A Bjorklund

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
    A Bjorklund
    Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Solvegatan 17, S 22362, Lund, Sweden
    Brain Res 886:82-98. 2000
  2. ncbi request reprint Cell replacement therapies for central nervous system disorders
    A Bjorklund
    The authors are at the Wallenberg Neuroscience Center, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Nat Neurosci 3:537-44. 2000
  3. ncbi request reprint Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
    C Rosenblad
    Department of Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Sweden
    Eur J Neurosci 11:1554-66. 1999
  4. ncbi request reprint Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
    C Rosenblad
    Wallenberg Neuroscience Center, Department of Physiology, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
    Exp Neurol 161:503-16. 2000
  5. ncbi request reprint Regulation of neuropeptide mRNA expression in the basal ganglia by intrastriatal and intranigral transplants in the rat Parkinson model
    C Winkler
    Lund University, Wallenberg Neuroscience Center, Department of Physiological Sciences, BMC A11, S 22184 Sweden
    Neuroscience 118:1063-77. 2003
  6. ncbi request reprint Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
    D Kirik
    Department of Physiology and Neuroscience, Lund University, Solvegatan 17, Lund, 223 62, Sweden
    Exp Neurol 152:259-77. 1998
  7. ncbi request reprint Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, 223 62 Lund, Sweden
    Eur J Neurosci 12:3871-82. 2000
  8. ncbi request reprint Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, 223 62 Lund, Sweden
    J Neurosci 20:4686-700. 2000
  9. doi request reprint Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
    M Decressac
    Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A11, Lund 22184, Sweden
    Neurobiol Dis 45:939-53. 2012
  10. ncbi request reprint In utero gene transfer reveals survival effects of nerve growth factor on rat brain cholinergic neurones during development
    A Martinez-Serrano
    Department of Physiology and Neuroscience, Wallenberg Neuroscience Center, University of Lund, Sweden
    Eur J Neurosci 10:263-71. 1998

