Patrik Brundin

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. doi request reprint Neural grafting in Parkinson's disease Problems and possibilities
    Patrik Brundin
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Prog Brain Res 184:265-94. 2010
  2. pmc Prion-like transmission of protein aggregates in neurodegenerative diseases
    Patrik Brundin
    Patrik Brundin is at the Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden
    Nat Rev Mol Cell Biol 11:301-7. 2010
  3. ncbi request reprint On the move to stimulate cell plasticity in the substantia nigra in Parkinson's disease
    Patrik Brundin
    Neuronal Survival Unit, BMC A10, Department of Experimental Medical Science, Wallenberg Neuroscience Center, 22184 Lund, Sweden
    Exp Neurol 201:1-6. 2006
  4. doi request reprint Research in motion: the enigma of Parkinson's disease pathology spread
    Patrik Brundin
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, SE 221 84 Lund, Sweden
    Nat Rev Neurosci 9:741-5. 2008
  5. ncbi request reprint Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice
    Joana M A C Gil
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A10, SE 221 84 Lund, Sweden
    Neurobiol Dis 20:744-51. 2005
  6. doi request reprint Absence of striatal newborn neurons with mature phenotype following defined striatal and cortical excitotoxic brain injuries
    Tomas Deierborg
    Neuronal Survival Unit, BMC A10, Dept of Experimental Medical Science, Wallenberg Neuroscience Center, 221 84 Lund, Sweden
    Exp Neurol 219:363-7. 2009
  7. ncbi request reprint Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor
    Young Hwan Ahn
    Wallenberg Neuroscience Center, Section for Neuronal Survival, BMC A10, SE 221 84 Lund, Sweden
    Brain Res Bull 66:135-42. 2005
  8. ncbi request reprint Increased metabolism in the R6/2 mouse model of Huntington's disease
    Jorien M M van der Burg
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University BMC A10, Lund, Sweden
    Neurobiol Dis 29:41-51. 2008
  9. doi request reprint A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP
    Christian Hansen
    Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, BMC A10, 221 84 Lund, Sweden
    Neurobiol Dis 56:145-55. 2013
  10. doi request reprint Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis
    Laurent Roybon
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 22184 Lund, Sweden
    Eur J Neurosci 29:232-43. 2009

Detail Information

Publications94

  1. doi request reprint Neural grafting in Parkinson's disease Problems and possibilities
    Patrik Brundin
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Prog Brain Res 184:265-94. 2010
    ..Finally, we discuss future possibilities offered by stem cells as potential sources of dopamine neurons that can be used for transplantation in PD...
  2. pmc Prion-like transmission of protein aggregates in neurodegenerative diseases
    Patrik Brundin
    Patrik Brundin is at the Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden
    Nat Rev Mol Cell Biol 11:301-7. 2010
    ..The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies...
  3. ncbi request reprint On the move to stimulate cell plasticity in the substantia nigra in Parkinson's disease
    Patrik Brundin
    Neuronal Survival Unit, BMC A10, Department of Experimental Medical Science, Wallenberg Neuroscience Center, 22184 Lund, Sweden
    Exp Neurol 201:1-6. 2006
  4. doi request reprint Research in motion: the enigma of Parkinson's disease pathology spread
    Patrik Brundin
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, SE 221 84 Lund, Sweden
    Nat Rev Neurosci 9:741-5. 2008
    ..We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease...
  5. ncbi request reprint Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice
    Joana M A C Gil
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A10, SE 221 84 Lund, Sweden
    Neurobiol Dis 20:744-51. 2005
    ..Reduced hippocampal neurogenesis may be a novel neuropathological feature in R6/2 mice that could be assessed when evaluating potential therapies...
  6. doi request reprint Absence of striatal newborn neurons with mature phenotype following defined striatal and cortical excitotoxic brain injuries
    Tomas Deierborg
    Neuronal Survival Unit, BMC A10, Dept of Experimental Medical Science, Wallenberg Neuroscience Center, 221 84 Lund, Sweden
    Exp Neurol 219:363-7. 2009
    ..Our study demonstrates that both the time window for labeling proliferating cells and the site of lesion are crucial when assessing neurogenesis following brain injury...
