Ake Borg

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. pmc Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers
    Ana Teresa Maia
    Cambridge Research Institute CRUK, Li Ka Shing Centre, Cancer Research UK, Robinson Way, Cambridge, CB2 0RE, UK
    Breast Cancer Res 14:R63. 2012
  2. pmc Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications
    Taru A Muranen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 8, Helsinki, FI 00029, Finland
    Breast Cancer Res 13:R90. 2011
  3. pmc Comparison of cisplatin sensitivity and the 18F fluoro-2-deoxy 2 glucose uptake with proliferation parameters and gene expression in squamous cell carcinoma cell lines of the head and neck
    Eva Henriksson
    Department of Otorhinolaryngology, University Hospital Malmo, SE 205 02 Malmo, Sweden
    J Exp Clin Cancer Res 28:17. 2009
  4. pmc Exploring the link between MORF4L1 and risk of breast cancer
    Griselda Martrat
    Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research IDIBELL, Gran Via 199, L Hospitalet del Llobregat 08908, Spain
    Breast Cancer Res 13:R40. 2011
  5. pmc Basal-like phenotype is not associated with patient survival in estrogen-receptor-negative breast cancers
    Mervi Jumppanen
    Department of Pathology, Seinajoki Central Hospital, Hanneksenrinne 7, FIN 60220 Seinäjoki, Finland
    Breast Cancer Res 9:R16. 2007
  6. pmc Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families
    Adalgeir Arason
    Department of Pathology, Landspitali LSH v Hringbraut, 101 Reykjavik, Iceland
    Breast Cancer Res 12:R50. 2010
  7. pmc Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study
    Ake Borg
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Hum Mutat 31:E1200-40. 2010
  8. doi request reprint Characterisation of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumours
    Karolina Holm
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Breast Cancer Res Treat 133:583-94. 2012
  9. pmc Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics
    Goran Jonsson
    Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Barngatan 2B, 5 Lund, Sweden
    Breast Cancer Res 12:R42. 2010
  10. pmc Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
    Karolina Holm
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, Lund, Sweden
    Breast Cancer Res 12:R36. 2010

Detail Information

Publications72

  1. pmc Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers
    Ana Teresa Maia
    Cambridge Research Institute CRUK, Li Ka Shing Centre, Cancer Research UK, Robinson Way, Cambridge, CB2 0RE, UK
    Breast Cancer Res 14:R63. 2012
    ..We have previously reported that BRCA2 shows differential allelic expression and we hypothesize that the known variable penetrance of BRCA2 mutations might be associated with this mechanism...
  2. pmc Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications
    Taru A Muranen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 8, Helsinki, FI 00029, Finland
    Breast Cancer Res 13:R90. 2011
    ..We investigated gene copy-number aberrations and gene-expression profiles that are typical for breast tumors of CHEK2 1100delC-mutation carriers...
  3. pmc Comparison of cisplatin sensitivity and the 18F fluoro-2-deoxy 2 glucose uptake with proliferation parameters and gene expression in squamous cell carcinoma cell lines of the head and neck
    Eva Henriksson
    Department of Otorhinolaryngology, University Hospital Malmo, SE 205 02 Malmo, Sweden
    J Exp Clin Cancer Res 28:17. 2009
    ....
  4. pmc Exploring the link between MORF4L1 and risk of breast cancer
    Griselda Martrat
    Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research IDIBELL, Gran Via 199, L Hospitalet del Llobregat 08908, Spain
    Breast Cancer Res 13:R40. 2011
    ..To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens...
  5. pmc Basal-like phenotype is not associated with patient survival in estrogen-receptor-negative breast cancers
    Mervi Jumppanen
    Department of Pathology, Seinajoki Central Hospital, Hanneksenrinne 7, FIN 60220 Seinäjoki, Finland
    Breast Cancer Res 9:R16. 2007
    ..We studied the clinical and biological features of the basal-phenotype tumors determined by immunohistochemistry (IHC) and cDNA microarrays especially within the ER-negative subgroup...
