Thomas Carlsson

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia
    Thomas Carlsson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, 221 84, Lund, Sweden
    Neurobiol Dis 21:657-68. 2006
  2. doi request reprint Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration
    Thomas Carlsson
    Department Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC D11, Lund, Sweden
    Brain 132:319-35. 2009
  3. doi request reprint Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats
    Tomas Bjorklund
    Department of Experimental Medical Science, Lund University, Brain Repair and Imaging in Neural Systems, Lund, Sweden
    J Neurochem 111:355-67. 2009
  4. doi request reprint Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
    Ana Munoz
    Department of Experimental Medical Science, Neurobiology Unit, Wallenberg Neuroscience Center, University of Lund, Lund, Sweden
    Brain 131:3380-94. 2008
  5. ncbi request reprint Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
    Thomas Carlsson
    CNS Disease Modeling Unit, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    J Neurosci 27:8011-22. 2007
  6. doi request reprint Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Mov Disord 25:S174-9. 2010
  7. doi request reprint Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Prog Brain Res 172:465-78. 2008
  8. ncbi request reprint The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease
    Nathalie Breysse
    Central Nervous System Disease Modeling Unit, Section for Neuroscience, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    J Neurosci 27:5849-56. 2007
  9. ncbi request reprint Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Brain 130:1819-33. 2007
  10. doi request reprint Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model
    Ana Munoz
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Exp Neurol 219:298-307. 2009

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia
    Thomas Carlsson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, 221 84, Lund, Sweden
    Neurobiol Dis 21:657-68. 2006
    ..The results indicate that graft-induced dyskinesias in PD patients may be linked to single, small graft deposits that provide an uneven, patchy reinnervation of the putamen...
  2. doi request reprint Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration
    Thomas Carlsson
    Department Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC D11, Lund, Sweden
    Brain 132:319-35. 2009
    ....
  3. doi request reprint Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats
    Tomas Bjorklund
    Department of Experimental Medical Science, Lund University, Brain Repair and Imaging in Neural Systems, Lund, Sweden
    J Neurochem 111:355-67. 2009
    ..Importantly, the BH4 synthesis from ectopic GCH1 expression was saturable, yielding optimal TH enzyme functionality between GCH1 : TH ratios of 1 : 3 and 1 : 7...
  4. doi request reprint Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
    Ana Munoz
    Department of Experimental Medical Science, Neurobiology Unit, Wallenberg Neuroscience Center, University of Lund, Lund, Sweden
    Brain 131:3380-94. 2008
    ..Our results support the importance of a clinical investigation of the effect of 5-HT(1A) and 5-HT(1B) agonists, particularly in combination, in dyskinetic l-DOPA-treated Parkinson's disease patients...
  5. ncbi request reprint Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
    Thomas Carlsson
    CNS Disease Modeling Unit, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    J Neurosci 27:8011-22. 2007
    ..We conclude that serotonin neurons in the grafts are likely to have a detrimental effect on L-DOPA-induced dyskinesias in cases in which the grafts contain no or few dopamine neurons...
  6. doi request reprint Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Mov Disord 25:S174-9. 2010
    ....
  7. doi request reprint Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Prog Brain Res 172:465-78. 2008
    ..Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication...
  8. ncbi request reprint The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease
    Nathalie Breysse
    Central Nervous System Disease Modeling Unit, Section for Neuroscience, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    J Neurosci 27:5849-56. 2007
    ....
  9. ncbi request reprint Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Brain 130:1819-33. 2007
    ....
  10. doi request reprint Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model
    Ana Munoz
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Exp Neurol 219:298-307. 2009
    ....
  11. doi request reprint Involvement of the serotonin system in L-dopa-induced dyskinesias
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Parkinsonism Relat Disord 14:S154-8. 2008
    ..These findings make the serotonin system an intriguing target for anti-dyskinetic therapies...
  12. ncbi request reprint Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors
    Thomas Carlsson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
    Brain 128:559-69. 2005
    ..These findings form a strong basis for replacing, or supplementing, conventional systemic L-DOPA therapy by continuous intrastriatal DOPA using in vivo gene transfer in the treatment of patients with advanced Parkinson's disease...
  13. ncbi request reprint Restoration of the striatal dopamine synthesis for Parkinson's disease: viral vector-mediated enzyme replacement strategy
    Thomas Carlsson
    CNS Disease Modeling Unit, Department of Experimental Medical Science, Lund University, BMC A11, 221 84 Lund, Sweden
    Curr Gene Ther 7:109-20. 2007
    ....
  14. ncbi request reprint Applications of lentiviral vectors for biology and gene therapy of neurological disorders
    Cecilia Lundberg
    Department of Experimental Medical Science, Lund University, BMC D11, 22184, Lund, Sweden
    Curr Gene Ther 8:461-73. 2008
    ..Moreover, the potential of these vectors in the development of gene therapy to treat neurological disorders is considerable, which is supported by the fact that clinical trials using rLVs are underway...
  15. pmc Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease
    Tomas Bjorklund
    Brain Repair and Imaging in Neural Systems, 22184 Lund, Sweden
    Brain 133:496-511. 2010
    ..Taken together these results show that vector-mediated continuous 3,4-dihydroxyphenylalanine delivery has the potential to provide significant symptomatic relief even in advanced stages of Parkinson's disease...
  16. ncbi request reprint Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor
    Biljana Georgievska
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, 22184, Lund, Sweden
    Eur J Neurosci 20:3121-30. 2004
    ....