Manolo Carta

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Tryptophan-deficient diet increases the neurochemical and behavioral response to amphetamine
    Manolo Carta
    Department of Sciences Applied for Biosystems, Section of Physiology and Human Nutrition, University of Cagliari, Via Porcell 4, I-09124 Cagliari, Italy
    Brain Res 1094:86-91. 2006
  2. ncbi Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Prog Brain Res 172:465-78. 2008
  3. ncbi Involvement of the serotonin system in L-dopa-induced dyskinesias
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Parkinsonism Relat Disord 14:S154-8. 2008
  4. ncbi Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Brain 130:1819-33. 2007
  5. ncbi Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration
    Thomas Carlsson
    Department Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC D11, Lund, Sweden
    Brain 132:319-35. 2009
  6. ncbi Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease
    Eunju Shin
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
    Neurobiol Dis 47:393-406. 2012
  7. ncbi Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
    Ana Munoz
    Department of Experimental Medical Science, Neurobiology Unit, Wallenberg Neuroscience Center, University of Lund, Lund, Sweden
    Brain 131:3380-94. 2008
  8. ncbi Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Mov Disord 25:S174-9. 2010
  9. ncbi Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model
    Ana Munoz
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Exp Neurol 219:298-307. 2009
  10. ncbi Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
    Thomas Carlsson
    CNS Disease Modeling Unit, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    J Neurosci 27:8011-22. 2007