  6. pmc Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families
    Adalgeir Arason
    Department of Pathology, Landspitali LSH v Hringbraut, 101 Reykjavik, Iceland
    Breast Cancer Res 12:R50. 2010
    ..To follow up suggestive loci, an additional 13 families from other Nordic countries were genotyped for selected markers...
  7. pmc Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study
    Ake Borg
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Hum Mutat 31:E1200-40. 2010
    ..Although some VUS inflict chemical differences at conserved residues, suggesting a deleterious effect, the majority are not associated with an increased risk of CBC...
  8. doi request reprint Characterisation of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumours
    Karolina Holm
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Breast Cancer Res Treat 133:583-94. 2012
    ..Amplification was equally prevalent in familial and sporadic tumours, but strikingly rare in BRCA1- and BRCA2-mutated tumours. We conclude that 11q13 includes many potential target genes in addition to CCND1...
  9. pmc Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics
    Goran Jonsson
    Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Barngatan 2B, 5 Lund, Sweden
    Breast Cancer Res 12:R42. 2010
    ..Additionally, breast tumors occurring in individuals with germline BRCA1 or BRCA2 mutations typically fall into distinct subtypes...
  10. pmc Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
    Karolina Holm
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, Lund, Sweden
    Breast Cancer Res 12:R36. 2010
    ..Each subtype has a characteristic expression pattern suggested to partly depend on cellular origin. We aimed to investigate whether the molecular subtypes also display distinct methylation profiles...
  11. pmc High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer
    Johan Staaf
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, Lund, Sweden
    Breast Cancer Res 12:R25. 2010
    ....
  12. ncbi request reprint Cytogenetic characterization and gene expression profiling of the trastuzumab-resistant breast cancer cell line JIMT-1
    Karin Rennstam
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2 1, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 172:95-106. 2007
    ..We conclude that cytogenetic and expression profiling of JIMT-1 revealed several new features that need further characterization and may shed light on trastuzumab resistance...
  13. pmc Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios
    Johan Staaf
    Department of Oncology, Clinical Sciences, Lund University, SE 22185 Lund, Sweden
    BMC Bioinformatics 9:409. 2008
    ..Therefore, we examined the effects of the conventionally used normalization method for Illumina Infinium arrays when applied to cancer samples...
  14. doi request reprint Detection and precise mapping of germline rearrangements in BRCA1, BRCA2, MSH2, and MLH1 using zoom-in array comparative genomic hybridization (aCGH)
    Johan Staaf
    Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden
    Hum Mutat 29:555-64. 2008
    ..g., focusing on breast cancer susceptibility genes, with increased capacity using multiformat design, and represents a valuable new tool and complement for genetic screening in clinical diagnostics...
  15. ncbi request reprint The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-like breast cancer
    Goran Jonsson
    Department of Oncology, CREATE Health Strategic Center for Translational Cancer Research, Lund University, Skåne Department of Oncology, Skane University Hospital, Lund, Sweden
    Cancer Res 72:4028-36. 2012
    ..Together, our findings show the existence of genetic heterogeneity within the basal-like breast cancer subtype that is based upon BRCA1 status...
  16. doi request reprint Identification of subtypes in human epidermal growth factor receptor 2--positive breast cancer reveals a gene signature prognostic of outcome
    Johan Staaf
    Department of Oncology, CREATE Health Strategic Center for TranslationalCancer Research, Lund University, Lund, Sweden
    J Clin Oncol 28:1813-20. 2010
    ....
  17. doi request reprint Detecting EGFR alterations in clinical specimens-pitfalls and necessities
    Sofi Isaksson
    Department of Clinical Sciences, Division of Oncology, Lund University, Medicon Village, SE 223 81, Lund, Sweden
    Virchows Arch 463:755-64. 2013
    ....
