C A Borrebaeck

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Antibodies in diagnostics - from immunoassays to protein chips
    C A Borrebaeck
    Dept of Immunotechnology, PO Box 7031, Lund University, S 220 07 Lund, Sweden
    Immunol Today 21:379-82. 2000
  2. ncbi request reprint Protein chips based on recombinant antibody fragments: a highly sensitive approach as detected by mass spectrometry
    C A Borrebaeck
    Lund University, Lund, Sweden
    Biotechniques 30:1126-30, 1132. 2001
  3. ncbi request reprint Antibody microarray-based oncoproteomics
    Carl A K Borrebaeck
    Lund University, Department of Immunotechnology, BMC D13, SE 221 84 Lund, Sweden
    Expert Opin Biol Ther 6:833-8. 2006
  4. pmc Grading breast cancer tissues using molecular portraits
    Niclas Olsson
    Department of Immunotechnology and CREATE Health, Lund University, Medicon Village, SE 223 81 Lund, Sweden
    Mol Cell Proteomics 12:3612-23. 2013
  5. pmc Proteomic analysis and discovery using affinity proteomics and mass spectrometry
    Niclas Olsson
    Department of Immunotechnology, Lund University, Lund, Sweden, and CREATE Health, BMC D13, Lund, Sweden
    Mol Cell Proteomics 10:M110.003962. 2011
  6. pmc Expanded clinical and experimental use of SOX11 - using a monoclonal antibody
    Lena Nordström
    Department of Immunotechnology, Lund University, BMCD13, Lund, SE 221 84, Sweden
    BMC Cancer 12:269. 2012
  7. ncbi request reprint Viewpoints in clinical proteomics: when will proteomics deliver clinically useful information?
    Carl A K Borrebaeck
    Department of Immunotechnology and CREATE Health Translational Cancer Center, Lund University, BMC D13, Lund, Sweden
    Proteomics Clin Appl 6:343-5. 2012
  8. pmc SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies
    Elin Gustavsson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Mol Cancer 9:187. 2010
  9. pmc A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests
    Henrik Johansson
    Department of Immunotechnology, Lund University, BMC D13, 21184 Lund, Sweden
    BMC Genomics 12:399. 2011
  10. ncbi request reprint Antibody evolution beyond Nature
    Carl A K Borrebaeck
    Department of Immunotechnology, Lund University, P O Box 7031, SE 220 07 Lund, Sweden
    Nat Biotechnol 20:1189-90. 2002

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Antibodies in diagnostics - from immunoassays to protein chips
    C A Borrebaeck
    Dept of Immunotechnology, PO Box 7031, Lund University, S 220 07 Lund, Sweden
    Immunol Today 21:379-82. 2000
    ..Antibodies are still very much in vogue and are now also being used in microarray analysis of the proteome using protein chips. Here, recent opportunities presented by antibodies as diagnostic tools are reviewed...
  2. ncbi request reprint Protein chips based on recombinant antibody fragments: a highly sensitive approach as detected by mass spectrometry
    C A Borrebaeck
    Lund University, Lund, Sweden
    Biotechniques 30:1126-30, 1132. 2001
    ..The assay readout allows the determination of single or multiple antigen-antibody interactions. Mass identity of the antigens, currently with a resolution of 8000, enables the detection of structural modifications of single proteins...
  3. ncbi request reprint Antibody microarray-based oncoproteomics
    Carl A K Borrebaeck
    Lund University, Department of Immunotechnology, BMC D13, SE 221 84 Lund, Sweden
    Expert Opin Biol Ther 6:833-8. 2006
    ..The present review focuses on the role of antibody microarrays in oncoproteomics and its potential to provide a truly proteome-wide analytical approach...
  4. pmc Grading breast cancer tissues using molecular portraits
    Niclas Olsson
    Department of Immunotechnology and CREATE Health, Lund University, Medicon Village, SE 223 81 Lund, Sweden
    Mol Cell Proteomics 12:3612-23. 2013
    ..Taken together, these molecular portraits could pave the way for improved classification and prognostication of breast cancer. ..