Collaborators

Detail Information

Publications22

  1. ncbi Tryptophan-deficient diet increases the neurochemical and behavioral response to amphetamine
    Manolo Carta
    Department of Sciences Applied for Biosystems, Section of Physiology and Human Nutrition, University of Cagliari, Via Porcell 4, I-09124 Cagliari, Italy
    Brain Res 1094:86-91. 2006
    ..These results indicate how response to psychostimulants might be altered in the presence of a tryptophan-deficient diet...
  2. ncbi Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Prog Brain Res 172:465-78. 2008
    ..Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication...
  3. ncbi Involvement of the serotonin system in L-dopa-induced dyskinesias
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Parkinsonism Relat Disord 14:S154-8. 2008
    ..These findings make the serotonin system an intriguing target for anti-dyskinetic therapies...
  4. ncbi Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Brain 130:1819-33. 2007
    ....
  5. ncbi Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration
    Thomas Carlsson
    Department Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC D11, Lund, Sweden
    Brain 132:319-35. 2009
    ....
  6. ncbi Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease
    Eunju Shin
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
    Neurobiol Dis 47:393-406. 2012
    ..Together, these results point to a critical role of both 5-HT(1) and D(2) receptors in the modulation of GID, and suggest that 5-HT neurons exert a modulatory role in the development of this side effect of neuronal transplantation...
  7. ncbi Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
    Ana Munoz
    Department of Experimental Medical Science, Neurobiology Unit, Wallenberg Neuroscience Center, University of Lund, Lund, Sweden
    Brain 131:3380-94. 2008
    ..Our results support the importance of a clinical investigation of the effect of 5-HT(1A) and 5-HT(1B) agonists, particularly in combination, in dyskinetic l-DOPA-treated Parkinson's disease patients...
  8. ncbi Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Mov Disord 25:S174-9. 2010
    ....
  9. ncbi Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model
    Ana Munoz
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Exp Neurol 219:298-307. 2009
    ....
  10. ncbi Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
    Thomas Carlsson
    CNS Disease Modeling Unit, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    J Neurosci 27:8011-22. 2007
    ..We conclude that serotonin neurons in the grafts are likely to have a detrimental effect on L-DOPA-induced dyskinesias in cases in which the grafts contain no or few dopamine neurons...
  11. ncbi Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats
    Tomas Bjorklund
    Department of Experimental Medical Science, Lund University, Brain Repair and Imaging in Neural Systems, Lund, Sweden
    J Neurochem 111:355-67. 2009
    ..Importantly, the BH4 synthesis from ectopic GCH1 expression was saturable, yielding optimal TH enzyme functionality between GCH1 : TH ratios of 1 : 3 and 1 : 7...
  12. ncbi Role of striatal L-DOPA in the production of dyskinesia in 6-hydroxydopamine lesioned rats
    Manolo Carta
    Department of Exp. Medical Science, Basal Ganglia Pathophysiology Unit, Lund University, Lund, Sweden
    J Neurochem 96:1718-27. 2006
    ..Individual differences in the central bioavailability of L-DOPA may provide a clue to the varying susceptibility to dyskinesia in Parkinson's disease...
  13. ncbi Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression
    Matthew Maingay
    Department of Experimental Medical Science, Section of Neuroscience, CNS Disease Modeling Unit, Lund University, Wallenberg Neuroscience Center, BMCA11, S 22184 Lund, Sweden
    Neurobiol Dis 23:522-32. 2006
    ....
  14. ncbi Amphetamine-induced rotation and L-DOPA-induced dyskinesia in the rat 6-OHDA model: a correlation study
    Elisabetta Tronci
    Wallenberg Neuroscience Center, Division of Neurobiology, Department of Experimental Medical Science, Lund University, Lund 221 84, Sweden
    Neurosci Res 73:168-72. 2012
    ..Moreover, SERT expression levels suggest that reduced striatal and pallidal serotonin innervation might have contributed to the lower dyskinesia levels observed in a subset of amphetamine-responsive rats...
  15. ncbi Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease
    Tomas Bjorklund
    Brain Repair and Imaging in Neural Systems, 22184 Lund, Sweden
    Brain 133:496-511. 2010
    ..Taken together these results show that vector-mediated continuous 3,4-dihydroxyphenylalanine delivery has the potential to provide significant symptomatic relief even in advanced stages of Parkinson's disease...
  16. ncbi Role of Serotonin Neurons in L-DOPA- and Graft-Induced Dyskinesia in a Rat Model of Parkinson's Disease
    Eunju Shin
    Division of Neurobiology, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
    Parkinsons Dis 2012:370190. 2012
    ..In this paper we will discuss the experimental and clinical evidence supporting the involvement of the serotonin system in both LID and GID...
  17. ncbi A simple method for large-scale generation of dopamine neurons from human embryonic stem cells
    Asuka Morizane
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    J Neurosci Res 88:3467-78. 2010
    ..We conclude that our protocol can be used to generate human DA neurons suitable for the study of disease mechanisms, toxicology, drug screening, and intracerebral transplantation...
  18. ncbi Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia
    Emanuela Santini
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    J Neurosci 27:6995-7005. 2007
    ....
  19. ncbi Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice
    Anders Borgkvist
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, S 17177 Stockholm, Sweden
    Mol Cell Neurosci 31:293-302. 2006
    ..Therefore, we suggest that the En1(cre/+); Otx2(flox/flox) mutant mouse model represents a genetic tool for investigating molecular and behavioural consequences of developmental neuronal dysfunction in the DAergic system...
  20. ncbi Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia
    Christine Konradi
    Laboratory of Neuroplasticity, McLean Hospital, Belmont, MA 02478, USA
    Neurobiol Dis 17:219-36. 2004
    ..Some basic maintenance chores such as ribosome protein biosynthesis were downregulated, possibly a response to expended ATP levels...
  21. ncbi The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons
    Francesco Errico
    CEINGE Biotecnologie Avanzate, Naples, Italy
    Mol Cell Neurosci 37:335-45. 2008
    ..Altogether, our results indicate that Rhes is an important modulator of dopaminergic transmission in the striatum...
  22. ncbi Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation
    Anke Brederlau
    Institute of Anatomy and Cell Biology, , Gothenburg, Sweden
    Stem Cells 24:1433-40. 2006
    ..This indicates that prolonged in vitro differentiation of hESCs is essential for preventing formation of teratomas...