Anders Bjorklund

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projections
    Ulrica Englund
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, S-221 84 Lund, Sweden
    Exp Neurol 173:1-21. 2002
  2. ncbi Cell therapy for Parkinson's disease: what next?
    Anders Bjorklund
    Wallenberg Neuroscience Center, Lund University, Sweden
    Mov Disord 28:110-5. 2013
  3. ncbi Dopamine neuron systems in the brain: an update
    Anders Bjorklund
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund SE 22184, Sweden
    Trends Neurosci 30:194-202. 2007
  4. ncbi Gene therapy for dopamine replacement in Parkinson's disease
    Anders Bjorklund
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Sci Transl Med 1:2ps2. 2009
  5. ncbi Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon
    Lachlan H Thompson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, and Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, BMC A11, SE 221 84 Lund, Sweden
    Exp Neurol 198:183-98. 2006
  6. ncbi Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis
    Marie E Jönsson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, S 22184 Lund, Sweden
    Exp Neurol 219:341-54. 2009
  7. ncbi Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease
    Eunju Shin
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
    Neurobiol Dis 47:393-406. 2012
  8. ncbi Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain
    Lachlan H Thompson
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Eur J Neurosci 30:625-38. 2009
  9. ncbi Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts
    Andreas Toft Sørensen
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A 11, Lund University, Lund, Sweden
    Eur J Neurosci 21:2793-9. 2005
  10. ncbi Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration
    Thomas Carlsson
    Department Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC D11, Lund, Sweden
    Brain 132:319-35. 2009

Detail Information

Publications61

  1. ncbi Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projections
    Ulrica Englund
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, S-221 84 Lund, Sweden
    Exp Neurol 173:1-21. 2002
    ..The extensive integration and differentiation of in vitro-expanded human neural progenitor cells indicate that multipotent progenitors are capable of responding in a regionally specific manner to cues present in the developing rat brain...
  2. ncbi Cell therapy for Parkinson's disease: what next?
    Anders Bjorklund
    Wallenberg Neuroscience Center, Lund University, Sweden
    Mov Disord 28:110-5. 2013
    ..2013 Movement Disorder Society...
  3. ncbi Dopamine neuron systems in the brain: an update
    Anders Bjorklund
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund SE 22184, Sweden
    Trends Neurosci 30:194-202. 2007
    ....
  4. ncbi Gene therapy for dopamine replacement in Parkinson's disease
    Anders Bjorklund
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Sci Transl Med 1:2ps2. 2009
    ..Now, a team of French and UK researchers reports promising results in a nonhuman primate model of PD, paving the way for clinical trials of this enzyme-replacement approach...
  5. ncbi Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon
    Lachlan H Thompson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, and Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, BMC A11, SE 221 84 Lund, Sweden
    Exp Neurol 198:183-98. 2006
    ..The Ngn2-GFP reporter construct used here thus provides a tool for the identification of mesDA neuron precursors in the VM and selective isolation of transplantable mesDA neuron precursors for transplantation...
  6. ncbi Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis
    Marie E Jönsson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, S 22184 Lund, Sweden
    Exp Neurol 219:341-54. 2009
    ..These results have implications for current efforts to develop well-characterized stem cell-derived mesDA progenitor cell preparations for cell therapy...
  7. ncbi Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease
    Eunju Shin
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
    Neurobiol Dis 47:393-406. 2012
    ..Together, these results point to a critical role of both 5-HT(1) and D(2) receptors in the modulation of GID, and suggest that 5-HT neurons exert a modulatory role in the development of this side effect of neuronal transplantation...
  8. ncbi Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain
    Lachlan H Thompson
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Eur J Neurosci 30:625-38. 2009
    ..Results from testing of amphetamine-induced rotational behaviour suggest, moreover, that dopamine neurons implanted into the substantia nigra are also capable of integrating into the host circuitry at the functional level...
  9. ncbi Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts
    Andreas Toft Sørensen
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A 11, Lund University, Lund, Sweden
    Eur J Neurosci 21:2793-9. 2005
    ..Our findings define specific electrophysiological characteristics of transplanted fetal dopaminergic neurons, and we provide the first direct evidence of functional synaptic integration of these neurons into host neural circuitries...
  10. ncbi Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration
    Thomas Carlsson
    Department Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC D11, Lund, Sweden
    Brain 132:319-35. 2009
    ....
