Karin Broberg

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15
    Karin Broberg
    Department of Occupational and Environmental Medicine, University Hospital, SE 221 85 Lund, Sweden
    Int J Oncol 21:321-6. 2002
  2. ncbi Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer
    Karin Broberg
    Department of Occupational and Environmental Medicine, Lund University, Sweden
    Carcinogenesis 26:1263-71. 2005
  3. ncbi Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries
    Lena S Jönsson
    Division of Occupational and Environmental Medicine, University Hospital, 221 85, Lund, Sweden
    Int Arch Occup Environ Health 81:913-9. 2008
  4. pmc Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study
    Karin Broberg
    Department of Occupational and Environmental Medicine, Lund University, Sweden
    Environ Health 7:15. 2008
  5. pmc Genetic variation in glutathione-related genes and body burden of methylmercury
    Karin Schläwicke Engström
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Environ Health Perspect 116:734-9. 2008
  6. pmc Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study
    Karin S Engström
    Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health 10:33. 2011
  7. doi Lung function in relation to 2-thiothiazolidine-4-carboxylic acid and genetic effect modification among rubber workers in Sweden
    Lena S Jönsson
    Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    J Occup Environ Med 50:1006-12. 2008
  8. ncbi Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries
    Lena S Jönsson
    Division of Occupational and Environmental Medicine and Psychiatric Epidemiology, University Hospital, 221 85, Lund, Sweden
    Int Arch Occup Environ Health 80:589-98. 2007
  9. pmc Polymorphisms in iron homeostasis genes and urinary cadmium concentrations among nonsmoking women in Argentina and Bangladesh
    Gerda Rentschler
    Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health Perspect 121:467-72, 472e1-7. 2013
  10. pmc Efficient arsenic metabolism--the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT
    Karin S Engström
    Section of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden
    PLoS ONE 8:e53732. 2013

Detail Information

Publications36

  1. ncbi Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15
    Karin Broberg
    Department of Occupational and Environmental Medicine, University Hospital, SE 221 85 Lund, Sweden
    Int J Oncol 21:321-6. 2002
    ..The breakpoint within RDC1 was localized in a previously uncharacterized exon of the gene, and our data suggest that RDC1 is subject to alternative splicing...
  2. ncbi Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer
    Karin Broberg
    Department of Occupational and Environmental Medicine, Lund University, Sweden
    Carcinogenesis 26:1263-71. 2005
    ..9-150). However, no significant interaction for cancer risk could be proven for telomere length, smoking and susceptibility genotypes of metabolizing and DNA-repairing genes...
  3. ncbi Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries
    Lena S Jönsson
    Division of Occupational and Environmental Medicine, University Hospital, 221 85, Lund, Sweden
    Int Arch Occup Environ Health 81:913-9. 2008
    ..Polymorphisms in genes, which are involved in the defense against reactive oxygen species and metabolism of toxic substances present in the vulcanization fumes, were analyzed...
  4. pmc Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study
    Karin Broberg
    Department of Occupational and Environmental Medicine, Lund University, Sweden
    Environ Health 7:15. 2008
    ..g., polyurethane foams and paints. TDI is known to cause respiratory symptoms and diseases. Because TDI causes symptoms in only a fraction of exposed workers, genetic factors may play a key role in disease susceptibility...
  5. pmc Genetic variation in glutathione-related genes and body burden of methylmercury
    Karin Schläwicke Engström
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Environ Health Perspect 116:734-9. 2008
    ..One possible explanation is hereditary differences in MeHg metabolism. MeHg is eliminated from the body as a glutathione (GSH) conjugate...
  6. pmc Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study
    Karin S Engström
    Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health 10:33. 2011
    ..The objective for this study was to elucidate whether genetic polymorphisms in glutathione-related genes modify the association between eicosapentaenoic+docosahexaenoic acid or methylmercury and risk of first ever myocardial infarction...
  7. doi Lung function in relation to 2-thiothiazolidine-4-carboxylic acid and genetic effect modification among rubber workers in Sweden
    Lena S Jönsson
    Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    J Occup Environ Med 50:1006-12. 2008
    ..What is the risk of impaired lung function in contemporary Swedish rubber workers and are there modifying effects of genetic variants?..
  8. ncbi Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries
    Lena S Jönsson
    Division of Occupational and Environmental Medicine and Psychiatric Epidemiology, University Hospital, 221 85, Lund, Sweden
    Int Arch Occup Environ Health 80:589-98. 2007
    ..The aim of the study was to determine TTCA levels and the modifying effects of glutathione-related genes in a group of Swedish rubber workers...
