Maria Björkqvist

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. pmc Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease
    Maria Björkqvist
    Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    PLoS ONE 7:e29868. 2012
  2. pmc Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's disease
    Erik Stomrud
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University SUS, 205 02 Malmo, Sweden
    Alzheimers Res Ther 2:20. 2010
  3. ncbi request reprint Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease
    Maria Björkqvist
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, Lund, Sweden
    Hum Mol Genet 15:1713-21. 2006
  4. ncbi request reprint Harnessing immune alterations in neurodegenerative diseases
    Maria Björkqvist
    Neuronal Survival Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, S 221 84 Lund, Sweden
    Neuron 64:21-4. 2009
  5. ncbi request reprint Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease
    Eugenia Papalexi
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 221 84 Lund, Sweden
    Eur J Neurosci 22:1541-6. 2005
  6. doi request reprint Islet beta-cell area and hormone expression are unaltered in Huntington's disease
    Karl Bacos
    Unit of Molecular Metabolism, Department of Experimental Medical Science, Lund University, CRC 91 11, 205 02 Malmo, Sweden
    Histochem Cell Biol 129:623-9. 2008
  7. ncbi request reprint The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis
    Maria Björkqvist
    Department of Cell and Molecular Biology, Lund, Sweden
    Hum Mol Genet 14:565-74. 2005
  8. ncbi request reprint Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice
    Jorien M M van der Burg
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC A10, Lund, Sweden
    Neurobiol Dis 44:1-8. 2011
  9. ncbi request reprint Increased metabolism in the R6/2 mouse model of Huntington's disease
    Jorien M M van der Burg
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University BMC A10, Lund, Sweden
    Neurobiol Dis 29:41-51. 2008
  10. doi request reprint Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion
    Ruben Smith
    Department of Experimental Medical Science, Lund University, Sweden
    Hum Mol Genet 18:3942-54. 2009

Detail Information

Publications29

  1. pmc Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease
    Maria Björkqvist
    Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    PLoS ONE 7:e29868. 2012
    ..Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies...
  2. pmc Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's disease
    Erik Stomrud
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University SUS, 205 02 Malmo, Sweden
    Alzheimers Res Ther 2:20. 2010
    ....
  3. ncbi request reprint Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease
    Maria Björkqvist
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, Lund, Sweden
    Hum Mol Genet 15:1713-21. 2006
    ..This progressive increase in cortisol may contribute to the clinical symptoms, such as muscular wasting, mood changes and some of the cognitive deficits that occur in HD...
  4. ncbi request reprint Harnessing immune alterations in neurodegenerative diseases
    Maria Björkqvist
    Neuronal Survival Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, S 221 84 Lund, Sweden
    Neuron 64:21-4. 2009
    ..Inflammation could be modified, with disease-slowing effects, by targeted interventions; it is also readily detectable and could serve as a source of valuable biomarkers...
  5. ncbi request reprint Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease
    Eugenia Papalexi
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 221 84 Lund, Sweden
    Eur J Neurosci 22:1541-6. 2005
    ..Gonadotropic hormone replacement did not mitigate weight loss or restore motor function in R6/2 males...
  6. doi request reprint Islet beta-cell area and hormone expression are unaltered in Huntington's disease
    Karl Bacos
    Unit of Molecular Metabolism, Department of Experimental Medical Science, Lund University, CRC 91 11, 205 02 Malmo, Sweden
    Histochem Cell Biol 129:623-9. 2008
    ..This may lead to a better understanding of HD and provide novel therapeutic targets for symptomatic treatment in HD...
  7. ncbi request reprint The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis
    Maria Björkqvist
    Department of Cell and Molecular Biology, Lund, Sweden
    Hum Mol Genet 14:565-74. 2005
    ..The blunting of exocytosis could be attributed to a 96% reduction in the number of insulin-containing secretory vesicles. Thus, diabetes in R6/2 mice is caused by a combination of deficient beta-cell mass and disrupted exocytosis...
