M A Cenci

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Transcription factors involved in the pathogenesis of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease
    M A Cenci
    Department of Physiological Sciences, Lund University, Lund, Sweden
    Amino Acids 23:105-9. 2002
  2. ncbi request reprint Persistent changes in striatal gene expression induced by long-term L-DOPA treatment in a rat model of Parkinson's disease
    J E Westin
    Department of Physiological Sciences, Section of Neurobiology, Lund University, Wallenberg Neuroscience Centre, BMC A11, S-221 84 Lund, Sweden
    Eur J Neurosci 14:1171-6. 2001
  3. doi request reprint Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease
    E L Lane
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
    Neurobiol Dis 32:220-8. 2008
  4. doi request reprint Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats
    E L Lane
    Neuronal Survival Unit, Department of Experimental Medical Science, Lund, Sweden
    Exp Neurol 219:355-8. 2009
  5. ncbi request reprint cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum
    M Andersson
    Department of Physiological Sciences, Neurobiology Division, Lund University, Wallenberg Neuroscience Centre, 221 84 Lund, Sweden
    J Neurosci 21:9930-43. 2001
  6. ncbi request reprint Alterations in cortical and basal ganglia levels of opioid receptor binding in a rat model of l-DOPA-induced dyskinesia
    P A Johansson
    Department of Physiological Sciences, Neurobiology Division, Wallenberg Neuroscience Centre, University of Lund, , Lund, S-223 62, Sweden
    Neurobiol Dis 8:220-39. 2001
  7. ncbi request reprint The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat
    E L Lane
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Neurobiol Dis 22:334-45. 2006
  8. ncbi request reprint Putaminal upregulation of FosB/ΔFosB-like immunoreactivity in Parkinson's disease patients with dyskinesia
    H S Lindgren
    Lund University, Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Sciences, Lund, Sweden
    J Parkinsons Dis 1:347-57. 2011
  9. ncbi request reprint Expression pattern of JunD after acute or chronic L-DOPA treatment: comparison with deltaFosB
    B Valastro
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, BMC F11, Lund 221 84, Sweden
    Neuroscience 144:198-207. 2007
  10. ncbi request reprint Cellular and behavioural effects of the adenosine A2a receptor antagonist KW-6002 in a rat model of l-DOPA-induced dyskinesia
    M Lundblad
    Department of Physiological Sciences, Wallenberg Neuroscience Centre, Neurobiology Division, Lund, Sweden
    J Neurochem 84:1398-410. 2003