  9. pmc Polymorphisms in iron homeostasis genes and urinary cadmium concentrations among nonsmoking women in Argentina and Bangladesh
    Gerda Rentschler
    Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health Perspect 121:467-72, 472e1-7. 2013
    ..Cadmium (Cd) is a human toxicant and carcinogen. Genetic variation might affect long-term accumulation. Cd is absorbed via iron transporters...
  10. pmc Efficient arsenic metabolism--the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT
    Karin S Engström
    Section of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden
    PLoS ONE 8:e53732. 2013
    ..This raises the possibility that several genes in this region are important for arsenic metabolism...
  11. pmc Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study
    Karin Broberg
    Department of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    BMC Cancer 9:140. 2009
    ..Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom syndrome). Thus, genetic variants of BLM and proteins that form complexes with BLM, such as TOP3A and RMI1, might affect cancer risk as well...
  12. doi Environmental arsenic exposure and DNA methylation of the tumor suppressor gene p16 and the DNA repair gene MLH1: effect of arsenic metabolism and genotype
    Mohammad Bakhtiar Hossain
    Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, SE 22185, Sweden
    Metallomics 4:1167-75. 2012
    ..022). Arsenic exposure was correlated with increased methylation, in blood, of genes encoding enzymes that suppress carcinogenesis, and the arsenic metabolism efficiency modified the degree of epigenetic alterations...
  13. ncbi Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions
    Karin Schläwicke Engström
    Department of Laboratory Medicine, Section of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Mutat Res 667:4-14. 2009
    ..The aim for this study was to identify genetic variants affecting arsenic metabolism...
  14. doi Telomere length and LINE1 methylation is associated with chromosomal aberrations in peripheral blood
    Huiqi Li
    Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Genes Chromosomes Cancer 52:1-10. 2013
    ..The results suggest that shorter telomere length and higher LINE1 methylation in peripheral blood lymphocytes are predisposition factors for increased frequency of chromosomal aberrations...
  15. pmc ATP13A2 (PARK9) polymorphisms influence the neurotoxic effects of manganese
    Gerda Rentschler
    Division of Occupational and Environmental Medicine, Lund University, SE 22185 Lund, Sweden
    Neurotoxicology 33:697-702. 2012
    ..This may be related to ferro-alloy smelters in the area, releasing manganese (Mn) in the air, soil and water for about a century. There exists individual susceptibility for Mn neurotoxicity...
  16. pmc Low-level environmental cadmium exposure is associated with DNA hypomethylation in Argentinean women
    Mohammad Bakhtiar Hossain
    Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health Perspect 120:879-84. 2012
    ..Cadmium, a common food pollutant, alters DNA methylation in vitro. Epigenetic effects might therefore partly explain cadmium's toxicity, including its carcinogenicity; however, human data on epigenetic effects are lacking...
  17. pmc Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism
    Karin Engström
    Department of Laboratory Medicine, Section of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health Perspect 119:182-8. 2011
    ..The fraction of urinary MMA is a marker for susceptibility to As-related diseases...
  18. ncbi Symptoms and immunologic markers among vulcanization workers in rubber industries in southern Sweden
    Lena S Jönsson
    Division of Occupational and Environmental Medicine, University Hospital, SE 221 85 Lund, Sweden
    Scand J Work Environ Health 33:272-9. 2007
    ..Furthermore, the relation between exposure and these biomarkers of response was examined using urinary levels of 2-thiothiazolidine-4-carboxylic acid (TTCA), which reflect the exposure...
  19. ncbi Eye and airway symptoms in low occupational exposure to toluene diisocyanate
    Margareta Littorin
    Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden
    Scand J Work Environ Health 33:280-5. 2007
    ....
  20. pmc Arsenic exposure through drinking water is associated with longer telomeres in peripheral blood
    Huiqi Li
    Department of Laboratory Medicine, Section of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Chem Res Toxicol 25:2333-9. 2012
    ..Arsenic in drinking water influences the telomere length, and this may be a mechanism for its carcinogenicity. A faster and less toxic arsenic metabolism diminishes arsenic-related telomere elongation...
  21. doi N-nitrosamines are associated with shorter telomere length
    Huiqi Li
    Section of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Scand J Work Environ Health 37:316-24. 2011
    ..Aiming to examine the relationship between DNA-damaging agents and average telomere length in peripheral blood, we conducted a cross-sectional study among 157 workers working in the rubber industry in Sweden...
  22. ncbi Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma
    Karin Broberg
    Department of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85, Lund, Sweden
    Cancer Lett 258:38-44. 2007
    ..7, 95% CI 1.1-6.0, whereas individuals <64 years showed OR=0.87, 95% CI 0.31-2.5. These results indicate a role of low-penetrance genes involved in BLM-associated homologous recombination for cancer risk...