  5. pmc Proteomic analysis and discovery using affinity proteomics and mass spectrometry
    Niclas Olsson
    Department of Immunotechnology, Lund University, Lund, Sweden, and CREATE Health, BMC D13, Lund, Sweden
    Mol Cell Proteomics 10:M110.003962. 2011
    ..In this study, we profiled extracts from human colon tissue, yeast cells lysate, and mouse liver tissue to demonstrate proof-of-concept...
  6. pmc Expanded clinical and experimental use of SOX11 - using a monoclonal antibody
    Lena Nordström
    Department of Immunotechnology, Lund University, BMCD13, Lund, SE 221 84, Sweden
    BMC Cancer 12:269. 2012
    ....
  7. ncbi request reprint Viewpoints in clinical proteomics: when will proteomics deliver clinically useful information?
    Carl A K Borrebaeck
    Department of Immunotechnology and CREATE Health Translational Cancer Center, Lund University, BMC D13, Lund, Sweden
    Proteomics Clin Appl 6:343-5. 2012
    ..Study design is then crucial and sample quality, bioinformatics approaches, prevalidation, using independent patient cohort need to attract increased attention before proteomics will contribute to the needs of personalized medicine...
  8. pmc SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies
    Elin Gustavsson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Mol Cancer 9:187. 2010
    ..SOX11 has been shown to prevent gliomagenesis in vivo but the causes and consequences of aberrant expression of SOX11 outside the CNS remain unexplained...
  9. pmc A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests
    Henrik Johansson
    Department of Immunotechnology, Lund University, BMC D13, 21184 Lund, Sweden
    BMC Genomics 12:399. 2011
    ..The aim is to replace animal experiments with in vitro tests displaying a higher predictive power...
  10. ncbi request reprint Antibody evolution beyond Nature
    Carl A K Borrebaeck
    Department of Immunotechnology, Lund University, P O Box 7031, SE 220 07 Lund, Sweden
    Nat Biotechnol 20:1189-90. 2002
  11. ncbi request reprint Human therapeutic antibodies
    C A Borrebaeck
    Department of Immunotechnology, Lund University, Sweden
    Curr Opin Pharmacol 1:404-8. 2001
    ....
  12. ncbi request reprint High-throughput proteomics using antibody microarrays: an update
    Carl A K Borrebaeck
    Lund University, Department of Immunotechnology and CREATE Health, BMC D13, SE 221 84 Lund, Sweden
    Expert Rev Mol Diagn 7:673-86. 2007
    ..This review describes an update of high-throughput proteomics, using antibody-based microarrays, focusing on key technological advances and novel applications that have emerged over the last 3 years...
  13. ncbi request reprint Tapping the potential of molecular libraries in functional genomics
    C A Borrebaeck
    Dept of Immunotechnology, Lund University, Sweden
    Immunol Today 19:524-7. 1998
    ..Success will require novel high-capacity technologies that can cope with very large numbers of molecules. Here, Carl Borrebaeck reviews recent developments in molecular libraries and their role in rational gene identification...
  14. ncbi request reprint Low affinity, antibody binding of an Escherichia coli-derived component
    M Ohlin
    Department of Immunotechnology, Lund University, Sweden
    FEMS Immunol Med Microbiol 13:161-8. 1996
    ..coli infections...
  15. ncbi request reprint Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries
    E Soderlind
    BioInvent Therapeutic AB, Lund, Sweden
    Nat Biotechnol 18:852-6. 2000
    ..Using the modularized assembly process to incorporate foreign sequences into an immunoglobulin scaffold, it is possible to vary as many as six CDRs at the same time, creating genetic and functional variation in antibody molecules...
  16. ncbi request reprint A central core structure in an antibody variable domain determines antigen specificity
    P Jirholt
    Department of Immunotechnology, Lund University, S-220 07 Lund, Sweden
    Protein Eng 14:67-74. 2001
    ..Furthermore, an explanation for the observed restricted germline gene usage in certain antibody responses against protein epitopes is provided...