  18. pmc CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers
    Eleonor Olsson
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    BMC Cancer 11:418. 2011
    ..We aimed to investigate potential associations between alternatively spliced isoforms of CD44 and CSCs as well as to various breast cancer biomarkers and molecular subtypes...
  19. doi request reprint Indistinguishable genomic profiles and shared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma: different sides of a single coin?
    Ana Carneiro
    Department of Oncology, Institute of Clinical Sciences, Lund University, Lund, Sweden
    Lab Invest 89:668-75. 2009
    ....
  20. pmc Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays
    Johan Staaf
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Genome Biol 9:R136. 2008
    ....
  21. ncbi request reprint Multiple metastases from cutaneous malignant melanoma patients may display heterogeneous genomic and epigenomic patterns
    Katja Harbst
    Department of Oncology, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Melanoma Res 20:381-91. 2010
    ..These data are further corroborated by a switch in CDH1 and CDH2 expression between metastases from the same patient. In conclusion, our results provide evidence for different models of metastatic progression in melanoma...
  22. pmc The CD44+/CD24- phenotype is enriched in basal-like breast tumors
    Gabriella Honeth
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, SE 221 85 Lund, Sweden
    Breast Cancer Res 10:R53. 2008
    ..We have explored the prevalence of cells with different CD44/CD24 phenotypes within breast cancer subtypes...
  23. pmc Molecular profiling reveals low- and high-grade forms of primary melanoma
    Katja Harbst
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Clin Cancer Res 18:4026-36. 2012
    ..This raises the possibility that a molecular structure exists even in the early stages of melanoma and that molecular determinants could underlie histophenotype and eventual patient outcome...
  24. doi request reprint Higher occurrence of childhood cancer in families with germline mutations in BRCA2, MMR and CDKN2A genes
    Susanne Magnusson
    Department of Oncology, Institution of Clinical Sciences, Lund University, Lund University Hospital, Lund, 22185, Sweden
    Fam Cancer 7:331-7. 2008
    ..4; 95% CI 3.5-44.1), MMR genes (OR 29.0; 95% CI 9.1-92.6), and CDKN2A (OR 30.2; 95% CI 7.0-131.1). This study suggests that the risk for childhood tumors is increased in families with germline mutations in the BRCA2, MMR and CDKN2A genes...
  25. doi request reprint Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene
    Helena Persson
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Cancer Res 71:78-86. 2011
    ..In summary, our work substantially expands the number of known miRNAs and highlights the complexity of small RNA expression in breast cancer...
  26. ncbi request reprint Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma
    Sofia K Gruvberger-Saal
    Department of Oncology and Theoretical Physics, Lund University, Lund, Sweden
    Clin Cancer Res 13:1987-94. 2007
    ..The aim of the present study was to elucidate the biology and prognostic role of the second ER, ERbeta, in patients treated with adjuvant tamoxifen...
  27. pmc Recurrent and multiple bladder tumors show conserved expression profiles
    David Lindgren
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    BMC Cancer 8:183. 2008
    ..Consequently, genetically less evolved tumors may appear chronologically later than genetically related but more evolved tumors...
  28. doi request reprint Swedish CDKN2A mutation carriers do not present the atypical mole syndrome phenotype
    Kari Nielsen
    Department of Clinical Sciences, Division of Dermatology, Lund Melanoma Study Group, Lund University, Lund, Sweden
    Melanoma Res 20:266-72. 2010
    ..The atypical mole syndrome phenotype was, however, not verified in the studied families and total naevus counts were low...
  29. doi request reprint The non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs
    Helena Persson
    Department of Oncology and CREATE Health Strategic Centre for Clinical Cancer Research, Lund University, BMC, 221 84 Lund, Sweden
    Nat Cell Biol 11:1268-71. 2009
    ..Our findings expand the repertoire of small regulatory RNAs and assign, for the first time, a function to vRNAs that may help explain the association between vault particles and drug resistance...
