B Ahren

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Reduced GLP-1 and insulin responses and glucose intolerance after gastric glucose in GRP receptor-deleted mice
    K Persson
    Department of Medicine, Lund University, Malmo, SE 205 02 Sweden
    Am J Physiol Endocrinol Metab 279:E956-62. 2000
  2. doi request reprint Are sulfonylureas less desirable than DPP-4 inhibitors as add-on to metformin in the treatment of type 2 diabetes?
    Bo Ahren
    Department of Clinical Sciences Lund, Lund University, B11 BMC, SE 221 84, Lund, Sweden
    Curr Diab Rep 11:83-90. 2011
  3. pmc Efficacy and safety of lixisenatide once-daily morning or evening injections in type 2 diabetes inadequately controlled on metformin (GetGoal-M)
    Bo Ahren
    Lund University, Lund, Sweden
    Diabetes Care 36:2543-50. 2013
  4. pmc Avoiding hypoglycemia: a key to success for glucose-lowering therapy in type 2 diabetes
    Bo Ahren
    Department of Clinical Sciences, Lund, Faculty of Medicine, Lund University, Lund, Sweden
    Vasc Health Risk Manag 9:155-63. 2013
  5. doi request reprint Incretin dysfunction in type 2 diabetes: clinical impact and future perspectives
    B Ahren
    Department of Clinical Sciences Lund, Lund University, Solvegatan 19, SE 221 84 Lund, Sweden
    Diabetes Metab 39:195-201. 2013
  6. doi request reprint Islet nerves in focus--defining their neurobiological and clinical role
    B Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    Diabetologia 55:3152-4. 2012
  7. doi request reprint Vildagliptin reduces glucagon during hyperglycemia and sustains glucagon counterregulation during hypoglycemia in type 1 diabetes
    Johan Farngren
    Department of Clinical Sciences, Lund University, B11 BMC, SE 221 84 Lund, Sweden
    J Clin Endocrinol Metab 97:3799-806. 2012
  8. doi request reprint Using albumin to improve the therapeutic properties of diabetes treatments
    B Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    Diabetes Obes Metab 14:121-9. 2012
  9. pmc A paleolithic diet is more satiating per calorie than a mediterranean-like diet in individuals with ischemic heart disease
    Tommy Jonsson
    Department of Clinical Science, B11 BMC, University of Lund, SE 221 84 Lund, Sweden
    Nutr Metab (Lond) 7:85. 2010
  10. pmc Disassociated relation between plasma tumor necrosis factor-alpha, interleukin-6 and increased body weight in Amerindian women: A long-term prospective study of natural body weight variation and impaired glucose tolerance
    Folke Lindgärde
    Vascular Center, Lund University, Skane University Hospital, S 205 02 Malmo, Sweden
    Diabetol Metab Syndr 2:38. 2010