  7. ncbi request reprint Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor
    Young Hwan Ahn
    Wallenberg Neuroscience Center, Section for Neuronal Survival, BMC A10, SE 221 84 Lund, Sweden
    Brain Res Bull 66:135-42. 2005
    ..We suggest that continuous and safe delivery of GDNF to the brain could be a potential way to optimize neural transplantation as a therapy for Parkinson's disease...
  8. ncbi request reprint Increased metabolism in the R6/2 mouse model of Huntington's disease
    Jorien M M van der Burg
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University BMC A10, Lund, Sweden
    Neurobiol Dis 29:41-51. 2008
    ..Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors...
  9. doi request reprint A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP
    Christian Hansen
    Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, BMC A10, 221 84 Lund, Sweden
    Neurobiol Dis 56:145-55. 2013
    ..Therefore, this α-syn-GFP-mouse model can provide a powerful tool that will facilitate the study of α-syn biology and its involvement in PD pathogenesis...
  10. doi request reprint Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis
    Laurent Roybon
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 22184 Lund, Sweden
    Eur J Neurosci 29:232-43. 2009
    ..Taken together, our data illustrate that Ngn2, neuroD and Tbr transcription factors are involved in postnatal neurogenesis in the olfactory bulb...
  11. doi request reprint Effects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3
    Laurent Roybon
    Neuronal Survival Unit, Department of Experimental Medical Science, 221 84 Lund, Sweden
    J Neurosci 28:3644-56. 2008
    ..Together, we demonstrate that induced overexpression of transcription factor genes has profound and specific effects on the differentiation of rat and human midbrain progenitors, although few dopamine neurons are generated...
  12. ncbi request reprint Depletion of rabphilin 3A in a transgenic mouse model (R6/1) of Huntington's disease, a possible culprit in synaptic dysfunction
    Ruben Smith
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A10, 221 84 Lund, Sweden
    Neurobiol Dis 20:673-84. 2005
    ..Our results indicate that a decrease in mRNA levels underlie the depletion of protein levels of rabphilin 3A, and we suggest that this reduction may be involved in causing impaired synaptic transmission in R6/1 mice...
  13. doi request reprint Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion
    Ruben Smith
    Department of Experimental Medical Science, Lund University, Sweden
    Hum Mol Genet 18:3942-54. 2009
    ..Thus, our findings have revealed a novel pathogenetic process by which mutant huntingtin may disrupt hormone exocytosis from beta-cells and possibly impair vesicular transport in any cell that expresses the pathogenic protein...
  14. ncbi request reprint Tyrosine hydroxylase expression is unstable in a human immortalized mesencephalic cell line--studies in vitro and after intracerebral grafting in vivo
    Gesine Paul
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, 22184 Lund, Sweden
    Mol Cell Neurosci 34:390-9. 2007
    ..Our data suggest that TH expression in vitro is inducible in neurons derived from the MESC2.10 cell line and that the dopaminergic phenotype of these cells in vivo might be unstable...
  15. ncbi request reprint Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease
    Maria Björkqvist
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, Lund, Sweden
    Hum Mol Genet 15:1713-21. 2006
    ..This progressive increase in cortisol may contribute to the clinical symptoms, such as muscular wasting, mood changes and some of the cognitive deficits that occur in HD...
  16. ncbi request reprint Combining neuroprotective treatment of embryonic nigral donor tissue with mild hypothermia of the graft recipient
    Jenny Karlsson
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
    Cell Transplant 14:301-9. 2005
    ..The study also emphasizes the importance of the immediate time after grafting for transplant survival, with relevance both for primary mesencephalic implants and stem cell grafts...
  17. ncbi request reprint Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice
    Ruxandra Iancu
    Neuronal Survival Unit, Wallenberg Neuroscience Centre, Department of Experimental Medical Sciences, Lunds University, BMC A10, 22184 Lund, Sweden
    Behav Brain Res 162:1-10. 2005
    ..This mouse model offers the opportunity to use transgenic mouse strains and study the interactions between genes of interest and toxins in relation to Parkinson's disease etiology in the future...
  18. ncbi request reprint Endothelial proliferation and increased blood-brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia
    Jenny E Westin
    Basal Ganglia Unit, Department of Experimental Medical Science, Lund University, S 221 84 Lund, Sweden
    J Neurosci 26:9448-61. 2006
    ..These microvascular changes are likely to affect the kinetics of L-DOPA entry into the brain, favoring the occurrence of motor complications...