  30. ncbi request reprint Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families
    Maria Henningson
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2 1, 221 85, Lund, Sweden
    Fam Cancer 6:445-52. 2007
    ....
  31. pmc Landscape of somatic allelic imbalances and copy number alterations in HER2-amplified breast cancer
    Johan Staaf
    Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Barngatan 2B, SE 22185 Lund, Sweden
    Breast Cancer Res 13:R129. 2011
    ....
  32. ncbi request reprint High-resolution genomic profiles of breast cancer cell lines assessed by tiling BAC array comparative genomic hybridization
    Goran Jonsson
    Department of Oncology, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 46:543-58. 2007
    ..The tiling BAC-arrays constitute a powerful tool for high-resolution genomic profiling suitable for cancer research and clinical diagnostics...
  33. ncbi request reprint Distinct genomic profiles in hereditary breast tumors identified by array-based comparative genomic hybridization
    Goran Jonsson
    Department of Oncology, University Hospital, Lund, Sweden
    Cancer Res 65:7612-21. 2005
    ..00005, respectively). Further validation may prove this tumor classifier to be useful for selecting familial breast cancer cases for further mutation screening, particularly, as these data can be obtained using archival tissue...
  34. pmc Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer
    Katja Lundgren
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Sweden
    Breast Cancer Res 10:R81. 2008
    ..Moreover, during 11q13 amplification a deletion of the distal 11q region has been described. In order to assess the potential impact of the deletion we examined a selected marker for this event...
  35. doi request reprint Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome
    Goran Jonsson
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Clin Cancer Res 16:3356-67. 2010
    ..Although spontaneous regression, likely due to immune defense activation, rarely occurs, we lack a biological rationale and predictive markers in selecting patients for immune therapy...
  36. ncbi request reprint Genetic profiles distinguish different types of hereditary ovarian cancer
    Katarina Domanska
    Institute of Clinical Sciences, Department of Oncology, Lund University, 22185 Lund, Sweden
    Oncol Rep 24:885-95. 2010
    ..The results indicate that HBOC and HNPCC associated ovarian cancer develop along distinct genetic pathways and genetic profiles can thus be applied to distinguish between different types of hereditary ovarian cancer...
  37. ncbi request reprint Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma
    Josefin Fernebro
    Department of Oncology, Lund University, SE 221 85 Lund, Sweden
    Int J Cancer 118:1165-72. 2006
    ..In conclusion, our findings demonstrate differentially expressed genes for the 2 major gene fusion variants in SS, SS18/SSX1 and SS18/SSX2, and thereby suggest that these result in different downstream effects...
  38. doi request reprint Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes
    Karolina Holm
    Department of Oncology, Clinical Sciences, Lund University, Skane University Hospital, SE 221 85 Lund, Sweden
    Mol Oncol 6:494-506. 2012
    ..Our observation that increased expression of EZH2 does not necessarily correlate with increased abundance of H3K27me3 supports the idea that EZH2 can have effects beyond epigenetic silencing of target genes in breast cancer...
  39. doi request reprint Prevalence of germline TP53 mutations and history of Li-Fraumeni syndrome in families with childhood adrenocortical tumors, choroid plexus tumors, and rhabdomyosarcoma: a population-based survey
    Susanne Magnusson
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Pediatr Blood Cancer 59:846-53. 2012
    ..In this study, we evaluated the frequency of germline TP53 mutations and family history in a population-based series of patients...
  40. doi request reprint High-resolution genomic profiling of male breast cancer reveals differences hidden behind the similarities with female breast cancer
    Ida Johansson
    Department of Oncology, Clinical Sciences, Lund University, BMC C13, 22184 Lund, Sweden
    Breast Cancer Res Treat 129:747-60. 2011
    ..MBC can be divided into two comprehensive genomic subgroups, which may be of prognostic value. The male-simple subgroup appears notably different from any genomic subgroup so far defined in FBC...