  11. ncbi Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections
    Lachlan Thompson
    Wallenberg Neuroscience Center, Department of Experimental Medical Research, Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, SE 221 84 Lund, Sweden
    J Neurosci 25:6467-77. 2005
    ....
  12. ncbi Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
    Ana Munoz
    Department of Experimental Medical Science, Neurobiology Unit, Wallenberg Neuroscience Center, University of Lund, Lund, Sweden
    Brain 131:3380-94. 2008
    ..Our results support the importance of a clinical investigation of the effect of 5-HT(1A) and 5-HT(1B) agonists, particularly in combination, in dyskinetic l-DOPA-treated Parkinson's disease patients...
  13. ncbi Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors
    Thomas Carlsson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
    Brain 128:559-69. 2005
    ..These findings form a strong basis for replacing, or supplementing, conventional systemic L-DOPA therapy by continuous intrastriatal DOPA using in vivo gene transfer in the treatment of patients with advanced Parkinson's disease...
  14. ncbi Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain
    Lachlan H Thompson
    Division of Neurobiology, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, S 22184 Lund, Sweden
    Exp Neurol 213:220-8. 2008
    ....
  15. ncbi The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease
    Shane Grealish
    Wallenberg Neuroscience Centre, Lund University, Lund, Sweden
    Brain 133:482-95. 2010
    ..Furthermore, the results have interesting implications for current efforts in this field to generate well-characterized and standardized preparations of transplantable dopamine neuronal progenitors from stem cells...
  16. ncbi Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, BMC A11, 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 100:2884-9. 2003
    ..This model offers new opportunities for the study of pathogenetic mechanisms and exploration of new therapeutic targets of particular relevance to human PD...
  17. ncbi Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
    Thomas Carlsson
    CNS Disease Modeling Unit, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    J Neurosci 27:8011-22. 2007
    ..We conclude that serotonin neurons in the grafts are likely to have a detrimental effect on L-DOPA-induced dyskinesias in cases in which the grafts contain no or few dopamine neurons...
  18. ncbi Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Mov Disord 25:S174-9. 2010
    ....
  19. ncbi Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 22184 Lund, Sweden
    Trends Neurosci 26:386-92. 2003
    ..Targeted overexpression of disease-causing genes by recombinant viral vectors provides a new and highly flexible approach for in vivo modeling of neurodegenerative diseases, not only in mice and rats but also in primates...
  20. ncbi Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Prog Brain Res 172:465-78. 2008
    ..Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication...
  21. ncbi Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease
    Shane Grealish
    Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A11, Lund 22184, Sweden
    Eur J Neurosci 31:2266-78. 2010
    ....
  22. ncbi Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons
    Martin Lundblad
    Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, Lund 221 84, Sweden
    Proc Natl Acad Sci U S A 109:3213-9. 2012
    ..Synaptic dysfunction and axonopathy would thus be the hallmark of presymptomatic and early-stage Parkinson disease, followed by neuronal degeneration and cell loss, characteristic of more advanced stages of the disease...
  23. ncbi Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor
    Young Hwan Ahn
    Wallenberg Neuroscience Center, Section for Neuronal Survival, BMC A10, SE 221 84 Lund, Sweden
    Brain Res Bull 66:135-42. 2005
    ..We suggest that continuous and safe delivery of GDNF to the brain could be a potential way to optimize neural transplantation as a therapy for Parkinson's disease...
  24. ncbi Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system
    Biljana Georgievska
    Department of Physiological Sciences, Division of Neurobiology, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
    J Neurosci 24:6437-45. 2004
    ..This compensatory mechanism is proposed to maintain long-term DA neuron function within the normal range...
  25. ncbi Direct conversion of human fibroblasts to dopaminergic neurons
    Ulrich Pfisterer
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, SE 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 108:10343-8. 2011
    ..Such subtype-specific induced neurons derived from human somatic cells could be valuable for disease modeling and cell replacement therapy...
  26. ncbi Phenotypic and molecular identity of cells in the adult subventricular zone. in vivo and after expansion in vitro
    Malin Parmar
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, SE 221 84 Lund, Sweden
    Mol Cell Neurosci 24:741-52. 2003
    ..However, under normal conditions, GSH2-expressing cells in the adult SVZ and in the in vitro expanded neurospheres appear to specify only olfactory bulb progenitors and not striatal progenitors...
