Bjorn Dahlback

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. pmc Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus
    Carl Ekman
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Skane University Hospital, Malmo, Sweden
    Rheumatology (Oxford) 50:1064-9. 2011
  2. pmc Gas6 and the receptor tyrosine kinase Axl in clear cell renal cell carcinoma
    Anna Gustafsson
    Department of Laboratory Medicine, Section for Clinical Chemistry, University Hospital Malmo, Lund University, Malmo, Sweden
    PLoS ONE 4:e7575. 2009
  3. pmc Decreased plasma concentrations of apolipoprotein M in sepsis and systemic inflammatory response syndromes
    Sunil B Kumaraswamy
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Skane University Hospital, Entrance 46, Malmo, SE 20502, Sweden
    Crit Care 16:R60. 2012
  4. ncbi request reprint Early days of APC resistance and FV Leiden
    Bjorn Dahlback
    Department of Laboratory Medicine, Section of Clinical Chemistry, Lund University, The Wallenberg Laboratory, MAS, SE 205 02 Malmo, Sweden
    Hamostaseologie 28:103-9. 2008
  5. ncbi request reprint Advances in understanding pathogenic mechanisms of thrombophilic disorders
    Bjorn Dahlback
    Department of Laboratory Medicine, Section of Clinical Chemistry, Lund University, University Hospital Malmo, Malmo, Sweden
    Blood 112:19-27. 2008
  6. pmc Human activated protein C variants in a rat model of arterial thrombosis
    Karl Malm
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, SE 20502 Malmo, Sweden
    Thromb J 6:16. 2008
  7. ncbi request reprint The tale of protein S and C4b-binding protein, a story of affection
    Bjorn Dahlback
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, Wallenberg laboratory 6th floor, University Hospital, Malmo, SE 20502 Malmo, Sweden
    Thromb Haemost 98:90-6. 2007
  8. ncbi request reprint Apolipoprotein M--a novel player in high-density lipoprotein metabolism and atherosclerosis
    Bjorn Dahlback
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital, Malmo, Sweden
    Curr Opin Lipidol 17:291-5. 2006
  9. doi request reprint Apolipoprotein M affecting lipid metabolism or just catching a ride with lipoproteins in the circulation?
    B Dahlback
    Department of Laboratory Medicine, University Hospital, University of Lund, Malmo, Sweden
    Cell Mol Life Sci 66:559-64. 2009
  10. ncbi request reprint Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition
    Bjorn Dahlback
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 25:1311-20. 2005

Collaborators

Detail Information

Publications82

  1. pmc Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus
    Carl Ekman
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Skane University Hospital, Malmo, Sweden
    Rheumatology (Oxford) 50:1064-9. 2011
    ..We have recently developed immunological methods to quantify the vitamin-K-dependent protein Gas6 and its soluble receptor sAxl in human plasma, which we have used to investigate the role of Gas6 and soluble Axl in SLE...
  2. pmc Gas6 and the receptor tyrosine kinase Axl in clear cell renal cell carcinoma
    Anna Gustafsson
    Department of Laboratory Medicine, Section for Clinical Chemistry, University Hospital Malmo, Lund University, Malmo, Sweden
    PLoS ONE 4:e7575. 2009
    ..We have recently found that the expression of the receptor tyrosine kinase Axl in the RCC tumors independently correlates with survival of the patients...
  3. pmc Decreased plasma concentrations of apolipoprotein M in sepsis and systemic inflammatory response syndromes
    Sunil B Kumaraswamy
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Skane University Hospital, Entrance 46, Malmo, SE 20502, Sweden
    Crit Care 16:R60. 2012
    ....
  4. ncbi request reprint Early days of APC resistance and FV Leiden
    Bjorn Dahlback
    Department of Laboratory Medicine, Section of Clinical Chemistry, Lund University, The Wallenberg Laboratory, MAS, SE 205 02 Malmo, Sweden
    Hamostaseologie 28:103-9. 2008
    ..This review is a personal historical annotation about the early days of APC resistance...
