Eva Degerman

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. pmc Identification of new signaling components in the sensory epithelium of human saccule
    Eva Degerman
    Section for Diabetes, Metabolism and Endocrinology, Department of Experimental Medical Sciences, Lund University Lund, Sweden
    Front Neurol 2:48. 2011
  2. pmc From PDE3B to the regulation of energy homeostasis
    Eva Degerman
    Department of Experimental Medical Science, Division for Diabetes, Metabolism and Endocrinology, Lund University, Lund, Sweden
    Curr Opin Pharmacol 11:676-82. 2011
  3. doi request reprint Expression of insulin signalling components in the sensory epithelium of the human saccule
    Eva Degerman
    Department of Experimental Medical Sciences, Section for Diabetes, Metabolism and Endocrinology, Lund University, Biomedical Center, C11, 221 84, Lund, Sweden
    Cell Tissue Res 352:469-78. 2013
  4. ncbi request reprint Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B
    Rebecka Lindh
    Department of Experimental Medical Sciences, Division for Diabetes, Metabolism and Endocrinology, Lund University, Lund, Sweden
    Biochim Biophys Acta 1773:584-92. 2007
  5. ncbi request reprint Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B
    Helena A Walz
    Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE 221 84 Lund, Sweden
    J Endocrinol 189:629-41. 2006
  6. pmc Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis
    Bilal Omar
    Lund University, Biomedical Center, C11 Department of Experimental Medical Science, 221 84 Lund, Sweden
    Cell Signal 21:760-6. 2009
  7. ncbi request reprint Dual effects of pituitary adenylate cyclase-activating polypeptide and isoproterenol on lipid metabolism and signaling in primary rat adipocytes
    Lina Akesson
    Section for Molecular Signaling, Department of Cell and Molecualar Biology, Lund University, Lund, Sweden
    Endocrinology 144:5293-9. 2003
  8. ncbi request reprint Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes
    Emilia Zmuda-Trzebiatowska
    Biomedical Center, C11, Department of Experimental Medical Science, 221 84 Lund, Sweden
    Cell Signal 18:382-90. 2006
  9. ncbi request reprint Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology
    Linda Härndahl
    Departments of Cell and Molecular Biology, Biomedical Center, C11, Land Sweden
    J Biol Chem 279:15214-22. 2004
  10. pmc Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism
    Karin Berger
    Department of Experimental Medical Sciences, Lund University, BMC C11, Lund, Sweden
    PLoS ONE 4:e4671. 2009