  19. ncbi request reprint Transplantation in Parkinson's disease: The future looks bright
    Gesine Paul
    Neuronal Survival Unit, Section for Neuroscience, Department of Experimental Medical Studies, Wallenberg Neuroscience Center, Lund, Sweden
    Adv Exp Med Biol 557:221-48. 2006
  20. doi request reprint Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease
    Emma Louise Lane
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund, Sweden
    Neurobiol Dis 35:42-51. 2009
    ..Our results suggest that amphetamine-induced AIMs in grafted animals primarily depend on an activation of dopamine receptors, and that serotonin neurons within either the grafts or the host brain play a negligible role...
  21. doi request reprint Islet beta-cell area and hormone expression are unaltered in Huntington's disease
    Karl Bacos
    Unit of Molecular Metabolism, Department of Experimental Medical Science, Lund University, CRC 91 11, 205 02 Malmo, Sweden
    Histochem Cell Biol 129:623-9. 2008
    ..This may lead to a better understanding of HD and provide novel therapeutic targets for symptomatic treatment in HD...
  22. ncbi request reprint Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
    Jia Yi Li
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Mov Disord 25:1091-6. 2010
    ..Our data indicate that Lewy bodies develop gradually in transplanted dopaminergic neurons in a fashion similar to that in dopaminergic neurons in the host substantia nigra...
  23. doi request reprint GABAergic differentiation induced by Mash1 is compromised by the bHLH proteins Neurogenin2, NeuroD1, and NeuroD2
    Laurent Roybon
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, 221 84 Lund, Sweden
    Cereb Cortex 20:1234-44. 2010
    ..Collectively, our results define the compensatory and cross-regulatory mechanisms that exist among basic helix-loop-helix transcription factors during neuronal fate specification...
  24. ncbi request reprint Stromal cell-derived inducing activity does not promote dopaminergic differentiation, but enhances differentiation and proliferation of neural stem cell-derived astrocytes
    Laurent Roybon
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A10, 221 84 Lund, Sweden
    Exp Neurol 196:373-80. 2005
    ....
  25. doi request reprint Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
    Jia Yi Li
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, 221 84 Lund, Sweden
    Nat Med 14:501-3. 2008
    ..However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief...
  26. pmc α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
    Christian Hansen
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    J Clin Invest 121:715-25. 2011
    ..In summary, intercellularly transferred α-syn interacts with cytoplasmic α-syn and can propagate α-syn pathology. These results suggest that α-syn propagation is a key element in the progression of Parkinson disease pathology...
  27. ncbi request reprint The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis
    Maria Björkqvist
    Department of Cell and Molecular Biology, Lund, Sweden
    Hum Mol Genet 14:565-74. 2005
    ..The blunting of exocytosis could be attributed to a 96% reduction in the number of insulin-containing secretory vesicles. Thus, diabetes in R6/2 mice is caused by a combination of deficient beta-cell mass and disrupted exocytosis...
  28. ncbi request reprint Cholinergic neuronal defect without cell loss in Huntington's disease
    Ruben Smith
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden
    Hum Mol Genet 15:3119-31. 2006
    ..Taken together, our data show that the cholinergic system is dysfunctional in R6/1 and HD patients. Consequently, they provide a rationale for testing of pro-cholinergic drugs in this disease...
  29. ncbi request reprint Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease
    Ruben Smith
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    J Neurochem 103:115-23. 2007
    ..SNAP 25 and rabphilin 3a are crucial for neurotransmitter release. Therefore, we suggest that a deficient pre-synaptic transmitter release may underlie some of the symptoms of HD...
  30. pmc Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
    Elodie Angot
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    PLoS ONE 7:e39465. 2012
    ..Our new model system could be used to test compounds that inhibit cell-to-cell transfer of α-synuclein and therefore might retard progression of Parkinson neuropathology...