  17. ncbi request reprint Design of atto-vial based recombinant antibody arrays combined with a planar wave-guide detection system
    Sara Ghatnekar-Nilsson
    Department of Solid State Physics, The Nanometer Structure Consortium, Lund University, Lund, Sweden
    Proteomics 7:540-7. 2007
    ..Taken together, these results outline the potential of the atto-vial array set-up for miniaturized affinity proteomics-based approaches...
  18. ncbi request reprint Detection of pancreatic cancer using antibody microarray-based serum protein profiling
    Johan Ingvarsson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Proteomics 8:2211-9. 2008
    ..Taken together, the data suggest that antibody microarray analysis of complex proteomes will be a useful tool to define disease associated protein signatures...
  19. ncbi request reprint Single framework recombinant antibody fragments designed for protein chip applications
    Cornelia Steinhauer
    Department of Immunotechnology, Lund University, Lund, Sweden
    Biotechniques . 2002
    ....
  20. ncbi request reprint Design of recombinant antibody microarrays for serum protein profiling: targeting of complement proteins
    Johan Ingvarsson
    Department of Immunotechnology, BMC D13, Lund University, SE 221 84 Lund, Sweden
    J Proteome Res 6:3527-36. 2007
    ....
  21. ncbi request reprint Improved affinity coupling for antibody microarrays: engineering of double-(His)6-tagged single framework recombinant antibody fragments
    Cornelia Steinhauer
    Department of Immunotechnology, Lund University, Lund, Sweden
    Proteomics 6:4227-34. 2006
    ..Taken together, the results demonstrate the generic potential of double-(His)(6)-tag recombinant antibodies for the facile fabrication of high-density antibody microarrays...
  22. ncbi request reprint Recombinant antibody microarrays--a viable option?
    Christer Wingren
    Department of Immunotechnology, Lund University, SE 220 07 Lund, Sweden
    Nat Biotechnol 21:223. 2003
  23. ncbi request reprint Design of recombinant antibody microarrays for cell surface membrane proteomics
    Linda Dexlin
    Deptartment of Immunotechnology, BMC D13, Lund University, SE 221 84 Lund, Sweden
    J Proteome Res 7:319-27. 2008
    ....
  24. doi request reprint Serum proteome profiling of metastatic breast cancer using recombinant antibody microarrays
    Anders Carlsson
    Department of Immunotechnology, Lund University, BMC D13, SE 221 84 Lund, Sweden
    Eur J Cancer 44:472-80. 2008
    ..In a longer perspective, antibody microarray analysis could provide a tool for the development of improved diagnostics and intensified biomarker discovery for breast cancer patients...
  25. ncbi request reprint The immune diversity in a test tube--non-immunised antibody libraries and functional variability in defined protein scaffolds
    E Soderlind
    BioInvent Therapeutic AB, Lund, Sweden
    Comb Chem High Throughput Screen 4:409-16. 2001
    ..This approach not only permits identification of a range of specific binders, but also facilitates further evolution of initially derived molecules into molecules with optimised functions...
  26. ncbi request reprint B cell lymphomas express CX3CR1 a non-B cell lineage adhesion molecule
    Ulrika Andréasson
    Department of Immunotechnology, Lund University, CREATE Health, Lund University, BMC D13, 221 84, Lund, Sweden
    Cancer Lett 259:138-45. 2008
    ..CX3CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX3CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma...
  27. ncbi request reprint Antibody microarrays: current status and key technological advances
    Christer Wingren
    Department of Immunotechnology, Lund University, Lund, Sweden
    OMICS 10:411-27. 2006
    ..This review will discuss the current status of the antibody microarray technology focusing on recent technological advances and key issues in the process of evolving the methodology into a high-performing proteomic research tool...
  28. ncbi request reprint From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies
    Sara Ek
    Department of Immunotechnology, Lund University, SE 22007 Lund, Sweden
    Mol Cell Proteomics 5:1072-81. 2006
    ....