Collaborators

Detail Information

Publications154 found, 100 shown here

  1. ncbi request reprint Reduced GLP-1 and insulin responses and glucose intolerance after gastric glucose in GRP receptor-deleted mice
    K Persson
    Department of Medicine, Lund University, Malmo, SE 205 02 Sweden
    Am J Physiol Endocrinol Metab 279:E956-62. 2000
    ....
  2. doi request reprint Are sulfonylureas less desirable than DPP-4 inhibitors as add-on to metformin in the treatment of type 2 diabetes?
    Bo Ahren
    Department of Clinical Sciences Lund, Lund University, B11 BMC, SE 221 84, Lund, Sweden
    Curr Diab Rep 11:83-90. 2011
    ..Overall, therefore, the conclusion emerges that SUs are less desirable than DPP-4 inhibitors in management of hyperglycemia in type 2 diabetes...
  3. pmc Efficacy and safety of lixisenatide once-daily morning or evening injections in type 2 diabetes inadequately controlled on metformin (GetGoal-M)
    Bo Ahren
    Lund University, Lund, Sweden
    Diabetes Care 36:2543-50. 2013
    ..To examine the efficacy and safety of lixisenatide (20 μg once daily, administered before the morning or evening meal) as add-on therapy in patients with type 2 diabetes insufficiently controlled with metformin alone...
  4. pmc Avoiding hypoglycemia: a key to success for glucose-lowering therapy in type 2 diabetes
    Bo Ahren
    Department of Clinical Sciences, Lund, Faculty of Medicine, Lund University, Lund, Sweden
    Vasc Health Risk Manag 9:155-63. 2013
    ..This article summarizes the current knowledge of hypoglycemia and its consequences with a special emphasis on its consequences for the choice of glucose-lowering therapy...
  5. doi request reprint Incretin dysfunction in type 2 diabetes: clinical impact and future perspectives
    B Ahren
    Department of Clinical Sciences Lund, Lund University, Solvegatan 19, SE 221 84 Lund, Sweden
    Diabetes Metab 39:195-201. 2013
    ..Identifying the mechanisms in greater detail would be important for understanding the strengths, weaknesses and efficacy of incretin therapy in individual patients to more specifically target this glucose-lowering therapy...
  6. doi request reprint Islet nerves in focus--defining their neurobiological and clinical role
    B Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    Diabetologia 55:3152-4. 2012
    ..These findings suggest novel neural-islet regulatory mechanisms as well as neural involvement in the development of diabetes, and therefore advance both basic and clinical knowledge of islet neurobiology...
  7. doi request reprint Vildagliptin reduces glucagon during hyperglycemia and sustains glucagon counterregulation during hypoglycemia in type 1 diabetes
    Johan Farngren
    Department of Clinical Sciences, Lund University, B11 BMC, SE 221 84 Lund, Sweden
    J Clin Endocrinol Metab 97:3799-806. 2012
    ..The dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits glucagon secretion at hyperglycemia but appears to enhance glucagon counterregulation during hypoglycemia in type 2 diabetes...
  8. doi request reprint Using albumin to improve the therapeutic properties of diabetes treatments
    B Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    Diabetes Obes Metab 14:121-9. 2012
    ..Here, we review the physiologic roles of albumin and how albumin technologies are being used to prolong duration of action of therapies for diabetes, including insulin and incretin-based therapies...
  9. pmc A paleolithic diet is more satiating per calorie than a mediterranean-like diet in individuals with ischemic heart disease
    Tommy Jonsson
    Department of Clinical Science, B11 BMC, University of Lund, SE 221 84 Lund, Sweden
    Nutr Metab (Lond) 7:85. 2010
    ..We now report findings on subjective ratings of satiety at meals and data on the satiety hormone leptin and the soluble leptin receptor from the same study...
  10. pmc Disassociated relation between plasma tumor necrosis factor-alpha, interleukin-6 and increased body weight in Amerindian women: A long-term prospective study of natural body weight variation and impaired glucose tolerance
    Folke Lindgärde
    Vascular Center, Lund University, Skane University Hospital, S 205 02 Malmo, Sweden
    Diabetol Metab Syndr 2:38. 2010
    ..A high proportion of palmitoleic acid (16:1n-7) in serum (s) and systolic blood pressure (SBP) were independent predictors of high p-glucose. Whether cytokines also contributed is, however, not known...
  11. pmc Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study
    Tommy Jonsson
    Department of Clinical Sciences, Lund, Lund University, Box 117, 221 00 Lund, Sweden
    Cardiovasc Diabetol 8:35. 2009
    ..Our aim was to compare the effects of a Paleolithic ('Old Stone Age') diet and a diabetes diet as generally recommended on risk factors for cardiovascular disease in patients with type 2 diabetes not treated with insulin...
  12. ncbi request reprint Dipeptidyl peptidase-4 inhibitors: clinical data and clinical implications
    Bo Ahren
    Department of Clinical Sciences, Division of Medicine, Lund University, Lund, Sweden
    Diabetes Care 30:1344-50. 2007
  13. ncbi request reprint [New strategy in type 2 diabetes tested in clinical trials. Glucagon-like peptide 1 (GLP-1) affects basic caused of the disease]
    Bo Ahren
    Institutionen för medicin, Lunds universitet, och sektionen för endokrinologi och diabetes, Universitetssjukhuset i Lund, Sweden
    Lakartidningen 102:545-9. 2005
    ..One strategy is the use of DPP-4 resistant GLP-1 receptor agonists (exenatide and liraglutide) and another strategy is to inhibit DPP-4 activity (LAF237). Both these strategies have been successful in clinical studies...
  14. ncbi request reprint Acylation stimulating protein stimulates insulin secretion
    B Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Int J Obes Relat Metab Disord 27:1037-43. 2003
    ..The effect is dependent on glucose phosphorylation, calcium uptake and protein kinase C. Stimulation of insulin secretion by ASP in vivo results in augmented glucose disposal...
  15. ncbi request reprint The insulin response to gastric glucose is reduced in PAC1 and GRP receptor gene deleted mice
    Bo Ahren
    Department of Medicine, B11 BMC, Lund University, SE 221 84 Lund, Sweden
    Nutr Metab Cardiovasc Dis 16:S17-21. 2006
    ....
  16. ncbi request reprint Gut peptides and type 2 diabetes mellitus treatment