  5. ncbi request reprint Advances in understanding pathogenic mechanisms of thrombophilic disorders
    Bjorn Dahlback
    Department of Laboratory Medicine, Section of Clinical Chemistry, Lund University, University Hospital Malmo, Malmo, Sweden
    Blood 112:19-27. 2008
    ....
  6. pmc Human activated protein C variants in a rat model of arterial thrombosis
    Karl Malm
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, SE 20502 Malmo, Sweden
    Thromb J 6:16. 2008
    ..Activated protein C (APC) inhibits coagulation by degrading activated factor V (FVa) and factor VIII (FVIIIa), protein S (PS) functioning as a cofactor to APC...
  7. ncbi request reprint The tale of protein S and C4b-binding protein, a story of affection
    Bjorn Dahlback
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, Wallenberg laboratory 6th floor, University Hospital, Malmo, SE 20502 Malmo, Sweden
    Thromb Haemost 98:90-6. 2007
  8. ncbi request reprint Apolipoprotein M--a novel player in high-density lipoprotein metabolism and atherosclerosis
    Bjorn Dahlback
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital, Malmo, Sweden
    Curr Opin Lipidol 17:291-5. 2006
    ..The purpose is to review recent information on the unusual structural properties of apolipoprotein M and its possible role in formation of pre-beta high-density lipoprotein and reverse cholesterol metabolism...
  9. doi request reprint Apolipoprotein M affecting lipid metabolism or just catching a ride with lipoproteins in the circulation?
    B Dahlback
    Department of Laboratory Medicine, University Hospital, University of Lund, Malmo, Sweden
    Cell Mol Life Sci 66:559-64. 2009
    ..Experiments in transgenic mice suggested apoM to have antiatherogenic properties; possible mechanisms include increased formation of pre-ss HDL, enhanced cholesterol mobilization from foam cells, and increased antioxidant properties...
  10. ncbi request reprint Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition
    Bjorn Dahlback
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 25:1311-20. 2005
    ..The molecular recognition of the protein C system is progressively being unraveled, giving us new insights into this fascinating and intricate molecular scenario at the atomic level...
  11. doi request reprint C4b-binding protein: a forgotten factor in thrombosis and hemostasis
    Bjorn Dahlback
    Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, Wallenberg Laboratory, Skane University Hospital, Malmo, Sweden
    Semin Thromb Hemost 37:355-61. 2011
    ..This review summarizes the current knowledge on C4BP with respect to its association with thrombosis and hemostasis...
  12. doi request reprint Coagulation and inflammation--close allies in health and disease
    Bjorn Dahlback
    Lund University, University Hospital, Malmo, Sweden
    Semin Immunopathol 34:1-3. 2012
    ..Dysregulation of the delicate balance between these systems contributes to the pathogenesis of many diseases...
  13. doi request reprint Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va
    Sinh Tran
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, SE 205 02 Malmo, Sweden
    J Biol Chem 283:6648-55. 2008
    ..Release of products of prothrombin activation from the prothrombinase complex would alleviate the protection, allowing APC-mediated inactivation of FVa...
  14. ncbi request reprint Factor V New Brunswick: Ala221Val associated with FV deficiency reproduced in vitro and functionally characterized
    Marten Steen
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, Sweden
    Blood 102:1316-22. 2003
    ..Rather, the Ala221Val substitution appears to interfere with the stability of the activated FVa mutant, the reduced stability possibly explaining the deficiency symptoms associated with the mutation...
  15. pmc Mapping of the factor Xa binding site on factor Va by site-directed mutagenesis
    Marten Steen
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, The Wallenberg Laboratory, MAS, SE 205 02 Malmo, Sweden
    J Biol Chem 283:20805-12. 2008
    ..These residues form an elongated charged factor Xa binding cluster on the factor Va surface...
  16. ncbi request reprint Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va
    Eva A Norstrøm
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, SE 205 02 Malmo, Sweden
    J Biol Chem 281:31486-94. 2006
    ....
  17. ncbi request reprint Functional properties of recombinant factor V mutated in a potential calcium-binding site
    Kristoffer W Sørensen
    Department of Clinical Chemistry, Lund University, Malmo University Hospital, Malmo, Sweden
    Biochemistry 43:5803-10. 2004
    ..We propose that the introduced substitutions disrupt the calcium-binding site in FV, thereby yielding a FV molecule that rapidly loses activity following thrombin-catalyzed activation most likely via dissociation of the HC and LC...