Collaborators

Detail Information

Publications33

  1. pmc Identification of new signaling components in the sensory epithelium of human saccule
    Eva Degerman
    Section for Diabetes, Metabolism and Endocrinology, Department of Experimental Medical Sciences, Lund University Lund, Sweden
    Front Neurol 2:48. 2011
    ..The dissection of the signaling networks utilizing these components and evaluating their roles will add new basic knowledge regarding inner ear physiology...
  2. pmc From PDE3B to the regulation of energy homeostasis
    Eva Degerman
    Department of Experimental Medical Science, Division for Diabetes, Metabolism and Endocrinology, Lund University, Lund, Sweden
    Curr Opin Pharmacol 11:676-82. 2011
    ..This article highlights the complexity involved in the regulation of PDE3B by hormones, and in the regulation of downstream metabolic effects by PDE3B in several interacting tissues...
  3. doi request reprint Expression of insulin signalling components in the sensory epithelium of the human saccule
    Eva Degerman
    Department of Experimental Medical Sciences, Section for Diabetes, Metabolism and Endocrinology, Lund University, Biomedical Center, C11, 221 84, Lund, Sweden
    Cell Tissue Res 352:469-78. 2013
    ....
  4. ncbi request reprint Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B
    Rebecka Lindh
    Department of Experimental Medical Sciences, Division for Diabetes, Metabolism and Endocrinology, Lund University, Lund, Sweden
    Biochim Biophys Acta 1773:584-92. 2007
    ..Several of the sites were phosphorylated by insulin as well as cAMP-increasing hormones indicating integration of the two signalling pathways upstream of PDE3B, maybe at the level of protein kinase B...
  5. ncbi request reprint Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B
    Helena A Walz
    Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE 221 84 Lund, Sweden
    J Endocrinol 189:629-41. 2006
    ..We conclude that accurate regulation of beta-cell cAMP is necessary for adequate islet adaptation to a perturbed metabolic environment and protective for the development of glucose intolerance and insulin resistance...
  6. pmc Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis
    Bilal Omar
    Lund University, Biomedical Center, C11 Department of Experimental Medical Science, 221 84 Lund, Sweden
    Cell Signal 21:760-6. 2009
    ..Taken together, these data suggest that PDE3B and PDE4 regulate cAMP pools that affect the activation/phosphorylation state of AMPK and that the effects of cyclic AMP on AMPK involve Epac1, PKA and lipolysis...
  7. ncbi request reprint Dual effects of pituitary adenylate cyclase-activating polypeptide and isoproterenol on lipid metabolism and signaling in primary rat adipocytes
    Lina Akesson
    Section for Molecular Signaling, Department of Cell and Molecualar Biology, Lund University, Lund, Sweden
    Endocrinology 144:5293-9. 2003
    ..e. storage of triglycerides...
  8. ncbi request reprint Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes
    Emilia Zmuda-Trzebiatowska
    Biomedical Center, C11, Department of Experimental Medical Science, 221 84 Lund, Sweden
    Cell Signal 18:382-90. 2006
    ..In summary, our data suggest that PDE3B, but not PDE4, contributes to the regulation of insulin-induced glucose uptake, GLUT-4 translocation, and lipogenesis presumably by regulation of a cAMP/Epac signalling mechanisms...
  9. ncbi request reprint Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology
    Linda Härndahl
    Departments of Cell and Molecular Biology, Biomedical Center, C11, Land Sweden
    J Biol Chem 279:15214-22. 2004
    ..Furthermore, morphological examinations demonstrated deranged islet cytoarchitecture. In conclusion, these results are consistent with an essential role for PDE3B in cAMP-mediated regulation of insulin release and glucose homeostasis...
  10. pmc Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism
    Karin Berger
    Department of Experimental Medical Sciences, Lund University, BMC C11, Lund, Sweden
    PLoS ONE 4:e4671. 2009
    ..Dysregulation of PDE3B could have a role in the development of fatty liver, a condition highly relevant in the context of type 2 diabetes...
  11. ncbi request reprint Long-term regulation of cyclic nucleotide phosphodiesterase type 3B and 4 in 3T3-L1 adipocytes
    Alina Oknianska
    Biomedical Center, C11, Department of Experimental Medical Science, 221 84 Lund, Sweden
    Biochem Biophys Res Commun 353:1080-5. 2007
    ..Altered expression of PDE3B and PDE4D in response to long-term treatment with insulin and catecholamines may contribute to altered regulation of metabolism in diabetes...
  12. ncbi request reprint Dimethylaminopurine inhibits metabolic effects of insulin in primary adipocytes
    Olga Göransson
    Department of Cell and Molecular Biology, Lund University, BMC, C11, S 221 84 Lund, Sweden
    J Nutr Biochem 15:303-12. 2004
    ..Inhibition of JNK by DMAP may therefore partly explain the negative impact of DMAP on insulin action in adipocytes...
  13. pmc Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets
    Emilia Heimann
    Department of Experimental Medical Science, Division for Diabetes, Metabolism and Endocrinology, Lund University, Lund, Sweden
    PLoS ONE 5:e14191. 2010
    ..Moreover, we conclude that several PDEs are present in human pancreatic islets...
  14. ncbi request reprint Novel mechanisms of the regulation of protein kinase B in adipocytes; implications for protein kinase A, Epac, phosphodiesterases 3 and 4
    Emilia Zmuda-Trzebiatowska
    Biomedical Center, C11, Department of Experimental Medical Science, 221 84 Lund, Sweden
    Cell Signal 19:81-6. 2007
    ..These PDE3B-dependent effects on ACC correlated with changes in lipogenesis. The Epac agonist, 8-pCPT-2'-O-Me-cAMP, mimicked the effect of PDE3B inhibition on ACC phosphorylation and lipogenesis...
  15. ncbi request reprint Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes
    Rebecka Nilsson
    Department of Experimental Medical Science, Lund University, BMC C11, 221 84 Lund, Sweden
    Cell Signal 18:1713-21. 2006
    ..Thus, PDE3B, a key enzyme in insulin signalling, appears to be associated with caveolae in adipocytes and this localization seems to be functionally important...
  16. ncbi request reprint Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes
    Svante Resjö
    Biomedical Center, C11, Lund University, SE 22184, Lund, Sweden
    Cell Signal 14:231-8. 2002
    ..In summary, our results suggest that PP2A is the principal phosphatase that dephosphorylates PKB in adipocytes...
  17. ncbi request reprint Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin
    Helena A Walz
    Department of Experimental Medical Science, Biomedical Center C11, Lund University, SE 221 84 Lund, Sweden