  29. ncbi request reprint Design of recombinant antibody microarrays for complex proteome analysis: choice of sample labeling-tag and solid support
    Christer Wingren
    Department of Immunotechnology, BMC D13, Lund University, Lund, Sweden
    Proteomics 7:3055-65. 2007
    ....
  30. ncbi request reprint Progress in miniaturization of protein arrays--a step closer to high-density nanoarrays
    Christer Wingren
    Department of Immunotechnology, Lund University, BMC D13, SE 221 84 Lund, Sweden
    Drug Discov Today 12:813-9. 2007
    ..This review describes the progress and key issues in designing miniaturized protein arrays...
  31. ncbi request reprint Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma
    Sara Ek
    Department of Immunotechnology, CREATE Health, Biomedical Center, Lund University, and Department of Pathology, Lund University Hospital, Sweden
    Blood 111:800-5. 2008
    ....
  32. doi request reprint Identification of a strongly activating human anti-CD40 antibody that suppresses HIV type 1 infection
    Peter Ellmark
    Department of Immunotechnology, Lund University, Lund, Sweden
    AIDS Res Hum Retroviruses 24:367-73. 2008
    ..This antibody was able to suppress HIV-1 infection in a human cell line (MonoMac 1) and may be a potential therapeutic candidate in HIV infection...
  33. ncbi request reprint Design of high-density antibody microarrays for disease proteomics: key technological issues
    Carl A K Borrebaeck
    Department of Immunotechnology, Lund University, Lund, Sweden
    J Proteomics 72:928-35. 2009
    ..In this mini-review we discuss key technological issues that must be addressed in a cross-disciplinary manner before true global proteome analysis can be performed using antibody microarrays...
  34. ncbi request reprint High-throughput proteomics using antibody microarrays
    Christer Wingren
    Department of Immunotechnology, Lund University, PO Box 7031, Lund, Sweden
    Expert Rev Proteomics 1:355-64. 2004
    ..Intense work is currently underway to develop this novel technology platform into the high-throughput proteomic tool required by the research community...
  35. ncbi request reprint One-step fractionation of complex proteomes enables detection of low abundant analytes using antibody-based microarrays
    Johan Ingvarsson
    Department of Immunotechnology, Lund University, P O Box 7031, SE 220 07 Lund, Sweden
    J Proteome Res 5:170-6. 2006
    ..The reduced complexity of the LMW fraction significantly improved the assay sensitivity, by improving the fluorescent tagging step and/or reducing the nonspecific binding to the substrates...
  36. ncbi request reprint Designing proteins to crystallize through beta-strand pairing
    Christer Wingren
    Department of Immunotechnology, Lund University, P O Box 7031, SE 220 07 Lund, Sweden
    Protein Eng 16:255-64. 2003
    ..Taken together, the procedures outline a rational protocol for crystallizing proteins by surface mutagenesis. The importance of these findings is discussed in relation to the crystallization of proteins in general...
  37. ncbi request reprint Transcriptional profiling and assessment of cell lines as in vitro models for mantle cell lymphoma
    Sara Ek
    Department of Immunotechnology, Lund University, P O Box 7031, SE 22007 Lund, Sweden
    Leuk Res 29:205-13. 2005
    ..Taken together, our data show that the cell lines are clearly derived from MCL tumours and expressed similar genetic and phenotypic signatures compared to primary tumours, which confirmed their usefulness as in vitro models...
  38. ncbi request reprint CD44-stimulated human B cells express transcripts specifically involved in immunomodulation and inflammation as analyzed by DNA microarrays
    Carl Magnus Hogerkorp
    Department of Immunotechnology, Lund University, Sweden
    Blood 101:2307-13. 2003
    ..Our results show that genes such as interleukin-6 (IL-6), IL-1alpha, and beta(2)-adrenergic receptor (beta(2)-AR) were specifically up-regulated by CD44 ligation, suggesting a novel role for CD44 in immunoregulation and inflammation...