  31. ncbi request reprint Midbrain expression of Delta-like 1 homologue is regulated by GDNF and is associated with dopaminergic differentiation
    Nicolaj S Christophersen
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, SE 22184 Lund, Sweden
    Exp Neurol 204:791-801. 2007
    ..10 cells was specifically upregulated by the addition of GDNF. Thus, our data suggest that Dlk1 expression precedes the appearance of TH in mesencephalic cells and that levels of Dlk1 are regulated by GDNF...
  32. doi request reprint A simple method for large-scale generation of dopamine neurons from human embryonic stem cells
    Asuka Morizane
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    J Neurosci Res 88:3467-78. 2010
    ..We conclude that our protocol can be used to generate human DA neurons suitable for the study of disease mechanisms, toxicology, drug screening, and intracerebral transplantation...
  33. doi request reprint Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease
    Philip Michael Gaughwin
    Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, S 221 84 Lund, Sweden
    Hum Mol Genet 20:2225-37. 2011
    ..Interestingly, miR-34b is significantly elevated in plasma from HD gene carriers prior to symptom onset. This is the first study suggesting that plasma miRs might be used as biomarkers for HD...
  34. ncbi request reprint Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice
    Jorien M M van der Burg
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC A10, Lund, Sweden
    Neurobiol Dis 44:1-8. 2011
    ..In summary, these observations suggest that the GI tract is affected in HD mice and that GI dysfunction contributes to nutritional deficiencies and weight loss...
  35. ncbi request reprint Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease
    Zuzanna Kurowska
    Wallenberg Neuroscience Center, Lund
    J Parkinsons Dis 1:83-92. 2011
    ..2% of them contain Lewy bodies. In conclusion, our results show that grafted dopaminergic neurons can survive for more than two decades. However, over time an increasing proportion of grafted neurons exhibit signs of degeneration. ..
  36. pmc α-Synuclein: the long distance runner
    Sonia George
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Brain Pathol 23:350-7. 2013
    ..We describe recent studies investigating cell-to-cell transfer of α-synuclein and focus our review on the long-distance axonal transport of α-synuclein along neurons...
  37. ncbi request reprint Failure of transdifferentiation of adult hematopoietic stem cells into neurons
    Laurent Roybon
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, Sweden
    Stem Cells 24:1594-604. 2006
    ..In conclusion, we demonstrate that adult HSC(LSK) cells do not have the capacity to leave the hematopoietic lineage and differentiate into neurons...
  38. ncbi request reprint Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease
    Eugenia Papalexi
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 221 84 Lund, Sweden
    Eur J Neurosci 22:1541-6. 2005
    ..Gonadotropic hormone replacement did not mitigate weight loss or restore motor function in R6/2 males...
  39. pmc A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
    Maria Björkqvist
    Neuronal Survival Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, S 221 00 Lund, Sweden
    J Exp Med 205:1869-77. 2008
    ..Collectively, our data suggest parallel central nervous system and peripheral pathogenic pathways of immune activation in HD...
  40. ncbi request reprint Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes
    Natalija Popovic
    Section for Neuronal Survival, Division of Neurobiology, Department of Physiological Sciences, Wallenberg Neuroscience Center, Lund University, BMC A10, Sweden
    Exp Neurol 193:65-74. 2005
    ..Further studies are, however, needed to investigate if GDNF given at earlier time points is beneficial...
  41. pmc Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis
    Laurent Roybon
    Department of Experimental Medical Science, Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund, Sweden
    PLoS ONE 4:e4779. 2009
    ..Taken together, we demonstrate a critical role of for Ngn2 and NeuroD1 in controlling neuronal commitment and hippocampal granule neuroblast formation, both during embryonic development and in post-natal hippocampal granule neurogenesis...
  42. doi request reprint Critical issues of clinical human embryonic stem cell therapy for brain repair
    Jia Yi Li
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A10, 221 84 Lund, Sweden
    Trends Neurosci 31:146-53. 2008
    ..We focus on hESC-derived dopamine-producing neurons that can be grafted in Parkinson's disease and identify critical experiments that need to be conducted before clinical trials can occur...
  43. ncbi request reprint Orexin loss in Huntington's disease
    Asa Petersen
    Department of Physiological Sciences, Section for Neuronal Survival, Lund, Sweden
    Hum Mol Genet 14:39-47. 2005
    ..Our results show that the loss of orexin is a novel and potentially very important pathology in HD...
  44. pmc What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?