    Cell Signal 19:1505-13. 2007
    ..We conclude that PDE3B, through hydrolysis of cAMP in pools regulated by Ca(2+), plays a regulatory role in depolarization-induced insulin secretion and that the enzyme is associated with the exocytotic machinery in beta-cells...
  18. ncbi request reprint Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice
    Eva Degerman
    Department of Cell and Molecular Biology, Biomedical Center, C11, 22184 Lund, Sweden
    Eur J Pharmacol 498:319-23. 2004
    ....
  19. ncbi request reprint VPAC2-R mediates the lipolytic effects of pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide in primary rat adipocytes
    Lina Akesson
    Section for Molecular Signaling, Department of Cell and Molecular Biology, Biomedical Center C11, Lund University, SE 221 84 Lund, Sweden
    Endocrinology 146:744-50. 2005
    ..These results therefore provide evidence that all three PACAP/VIP receptor subtypes are expressed in primary rat adipocytes, but that the VPAC2-R subtype is responsible for mediating the lipolytic effects induced by PACAP38 and VIP...
  20. doi request reprint Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes
    Sofia A Andersson
    Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    Mol Cell Endocrinol 364:36-45. 2012
    ..Our data support that reduced expression of exocytotic genes contributes to impaired insulin secretion, and suggest decreased expression of these genes as part of T2D pathogenesis...
  21. doi request reprint Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes
    Christine Berggreen
    Department of Experimental Medical Science, Lund University, BMC, C11, SE 221 84 Lund, Sweden
    Am J Physiol Endocrinol Metab 296:E635-46. 2009
    ..In summary, we propose that PKB is required for the positive effects of insulin on lipid storage and that regulation of PDE3B and AMPK by PKB is important for these effects...
  22. pmc Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B
    Bilal Omar
    Department of Experimental Medical Sciences, Diabetes, Metabolism and Endocrinology, Biomedical Center, Lund University, Lund, Sweden
    Biochem Biophys Res Commun 425:812-7. 2012
    ..Given the established link between osteopontin and insulin resistance, our data suggest that GIP by stimulating osteopontin expression, also could promote insulin resistance in adipocytes...
  23. doi request reprint Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity
    Ulrika Andersson
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Mol Nutr Food Res 55:S290-3. 2011
    ..ARs were also shown to inhibit HSL activity in an in vitro assay...
  24. ncbi request reprint Chemical derivatization of phosphoserine and phosphothreonine containing peptides to increase sensitivity for MALDI-based analysis and for selectivity of MS/MS analysis
    Giorgio Arrigoni
    Department of Protein Technology, Lund University, Lund, Sweden
    Proteomics 6:757-66. 2006
    ..The optimisation of the approach is described for a standard model peptide and protein and then applied to phosphorylation analysis in two biologically derived proteins purified from different experimental systems...
  25. ncbi request reprint Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin
    Linda Härndahl
    Department of Cell and Molecular Biology, Biomedical Centre, C11, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 277:37446-55. 2002
    ..The findings suggest a significant role of PDE3B as an important regulator of insulin secretory processes...
  26. ncbi request reprint C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes
    Jie Mei
    Section for Molecular Signalling, Department of Cell and Molecular Biology, Lund University, Sweden
    Diabetes 51:631-7. 2002
    ..Furthermore, PDE3B is demonstrated to be a target for troglitazone action in adipocytes...
  27. doi request reprint Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties
    Jessica Nilsson
    Chemical Physics, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden
    J Inorg Biochem 105:1795-800. 2011
    ..The speciations of complexes 1 and 2 were studied over the pH range 2-10. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect...
  28. ncbi request reprint Ser-474 is the major target of insulin-mediated phosphorylation of protein kinase B beta in primary rat adipocytes
    Olga Göransson
    Section for Molecular Signalling, Department of Cell and Molecular Biology, Lund University, BMC, C11, S 221 84 Lund, Sweden
    Cell Signal 14:175-82. 2002
    ....
  29. ncbi request reprint Superantigen activates the gp130 receptor on adipocytes resulting in altered adipocyte metabolism
    Elin Banke
    Department of Experimental Medical Science, Lund University, BMC, 221 84 Lund, Sweden Electronic address
    Metabolism 63:831-40. 2014
    ....
  30. pmc Link between GIP and osteopontin in adipose tissue and insulin resistance
    Emma Ahlqvist
    Department of Clinical Sciences, Diabetes, and Endocrinology, University Hospital Malmo, Lund University, Malmo, Sweden
    Diabetes 62:2088-94. 2013
    ..Carriers of the GIPR rs10423928 A allele showed protective properties via reduced GIP effects. Identification of this unprecedented link between GIP and OPN in adipose tissue might open new avenues for therapeutic interventions...
  31. doi request reprint Cell-cell communication between adipocytes and pancreatic beta-cells in acoustically levitated droplets
    Sabina Santesson
    Pure and Applied Biochemistry, Center for Chemistry and Chemical Engineering, Lund University, P O Box 124, SE 221 00 Lund, Sweden
    Integr Biol (Camb) 1:595-601. 2009
    ..The results show the applicability of the airborne analytical system for single cell analysis and for cell-cell communication studies as well as the potential for future analysis directly from human cells obtained from clinical biopsies...
  32. ncbi request reprint Macroporous gel particles as robust macroporous matrices for cell immobilization
    Fatima M Plieva
    Department of Biotechnology, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden
    Biotechnol J 3:410-7. 2008
    ..High retained activity of yeast (77-92%) and Escherichia coli (50-91%) cells immobilized in MGs after drying and storage in the dried state was due to the high structural stability and heterogeneous porous structure of the MGs...
  33. ncbi request reprint Perilipin and adipophilin expression in lipid loaded macrophages
    Jenny Persson
    Experimental Cardiovascular Research, Department of Clinical Sciences Malmo, Lund University, Clinical Research Centre 91 12, UMAS Ing 72, 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 363:1020-6. 2007
    ..This protein expression pattern may hinder lipid turnover in macrophage foam cells, thereby increasing lipid content of atherosclerotic plaques...