  39. pmc Modulation of the CD40-CD40 ligand interaction using human anti-CD40 single-chain antibody fragments obtained from the n-CoDeR phage display library
    Peter Ellmark
    Department of Immunotechnology, Lund University, Lund, Sweden
    Immunology 106:456-63. 2002
    ..In conclusion, this panel of human anti-CD40 scFv fragments displays a number of distinct properties, which may constitute a valuable source when evaluating candidates for in vivo trials...
  40. doi request reprint Histamine H(4) receptor antagonism inhibits allergen-specific T-cell responses mediated by human dendritic cells
    Kristina Lundberg
    Department of Immunotechnology, BMC D13, Lund University, SE 221 84 Lund, Sweden
    Eur J Pharmacol 651:197-204. 2011
    ..This finding indicates that the H(4) receptor is a potential treatment target in human allergic conditions...
  41. ncbi request reprint Insertions and deletions in hypervariable loops of antibody heavy chains contribute to molecular diversity
    M Ohlin
    Department of Immunotechnology, Lund University, Sweden
    Mol Immunol 35:233-8. 1998
    ..Since these major genetic modifications occur within or immediately adjacent to loops contributing to the antigen-binding site, they are likely to affect the binding properties of the mutated antibodies...
  42. ncbi request reprint Antibody evolution from the centre to the periphery: applied to a human antibody fragment recognising the tumour-associated antigen mucin-1
    Pernilla Jirholt
    The Wallenberg Laboratory, Department of Immunotechnology, Lund University, P O Box 7013, 220 07 Lund, Sweden
    J Mol Biol 318:407-16. 2002
    ..These or related molecules obtained by this approach will serve as a starting point for the development of fully human antibodies for use in mucin-1 specific tumour therapy of diagnosis...
  43. ncbi request reprint Mantle cell lymphomas express a distinct genetic signature affecting lymphocyte trafficking and growth regulation as compared with subpopulations of normal human B cells
    Sara Ek
    Department of Immunotechnology, Lund University, SE 220 07, Sweden
    Cancer Res 62:4398-405. 2002
    ..Furthermore, hierarchical cluster analysis revealed two subpopulations of MCLs, which indicates that despite the homogeneous and strong overexpression of cyclin D1, further subtyping might be possible...
  44. ncbi request reprint Identification of molecular targets associated with transformed diffuse large B cell lymphoma using highly purified tumor cells
    Ulrika Andréasson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Am J Hematol 84:803-8. 2009
    ..Galectin-3 and NEK2 both identified a subgroup of DLBCL-tr, and the function of these protein markers also suggests a biological role in the transformation process...
  45. ncbi request reprint Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples
    Ulrika Andréasson
    Department of Immunotechnology, Lund University, Sweden
    Am J Hematol 85:418-25. 2010
    ..The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treatment...
  46. doi request reprint Sensitivity of HIV type 1 primary isolates to human anti-CD40 antibody-mediated suppression is related to coreceptor use
    Sisay A Abayneh
    Division of Medical Microbiology, Department of Laboratory Medicine, Lund University, Lund, Sweden
    AIDS Res Hum Retroviruses 24:447-52. 2008
    ..The results indicate that HIV-1 replication is inhibited by human anti-CD40 monoclonal antibodies through the mechanism of CC-chemokine induction. This effect is thus restricted to HIV-1 isolates sensitive to inhibition by CC-chemokines...
  47. ncbi request reprint Profiling of internalizing tumor-associated antigens on breast and pancreatic cancer cells by reversed genomics
    Johan Fransson
    Department of Immunotechnology, Lund University, P O Box 7031, SE 220 07 Lund, Sweden
    Cancer Lett 208:235-42. 2004
    ..The ability of the selected antibodies to undergo receptor-mediated internalization was verified by confocal microscopy, thus proving our strategy to provide a unique set of human antibodies, potentially useful in immunotherapy...
  48. ncbi request reprint The human IgE-encoding transcriptome to assess antibody repertoires and repertoire evolution
    Ulrika Andréasson
    Department of Immunotechnology, Lund University, Lund, Sweden
    J Mol Biol 362:212-27. 2006
    ....