  18. ncbi request reprint Defining the factor Xa-binding site on factor Va by site-directed glycosylation
    Marten Steen
    Department of Clinical Chemistry, Division of Laboratory Medicine, Lund University, The Wallenberg Laboratory, Malmo General Hospital, Malmo SE 205 02, Sweden
    J Biol Chem 277:50022-9. 2002
    ..FXa complex assembly...
  19. doi request reprint Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival
    Anna Gustafsson
    Lund University, Department of Laboratory Medicine, Sections for Clinical Chemistry, University Hospital Malmo, Malmo SE 205 02, Sweden
    Clin Cancer Res 15:4742-9. 2009
    ..Overexpression of the receptor tyrosine kinase Axl is implicated in several cancers. Therefore, we conducted this study to determine the expression of Axl and its ligand Gas6 in various renal cell carcinoma (RCC) types and in oncocytoma...
  20. ncbi request reprint Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding
    Yong Hui Sun
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
    Blood 101:2277-84. 2003
    ..The unique properties of QGNSEDY-APC suggest this APC variant possibly to have greater therapeutic potential than WT APC...
  21. ncbi request reprint Anionic phospholipids lose their procoagulant properties when incorporated into high density lipoproteins
    Cecilia Oslakovic
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, SE 20502 Malmo, Sweden
    J Biol Chem 284:5896-904. 2009
    ..This anionic phospholipid scavenger function may be an important mechanism to control the exposure of such phospholipids to circulating blood and thereby prevent inappropriate stimulation of blood coagulation...
  22. ncbi request reprint Mutations in alpha-chain of C4BP that selectively affect its factor I cofactor function
    Anna M Blom
    Lund University Department of Clinical Chemistry, University Hospital Malmo, The Wallenberg Laboratory, S 205 02 Malmo, Sweden and INSERM U428, Universite Paris V, Paris 75006, France
    J Biol Chem 278:43437-42. 2003
    ..It appears that C4b and C3b do not undergo the same conformational changes upon binding to the C4BP mutants as during the interaction with the wild type C4BP, which then results in the observed loss of the cofactor activity...
  23. pmc Reevaluation of the role of HDL in the anticoagulant activated protein C system in humans
    Cecilia Oslakovic
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
    J Clin Invest 120:1396-9. 2010
    ..These results demonstrate that HDL does not stimulate the APC/protein S effect and that the activity previously reported to be a property of HDL is instead caused by contaminating negatively charged phospholipid membranes...
  24. ncbi request reprint Functions of human complement inhibitor C4b-binding protein in relation to its structure
    Anna M Blom
    Lund University, University Hospital Malmo, S 205 02 Malmo, Sweden
    Arch Immunol Ther Exp (Warsz) 52:83-95. 2004
    ....
  25. ncbi request reprint Structural requirements of anticoagulant protein S for its binding to the complement regulator C4b-binding protein
    Tusar Kanti Giri
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, S 20502 Malmo, Sweden
    J Biol Chem 277:15099-106. 2002
    ..A recently developed three-dimensional model of the sex hormone-binding globulin-like region of protein S was used to analyze available experimental data...
  26. pmc Structural stability and heat-induced conformational change of two complement inhibitors: C4b-binding protein and factor H
    Lena Kask
    Lund University, The Wallenberg Laboratory, Department of Clinical Chemistry, University Hospital Malmo, S 205 02 Malmo, Sweden
    Protein Sci 13:1356-64. 2004
    ..These findings are of interest because CCP-containing complement inhibitors have been proposed as clinical agents to be used to control unwanted complement activation that contributes to many diseases...
  27. ncbi request reprint Factor V and thrombotic disease: description of a janus-faced protein
    Gerry A F Nicolaes
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital Malmo, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 22:530-8. 2002
    ..This review gives a description of the dualistic character of FV and describes the gene-gene and gene-environment interactions that are important for the involvement of FV in the etiology of venous thromboembolism...