  41. doi request reprint Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridization
    Anna Isinger-Ekstrand
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, Lund, Sweden
    Cancer Genet Cytogenet 200:120-6. 2010
    ..These data suggest that molecular diagnostics and targeted therapies can be applied to adenocarcinomas of the distal esophagus and gastroesophageal junction alike...
  42. doi request reprint Zoom-in array comparative genomic hybridization (aCGH) to detect germline rearrangements in cancer susceptibility genes
    Johan Staaf
    Department of Oncology, Clinical Sciences, CREATE Health Strategic Centre For Translational Cancer Research, Lund University, Lund, Sweden
    Methods Mol Biol 653:221-35. 2010
    ..Furthermore, zoom-in aCGH can be streamlined for a particular application, for example, focusing on breast cancer susceptibility genes, with increased capacity using multiformat design...
  43. ncbi request reprint Impact of teenage oral contraceptive use in a population-based series of early-onset breast cancer cases who have undergone BRCA mutation testing
    Helena Jernstrom
    Department of Oncology, Clinical Sciences, Lund University Hospital, SE 221 85 Lund, Sweden
    Eur J Cancer 41:2312-20. 2005
    ..Each year of OC use prior to age 20 years conferred a significantly increased risk for early-onset breast cancer, while there was no risk associated with use after age 20 years...
  44. ncbi request reprint MiRNA expression in urothelial carcinomas: important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31
    Srinivas Veerla
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Int J Cancer 124:2236-42. 2009
    ..In addition, these latter miRNAs were shown to be excellent prognostic markers for death by disease as outcome. The presented data shows that pathological subtypes of urothelial carcinoma show distinct miRNA gene expression signatures...
  45. ncbi request reprint The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes
    Lars Nilsson
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, Sweden
    Blood 110:3005-14. 2007
    ..These studies establish the importance of molecular characterization of distinct stages of cancer stem and progenitor cells to enhance the resolution of stage-specific dysregulated gene expression...
  46. ncbi request reprint The Wilms' tumor gene 1 (WT1) induces expression of the N-myc downstream regulated gene 2 (NDRG2)
    Emelie Svensson
    Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden
    DNA Cell Biol 26:589-97. 2007
    ..These results show that the expression of the NDRG2 gene is directly or indirectly induced by WT1, and provide the first insights into transcriptional regulation of the NDRG2 gene, including demonstration of a novel splice variant...
  47. pmc The HER2-encoded miR-4728-3p regulates ESR1 through a non-canonical internal seed interaction
    Inga Newie
    BioCare, Strategic Cancer Research Program, Lund, Sweden Department of Oncology and Pathology, Lund University Cancer Center, Lund, Sweden
    PLoS ONE 9:e97200. 2014
    ..In summary, we present here an alternative mode of miRNA regulation and demonstrate this dual function of the HER2 locus, linking the two major biomarkers in breast cancer. ..
  48. ncbi request reprint Mapping of a novel ocular and cutaneous malignant melanoma susceptibility locus to chromosome 9q21.32
    Goran Jonsson
    Department of Oncology, University Hospital, Lund, Sweden
    J Natl Cancer Inst 97:1377-82. 2005
    ....
  49. pmc Genetic profiling differentiates second primary tumors from metastases in adult metachronous soft tissue sarcoma
    Josefin Fernebro
    Department of Oncology, Institute of Clinical Sciences, Lund University Hospital, 221 85 Lund, Sweden
    Sarcoma 2008:431019. 2008
    ....
  50. ncbi request reprint Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
    Linda Holmquist-Mengelbier
    Division of Molecular Medicine, Department of Laboratory Medicine, Lund University, University Hospital MAS, SE 205 02 Malmo, Sweden
    Cancer Cell 10:413-23. 2006
    ..Our results demonstrate the relevance of HIF-2alpha in neuroblastoma progression and have general tumor biological implications...