Detail Information

Publications19

  1. ncbi request reprint Transcription factors involved in the pathogenesis of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease
    M A Cenci
    Department of Physiological Sciences, Lund University, Lund, Sweden
    Amino Acids 23:105-9. 2002
    ..Antisense-mediated knockdown of CREB (cyclic AMP response-element binding proteins) has however no effect. Our results identify fosB as a potential target for adjunctive antiparkinsonian therapies...
  2. ncbi request reprint Persistent changes in striatal gene expression induced by long-term L-DOPA treatment in a rat model of Parkinson's disease
    J E Westin
    Department of Physiological Sciences, Section of Neurobiology, Lund University, Wallenberg Neuroscience Centre, BMC A11, S-221 84 Lund, Sweden
    Eur J Neurosci 14:1171-6. 2001
    ....
  3. doi request reprint Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease
    E L Lane
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
    Neurobiol Dis 32:220-8. 2008
    ..These results indicate that an inflammatory response in and around grafted dopaminergic neurons is not sufficient to evoke dyskinetic behaviors in experimental models of PD...
  4. doi request reprint Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats
    E L Lane
    Neuronal Survival Unit, Department of Experimental Medical Science, Lund, Sweden
    Exp Neurol 219:355-8. 2009
    ....
  5. ncbi request reprint cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum
    M Andersson
    Department of Physiological Sciences, Neurobiology Division, Lund University, Wallenberg Neuroscience Centre, 221 84 Lund, Sweden
    J Neurosci 21:9930-43. 2001
    ..Moreover, our results reveal an unexpected alteration of nuclear signaling mechanisms in the parkinsonian striatum treated with l-DOPA, where AP-1 transcription factors appear to supersede CREB in the activation of CRE-containing genes...
  6. ncbi request reprint Alterations in cortical and basal ganglia levels of opioid receptor binding in a rat model of l-DOPA-induced dyskinesia
    P A Johansson
    Department of Physiological Sciences, Neurobiology Division, Wallenberg Neuroscience Centre, University of Lund, , Lund, S-223 62, Sweden
    Neurobiol Dis 8:220-39. 2001
    ....
  7. ncbi request reprint The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat
    E L Lane
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Neurobiol Dis 22:334-45. 2006
    ..In conclusion, robust and reproducible AIMs were evoked in rats with large grafts by blockade of monoamine reuptake. These AIMs may provide a new tool for assessing dyskinetic effects of neural grafting...
  8. ncbi request reprint Putaminal upregulation of FosB/ΔFosB-like immunoreactivity in Parkinson's disease patients with dyskinesia
    H S Lindgren
    Lund University, Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Sciences, Lund, Sweden
    J Parkinsons Dis 1:347-57. 2011
    ..The present findings support the hypothesis of an involvement of ΔFosB-related transcription factors in the molecular mechanisms of L-DOPA-induced dyskinesia. ..
  9. ncbi request reprint Expression pattern of JunD after acute or chronic L-DOPA treatment: comparison with deltaFosB
    B Valastro
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, BMC F11, Lund 221 84, Sweden
    Neuroscience 144:198-207. 2007
    ..The upregulation of deltaFosB protein, but not JunD, is likely to reflect an increased stability of the deltaFosB proteins without ongoing enhanced transcription of the encoding genes...
  10. ncbi request reprint Cellular and behavioural effects of the adenosine A2a receptor antagonist KW-6002 in a rat model of l-DOPA-induced dyskinesia
    M Lundblad
    Department of Physiological Sciences, Wallenberg Neuroscience Centre, Neurobiology Division, Lund, Sweden
    J Neurochem 84:1398-410. 2003
    ..Cotreatment with KW-6002 and L-DOPA potentiates the therapeutic effect but not the dyskinesiogenic potential of the latter drug...
  11. ncbi request reprint Role of striatal L-DOPA in the production of dyskinesia in 6-hydroxydopamine lesioned rats
    Manolo Carta
    Department of Exp Medical Science, Basal Ganglia Pathophysiology Unit, Lund University, Lund, Sweden
    J Neurochem 96:1718-27. 2006
    ..Individual differences in the central bioavailability of L-DOPA may provide a clue to the varying susceptibility to dyskinesia in Parkinson's disease...
  12. doi request reprint Advances in understanding L-DOPA-induced dyskinesia
    M A Cenci
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, S 221 84 Lund, Sweden
    Curr Opin Neurobiol 17:665-71. 2007
    ..Further research on L-DOPA-induced dyskinesia will contribute to a deeper understanding of the functional interplay between neurotransmitters and neuromodulators in the motor circuits of the basal ganglia...
  13. ncbi request reprint A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function
    M Lundblad
    Department of Physiological Sciences, Neurobiology Division, Wallenberg Neuroscience Centre, Lund University, S 223 62 Lund, Sweden
    Neurobiol Dis 16:110-23. 2004
    ..The mouse model of L-DOPA-induced dyskinesia will provide a useful tool to study the molecular determinants of this movement disorder in transgenic mice strains...
  14. ncbi request reprint Regulation of neuropeptide mRNA expression in the basal ganglia by intrastriatal and intranigral transplants in the rat Parkinson model
    C Winkler
    Lund University, Wallenberg Neuroscience Center, Department of Physiological Sciences, BMC A11, S 22184 Sweden
    Neuroscience 118:1063-77. 2003
    ..A full reconstruction of the nigrostriatal pathway or, alternatively, modulation of basal ganglia function by grafting in non-striatal regions may be required to further improve the functional outcome in the DA-denervated brain...
  15. ncbi request reprint Current options and future possibilities for the treatment of dyskinesia and motor fluctuations in Parkinson's disease
    M A Cenci
    Basal Ganglia Pathophysiology Unit, Dept Experimental Medical Science, Lund University, Sweden
    CNS Neurol Disord Drug Targets 10:670-84. 2011
    ....
  16. ncbi request reprint L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA
    M A Cenci
    Wallenberg Neuroscience Center, Institute of Physiology and Neuroscience, University of Lund, 223 62 Lund, Sweden
    Eur J Neurosci 10:2694-706. 1998
    ..Due to its treatment-dependent expression, and strong correlation with the associated dyskinetic symptoms, striatal PDyn mRNA, in particular, may play a role in the mechanisms of behavioural sensitization brought about by the drug...
  17. ncbi request reprint Time course of striatal DeltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment
    M Andersson
    Department of Physiological Sciences, Neurobiology Division, Lund University, Wallenberg Neuroscience Center, BMC A11, Sweden
    Eur J Neurosci 17:661-6. 2003
    ..In the dopamine-denervated striatum, these proteins may exert sustained effects on the expression of their target genes long after discontinuation of L-DOPA pharmacotherapy...
  18. ncbi request reprint Pharmacological validation of a mouse model of l-DOPA-induced dyskinesia
    M Lundblad
    Wallenberg Neuroscience Centre, Section of Basal Ganglia Pathophysiology, BMC A11, S 221 84 Lund, Sweden
    Exp Neurol 194:66-75. 2005
    ..The present data indicate that the mouse AIMs are indeed a functional equivalent of l-DOPA-induced dyskinesia...
  19. ncbi request reprint Effects of pulsatile L-DOPA treatment in the double lesion rat model of striatonigral degeneration (multiple system atrophy)
    N Stefanova
    Department of Neurology, University Hospital of Innsbruck, Innsbruck, Austria
    Neurobiol Dis 15:630-9. 2004
    ....