  28. doi request reprint Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia
    Josefin Ahnström
    Lund University, Department of Laboratory Medicine, Division of Clinical Chemistry, Wallenberg Laboratory, Entrance 46, Floor 6, University Hospital, Malmo, S 20502 Malmo, Sweden
    Clin Biochem 43:599-603. 2010
    ..Apolipoproteins affect development of atherosclerosis, but their involvement in the pathogenesis of critical limb ischemia (CLI), a severe form of atherosclerosis, has not previously been examined...
  29. pmc Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer
    Danuta Martuszewska
    Department of Laboratory Medicine, Section for Clinical Chemistry, Lund University, University Hospital Malmo, Malmo, Sweden
    PLoS ONE 4:e4350. 2009
    ..Here, we have for the first time evaluated the significance of all four Tensins in a study of human renal cell carcinoma (RCC), as well as probed the biological function of Tensin3...
  30. ncbi request reprint The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases
    Sassan Hafizi
    Department of Laboratory Medicine, Section for Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Int J Biochem Cell Biol 37:2344-56. 2005
    ..This novel insight into the signalling interactions of Axl and Sky may shed further light on their suspected roles in tumourigenesis, inflammation as well as other cell proliferative diseases...
  31. ncbi request reprint Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M
    Josefin Ahnström
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, SE 20502 Malmo, Sweden
    J Lipid Res 48:1754-62. 2007
    ..In conclusion, the binding of retinol and retinoic acid supports the hypothesis that apoM is a lipocalin. The physiological relevance of this binding has yet to be elucidated...
  32. ncbi request reprint Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis
    Marten Steen
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, Sweden
    Blood 103:3381-7. 2004
    ..These findings explain the association of the FV-Ile359Thr mutation with thrombosis...
  33. ncbi request reprint Enhanced rate of cleavage at Arg-306 and Arg-506 in coagulation factor Va by Gla domain-mutated human-activated protein C
    Yong Hui Sun
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, Malmo, S 20502 Malmo, Sweden
    J Biol Chem 279:47528-35. 2004
    ..The results obtained with QGNSEDY-APC provide insights into the importance of the APC-phospholipid interaction for the APC-mediated cleavages at Arg-306 and Arg-506 in FVa...
  34. doi request reprint Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia
    Carl Ekman
    Lund University, Department of Laboratory Medicine, Clinical Chemistry, Wallenberg Laboratory, Entrance 46, Floor 6, University Hospital, SE 20502 Malmo, Sweden
    Clin Biochem 43:873-6. 2010
    ..Gas6-mediated Axl-signaling influences endothelial activation, neointima formation and immune regulation. Axl can be cleaved and soluble Axl (sAxl) is detectable in circulation...
  35. doi request reprint Individual domains of Tensin2 exhibit distinct subcellular localisations and migratory effects
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Int J Biochem Cell Biol 42:52-61. 2010
    ..In conclusion, our results indicate that differential proteolytic cleavage of Tensin2 can liberate domains with discrete localisations and functions, which has implications for the role of Tensins in cancer cell survival and motility...
  36. ncbi request reprint The C4b-binding protein-protein S complex inhibits the phagocytosis of apoptotic cells
    Lena Kask
    Lund University, The Wallenberg Laboratory, Department of Clinical Chemistry, University Hospital Malmö S 205 02 Malmö, Sweden
    J Biol Chem 279:23869-73. 2004
    ..Although the presence of the C4BP-PS complex on apoptotic cells may lead to decreased phagocytosis, it may still be beneficial to the host, since it could prevent secondary necrosis because it inhibits further complement attack...
  37. doi request reprint Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 399:396-401. 2010
    ..In summary, we provide evidence that Tensin2, in addition to regulating cytoskeletal dynamics, influences phosphoinositide-Akt signalling through its PTPase domain...
  38. ncbi request reprint C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration
    Sassan Hafizi
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, Malmo, Sweden
    FASEB J 19:971-3. 2005
    ..However, the particular domain organization of C1-TEN may enable it to regulate RTK and other signaling complexes that are linked to Akt/PKB signaling in a unique manner...
  39. ncbi request reprint Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor Va
    Eva A Norstrøm
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Sweden
    J Biol Chem 278:24904-11. 2003
    ..These results provide new insights into the mechanism of APC cofactor activity of protein S and the importance of phospholipid composition...