  51. ncbi request reprint Differences in IGFBP-3 regulation between young healthy women from BRCAX families and those belonging to BRCA1/2 families
    Helena Jernstrom
    Department of Oncology, Lund University, Lund, Sweden
    Eur J Cancer Prev 15:233-41. 2006
    ..It is possible that a subgroup of the BRCAX families has an increased risk of breast cancer because of high IGFBP-3 levels...
  52. ncbi request reprint Characterization of a novel breast carcinoma xenograft and cell line derived from a BRCA1 germ-line mutation carrier
    Oskar T Johannsson
    Departments of Oncology, University Hospital, Lund, Sweden
    Lab Invest 83:387-96. 2003
    ..We conclude that L56Br-X1 and L56Br-C1 are useful model systems for studies of the pathogenesis and new therapeutic modalities of BRCA1-induced human breast cancer...
  53. pmc Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x
    Mev Dominguez-Valentin
    Department of Oncology, Institute of Clinical Sciences, Lund University, Lund, Sweden
    PLoS ONE 8:e71755. 2013
    ..The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects...
  54. pmc Non-coding antisense transcription detected by conventional and single-stranded cDNA microarray
    Johan Vallon-Christersson
    Department of Oncology, Institute of Clinical Sciences, and SWEGENE DNA microarray resource center, Lund University, Barngatan 2 1, SE 221 85 Lund, Sweden
    BMC Genomics 8:295. 2007
    ..Therefore, we profiled transcription of sense and antisense independently by using strand-specific cDNA microarrays...
  55. ncbi request reprint Microarray analysis of gliomas reveals chromosomal position-associated gene expression patterns and identifies potential immunotherapy targets
    Oscar Persson
    Department of Neurosurgery, The Rausing Laboratory, Lund University, 22100 Lund, Sweden
    J Neurooncol 85:11-24. 2007
    ..g. CD44 and tenascin-C). Software for the chromosome analysis was developed and is freely available at http://base.thep.lu.se...
  56. pmc GOBO: gene expression-based outcome for breast cancer online
    Markus Ringner
    Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden
    PLoS ONE 6:e17911. 2011
    ..The design and implementation of GOBO facilitate easy incorporation of additional query functions and applications, as well as additional data sets irrespective of tumor type and array platform...
  57. ncbi request reprint The contribution of the hereditary nonpolyposis colorectal cancer syndrome to the development of ovarian cancer
    Susanne Malander
    Department of Oncology, Institute of Clinical Sciences, Lund University Hospital, SE 221 85 Lund, Sweden
    Gynecol Oncol 101:238-43. 2006
    ....
  58. ncbi request reprint Human neuroblastoma cells exposed to hypoxia: induction of genes associated with growth, survival, and aggressive behavior
    Annika Jögi
    Department of Laboratory Medicine, Division of Molecular Medicine, University Hospital MAS, Lund University, S 205 02 Malmo, Sweden
    Exp Cell Res 295:469-87. 2004
    ....
  59. doi request reprint Histological specificity of alterations and expression of KIT and KITLG in non-small cell lung carcinoma
    Annette Salomonsson
    Division of Oncology, Department of Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 52:1088-96. 2013
    ....
  60. pmc Cancer incidence in relatives of a population-based set of cases of early-onset breast cancer with a known BRCA1 and BRCA2 mutation status
    Niklas Loman
    Department of Oncology, Lund University Hospital, Lund, Sweden
    Breast Cancer Res 5:R175-86. 2003
    ..In families with a BRCA1 or a BRCA2 mutation, individual carrier status predicts the risk of breast cancer. In relatives of cases where both BRCA1 and BRCA2 mutations are excluded, the risk remains undetermined...
  61. ncbi request reprint Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer
    Anna Isinger Ekstrand
    Department of Oncology, Institute of Clinical Sciences, Lund University, 221 85 Lund, Sweden
    Fam Cancer 9:125-9. 2010
    ....