    Christopher J R Dunning
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Prion 7:92-7. 2013
    ..In this mini-review we explore the evidence that misfolded α-synuclein underlies the spread of pathology in Parkinson disease and discuss why it should be considered a prion-like protein...
  45. pmc Asialoerythropoietin is not effective in the R6/2 line of Huntington's disease mice
    Joana M A C Gil
    Section for Neuronal Survival, Wallenberg Neuroscience Center, BMC A10, Lund University, Sweden
    BMC Neurosci 5:17. 2004
    ..R6/2 transgenic HD mice were treated with this cytokine from five to twelve weeks of age...
  46. doi request reprint Identification of molecules derived from human fibroblast feeder cells that support the proliferation of human embryonic stem cells
    Sergey V Anisimov
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A10, Solvegatan 17, 221 84, Lund, Sweden
    Cell Mol Biol Lett 16:79-88. 2011
    ..Among these, the C-KIT, leptin and pigment epithelium-derived factor (PEDF) genes were the most interesting candidates...
  47. ncbi request reprint Cocaine- and amphetamine-regulated transcript is increased in Huntington disease
    Maria Björkqvist
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, Sweden
    Mov Disord 22:1952-4. 2007
    ..Increased CART levels in HD therefore hold promise as a biomarker as well as a potential pathogenic mediator of symptoms...
  48. doi request reprint Reduced neurogenesis in the rat hippocampus following high fructose consumption
    Karin Van der Borght
    Neuronal Survival Unit, Department of Experimental Medical Science, BMC A10, Lund University, Lund, Sweden
    Regul Pept 167:26-30. 2011
    ..The results presented in the present study add to the list of harmful effects associated with prolonged and excessive consumption of sugary beverages and soft drinks...
  49. pmc "NeuroStem Chip": a novel highly specialized tool to study neural differentiation pathways in human stem cells
    Sergey V Anisimov
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
    BMC Genomics 8:46. 2007
    ..Nevertheless, the cellular mechanisms that underlie the development of neurons in vitro as they are subjected to the specific differentiation protocols are often poorly understood...
  50. ncbi request reprint Stem cell-based therapy for Parkinson's disease
    Ana Sofia Correia
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Ann Med 37:487-98. 2005
    ..Finally, we discuss how human embryonic stem cells can be differentiated into dopaminergic neurons, and issues such as the numbers of dopaminergic neurons required for success and the risk for teratoma formation after implantation...
  51. ncbi request reprint Reduced expression of PSA-NCAM in the hippocampus and piriform cortex of the R6/1 and R6/2 mouse models of Huntington's disease
    Karin Van der Borght
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC A10, 22184 Lund, Sweden
    Exp Neurol 204:473-8. 2007
    ..We hypothesize that the decrease in NCAM polysialylation reflects an impaired plasticity and might underlie some of the early symptoms in HD...
  52. ncbi request reprint Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line
    Julie Lotharius
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Lund 221 84, Sweden
    J Biol Chem 277:38884-94. 2002
    ....
  53. pmc Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease
    Géraldine H Petit
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, BMC B11, Lund University, Lund, Sweden
    PLoS ONE 8:e60691. 2013
    ..The findings correlate with preliminary clinical observations suggesting that rasagiline ameliorates olfactory deficits in Parkinson's disease...
  54. ncbi request reprint Neural transplantation for the treatment of Parkinson's disease
    Anders Bjorklund
    Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Sweden
    Lancet Neurol 2:437-45. 2003
  55. ncbi request reprint Comparison between survival of lazaroid-treated embryonic nigral neurons in cell suspensions, cultures and transplants
    Jenny Karlsson
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, BMC A10, S 221 84, Lund, Sweden
    Brain Res 955:268-80. 2002
    ....
  56. doi request reprint Cell transplantation in Parkinson's disease: problems and perspectives
    Laura E Allan
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, Sweden
    Curr Opin Neurol 23:426-32. 2010
    ..We also highlight the challenges which remain to be met in order for cell therapy to become clinically effective and safe...
  57. doi request reprint Emerging restorative treatments for Parkinson's disease
    Tomas Deierborg
    Neuronal Survival Unit, BMC A10, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, Sweden
    Prog Neurobiol 85:407-32. 2008
    ..e. neural and embryonic stem cells, to differentiate into dopaminergic neurons. Finally, we discuss adult neurogenesis as a potential tool for restoring lost dopamine neurons in patients suffering from Parkinson's disease...