  40. ncbi request reprint Role of CCP2 of the C4b-binding protein beta-chain in protein S binding evaluated by mutagenesis and monoclonal antibodies
    Joanna H Webb
    Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, Sweden
    Eur J Biochem 270:93-100. 2003
    ..Taken together, the results suggest that the role of CCP2 in protein S binding is to orient and stabilize CCP1 rather than to be directly part of the binding site...
  41. ncbi request reprint Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells
    Joanna H Webb
    Division of Clinical Chemistry, Department of Laboratory Medicine, University Hospital Malmo, Lund University, Sweden
    J Immunol 169:2580-6. 2002
    ....
  42. ncbi request reprint Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, Wallenberg Laboratory, University Hospital Malmo, Sweden
    FEBS J 273:5231-44. 2006
    ..Further knowledge of this exquisite ligand-receptor system and the circumstances of its activation should provide the basis for development of novel therapies for the above diseases...
  43. ncbi request reprint C4b-binding protein and factor H compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack
    Leendert A Trouw
    Department of Laboratory Medicine, University Hospital Malmo, 5 20502 Malmö, Sweden
    J Biol Chem 282:28540-8. 2007
    ..In conclusion, during late apoptosis, cells acquire fluid phase complement inhibitors that compensate for the down-regulation of m-C-Reg and protect against excessive complement activation and lysis...
  44. ncbi request reprint Functional characterization of recombinant FV Hong Kong and FV Cambridge
    Eva Norstrøm
    Department of Clinical Chemistry, Division of Laboratory Medicine, Lund University, University Hospital Malmo, Sweden
    Blood 100:524-30. 2002
    ..In conclusion, we demonstrate that recombinant FV Cambridge and Hong Kong behave identically in in vitro assays and provide a mechanism for the low thrombotic risk associated with these FV mutations...
  45. ncbi request reprint The binding of protein S and the protein S-C4BP complex to neutrophils is apoptosis dependent
    Joanna H Webb
    Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, Sweden
    Blood Coagul Fibrinolysis 14:355-9. 2003
    ..Thus, we conclude that binding of protein S and the C4BP-protein S complex to neutrophils is not cell specific, but rather apoptosis dependent...
  46. pmc Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis
    Jun Wu
    Department of Laboratory Medicine, Section of Clinical Chemistry, Lund University, Wallenberg Laboratory, Skane University Hospital, Södra Förstadsgatan 101, Malmo, SE 205 02, Sweden
    Arthritis Res Ther 13:R62. 2011
    ..The objective of this study was to elucidate whether the plasma levels of soluble Mer (sMer) and Tyro3 (sTyro3) were increased in systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), or critical limb ischemia (CLI)...
  47. doi request reprint Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl as markers of large abdominal aortic aneurysms
    Carl Ekman
    Lund University, Department of Laboratory Medicine, Clinical Chemistry, Wallenberg Laboratory, Malmö Universitary Hospital, Entrance 46, Floor 6, SE 20502 Malmo, Sweden
    Clin Biochem 43:110-4. 2010
    ..The aim of this study was to determine plasma concentrations of Gas6 and sAxl in patients with abdominal aortic aneurysms (AAA) and to evaluate if Gas6 and sAxl can be used as biomarkers...
  48. ncbi request reprint Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M
    Kirsten Faber
    Department of Clinical Biochemistry, Univeristy of Lund, University Hospital, Malmo, Sweden
    Mol Endocrinol 20:212-8. 2006
    ..The results suggest that apoM binds to megalin and that megalin-mediated endocytosis in kidney proximal tubules prevents apoM excretion in the urine...
  49. doi request reprint Apolipoprotein M associates to lipoproteins through its retained signal peptide
    Olof Axler
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
    FEBS Lett 582:826-8. 2008
    ..In contrast, the size of the Q22A mutant corresponded to free, unassociated apoM. This strongly indicates that the signal peptide is indeed necessary for apoM's ability to associate with lipid...