  49. ncbi request reprint Microarrays based on affinity-tagged single-chain Fv antibodies: sensitive detection of analyte in complex proteomes
    Christer Wingren
    Department of Immunotechnology, Lund University, Lund, Sweden
    Proteomics 5:1281-91. 2005
    ..This is a prerequisite for the design of high-density antibody arrays applied in high-throughput proteomics...
  50. ncbi request reprint Mantle cell lymphomas acquire increased expression of CCL4, CCL5 and 4-1BB-L implicated in cell survival
    Sara Ek
    Department of Immunotechnology, Lund University, Lund, Sweden
    Int J Cancer 118:2092-7. 2006
    ..Signaling through 4-1BB-L allows B cells to proliferate and the expression of its ligand, by the intra-tumoral mesh of follicular dendritic cells (FDC), could thus serve as a paracrine loop facilitating growth and survival of MCL cells...
  51. ncbi request reprint Identification of protein expression signatures associated with Helicobacter pylori infection and gastric adenocarcinoma using recombinant antibody microarrays
    Peter Ellmark
    Department of Immunotechnology, Lund University, BMC D13, SE 22184 Lund, Sweden
    Mol Cell Proteomics 5:1638-46. 2006
    ..In a longer perspective, this study may improve the understanding of H. pylori-induced stomach cancer and lead to development of improved diagnostics...
  52. ncbi request reprint Characteristics of human antibody repertoires following active immune responses in vivo
    M Ohlin
    Department of Immunotechnology, Lund University, Sweden
    Mol Immunol 33:583-92. 1996
    ..In summary, the T cell-dependent antibody response against foreign antigens appears to differ from the average circulating B cell in several ways, and thus does not seem to represent a random selection of the available repertoire...
  53. ncbi request reprint Global reprogramming of dendritic cells in response to a concerted action of inflammatory mediators
    Malin Lindstedt
    Department of Immunotechnology, Lund University, PO Box 7031, 220 07 Sweden
    Int Immunol 14:1203-13. 2002
    ..This transcriptional reorganization may reflect the effect of in vivo released inflammatory mediators induced by endogenous or pathogenic stimulation...
  54. ncbi request reprint Immunomodulatory nanoparticles as adjuvants and allergen-delivery system to human dendritic cells: Implications for specific immunotherapy
    Sissela Broos
    Department of Immunotechnology, Lund University, Lund, Sweden
    Vaccine 28:5075-85. 2010
    ..Thus, gamma-PGA NPs are promising as sophisticated adjuvants and allergen-delivery systems in allergen-specific immunotherapy...
  55. doi request reprint Attovial-based antibody nanoarrays
    Peter Ellmark
    Department of Immunotechnology, Lund University, Lund, Sweden
    Proteomics 9:5406-13. 2009
    ..Finally, we demonstrated proof-of-concept for individual functionalization of the attovials with a recombinant antibody...
  56. ncbi request reprint Functionally associated targets in mantle cell lymphoma as defined by DNA microarrays and RNA interference
    Eva Ortega-Paino
    Department of Immunotechnology, Lund University, Lund, Sweden
    Blood 111:1617-24. 2008
    ....
  57. doi request reprint CD4+ T cells have a key instructive role in educating dendritic cells in allergy
    Kristina Larsson
    Department of Immunotechnology, Lund University, Sweden
    Int Arch Allergy Immunol 149:1-15. 2009
    ..However, the transcriptional profile of DCs educated by T cells in allergy is unknown...
  58. ncbi request reprint Rapid induction of apoptosis in B-cell lymphoma by functionally isolated human antibodies
    Johan Fransson
    Department of Immunotechnology, Lund University, Lund, Sweden
    Int J Cancer 119:349-58. 2006
    ....
  59. ncbi request reprint Genome-wide comparison of phage M13-infected vs. uninfected Escherichia coli
    Fredrik Karlsson
    Department of Immunotechnology, Lund University, Sweden
    Can J Microbiol 51:29-35. 2005
    ..Thus, global transcriptional analysis and functional analysis revealed previously unknown host responses to filamentous phage infection...