  27. ncbi Neural transplantation for the treatment of Parkinson's disease
    Anders Bjorklund
    Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Sweden
    Lancet Neurol 2:437-45. 2003
  28. ncbi Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors
    Rohit Sachdeva
    Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 107:11602-7. 2010
    ..The properties and versatility of the microRNA-regulated vectors allows broad use of these vectors in stem cell applications...
  29. ncbi The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease
    Nathalie Breysse
    Central Nervous System Disease Modeling Unit, Section for Neuroscience, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
    J Neurosci 27:5849-56. 2007
    ....
  30. ncbi Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease
    Ayse Ulusoy
    Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Prog Brain Res 184:89-111. 2010
    ....
  31. ncbi Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
    Jia Yi Li
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Mov Disord 25:1091-6. 2010
    ..Our data indicate that Lewy bodies develop gradually in transplanted dopaminergic neurons in a fashion similar to that in dopaminergic neurons in the host substantia nigra...
  32. ncbi Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia
    Thomas Carlsson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, 221 84, Lund, Sweden
    Neurobiol Dis 21:657-68. 2006
    ..The results indicate that graft-induced dyskinesias in PD patients may be linked to single, small graft deposits that provide an uneven, patchy reinnervation of the putamen...
  33. ncbi Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model
    Ana Munoz
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Exp Neurol 219:298-307. 2009
    ....
  34. ncbi Neuronal differentiation following transplantation of expanded mouse neurosphere cultures derived from different embryonic forebrain regions
    Cecilia Eriksson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
    Exp Neurol 184:615-35. 2003
    ....
  35. ncbi Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry
    Ulrica Englund
    Sections of Neurobiology and Restorative Neurology, Wallenberg Neuroscience Center, BMC A-11, Lund University, S-221 84 Lund, Sweden Europe
    Proc Natl Acad Sci U S A 99:17089-94. 2002
    ....
  36. ncbi Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Brain 130:1819-33. 2007
    ....
  37. ncbi Involvement of the serotonin system in L-dopa-induced dyskinesias
    Manolo Carta
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Parkinsonism Relat Disord 14:S154-8. 2008
    ..These findings make the serotonin system an intriguing target for anti-dyskinetic therapies...
  38. ncbi Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
    Elodie Angot
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    PLoS ONE 7:e39465. 2012
    ..Our new model system could be used to test compounds that inhibit cell-to-cell transfer of α-synuclein and therefore might retard progression of Parkinson neuropathology...
  39. ncbi Cell therapy for Parkinson's disease: problems and prospects
    Anders Bjorklund
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, S 22184 Lund, Sweden
    Novartis Found Symp 265:174-86; discussion 187, 204-211. 2005
    ....
  40. ncbi In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway
    Dwain K Irvin
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A 11, SE 22184 Lund, Sweden
    Neurobiol Dis 30:343-52. 2008
    ..Noggin transduction did not result in the generation of new neurons, but interestingly, greatly increased the number of oligodendrocytes generated from newborn cells...
  41. ncbi In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133
    Perrine Barraud
    Research Center for Stem Cell Biology and Cell Therapy, BMC A11, Lund University, Lund, Sweden
    J Neurosci Res 85:250-9. 2007
    ..Therefore, we propose that SSEA4 associated with CD133 can be used for both the positive selection and the enrichment of neural stem/progenitor cells from human embryonic forebrain...
  42. ncbi Differentiation of the RN33B cell line into forebrain projection neurons after transplantation into the neonatal rat brain
    Cecilia Lundberg
    Wallenberg Neuroscience Center, Lund University, S-221 84, Sweden
    Exp Neurol 175:370-87. 2002
    ....
  43. ncbi Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector
    Biljana Georgievska
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Sweden
    Neuroreport 13:75-82. 2002
    ..Sprouting of the lesioned axons was observed along the nigrostriatal pathway, precisely corresponding to the areas containing anterogradely transported GDNF...
  44. ncbi L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson's disease: relation to motor and cellular parameters of nigrostriatal function
    Christian Winkler
    Department of Physiological Sciences, Neurobiology Division, Wallenberg Neuroscience Center, Lund University, BMC A11, S-221 84, Lund, Sweden
    Neurobiol Dis 10:165-86. 2002
    ....