  50. ncbi request reprint Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts
    Jonas Stenhoff
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, Malmo SE 205 02, Sweden
    Biochem Biophys Res Commun 319:871-8. 2004
    ..These findings implicate vitamin K-dependent biochemical reactions in growth processes in development and in disease...
  51. doi request reprint Polystyrene nanoparticles affecting blood coagulation
    Cecilia Oslakovic
    Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, Skane University Hospital, Malmo, Sweden
    Nanomedicine 8:981-6. 2012
    ..In contrast, carboxyl-modified NPs were able to act as a surface for activation of the intrinsic pathway of blood coagulation in plasma. These results highlight the influence of NPs on a biologically important pathway...
  52. ncbi request reprint Antithrombotic and anticoagulant effects of wild type and Gla-domain mutated human activated protein C in rats
    Karl Malm
    Department of Clinical Sciences, Division of Reconstructive Surgery, University Hospital, Malmo, Sweden
    Thromb Res 120:531-9. 2007
    ..Compared to the control group, none of the hAPC preparations had significant antithrombotic effect or increased arteriotomy bleeding...
  53. doi request reprint Mouse recombinant protein C variants with enhanced membrane affinity and hyper-anticoagulant activity in mouse plasma
    Michael J Krisinger
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
    FEBS J 276:6586-602. 2009
    ..This mouse APC variant will be attractive to use in mouse models aiming to elucidate the in vivo effects of APC variants with enhanced anticoagulant activity...
  54. ncbi request reprint Use of selective factor V Leiden screening in pregnancy to identify candidates for anticoagulants
    Pelle G Lindqvist
    Department of Obstetrics and Gynecology, Lund University, University Hospital, Malmo, Sweden
    Obstet Gynecol 100:332-6. 2002
    ..However, selective screening for factor V Leiden has not been evaluated previously for identifying women who might benefit from anticoagulant prophylaxis during pregnancy...
  55. ncbi request reprint Analysis of Gas6 in human platelets and plasma
    Istvan Balogh
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, Sweden
    Arterioscler Thromb Vasc Biol 25:1280-6. 2005
    ..The aim of this study was to investigate the presence of Gas6 in human platelets and plasma and determine its role in platelet function...
  56. doi request reprint Plasma concentrations of apolipoproteins A-I, B and M in patients with abdominal aortic aneurysms
    Josefin Ahnström
    Wallenberg Laboratory, Department of Laboratory Medicine, Clinical Chemistry, Lund University, SE 205 02 Malmo, Sweden
    Clin Biochem 43:407-10. 2010
    ..The aim was to investigate whether apoA-I, apoB and apoM are independently associated with AAA...
  57. ncbi request reprint Characterization of apoM in normal and genetically modified mice
    Kirsten Faber
    Division of Clinical Chemistry, Department of Laboratory Medicine, University of Lund, University Hospital Malmo, S 20502 Malmo, Sweden
    J Lipid Res 45:1272-8. 2004
    ..The substantially decreased apoM levels in apoA-I-deficient mice suggest a connection between apoM and apoA-I metabolism...
  58. ncbi request reprint Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases
    Sassan Hafizi
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Cytokine Growth Factor Rev 17:295-304. 2006
    ..In this way, we hope to gain a greater understanding of the mechanisms that set each of them apart, and that relay their associated functions...
  59. doi request reprint Structural changes in apolipoproteins bound to nanoparticles
    Risto Cukalevski
    Biochemistry and Structural Biology, Lund University, Lund, Sweden
    Langmuir 27:14360-9. 2011
    ..Thus, surface charge is a critical parameter for predicting structural changes in adsorbed proteins, yet the effect is specific for each protein...
  60. doi request reprint Complete high-density lipoproteins in nanoparticle corona
    Erik Hellstrand
    Biophysical Chemistry, Lund University, Sweden
    FEBS J 276:3372-81. 2009
    ..Apolipoproteins have been identified as binding to many other nanoparticles, suggesting that lipid and lipoprotein binding is a general feature of nanoparticles under physiological conditions...
  61. ncbi request reprint Blood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis of bleeding and thrombotic diseases
    Bjorn Dahlback
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
    J Intern Med 257:209-23. 2005
    ..Genetic or acquired disturbances of the natural balance between the pro- and anticoagulant systems may result in bleeding or thrombotic diseases...