  58. ncbi request reprint Enriched environment attenuates cell genesis in subventricular zone after focal ischemia in mice and decreases migration of newborn cells to the striatum
    Josefine Nygren
    Experimental Brain Research, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Stroke 37:2824-9. 2006
    ..Housing rodents in an enriched environment improves motor function after stroke injury. We have investigated whether changes in cell genesis can explain the beneficial effects of an enriched environment...
  59. pmc The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies
    Jia Yi Li
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund, Sweden
    NeuroRx 2:447-64. 2005
    ..We also, at the end, critically assess the relevance of the HD mouse models compared with the human disease and discuss how they can be best used in the future...
  60. pmc No evidence for new dopaminergic neurons in the adult mammalian substantia nigra
    Helena Frielingsdorf
    Section for Neuronal Survival, Wallenberg Neuroscience Center, BMC A 10, Lund University, SE 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 101:10177-82. 2004
    ..We conclude that it is unlikely that dopaminergic neurons are generated in the adult mammalian substantia nigra...
  61. ncbi request reprint Ultrastructural characterization of dissociated embryonic ventral mesencephalic tissue treated with neuroprotectants
    Young Hwan Ahn
    Section for Neuronal Survival, Wallenberg Neuroscience Center, BMC A10, Lund University, SE 221 84 Lund, Sweden
    Cell Transplant 12:235-41. 2003
    ..The results indicate that tirilazad mesylate protects only a small subpopulation of embryonic mesencephalic cells from degeneration induced by mechanical trauma during tissue dissection and dissociation...
  62. ncbi request reprint Huntington's disease: the mystery unfolds?
    Asa Petersen
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Lund, Sweden
    Int Rev Neurobiol 53:315-39. 2002
  63. ncbi request reprint Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease
    Melinda M Zeron
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, 221 84, Lund, Sweden
    Neuron 33:849-60. 2002
    ..Moreover, increased NMDA-evoked current amplitude and caspase-3 activity were observed in transgenic striatal neurons. Our data support a role for NR2B-subtype NMDAR activation as a trigger for selective neuronal degeneration in HD...
  64. doi request reprint Alpha-synuclein transfers from neurons to oligodendrocytes
    Juan F Reyes
    Neuronal Survival Unit, BMC B11, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Glia 62:387-98. 2014
    ..Our findings support the hypothesis of a neuron-to-oligodendrocyte transfer of α-syn, a mechanism that may play a crucial role in the progression and pathogenesis of MSA...
  65. ncbi request reprint Huntington's disease: a synaptopathy?
    Jia Yi Li
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84, Lund, Sweden
    Trends Mol Med 9:414-20. 2003
    ..We also suggest that abnormal synaptic transmission underlies the early symptoms of HD and can contribute to the triggering of cell death in later stages of the disease...
  66. doi request reprint Can Parkinson's disease pathology be propagated from one neuron to another?
    Christopher J R Dunning
    Neuronal Survival Unit, Wallenberg Neuroscience Centre, Lund University, BMC B11, 22184 Lund, Sweden
    Prog Neurobiol 97:205-19. 2012
    ..We then examine the future implications of a critical role in disease pathogenesis of α-synuclein for the classification, diagnosis and treatment of Parkinson's disease in the future...
  67. pmc The adult human brain harbors multipotent perivascular mesenchymal stem cells
    Gesine Paul
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    PLoS ONE 7:e35577. 2012
    ..Future studies will elucidate whether these cells may play a role for disease or may represent a reservoir that can be exploited in efforts to repair the diseased human brain...
  68. ncbi request reprint Dyskinesias following neural transplantation in Parkinson's disease
    Peter Hagell
    Section of Restorative Neurology, Wallenberg Neuroscience Center, SE 221 84 Lund, Sweden
    Nat Neurosci 5:627-8. 2002
    ....
  69. doi request reprint Beyond the brain: widespread pathology in Huntington's disease
    Jorien M M van der Burg
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University BMC A10, Lund, Sweden
    Lancet Neurol 8:765-74. 2009
    ....