  23. ncbi Influence of polymorphic metabolic enzymes on biotransformation and effects of diphenylmethane diisocyanate
    Margareta Littorin
    Department of Occupational and Environmental Medicine, University Hospital, 221 85 Lund, Sweden
    Int Arch Occup Environ Health 81:429-41. 2008
    ....
  24. ncbi Cadmium concentrations in human blood and urine are associated with polymorphisms in zinc transporter genes
    Gerda Rentschler
    Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Metallomics 6:885-91. 2014
    ..Variation in susceptibility to cadmium (Cd) toxicity may partly be due to differences in Cd toxicokinetics. Experimental studies indicate that zinc (Zn) homeostasis proteins transport Cd...
  25. pmc Ranking of genome-wide association scan signals by different measures
    Ulf Stromberg
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Int J Epidemiol 38:1364-73. 2009
    ....
  26. pmc Polymorphisms in genes encoding potential mercury transporters and urine mercury concentrations in populations exposed to mercury vapor from gold mining
    Karin Engström
    Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health Perspect 121:85-91. 2013
    ..Persons working or living in mining areas have high urinary concentrations of Hg (U-Hg). Differences in genes encoding potential Hg-transporters may affect uptake and elimination of Hg...
  27. pmc Lithium in drinking water and thyroid function
    Karin Broberg
    Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health Perspect 119:827-30. 2011
    ..Lithium is used worldwide for treatment of bipolar disorder and treatment-resistant depression. One known side effect is altered thyroid function...
  28. ncbi Polymorphisms in glutathione-related genes affect methylmercury retention
    Hipolito M Custodio
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Arch Environ Health 59:588-95. 2004
    ..These findings indicate that GCLC polymorphisms that affect GSH production also affect methylmercury retention, and that GSTP1 may play a role in conjugating methylmercury with GSH...
  29. doi Chronic exposure to cadmium and arsenic strongly influences concentrations of 8-oxo-7,8-dihydro-2'-deoxyguanosine in urine
    Karin S Engström
    Section of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, 221 85 Lund, Sweden
    Free Radic Biol Med 48:1211-7. 2010
    ..0026, p=0.004), and plasma Ft (beta=0.20, p< 0.001). A joint effect was seen for urinary Cd and As, but whether this effect was additive or multiplicative was difficult to discern...
  30. ncbi Genetic influences on the retention of inorganic mercury
    Hipolito M Custodio
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Arch Environ Occup Health 60:17-23. 2005
    ..These results indicate that genotypes with decreased GSH availability for mercury conjugation affect the metabolism of inorganic mercury...
  31. pmc Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina
    Karin Schläwicke Engström
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, 22185 Lund, Sweden
    Environ Health Perspect 115:599-605. 2007
    ..In conclusion, these findings indicate that polymorphisms in AS3MT-and possibly GSTM1, GSTT1, MTR, and MTHFR-are responsible for a large part of the interindividual variation in As metabolism and susceptibility...
  32. ncbi Biomarkers of exposure in Monday morning urine samples as a long-term measure of exposure to aromatic diisocyanates
    Håkan Tinnerberg
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, Lund University, S 221 85, Lund, Sweden
    Int Arch Occup Environ Health 87:365-72. 2014
    ....
  33. doi Selection of influential genetic markers among a large number of candidates based on effect estimation rather than hypothesis testing: an approach for genome-wide association studies
    Ulf Stromberg
    Department of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Epidemiology 19:302-8. 2008
    ..We discuss the potential of this estimation-based approach for genome-wide association studies...
  34. doi Cadmium, mercury, and lead in kidney cortex are not associated with urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in living kidney donors
    Mohammad Bakhtiar Hossain
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, SE 22185, Lund, Sweden
    Int Arch Occup Environ Health 87:315-22. 2014
    ..We determined whether kidney concentrations of cadmium, mercury, and lead, which may generate oxidative DNA damage, were associated with urinary 8-oxodG or not...
  35. ncbi Proteoglycan production in disomic and trisomy 7-carrying human synovial cells
    Erik Eklund
    Department of Cell and Molecular Biology, Sec f Cell and Matrix Biology, Lund University, BMC C13, S 221 84, Lund, Sweden
    Matrix Biol 21:325-35. 2002
    ..Thus, we suggest that the increased amount of versican in cultures of trisomy 7-carrying cells relates to an autocrine loop involving an increased IL-6 production...
  36. ncbi Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review
    Eliane Kellen
    Department of General Practice, Katholieke Universiteit Leuven, Comprehensive Cancer Institute Limburg, Limburg, Belgium
    Am J Epidemiol 165:1221-30. 2007
    ..Case-only analyses did not detect an interaction between the GSTP1 genotype and smoking status (never/ever). GSTP1 Ile 105Val appears to be associated with a modest increase in the risk of bladder cancer...