  62. ncbi request reprint Large deletions of the PROS1 gene in a large fraction of mutation-negative patients with protein S deficiency
    Anna M Johansson
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    Thromb Haemost 94:951-7. 2005
    ..In conclusion: Large deletions of PROS1 are relatively common in protein S deficiency patients and screening for large deletions in PROS1 mutation-negative individuals are therefore warranted...
  63. ncbi request reprint The anticoagulant protein C pathway
    Bjorn Dahlback
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, SE 205 02 Malmo, Sweden
    FEBS Lett 579:3310-6. 2005
    ..Genetic defects affecting the protein C system are the most common risk factors of venous thrombosis. The protein C system contains multi-domain proteins, the molecular recognition of which will be reviewed...
  64. ncbi request reprint Prevention of thrombosis following deep arterial injury in rats by bovine activated protein C requiring co-administration of bovine protein S
    Karl Malm
    Department of Plastic and Reconstructive Surgery, University Hospital Malmo, S 205 02 Malmo, Sweden
    Thromb Haemost 90:227-34. 2003
    ....
  65. ncbi request reprint An ELISA for apolipoprotein M reveals a strong correlation to total cholesterol in human plasma
    Olof Axler
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital Malmo, SE 20502 Malmo, Sweden
    J Lipid Res 48:1772-80. 2007
    ..In conclusion, a sandwich ELISA for the measurement of apoM in human plasma shows that apoM concentration is strongly correlated to total cholesterol in healthy individuals...
  66. ncbi request reprint Complement inhibitor C4b-binding protein-friend or foe in the innate immune system?
    Anna M Blom
    The Wallenberg Laboratory, Department of Clinical Chemistry, University Hospital Malmo, Lund University, S 205 02 Malmo, Sweden
    Mol Immunol 40:1333-46. 2004
    ..This contributes to the serum resistance and the pathogenicity of these bacteria. In this review, the structural requirements and functional importance of the interactions between C4BP and its various ligands are discussed...
  67. ncbi request reprint Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin
    Sassan Hafizi
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 299:793-800. 2002
    ..In summary, we have identified a novel multi-domain intracellular protein that interacts with Axl and which may furthermore be involved in other signal transduction pathways...
  68. pmc Plasma concentrations of Gas6 (growth arrest specific protein 6) and its soluble tyrosine kinase receptor sAxl in sepsis and systemic inflammatory response syndromes
    Carl Ekman
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Skane University Hospital, Entrance 46, SE 20502 Malmo, Sweden
    Crit Care 14:R158. 2010
    ..The soluble of form Axl (sAxl), which is present in plasma, can bind Gas6 and inhibit Axl-mediated cell signalling...
  69. doi request reprint Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies
    Josefin Ahnström
    Department of Laboratory Medicine, Clinical Chemistry, University of Lund, University Hospital, Malmo, Sweden
    J Lipid Res 49:1912-7. 2008
    ..97 (0.74-1.27) and 0.92 (0.84-1.02), respectively]. In conclusion, no association between apoM and CHD could be found in this study...
  70. ncbi request reprint CCP1-4 of the C4b-binding protein alpha-chain are required for factor I mediated cleavage of complement factor C3b
    Anna M Blom
    The Wallenberg Laboratory, Department of Clinical Chemistry, Lund University, University Hospital Malmo, S 205 02 Malmo, Sweden
    Mol Immunol 39:547-56. 2003
    ..However, in both cases 1,000-fold molar excess of C4BP over factor H (FH), well known inhibitor of the alternative pathway, was required to obtain the same effect...
  71. ncbi request reprint HDL stimulates apoM secretion
    Josefin Ahnström
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, Malmo, SE 20502 Malmo, Sweden
    Protein Pept Lett 17:1285-9. 2010
    ..In conclusion, due to its retained signal peptide, apoM is poorly secreted unless HDL is either coexpressed or added to the culture medium...