  70. ncbi request reprint Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease
    Julie Lotharius
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Hum Mol Genet 11:2395-407. 2002
    ..The breakdown of this labile neurotransmitter in the cytoplasm could, in turn, promote oxidative stress and metabolic dysfunction, both of which have been observed in nigral tissue from PD patients...
  71. ncbi request reprint From bench to bed: the potential of stem cells for the treatment of Parkinson's disease
    Asuka Morizane
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A10, 221 84, Lund, Sweden
    Cell Tissue Res 331:323-36. 2008
    ..We draw special attention to some key problems that face the translation of stem cell technology into the clinical arena...
  72. ncbi request reprint Restorative cell therapy for Parkinson's disease: a quest for the perfect cell
    Vanessa J Hall
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Solvegatan 17, BMC A10, Lund 22184, Sweden
    Semin Cell Dev Biol 18:859-69. 2007
    ....
  73. ncbi request reprint Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein
    Julie Lotharius
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A10, 221 84 Lund, Sweden
    Nat Rev Neurosci 3:932-42. 2002
  74. doi request reprint Are synucleinopathies prion-like disorders?
    Elodie Angot
    Wallenberg Neuroscience Centre, Lund University, Sweden
    Lancet Neurol 9:1128-38. 2010
    ..This model suggests that strategies aimed at prevention of cell-to-cell transfer of α-synuclein could retard progression of symptoms in Parkinson's disease and other synucleinopathies...
  75. pmc Fibroblast growth factor-20 increases the yield of midbrain dopaminergic neurons derived from human embryonic stem cells
    Ana Sofia Correia
    Neuronal Survival Unit, Department of Experimental Medical Science, Lund University, Wallenberg Neuroscience Center, Lund Sweden
    Front Neuroanat 1:4. 2007
    ..Taken together, our results indicate that FGF-20 specifically increases the yield of dopaminergic neurons from hESCs grown on PA6 feeder cells and at least part of this effect is due to a reduction in cell death...
  76. ncbi request reprint Stem cell therapy for Parkinson's disease: where do we stand?
    Laurent Roybon
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, BMC A10, 22184 Lund, Sweden
    Cell Tissue Res 318:261-73. 2004
    ....
  77. ncbi request reprint Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression
    Oskar Hansson
    Section for Neuronal Survival, Wallenberg Neuroscience Center, BMC A10, Department of Physiological Sciences, Lund University, Sweden
    Brain Res 970:47-57. 2003
    ..Interestingly, the polyglutamine protein affected the potential rescuing agent, because in older R6/2-Hsp70 mice a large proportion of the Hsp70 protein was sequestrated in nuclear inclusions...
  78. pmc Growth factors and feeder cells promote differentiation of human embryonic stem cells into dopaminergic neurons: a novel role for fibroblast growth factor-20
    Ana Sofia Correia
    Neuronal Survival Unit, Department of Experimental Medical Science, Lund University, Wallenberg Neuroscience Center Lund, Sweden sofi
    Front Neurosci 2:26-34. 2008
    ..Taken together, our data indicate that FGF-20 has potent effects to generate large number of dopaminergic neurons derived from hESCs, which may be useful for hESC-based therapy in PD...
  79. doi request reprint Stage-specific modulation of cortical neuronal development by Mmu-miR-134
    Philip Gaughwin
    Department of Stem Cell and Developmental Biology, A STAR Genome Institute of Singapore 138672, Singapore
    Cereb Cortex 21:1857-69. 2011
    ....
  80. ncbi request reprint Harnessing endogenous stem cells to treat neurodegenerative disorders of the basal ganglia
    Paul Mohapel
    Section for Neuronal Survival, Wallenberg Neuroscience Center, BMC A 10, Lund University, SE 221 84 Lund, Sweden
    Parkinsonism Relat Disord 10:259-64. 2004
    ..The future challenges lay in directing these new cells to adopt the appropriate neuronal phenotypes and to re-establish proper connections and functional circuitry...
  81. doi request reprint Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease
    Elodie Angot
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden
    Parkinsonism Relat Disord 15:S143-7. 2009
    ..Finally, we discuss which molecular species of alpha-syn (monomer, oligomer, fibril) could be the seeding-competent species and whether this seeding process could be a common mechanism in neurodegenerative diseases...