  62. pmc Expression profiling to predict outcome in breast cancer: the influence of sample selection
    Sofia K Gruvberger
    Department of Oncology, The Jubileum Institute, Lund University Hospital, Lund, Sweden
    Breast Cancer Res 5:23-6. 2003
    ..We conclude that it may be important to define prognostic expression profiles separately for estrogen receptor-alpha-positive and estrogen receptor-alpha-negative tumors...
  63. ncbi request reprint Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression o
    Josef Davidsson
    Department of Clinical Genetics, Lund University Hospital, Sweden
    Hum Mol Genet 16:2215-25. 2007
    ..However, involvement of these genes in dup(1q)-positive ALLs and BLs has previously not been reported...
  64. ncbi request reprint Intratumor versus intertumor heterogeneity in gene expression profiles of soft-tissue sarcomas
    Princy Francis
    Department of Oncology, Lund University, Lund, Sweden
    Genes Chromosomes Cancer 43:302-8. 2005
    ..We concluded that intratumor variability exists but that accurate gene expression profiling also could be obtained using single samples from a large STS...
  65. pmc CHEK2 1100delC in patients with metachronous cancers of the breast and the colorectum
    Anna Isinger
    Department of Oncology, Institute of Clinical Sciences, Lund University, 221 85 Lund, Sweden
    BMC Cancer 6:64. 2006
    ....
  66. doi request reprint Screening for copy-number alterations and loss of heterozygosity in chronic lymphocytic leukemia--a comparative study of four differently designed, high resolution microarray platforms
    Rebeqa Gunnarsson
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Hematology and Transplantation, Lund University, Lund, Sweden
    Genes Chromosomes Cancer 47:697-711. 2008
    ..Large-scale studies of genomic aberrations are now feasible, but new tools for LOH analysis are requested...
  67. ncbi request reprint Predicting continuous values of prognostic markers in breast cancer from microarray gene expression profiles
    Sofia K Gruvberger-Saal
    Department of Oncology and Complex Systems Division, Lund University, Lund, Sweden
    Mol Cancer Ther 3:161-8. 2004
    ..This and similar studies may be used to increase our understanding of the biology underlying these markers as well as to improve the currently available prognostic markers for breast cancer...
  68. ncbi request reprint Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis
    Anjila Koul
    Department of Oncology, Lund University Hospital, Lund, Sweden
    Cancer 94:2369-79. 2002
    ..Although microsatellite inability is reported in approximately 25% of endometrial carcinomas, its relation with the 2 pathogenetic types is not investigated...
  69. ncbi request reprint Cancer-associated fibroblasts expressing CXCL14 rely upon NOS1-derived nitric oxide signaling for their tumor-supporting properties
    Martin Augsten
    Authors Affiliations Department of Oncology Pathology, Karolinska Institutet, Stockholm Department of Oncology, Lund University, Lund, Sweden
    Cancer Res 74:2999-3010. 2014
    ..Collectively, our findings defined key components of a signaling network that maintains the protumoral functions of CXCL14-stimulated CAF, and they identified NOS1 as intervention target for CAF-directed cancer therapy...
  70. ncbi request reprint Patterns of chromosomal imbalances defines subgroups of breast cancer with distinct clinical features and prognosis. A study of 305 tumors by comparative genomic hybridization
    Karin Rennstam
    Jubileum Institute, Department of Oncology, University Hospital, Lund, Swedenland
    Cancer Res 63:8861-8. 2003
    ..We conclude that patterns of copy number gains and losses define breast tumors with distinct clinicopathological features and patient prognosis...
  71. ncbi request reprint Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells
    Susanna Obad
    Department of Hematology, Lund University, BMC C14, Lund S 221 84, Sweden
    Oncogene 23:4050-9. 2004
    ....
  72. pmc BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data
    Lao H Saal
    Complex Systems Division, Department of Theoretical Physics, Lund University, SE 22362 Lund, Sweden
    Genome Biol 3:SOFTWARE0003. 2002
    ..All software necessary to run a local server is freely available...