sweden
Genes Chromosomes Cancer 46:594-606. 2007..By FISH, we could also show that breakpoints in bands 10q22-23 do not affect the MYST4 gene, whereas breakpoints in 6p21 or 8q11-12 occasionally target the HMGA1 or PLAG1 genes, respectively, also in conventional lipomas... - Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genesYuesheng Jin
Department of Clinical Genetics, University and Regional Laboratories, Skane University Hospital, Lund University, Lund, Sweden
Genes Chromosomes Cancer 51:510-20. 2012..Apart from providing a diagnostic marker for soft tissue angiofibroma, the results also suggest that this tumor constitutes an interesting model for evaluating the cellular effects of AHR signaling... - Molecular cytogenetic characterization of an ins(4;X) occurring as the sole abnormality in an aggressive, poorly differentiated soft tissue sarcomaCecilia Surace
Department of Clinical Genetics, Lund University Hospital, SE-221 85, Lund, Sweden
Virchows Arch 447:869-74. 2005..Our results suggest that BCOR and/or an ECM-like protein could be involved in the pathogenesis of a subgroup of PNET or PNET-like sarcomas... - A prognostic model for soft tissue sarcoma of the extremities and trunk wall based on size, vascular invasion, necrosis, and growth patternAna Carneiro
Department of Oncology, Institute of Clinical Sciences, Skane University Hospital, Lund University, Lund, Sweden
Cancer 117:1279-87. 2011..Prognostic systems used in clinical practice identify high-risk patients based on various factors, including age, tumor size and depth, histological type, necrosis, and grade... - Ezrin expression predicts local recurrence and development of metastases in soft tissue sarcomasAna Carneiro
Department of Oncology, Institute of Clinical Sciences Lund, Skane University Hospital, Lund University, Lund, Sweden
J Clin Pathol 64:689-94. 2011..Ezrin is a cytoskeletal protein involved in tumour growth and invasion. Ezrin expression has been suggested to play a role in metastasis in paediatric osteosarcoma and rhabdomyosarcoma... - Core-needle biopsy performed by the cytopathologist: a technique to complement fine-needle aspiration of soft tissue and bone lesionsHenryk A Domanski
Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden
Cancer 105:229-39. 2005..The main limitation of FNAC of soft tissue and bone neoplasms is in the evaluation of tissue architecture. In addition cytologic specimens are not always adequate for ancillary studies... - Improved prognostication in soft tissue sarcoma: independent information from vascular invasion, necrosis, growth pattern, and immunostaining using whole-tumor sections and tissue microarraysJacob Engellau
Department of Oncology, Lund University Hospital, SE 221 85 Lund, Sweden
Hum Pathol 36:994-1002. 2005.... - Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation: a case report with fine-needle aspiration biopsy, histopathology, electron microscopy, and cytogeneticsHenryk A Domanski
Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden
Ultrastruct Pathol 27:363-8. 2003.... - Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcomaIoannis Panagopoulos
Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
Genes Chromosomes Cancer 35:340-52. 2002.... - Chromosome banding analysis of cells from fine-needle aspiration biopsy samples from soft tissue and bone tumors: is it clinically meaningful?Charles Walther
Department of Pathology, University and Regional Laboratories, Lund University Hospital, Lund University, Lund, Sweden
Cancer Genet 204:203-6. 2011..Our preliminary data suggest that if a pretreatment karyotype is wanted, the cytogenetic analysis should be made on cells from CN samples, close to half of which showed an aberrant karyotype... - Unstable translocation (8;22) in a case of giant cell reparative granulomaAnna Johnsson
Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
Cancer Genet Cytogenet 177:59-63. 2007..We conclude that our case of GCRG shared several cytogenetic characteristics with GCTB but none with ABC... - Fine-needle aspiration of primary osteosarcoma: a cytological-histological studyHenryk A Domanski
Department of Pathology and Cytology, University Hospital, Lund, Sweden
Diagn Cytopathol 32:269-75. 2005..We conclude that FNA smears from high-grade OS have characteristic features, which together with clinical and radiological data and ancillary studies allow correct diagnosis in most tumors... - FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1Emely Möller
Department of Clinical Genetics, University and Regional Laboratories, Skane University Hospital, Lund University, Lund, Sweden
Clin Cancer Res 17:2646-56. 2011..The present study aimed to extract LGFMS-specific, and putatively FUS-CREB3L2-dependent, gene expression patterns to learn more about the pathogenesis of this tumor... - A novel fusion gene, SS18L1/SSX1, in synovial sarcomaClelia Tiziana Storlazzi
Department of Clinical Genetics, University Hospital, Lund, Sweden
Genes Chromosomes Cancer 37:195-200. 2003..Thus, the existence of genetic heterogeneity has to be taken into account when RT-PCR is used for the diagnosis of synovial sarcoma... - Gene expression and single nucleotide polymorphism array analyses of spindle cell lipomas and conventional lipomas with 13q14 deletionHammurabi Bartuma
Department of Clinical Genetics, University and Regional Laboratories, Skane University Hospital, Lund University, Lund, Sweden