  82. ncbi request reprint Stem cells: hype or hope?
    Gesine Paul
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden
    Drug Discov Today 7:295-302. 2002
    ..The new options raise several fundamental ethical issues. This review gives an overview of the scientific basis underlying the hope generated by stem cell research and discusses current ethical and funding regulations...
  83. ncbi request reprint Evidence for dopaminergic re-innervation by embryonic allografts in an optimized rat model of the Parkinsonian variant of multiple system atrophy
    Zoe Puschban
    Experimental Neurodegeneration Laboratory, Department of Neurology, University Hospital Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Brain Res Bull 68:54-8. 2005
    ..e. early stage disease with limited striatal dysfunction...
  84. ncbi request reprint [Free radicals and ailing proteins--the culprits behind Parkinson disease?]
    Ruben Smith
    Universitetssjukhuset, Lund
    Lakartidningen 100:1324-6, 1329-30. 2003
    ..Indeed, nigral tissue from idiopathic Parkinson's disease patients shows signs of oxidative damage. In this article we propose that dopamine-induced oxidative stress might be a common final pathway in the pathogenesis of the disease...
  85. ncbi request reprint Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway
    Julie Lotharius
    Department of Disease Biology, H Lundbeck A S, 2500 Valby, Denmark
    J Neurosci 25:6329-42. 2005
    ....
  86. ncbi request reprint Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus
    Inês M Araújo
    Center for Neuroscience and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal
    J Neurochem 105:666-76. 2008
    ..Taken together, our data suggest that early calpain activation, but not caspase activation, is involved in neurotoxicity in the hippocampus after status epilepticus...
  87. ncbi request reprint Decreased VIP and VPAC2 receptor expression in the biological clock of the R6/2 Huntington's disease mouse
    Jan Fahrenkrug
    Department of Clinical Biochemistry, Bispebjerg University Hospital, Copenhagen NV, Denmark
    J Mol Neurosci 31:139-48. 2007
    ..In conclusion, we propose that impaired VIPergic signaling is an additional candidate mechanism for disruption of circadian rhythms in R6/2 mice...
  88. doi request reprint Increased thirst and drinking in Huntington's disease and the R6/2 mouse
    Nigel I Wood
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    Brain Res Bull 76:70-9. 2008
    ..We suggest that increased thirst may be an important and clinically relevant biomarker for the study of disease progression in HD...
  89. ncbi request reprint Large stem cell grafts could lead to erroneous interpretations of behavioral results?
    Nicolaj Strøyer Christophersen
    Nat Med 13:118; author reply 118-9. 2007
  90. ncbi request reprint Induction of dopaminergic neurons from growth factor expanded neural stem/progenitor cell cultures derived from human first trimester forebrain
    Nicolaj S Christophersen
    NsGene A S, Cellular Development, Baltorpvej 154, DK 2750 Ballerup, Denmark
    Brain Res Bull 70:457-66. 2006
    ..Additional experiments, however, are required to improve the survival and phenotypic stability of these cells before they can be considered useful for cell replacement therapy in Parkinson's disease...
  91. ncbi request reprint GDNF treatment in Parkinson's disease: time for controlled clinical trials?
    Patrik Brundin
    Brain 125:2149-51. 2002
  92. ncbi request reprint Funding embryonic stem-cell research: will commerce counteract collaboration?
    Gesine Paul
    Drug Discov Today 7:22-3. 2002
  93. ncbi request reprint Proteolysis of NR2B by calpain in the hippocampus of epileptic rats
    Inês M Araújo
    Center for Neuroscience and Cell Biology, Department of Zoology, Faculty of Medicine, University of Coimbra, 3004 517 Coimbra, Portugal
    Neuroreport 16:393-6. 2005
    ....
  94. ncbi request reprint Cyclosporin A and Bcl-2 do not inhibit quinolinic acid-induced striatal excitotoxicity in rodents
    Evelise N Maciel
    Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, 13083 970, Campinas, SP, Brazil
    Exp Neurol 183:430-7. 2003
    ..We conclude that quinolinic acid-mediated striatal excitotoxicity is not dependent on MPT and Bcl-2-sensitive apoptotic cell death pathways...