Affiliation: Lund University
- Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritisA Corthay
Department of Cell and Molecular Biology, Lund University, Sweden
Eur J Immunol 28:2580-90. 1998..We conclude that this glycopeptide is immunodominant in CIA and that posttranslational modifications of CII create new T cell determinants that generate a diverse TCR repertoire...
- Role of glycopeptide-specific T cells in collagen-induced arthritis: an example how post-translational modification of proteins may be involved in autoimmune diseaseA Corthay
Section for Medical Inflammation Research, Lund University, Sweden
Ann Med 33:456-65. 2001..These data open the possibility that outoimmune disease may be caused by the creation of new epitopes by posttranslational modification of proteins under circumstances such as trauma, inflammation or ageing...
- Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) miceA Corthay
Department of Cell and Molecular Biology, Section for Medical Inflammation Research, Lund University, Solvegatan 19, 221 00 Lund, Sweden
Int Immunol 11:1065-73. 1999..We conclude that alphabeta T cells are necessary for CIA development and for an IgG response towards CII, whereas gammadelta T cells are neither necessary nor sufficient for development of CIA...