  60. doi request reprint Distribution, cellular localization, and therapeutic potential of the tumor-associated antigen Ku70/80 in glioblastoma multiforme
    Oscar Persson
    Department of Neurosurgery and The Rausing Laboratory, Lund University, Universitetssjukhuset EA14, 221 85, Lund, Sweden
    J Neurooncol 97:207-15. 2010
    ..These results imply that Ku70/80 is a potential target for immunotherapy of glioblastoma multiforme...
  61. ncbi request reprint Biocompatibility of surfaces for antibody microarrays: design of macroporous silicon substrates
    Cornelia Steinhauer
    Department of Immunotechnology, Lund University, P O Box 7031, SE 220 07 Lund, Sweden
    Anal Biochem 341:204-13. 2005
    ..Taken together, designed surfaces based on silicon can undoubtedly meet the requirements of the next generation of solid supports for antibody microarrays...
  62. ncbi request reprint Increased expression of Ki-67 in mantle cell lymphoma is associated with de-regulation of several cell cycle regulatory components, as identified by global gene expression analysis
    Sara Ek
    Department of Immunotechnology, Lund University, Sweden
    Haematologica 89:686-95. 2004
    ..Furthermore, primary and relapsed tumors were compared to identify the possible growth advantages possessed by cells which persist after therapy and which might evolve into a tumor relapse...
  63. ncbi request reprint A novel mammalian display system for the selection of protein-protein interactions by decoy receptor engagement
    Peter Ellmark
    Department of Immunotechnology, Lund University, Lund, Sweden
    J Mol Recognit 17:316-22. 2004
    ..This demonstrates that the approach may serve as a tool in post-genomic research for identifying protein-protein interactions, without prior knowledge of either component...
  64. pmc Cytomegalovirus glycoprotein B-specific antibody analysis using electrochemiluminescence detection-based techniques
    M Ohlin
    Department of Immunotechnology, Lund University, Sweden
    Clin Diagn Lab Immunol 4:107-11. 1997
    ..Indirect binding assays showed wide linear assay ranges and revealed that serum samples diluted in parallel with a monoclonal antibody-based standard, simplifying quantitative analytical assessments...
  65. ncbi request reprint Selective infection of E. coli as a function of a specific molecular interaction
    Nina Nilsson
    Department of Immunotechnology, Lund University, Lund, Sweden
    J Mol Recognit 15:27-32. 2002
    ....
  66. ncbi request reprint Gene family clustering identifies functionally associated subsets of human in vivo blood and tonsillar dendritic cells
    Malin Lindstedt
    Department of Immunotechnology, Lund University, Lund, Sweden
    J Immunol 175:4839-46. 2005
    ..The data demonstrated a functionally distinct association of each of the seven subsets based on their signatures, involving regulatory genes in adaptive and innate immunity...
  67. ncbi request reprint The human CD77- B cell population represents a heterogeneous subset of cells comprising centroblasts, centrocytes, and plasmablasts, prompting phenotypical revision
    Carl Magnus Hogerkorp
    Department of Immunotechnology, Lund University, 221 84 Lund, Sweden
    J Immunol 177:4341-9. 2006
    ..Together this demonstrates that CD77 does not discriminate centroblasts and centrocytes and that the CD77(-) population represents a heterogeneous subset of cells, comprising centroblasts, centrocytes, and plasmablast...
  68. doi request reprint Strategy for surveying the proteome using affinity proteomics and mass spectrometry
    Christer Wingren
    Department of Immunotechnology, Lund University, Lund, Sweden
    Proteomics 9:1511-7. 2009
    ..The biological sample is digested, exposed to these immobilized antibodies, whereby motif-containing peptides are specifically captured, enriched and subsequently detected and identified using MS...