  8. ncbi request reprint Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice
    Jorien M M van der Burg
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC A10, Lund, Sweden
    Neurobiol Dis 44:1-8. 2011
    ..In summary, these observations suggest that the GI tract is affected in HD mice and that GI dysfunction contributes to nutritional deficiencies and weight loss...
  9. ncbi request reprint Increased metabolism in the R6/2 mouse model of Huntington's disease
    Jorien M M van der Burg
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University BMC A10, Lund, Sweden
    Neurobiol Dis 29:41-51. 2008
    ..Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors...
  10. doi request reprint Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion
    Ruben Smith
    Department of Experimental Medical Science, Lund University, Sweden
    Hum Mol Genet 18:3942-54. 2009
    ..Thus, our findings have revealed a novel pathogenetic process by which mutant huntingtin may disrupt hormone exocytosis from beta-cells and possibly impair vesicular transport in any cell that expresses the pathogenic protein...
  11. doi request reprint Increased orexin levels in the cerebrospinal fluid the first year after a suicide attempt
    Lena Brundin
    Division of Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden
    J Affect Disord 113:179-82. 2009
    ..We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms...
  12. ncbi request reprint Orexin loss in Huntington's disease
    Asa Petersen
    Department of Physiological Sciences, Section for Neuronal Survival, Lund, Sweden
    Hum Mol Genet 14:39-47. 2005
    ..Our results show that the loss of orexin is a novel and potentially very important pathology in HD...
  13. ncbi request reprint Cocaine and amphetamine regulated transcript (CART) in suicide attempters
    Lena Brundin
    Division of Psychiatry, Department of Clinical Sciences, Lund University, Kioskgatan 19, SE 221 85, Lund, Sweden
    Psychiatry Res 158:117-22. 2008
    ..Further studies on the role of CART in psychiatric diseases where concentration difficulties are prominent, such as attention deficit disorder, are warranted...
  14. pmc No diagnostic value of plasma clusterin in Alzheimer's disease
    Edina Silajdzic
    Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    PLoS ONE 7:e50237. 2012
    ..There was a slight, but significant, increase in plasma clusterin in patients with depression compared to all other groups tested, which may warrant further investigation...
  15. pmc A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
    Maria Björkqvist
    Neuronal Survival Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, S 221 00 Lund, Sweden
    J Exp Med 205:1869-77. 2008
    ..Collectively, our data suggest parallel central nervous system and peripheral pathogenic pathways of immune activation in HD...
  16. ncbi request reprint Hypothalamic-endocrine aspects in Huntington's disease
    Asa Petersen
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 22184 Lund, Sweden
    Eur J Neurosci 24:961-7. 2006
    ..Investigating neuroendocrine changes in HD opens up the possibility of finding biomarkers to evaluate future therapies for HD, as well as of identifying novel targets for therapeutic interventions...
  17. doi request reprint Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease
    Philip Michael Gaughwin
    Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, S 221 84 Lund, Sweden
    Hum Mol Genet 20:2225-37. 2011
    ..Interestingly, miR-34b is significantly elevated in plasma from HD gene carriers prior to symptom onset. This is the first study suggesting that plasma miRs might be used as biomarkers for HD...
  18. ncbi request reprint Cocaine- and amphetamine-regulated transcript is increased in Huntington disease
    Maria Björkqvist
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, Sweden
    Mov Disord 22:1952-4. 2007
    ..Increased CART levels in HD therefore hold promise as a biomarker as well as a potential pathogenic mediator of symptoms...
  19. ncbi request reprint Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder
    Lena Brundin
    Division of Psychiatry, Department of Clinical Sciences, Lund University, Kioskgatan 19, SE 221 85 Lund, Sweden
    Eur Neuropsychopharmacol 17:573-9. 2007
    ..Our results suggest that suicidal patients with MDD have distinct neurobiological features, involving compromised levels of hypothalamic peptides regulating the state of arousal...