  72. ncbi request reprint Carriership of Factor V Leiden and evolutionary selection advantage
    Pelle G Lindqvist
    Clinical Sciences, Malmo, Obstetrics and Gynecology, Sweden
    Curr Med Chem 15:1541-4. 2008
    ..In addition, FVL carriers possibly have a survival advantage during sepsis. In conclusion, the high prevalence of FVL may be the result of one or more evolutionary selection advantages...
  73. pmc Dependence on vitamin K-dependent protein S for eukaryotic cell secretion of the beta-chain of C4b-binding protein
    Sofia Carlsson
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Skane University Hospital, SE 205 02 Malmo, Sweden
    J Biol Chem 285:32038-46. 2010
    ..This provides an explanation for the decreased β-chain levels observed in PS-deficient patients...
  74. doi request reprint Plasma levels of apolipoprotein M in normal and complicated pregnancy
    Josefin Ahnström
    Department of Laboratory Medicine, University Hospital, Lund University, Malmo, Sweden
    Acta Obstet Gynecol Scand 89:1214-7. 2010
    ..77 micromol/l, 0.88 micromol/l at 40 gestational weeks, and 1.05 micromol/l in the postpartum period (p < 0.0001). No differences in plasma concentrations of apoM were found among the studied pregnancy complications...
  75. ncbi request reprint Thrombin-mediated proteolysis of factor V resulting in gradual B-domain release and exposure of the factor Xa-binding site
    Marten Steen
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, SE 205 02 Malmo, Sweden
    J Biol Chem 277:38424-30. 2002
    ..In conclusion, we demonstrate FV activation to be associated with the stepwise release of the B-domain, which results in a gradual exposure of the FXa-binding site...
  76. ncbi request reprint Diagnosing protein S deficiency: analytical considerations
    Kristina E M Persson
    Department of Clinical Chemistry, Lund University, University Hospital, SE 205 02 Malmo, Sweden
    Clin Lab 49:103-10. 2003
    ..Development of new methods and strict protocols for standardization and sample handling will considerably improve the ability to predict protein S deficiency...
  77. ncbi request reprint Molecular basis of quantitative factor V deficiency associated with factor V R2 haplotype
    Tomio Yamazaki
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital, Malmo, Sweden
    Blood 100:2515-21. 2002
    ....
  78. ncbi request reprint Reactions to awareness of activated protein C resistance carriership: a descriptive study of 270 women
    Pelle G Lindqvist
    Department of Obstetrics and Gynecology, University Hospital MAS, Malmo, Sweden
    Acta Obstet Gynecol Scand 82:467-70. 2003
    ..This is a heritable condition with a lifelong increased risk of venous thromboembolism. We performed this study to investigate women's reactions to their awareness of being APC-resistant and the consequences of this awareness...
  79. ncbi request reprint Progress in the understanding of the protein C anticoagulant pathway
    Bjorn Dahlback
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, Malmo, Sweden
    Int J Hematol 79:109-16. 2004
    ..APC has emerged in recent years as a useful therapeutic compound in the treatment of severe septic shock. The beneficial effect of APC is believed be due to both its anticoagulant and its anti-inflammatory properties...
  80. ncbi request reprint Low-molecular-weight heparin (dalteparin) effectively prevents thrombosis in a rat model of deep arterial injury
    Karl Malm
    Department of Plastic and Reconstructive Surgery, University Hospital, Malmo, Sweden
    Plast Reconstr Surg 111:1659-66. 2003
    ..In contrast to heparin, dalteparin did not increase the surgical bleeding, which indicates that dalteparin instead of heparin can be used to prevent thrombosis in microvascular surgery...
  81. ncbi request reprint The importance of the protein C system in the pathogenesis of venous thrombosis
    Bjorn Dahlback
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, Malmo, SE 205 02, Sweden
    Hematology 10:138-9. 2005
  82. ncbi request reprint Structural requirements for the intracellular subunit polymerization of the complement inhibitor C4b-binding protein
    Lena Kask
    The Wallenberg Laboratory, Department of Clinical Chemistry, Lund University, University Hospital, SE 205 02 Malmo, Sweden
    Biochemistry 41:9349-57. 2002
    ..Gel filtration analysis of these variants demonstrated the whole alpha-helix region to be required for the formation of stable polymers of C4BP, which were further stabilized by the formation of disulfide bonds...