  45. ncbi Amphetamine-induced rotation and L-DOPA-induced dyskinesia in the rat 6-OHDA model: a correlation study
    Elisabetta Tronci
    Wallenberg Neuroscience Center, Division of Neurobiology, Department of Experimental Medical Science, Lund University, Lund 221 84, Sweden
    Neurosci Res 73:168-72. 2012
    ..Moreover, SERT expression levels suggest that reduced striatal and pallidal serotonin innervation might have contributed to the lower dyskinesia levels observed in a subset of amphetamine-responsive rats...
  46. ncbi Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer
    Biljana Georgievska
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 221 84, Lund, Sweden
    Exp Neurol 177:461-74. 2002
    ....
  47. ncbi GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease
    Mickael Decressac
    Wallenberg Neuroscience Centre, Solvegatan 17, 221 84 Lund, Sweden
    Brain 134:2302-11. 2011
    ....
  48. ncbi Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, 221 84, Lund, Sweden
    J Neurosci 22:2780-91. 2002
    ..Targeted overexpression of alpha-synuclein in the nigrostriatal system may provide a new animal model of Parkinson's disease that reproduces some of the cardinal pathological, neurochemical, and behavioral features of the human disease...
  49. ncbi Regional specification of neurosphere cultures derived from subregions of the embryonic telencephalon
    Malin Parmar
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Solvegatan 17, BMC A11, S 221 84 Lund, Sweden
    Mol Cell Neurosci 21:645-56. 2002
    ....
  50. ncbi Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion
    Jens M Nygren
    Hematopoietic Stem Cell Laboratory, Lund University, BMC B10, Klinikgatan 26, 221 84 Lund, Sweden
    Nat Cell Biol 10:584-92. 2008
    ..Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation...
  51. ncbi Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11 22466, Lund, Sweden
    Brain 128:1478-9. 2005
  52. ncbi Dyskinesias following neural transplantation in Parkinson's disease
    Peter Hagell
    Section of Restorative Neurology, Wallenberg Neuroscience Center, SE-221 84 Lund, Sweden
    Nat Neurosci 5:627-8. 2002
    ....
  53. ncbi Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
    Jia Yi Li
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, 221 84 Lund, Sweden
    Nat Med 14:501-3. 2008
    ..However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief...
  54. ncbi α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons
    Mickael Decressac
    Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A11, Lund 22184, Sweden
    Sci Transl Med 4:163ra156. 2012
    ..These results suggest that Nurr1 is a regulator of neurotrophic factor signaling and a key player in the cellular defense against α-synuclein toxicity...
  55. ncbi Cell therapeutics in Parkinson's disease
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, University Hospital, SE 22184 Lund, Sweden
    Neurotherapeutics 8:539-48. 2011
    ..Finally, we discuss the scientific and clinical advancements that will be necessary to develop a competitive cell therapy for PD patients...
  56. ncbi Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, BMC A11, S-221 84, Lund, Sweden
    Proc Natl Acad Sci U S A 99:4708-13. 2002
    ....
  57. ncbi Migration patterns and phenotypic differentiation of long-term expanded human neural progenitor cells after transplantation into the adult rat brain
    Ulrica Englund
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
    Brain Res Dev Brain Res 134:123-41. 2002
    ..Although the survival time was over 3 months in the present study a large fraction of the grafted cells remained undifferentiated in a stem or progenitor cell stage as revealed by the expression of nestin and/or GFAP...
  58. ncbi Striatal neuron differentiation from neurosphere-expanded progenitors depends on Gsh2 expression
    Josephine B Jensen
    Wallenberg Neuroscience Center, Section of Neurobiology, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, SE-221 84 Lund, Sweden
    J Neurosci 24:6958-67. 2004
    ..Furthermore, we show that the ability of the expanded LGE cells to respond to the developmental cues presented by the primary cells depends on the maintained expression of Gsh2 in the expanded cells...
  59. ncbi Localized striatal delivery of GDNF as a treatment for Parkinson disease
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 22184 Lund, Sweden
    Nat Neurosci 7:105-10. 2004
  60. ncbi Generation of transplantable striatal projection neurons from human ESCs
    Malin Parmar
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
    Cell Stem Cell 10:349-50. 2012
    ..The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology of Huntington's disease...
  61. ncbi Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse
    Perrine Barraud
    Wallenberg Neuroscience Center, BMC A11, Section of Neurobiology, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, University, SE-221 84 Lund, Sweden
    Eur J Neurosci 22:1555-69. 2005
    ..Thus, not all Sox1-GFP cells possess the same capacity for neuronal differentiation in vivo...