  69. pmc CD27- CD4+ memory T cells define a differentiated memory population at both the functional and transcriptional levels
    Asa Schiött
    Department of Immunotechnology, Lund University, Sweden
    Immunology 113:363-70. 2004
    ..These gene data strongly support the different functional profiles of CD27+ and CD27- memory populations, in terms of protein expression and the capacity to respond to antigen...
  70. ncbi request reprint Augmented Phl p 5-specific Th2 response after exposure of dendritic cells to allergen in complex with specific IgE compared to IgG1 and IgG4
    Kristina Lundberg
    Department of Immunotechnology, Lund University, Lund, Sweden
    Clin Immunol 128:358-65. 2008
    ....
  71. pmc Pre-assembly of the extracellular domains of CD40 is not necessary for rescue of mouse B cells from anti-immunoglobulin M-induced apoptosis
    Peter Ellmark
    Department of Immunotechnology, Lund University Lund, Sweden
    Immunology 108:452-7. 2003
    ..Furthermore, our data imply that conformational changes initiated in the extracellular domains of CD40 are not essential for signal transduction...
  72. ncbi request reprint Antibody-mediated neutralization of cytomegalovirus: modulation of efficacy induced through the IgG constant region
    Christina Furebring
    Department of Immunotechnology, Lund University, Lund, Sweden
    Mol Immunol 38:833-40. 2002
    ....
  73. ncbi request reprint Germinal centers regulate human Th2 development
    Bengt Johansson-Lindbom
    Department of Immunotechnology, Lund University, Lund, Sweden
    J Immunol 171:1657-66. 2003
    ....
  74. pmc The mechanism of bacterial infection by filamentous phages involves molecular interactions between TolA and phage protein 3 domains
    Fredrik Karlsson
    Department of Immunotechnology, Lund University, SE 220 07 Lund, Sweden
    J Bacteriol 185:2628-34. 2003
    ..The multiple roles for each of the separate g3p and TolA domains imply a delicate interaction network during the phage infection process and a model for the infection mechanism is hypothesized...
  75. ncbi request reprint Germinal center B cells constitute a predominant physiological source of IL-4: implication for Th2 development in vivo
    Bengt Johansson-Lindbom
    Department of Immunotechnology, Lund University, Lund, Sweden
    J Immunol 168:3165-72. 2002
    ..Our results show that GCs provide the most appropriate microenvironment for IL-4-dependent Th2 polarization in vivo and imply a critical role for GC B cells in this differentiation process...
  76. ncbi request reprint Genomic and functional delineation of dendritic cells and memory T cells derived from grass pollen-allergic patients and healthy individuals
    Malin Lindstedt
    Department of Immunotechnology, Lund University, PO Box 7031, S 220 07 Lund, Sweden
    Int Immunol 17:401-9. 2005
    ..The panel of differentially expressed genes in the allergic group will form the basis for an increased understanding of the molecular mechanisms in allergy...
  77. pmc Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells
    Kristina Larsson
    Department of Immunotechnology, Lund University, Sweden
    Immunology 117:156-66. 2006
    ..This delineation of the cellular and transcriptional activity of MUTZ-3, in response to maturational stimuli, demonstrates the significance of this cell line as a model for functional studies of inflammatory responses...
  78. ncbi request reprint Nanosphere induced gene expression in human dendritic cells
    Michiya Matsusaki
    Department of Molecular Chemistry, Graduate School of Engineering, Osaka University and CREST, Osaka, Japan
    Nano Lett 5:2168-73. 2005
    ....
  79. ncbi request reprint ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome
    Michael J Taussig
    Technology Research Group, The Babraham Institute, Cambridge CB22 3AT, UK
    Nat Methods 4:13-7. 2007
    ..Given the huge diversity of the proteome, the scale of the project is potentially immense but nevertheless feasible in the context of a pan-European or even worldwide coordination...
  80. ncbi request reprint High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma
    Erik Björck
    Department of Molecular Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Blood 105:2908-15. 2005
    ..CCNB1 expression had an independent prognostic value when included in a multivariate analysis together with the 5 parameters of the follicular lymphoma international prognostic index...