Research Topics
Genomes and Genes | Maria BjörkqvistSummaryAffiliation: Lund University Country: Sweden Publications
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Publications
Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's diseaseMaria Björkqvist
Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
PLoS ONE 7:e29868. 2012..Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies...- Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's diseaseErik Stomrud
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University SUS, 205 02 Malmo, Sweden
Alzheimers Res Ther 2:20. 2010.... 
Harnessing immune alterations in neurodegenerative diseasesMaria Björkqvist
Neuronal Survival Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, S 221 84 Lund, Sweden
Neuron 64:21-4. 2009..Inflammation could be modified, with disease-slowing effects, by targeted interventions; it is also readily detectable and could serve as a source of valuable biomarkers...
Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's diseaseMaria Björkqvist
Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, Lund, Sweden
Hum Mol Genet 15:1713-21. 2006..This progressive increase in cortisol may contribute to the clinical symptoms, such as muscular wasting, mood changes and some of the cognitive deficits that occur in HD...- Islet beta-cell area and hormone expression are unaltered in Huntington's diseaseKarl Bacos
Unit of Molecular Metabolism, Department of Experimental Medical Science, Lund University, CRC 91 11, 205 02 Malmo, Sweden
Histochem Cell Biol 129:623-9. 2008..This may lead to a better understanding of HD and provide novel therapeutic targets for symptomatic treatment in HD... - Gastrointestinal dysfunction contributes to weight loss in Huntington's disease miceJorien M M van der Burg
Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC A10, Lund, Sweden
Neurobiol Dis 44:1-8. 2011..In summary, these observations suggest that the GI tract is affected in HD mice and that GI dysfunction contributes to nutritional deficiencies and weight loss... - The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosisMaria Björkqvist
Department of Cell and Molecular Biology, Lund, Sweden
Hum Mol Genet 14:565-74. 2005..The blunting of exocytosis could be attributed to a 96% reduction in the number of insulin-containing secretory vesicles. Thus, diabetes in R6/2 mice is caused by a combination of deficient beta-cell mass and disrupted exocytosis... - Increased metabolism in the R6/2 mouse model of Huntington's diseaseJorien M M van der Burg
Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University BMC A10, Lund, Sweden
Neurobiol Dis 29:41-51. 2008..Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors... - Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretionRuben Smith
Department of Experimental Medical Science, Lund University, Sweden
Hum Mol Genet 18:3942-54. 2009..Thus, our findings have revealed a novel pathogenetic process by which mutant huntingtin may disrupt hormone exocytosis from beta-cells and possibly impair vesicular transport in any cell that expresses the pathogenic protein... - Cocaine and amphetamine regulated transcript (CART) in suicide attemptersLena Brundin
Division of Psychiatry, Department of Clinical Sciences, Lund University, Kioskgatan 19, SE 221 85, Lund, Sweden
Psychiatry Res 158:117-22. 2008..Further studies on the role of CART in psychiatric diseases where concentration difficulties are prominent, such as attention deficit disorder, are warranted... - Increased orexin levels in the cerebrospinal fluid the first year after a suicide attemptLena Brundin
Division of Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden
J Affect Disord 113:179-82. 2009..We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms... - A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's diseaseMaria Björkqvist
Neuronal Survival Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, S 221 00 Lund, Sweden
J Exp Med 205:1869-77. 2008..Collectively, our data suggest parallel central nervous system and peripheral pathogenic pathways of immune activation in HD... - Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorderLena Brundin
Division of Psychiatry, Department of Clinical Sciences, Lund University, Kioskgatan 19, SE 221 85 Lund, Sweden
Eur Neuropsychopharmacol 17:573-9. 2007..Our results suggest that suicidal patients with MDD have distinct neurobiological features, involving compromised levels of hypothalamic peptides regulating the state of arousal... - Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's diseasePhilip Michael Gaughwin
Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, S 221 84 Lund, Sweden