Detail Information

Publications21

  1. ncbi request reprint Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
    A Bjorklund
    Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Solvegatan 17, S 22362, Lund, Sweden
    Brain Res 886:82-98. 2000
    ....
  2. ncbi request reprint Cell replacement therapies for central nervous system disorders
    A Bjorklund
    The authors are at the Wallenberg Neuroscience Center, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Nat Neurosci 3:537-44. 2000
    ..Clinical trials in Parkinson's disease suggest that similar approaches may also work in the diseased human brain. But how realistic is it that cell replacement can be developed into effective clinical therapy?..
  3. ncbi request reprint Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
    C Rosenblad
    Department of Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Sweden
    Eur J Neurosci 11:1554-66. 1999
    ..The lower efficacy of NTN after IS, and particularly ICV, administration may be explained by the poor solubility and diffusion properties at neutral pH...
  4. ncbi request reprint Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
    C Rosenblad
    Wallenberg Neuroscience Center, Department of Physiology, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
    Exp Neurol 161:503-16. 2000
    ..We conclude that functional recovery in the partial lesion model depends not only on preservation of the nigral cell bodies, but more critically on the ability of GDNF to promote significant reinnervation of the denervated striatum...
  5. ncbi request reprint Regulation of neuropeptide mRNA expression in the basal ganglia by intrastriatal and intranigral transplants in the rat Parkinson model
    C Winkler
    Lund University, Wallenberg Neuroscience Center, Department of Physiological Sciences, BMC A11, S 22184 Sweden
    Neuroscience 118:1063-77. 2003
    ..A full reconstruction of the nigrostriatal pathway or, alternatively, modulation of basal ganglia function by grafting in non-striatal regions may be required to further improve the functional outcome in the DA-denervated brain...
  6. ncbi request reprint Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
    D Kirik
    Department of Physiology and Neuroscience, Lund University, Solvegatan 17, Lund, 223 62, Sweden
    Exp Neurol 152:259-77. 1998
    ....
  7. ncbi request reprint Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, 223 62 Lund, Sweden
    Eur J Neurosci 12:3871-82. 2000
    ....
  8. ncbi request reprint Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, 223 62 Lund, Sweden
    J Neurosci 20:4686-700. 2000
    ..GDNF transgene expression was maintained at high levels throughout this period. These results provide evidence that rAAV is a highly efficient vector system for long-term expression of therapeutic proteins in the nigrostriatal system...
  9. doi request reprint Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
    M Decressac
    Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A11, Lund 22184, Sweden
    Neurobiol Dis 45:939-53. 2012
    ..This model provides new interesting possibilities for studies of stage-specific pathologic mechanisms and identification of targets for disease-modifying therapeutic interventions linked to early or late stages of the disease...
  10. ncbi request reprint In utero gene transfer reveals survival effects of nerve growth factor on rat brain cholinergic neurones during development
    A Martinez-Serrano
    Department of Physiology and Neuroscience, Wallenberg Neuroscience Center, University of Lund, Sweden
    Eur J Neurosci 10:263-71. 1998
    ..The present results suggest that overexpression of NGF during development may promote the survival of distinct populations of central cholinergic neurones into adulthood...
  11. ncbi request reprint Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 221 84 Lund, Sweden
    Eur J Neurosci 13:1589-99. 2001
    ....
  12. ncbi request reprint In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
    C Rosenblad
    Wallenberg Neuroscience Center, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
    Mol Cell Neurosci 15:199-214. 2000
    ..We conclude that NBN/ART, similarly to GDNF, is a potent neuroprotective factor for the nigrostriatal DA neurons in vivo...
  13. ncbi request reprint Growth and functional efficacy of intrastriatal nigral transplants depend on the extent of nigrostriatal degeneration
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, 22184, Lund, Sweden
    J Neurosci 21:2889-96. 2001
    ..These data have implications for the optimal use of fetal nigral transplants in Parkinson patients in different stages of the disease...
  14. pmc Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middle-aged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging
    A Martinez-Serrano
    Wallenberg Neuroscience Center, University of Lund, Solvegatan 17, S 223 62 Lund, Sweden
    Proc Natl Acad Sci U S A 95:1858-63. 1998
    ....
  15. ncbi request reprint Incorporation of mouse neural progenitors transplanted into the rat embryonic forebrain is developmentally regulated and dependent on regional and adhesive properties
    M Olsson
    Wallenberg Neuroscience Center, Department of Physiology and Neuroscience, University of Lund, Sweden
    Eur J Neurosci 10:71-85. 1998
    ....
  16. doi request reprint Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease
    M Decressac
    Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A11, Lund 22184, Sweden
    Exp Neurol 235:306-15. 2012
    ..This study suggests that the AAV-α-syn model replicates the human pathology more closely than either of the other two 6-OHDA lesion models...
  17. ncbi request reprint Injury induced c-Jun expression and phosphorylation in the dopaminergic nigral neurons of the rat: correlation with neuronal death and modulation by glial-cell-line-derived neurotrophic factor
    E Vaudano
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Eur J Neurosci 13:1-14. 2001
    ..We conclude that c-Jun induction and phosphorylation may be involved in the cellular events leading to death of nigral dopaminergic neurons in vivo and that this response can be modulated by glial-cell-line-derived-neurotrophic factor...
  18. ncbi request reprint Amelioration of spatial navigation and short-term memory deficits by grafts of foetal basal forebrain tissue placed into the hippocampus and cortex of rats with selective cholinergic lesions
    G Leanza
    Wallenberg Neuroscience Center, Lund University, Sweden
    Eur J Neurosci 10:2353-70. 1998
    ....
  19. ncbi request reprint Chimeric stem cells
    A Bjorklund
    Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Trends Mol Med 7:144-6. 2001
    ..There have been many commentaries on all of these issues in prominent journals and newspapers over recent months. In this article, we take a critical look at new data that underpin the last of these claims: the chimeric stem cell...
  20. ncbi request reprint L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA
    M A Cenci
    Wallenberg Neuroscience Center, Institute of Physiology and Neuroscience, University of Lund, 223 62 Lund, Sweden
    Eur J Neurosci 10:2694-706. 1998
    ..Due to its treatment-dependent expression, and strong correlation with the associated dyskinetic symptoms, striatal PDyn mRNA, in particular, may play a role in the mechanisms of behavioural sensitization brought about by the drug...
  21. ncbi request reprint Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2
    E Andersson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, Sweden
    Development 133:507-16. 2006
    ....