  20. ncbi request reprint CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats
    Nils Wierup
    Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Lund University, Sweden
    Diabetes 55:305-11. 2006
    ..We conclude that CART is a regulator of islet hormone secretion and that CART is upregulated in the beta-cells of type 2 diabetic rats...
  21. doi request reprint Beyond the brain: widespread pathology in Huntington's disease
    Jorien M M van der Burg
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University BMC A10, Lund, Sweden
    Lancet Neurol 8:765-74. 2009
    ....
  22. ncbi request reprint Increased levels of hemoglobin and alpha1-microglobulin in Huntington's disease
    Magnus G Olsson
    Division of Infection Medicine, Department of Clinical Sciences, Lund University, 221 84 Lund, Sweden
    Front Biosci (Elite Ed) 4:950-7. 2012
    ..The results suggest that hemolysis may be linked to the pathogenesis of Huntington's disease and that assay of hemoglobin and alpha1-microglobulin may provide biomarkers that are linked to biologically relevant processes...
  23. ncbi request reprint Skeletal muscle atrophy in r6/2 mice - altered circulating skeletal muscle markers and gene expression profile changes
    Anna Magnusson-Lind
    Brain Disease Biomarker Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    J Huntingtons Dis 3:13-24. 2014
    ....
  24. pmc Euploidy in somatic cells from R6/2 transgenic Huntington's disease mice
    Asa Petersen
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
    BMC Cell Biol 6:34. 2005
    ..Aneuploidy is normally a feature closely connected to neoplastic disease. To further explore this unexpected aspect of HD, we studied cultures derived from 6- and 12-week-old R6/2 fibroblasts, skeletal muscle cells, and liver cells...
  25. ncbi request reprint Orexin and psychiatric symptoms in suicide attempters
    Lena Brundin
    Division of Psychiatry, Department of Clinical Sciences, Lund University, Sweden
    J Affect Disord 100:259-63. 2007
    ..In the present study, we investigated the relationship between cerebrospinal fluid (CSF) orexin and specific psychiatric symptoms in suicidal patients...
  26. ncbi request reprint A Critical Evaluation of Inflammatory Markers in Huntington's Disease Plasma
    Edina Silajdzic
    Department of Experimental Medical Science, Brain Disease Biomarker Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    J Huntingtons Dis 2:125-34. 2013
    ..It has previously been demonstrated that a widespread, progressive innate immune response is detectable in plasma throughout the course of HD...
  27. pmc Abnormal peripheral chemokine profile in Huntington's disease
    Edward Wild
    UCL Institute of Neurology, London, UK Bristol University, UK Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK Lund University Diabetes Center Malmö Sweden and Department of Neurology, University of Ulm, Ulm, Germany
    PLoS Curr 3:RRN1231. 2011
    ..We conclude that, like cytokines, chemokines may be linked to the pathogenesis of HD, and that immune molecules may be valuable in tracking and exploring the pathogenesis of HD...
  28. ncbi request reprint Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine
    Nils Wierup
    Lund University, Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Unit of Neuroendocrine Cell Biology, BMC B11, SE 22 184 Lund, Sweden
    J Clin Endocrinol Metab 92:3573-81. 2007
    ..Hitherto, mapping studies of ghrelin cells covering the entire gastrointestinal (GI) tract in humans have been lacking. Furthermore, the phenotype of extragastric ghrelin cells is not known...
  29. ncbi request reprint Role of gastrin in the development of gastric mucosa, ECL cells and A-like cells in newborn and young rats
    Maria Björkqvist
    Department of Pharmacology, Institute of Physiological Sciences, University of Lund, Solvegatan 19, BMC F13, S 227 34, Lund, Sweden
    Regul Pept 108:73-82. 2002
    ..In contrast, the development of the A-like cells is independent of gastrin at all stages...