Hum Mol Genet 20:2225-37. 2011..Interestingly, miR-34b is significantly elevated in plasma from HD gene carriers prior to symptom onset. This is the first study suggesting that plasma miRs might be used as biomarkers for HD... - Orexin loss in Huntington's diseaseAsa Petersen
Department of Physiological Sciences, Section for Neuronal Survival, Lund, Sweden
Hum Mol Genet 14:39-47. 2005..Our results show that the loss of orexin is a novel and potentially very important pathology in HD... - Cocaine- and amphetamine-regulated transcript is increased in Huntington diseaseMaria Björkqvist
Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, Sweden
Mov Disord 22:1952-4. 2007..Increased CART levels in HD therefore hold promise as a biomarker as well as a potential pathogenic mediator of symptoms... - Hypothalamic-endocrine aspects in Huntington's diseaseAsa Petersen
Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 22184 Lund, Sweden
Eur J Neurosci 24:961-7. 2006..Investigating neuroendocrine changes in HD opens up the possibility of finding biomarkers to evaluate future therapies for HD, as well as of identifying novel targets for therapeutic interventions... - CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic ratsNils Wierup
Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Lund University, Sweden
Diabetes 55:305-11. 2006..We conclude that CART is a regulator of islet hormone secretion and that CART is upregulated in the beta-cells of type 2 diabetic rats... - Beyond the brain: widespread pathology in Huntington's diseaseJorien M M van der Burg
Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University BMC A10, Lund, Sweden
Lancet Neurol 8:765-74. 2009.... - Increased levels of hemoglobin and alpha1-microglobulin in Huntington's diseaseMagnus G Olsson
Division of Infection Medicine, Department of Clinical Sciences, Lund University, 221 84 Lund, Sweden
Front Biosci (Elite Ed) 4:950-7. 2012..The results suggest that hemolysis may be linked to the pathogenesis of Huntington's disease and that assay of hemoglobin and alpha1-microglobulin may provide biomarkers that are linked to biologically relevant processes... - Euploidy in somatic cells from R6/2 transgenic Huntington's disease miceAsa Petersen
Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
BMC Cell Biol 6:34. 2005..Aneuploidy is normally a feature closely connected to neoplastic disease. To further explore this unexpected aspect of HD, we studied cultures derived from 6- and 12-week-old R6/2 fibroblasts, skeletal muscle cells, and liver cells... - Orexin and psychiatric symptoms in suicide attemptersLena Brundin
Division of Psychiatry, Department of Clinical Sciences, Lund University, Sweden
J Affect Disord 100:259-63. 2007..In the present study, we investigated the relationship between cerebrospinal fluid (CSF) orexin and specific psychiatric symptoms in suicidal patients... - Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's diseaseEugenia Papalexi
Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 221 84 Lund, Sweden
Eur J Neurosci 22:1541-6. 2005..Gonadotropic hormone replacement did not mitigate weight loss or restore motor function in R6/2 males... - No diagnostic value of plasma clusterin in Alzheimer's diseaseEdina Silajdzic
Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
PLoS ONE 7:e50237. 2012..There was a slight, but significant, increase in plasma clusterin in patients with depression compared to all other groups tested, which may warrant further investigation... - Abnormal peripheral chemokine profile in Huntington's diseaseEdward Wild
UCL Institute of Neurology, London, UK Bristol University, UK Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK Lund University Diabetes Center Malmö Sweden and Department of Neurology, University of Ulm, Ulm, Germany
PLoS Curr 3:RRN1231. 2011..We conclude that, like cytokines, chemokines may be linked to the pathogenesis of HD, and that immune molecules may be valuable in tracking and exploring the pathogenesis of HD... - Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestineNils Wierup
Lund University, Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Unit of Neuroendocrine Cell Biology, BMC B11, SE 22 184 Lund, Sweden
J Clin Endocrinol Metab 92:3573-81. 2007..Hitherto, mapping studies of ghrelin cells covering the entire gastrointestinal (GI) tract in humans have been lacking. Furthermore, the phenotype of extragastric ghrelin cells is not known... - Role of gastrin in the development of gastric mucosa, ECL cells and A-like cells in newborn and young ratsMaria Björkqvist
Department of Pharmacology, Institute of Physiological Sciences, University of Lund, Solvegatan 19, BMC F13, S 227 34, Lund, Sweden
Regul Pept 108:73-82. 2002..In contrast, the development of the A-like cells is independent of gastrin at all stages...