Genes Chromosomes Cancer 50:619-32. 2011.... - Cytogenetic and molecular cytogenetic findings in lipoblastomaHammurabi Bartuma
Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
Cancer Genet Cytogenet 183:60-3. 2008..As 8q11 approximately q13 rearrangements have been reported in only 3% of conventional lipomas and never in myxoid liposarcoma, cytogenetic analysis or FISH for the PLAG1 gene can provide useful differential diagnostic information... - Recurrent rearrangement of the PHF1 gene in ossifying fibromyxoid tumorsSamuel Gebre-Medhin
Department of Clinical Genetics, University and Regional Laboratories, Lund University, Sweden
Am J Pathol 181:1069-77. 2012..Thus, the results indicate that deregulation of PRC2 target genes is crucial for OFMT development... - Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumorsAnna Dahlén
Department of Clinical Genetics, University Hospital, Lund, Sweden
Int J Cancer 103:616-23. 2003..Our findings strongly indicate that deletion of a limited region (approximately 2.5 Mbp) within 13q14, distal to the RB1-locus, is of importance in the development of a subset of lipomatous tumors... - Cytologic features of primary, recurrent, and metastatic dermatofibrosarcoma protuberansHenryk A Domanski
Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden
Cancer 96:351-61. 2002..Its diagnosis may be difficult to render from cytologic smears, as it shares some features with other spindle cell lesions occurring in the skin and soft tissue... - Genetic profiling differentiates second primary tumors from metastases in adult metachronous soft tissue sarcomaJosefin Fernebro
Department of Oncology, Institute of Clinical Sciences, Lund University Hospital, 221 85 Lund, Sweden
Sarcoma 2008:431019. 2008.... - FNA diagnosis of dermatofibrosarcoma protuberansHenryk A Domanski
Department of Pathology and Cytology, Lund University Hospital, Sweden
Diagn Cytopathol 32:299-302. 2005..FNA features alone are not sufficiently characteristic to permit a confident diagnosis of DFSP. Correct diagnosis requires an awareness of the clinical history and the use of ancillary studies... - Molecular cytogenetic characterization of recurrent translocation breakpoints in bizarre parosteal osteochondromatous proliferation (Nora's lesion)Malin Nilsson
Department of Clinical Genetics and Pathology, University Hospital, Lund, Sweden
Hum Pathol 35:1063-9. 2004..Several genes are located within the 2 sequences spanning the breakpoints, and further studies should be performed to determine whether any of these are involved in the formation of a fusion gene... - Fine-needle aspiration cytology of soft tissue lesions: diagnostic challengesHenryk A Domanski
Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden
Diagn Cytopathol 35:768-73. 2007..FNAC of soft tissue lesions is facilitated when limited to specialized orthopedic-oncologic centers with a well-integrated multidisciplinary team and experience in the evaluation and therapy of soft tissue lesions... - Fine-needle aspiration smears from lipomatous hemangiopericytoma need not be confused with myxoid liposarcomaHenryk A Domanski
Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden
Diagn Cytopathol 29:287-91. 2003..Correct diagnosis requires an awareness of cytologic features of this rare tumor and the use of ancillary studies... - Elastofibroma dorsi has distinct cytomorphologic features, making diagnostic surgical biopsy unnecessary: cytomorphologic study with clinical, radiologic, and electron microscopic correlationsHenryk A Domanski
Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden
Diagn Cytopathol 29:327-33. 2003..The current study suggests that the fine-needle aspiration (FNA) features are highly diagnostic, permitting a firm diagnosis of EFD in a typical clinical setting and eliminating the need for preoperative histologic examination... - Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic featuresFredrik Mertens
Department of Clinical Genetics, University and Regional Laboratories, Skane University Hospital, Lund University, Lund, Sweden
Clin Sarcoma Res 1:10. 2011..abstract:.. - Intratumor versus intertumor heterogeneity in gene expression profiles of soft-tissue sarcomasPrincy Francis
Department of Oncology, Lund University, Lund, Sweden
Genes Chromosomes Cancer 43:302-8. 2005..We concluded that intratumor variability exists but that accurate gene expression profiling also could be obtained using single samples from a large STS... - Cytologic features of angioleiomyoma: cytologic-histologic study of 10 casesHenryk A Domanski
Department of Pathology and Cytology, Lunds University Hospital, Lund, Sweden
Diagn Cytopathol 27:161-6. 2002..Smears from ALM are not sufficiently characteristic to permit a histotype diagnosis, but together with typical clinical data (painful or tender nodule) may help to exclude other skin or subcutaneous lesions... - Fine-needle aspiration of ganglioneuromaHenryk A Domanski
Department of Pathology and Cytology, Lund University Hospital, S 221 85 Lund, Sweden
Diagn Cytopathol 32:363-6. 2005..Immunocytochemistry can help to establish the neurogenic origin of the tumor cells... - Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeurosesIoannis Panagopoulos
Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
Int J Cancer 99:560-7. 2002..In addition, topoisomerase I consensus sequences were found close to the junctions, suggesting that this enzyme may participate in the genesis of the EWS/ATF1 fusion...