    Bo Ahren
    Department of Medicine, Lund University, B11 BMC, Lund SE 221 84, Sweden
    Curr Diab Rep 3:365-72. 2003
    ..These two approaches are explored in clinical investigations...
  17. ncbi request reprint Characterization of GLP-1 effects on beta-cell function after meal ingestion in humans
    Bo Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Diabetes Care 26:2860-4. 2003
    ..Previously, beta-cell effects of GLP-1 have been characterized in humans during graded intravenous infusions of glucose, whereas its effects after more physiological stimuli, like meal intake, are not known...
  18. ncbi request reprint [Reclaim the clinical research--proposal to an action plan]
    Bo Ahren
    Institutionen för medicin, Universitetssjukhuset i Lund
    Lakartidningen 100:1361. 2003
  19. ncbi request reprint Increased insulin sensitivity is associated with reduced insulin and glucagon secretion and increased insulin clearance in man
    Bo Ahren
    Department of Medicine B A, Lund University, Lund SE 221 84, Sweden
    J Clin Endocrinol Metab 88:1264-70. 2003
    ..8 +/- 6.7 vs. 90.1 +/- 9.9 ng/liter at fasting glucose, P = 0.009). We conclude that high insulin sensitivity results in low islet hormone secretion and increased insulin clearance...
  20. ncbi request reprint Insufficient islet compensation to insulin resistance vs. reduced glucose effectiveness in glucose-intolerant mice
    Bo Ahren
    Department of Medicine, Lund University, SE 221 84 Lund, Sweden
    Am J Physiol Endocrinol Metab 283:E738-44. 2002
    ..Thus glucose intolerance induced by high-fat diet is, in early phases, solely explained by reduced glucose effectiveness, whereas insufficient early insulin secretion is of importance after long-term feeding...
  21. ncbi request reprint DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide
    Bo Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    Regul Pept 143:97-103. 2007
    ..Treatment with vildagliptin restored the islet topography. We therefore conclude that DPP-4 inhibition improves islet function and islet topography in mice with beta-cell specific transgenic overexpression of human IAPP...
  22. ncbi request reprint Improved meal-related insulin processing contributes to the enhancement of B-cell function by the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes
    B Ahren
    Department of Clinical Sciences, Division of Medicine, Lund University, Lund, Sweden
    Horm Metab Res 39:826-9. 2007
    ..023) and postprandially (p=0.004). In conclusion, a more efficient B-cell insulin processing provides further evidence that vildagliptin treatment ameliorates abnormal B-cell function in patients with type 2 diabetes...
  23. ncbi request reprint DPP-4 inhibitors
    Bo Ahren
    Department of Clinical Sciences, Division of Medicine, B11 BMC, SE 221 84 Lund University, Lund, Sweden
    Best Pract Res Clin Endocrinol Metab 21:517-33. 2007
    ..DPP-4 inhibition is suggested to be a first-line treatment of type-2 diabetes, particularly in its early stages in combination with metformin. However, the durability and long-term safety of DPP-4 inhibition remain to be established...
  24. ncbi request reprint Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
    Bo Ahren
    Department of Medicine, Lund University, Malmo, Sweden
    Diabetes Care 25:869-75. 2002
    ....
  25. ncbi request reprint GLP-1-based therapy of type 2 diabetes: GLP-1 mimetics and DPP-IV inhibitors
    Bo Ahren
    Department of Clinical Sciences, Division of Medicine, Lund University, SE 221 84 Lund, Sweden
    Curr Diab Rep 7:340-7. 2007
    ..6% to 1.1% from baseline levels of 7.7% to 8.5%. They are efficient both in monotherapy and in combination with metformin or thiazolidinediones. Both treatments are well tolerated with low risk of hypoglycemia...
  26. ncbi request reprint Insulin secretion and insulin sensitivity in relation to fasting glucose in healthy subjects
    Bo Ahren
    Department of Medicine, Lund University, B11 BMC, SE 221 84 Lund, Sweden
    Diabetes Care 30:644-8. 2007
    ..This study evaluated insulin secretion and insulin sensitivity in healthy subjects with normal fasting glucose...
  27. ncbi request reprint Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice
    Bo Ahren
    Dept of Medicine, B11 BMC, SE 221 84 Lund, Sweden
    Am J Physiol Regul Integr Comp Physiol 286:R269-72. 2004
    ..It is concluded that GLP-1-induced insulin secretion at a low dose in mice is dependent on intact sensory nerves and therefore indirectly mediated and that this distinguishes GLP-1 from other examined insulin secretagogues...
  28. ncbi request reprint What mediates the benefits associated with dipeptidyl peptidase-IV inhibition?
    B Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Diabetologia 48:605-7. 2005
  29. ncbi request reprint Type 2 diabetes, insulin secretion and beta-cell mass
    B Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Curr Mol Med 5:275-86. 2005
    ..This may possibly be achieved by stimulating insulin secretion, supporting islet stimulating mechanisms, removing toxic beta-cell insults and inhibiting beta cell apoptosis...
  30. ncbi request reprint GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes
    B Ahren
    Department of Medicine, Lund University, SE 221 84 Lund, Sweden
    Horm Metab Res 36:867-76. 2004
    ..Both these strategies have been successful in animal studies and in clinical studies of up to one year's treatment. This review will summarize the background and the current (mid 2004) clinical experience with these two strategies...
  31. ncbi request reprint GLP-1 and extra-islet effects
    B Ahren
    Department of Medicine, Lund University, SE 221 84 Lund, Sweden
    Horm Metab Res 36:842-5. 2004
    ..The physiological relevance of these actions and their contribution to the overall antidiabetic action of GLP-1 when used in treatment of type 2 diabetes remains to be established...
  32. ncbi request reprint Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year
    Bo Ahren
    Department of Medicine, Lund University, B11 BMC, SE 221 84 Lund, Sweden
    Diabetes Care 28:1936-40. 2005
    ..To examine the effects of dipeptidyl peptidase-IV (DPP-4) inhibition on meal-related beta-cell function and insulin sensitivity over 52 weeks in type 2 diabetes...
  33. ncbi request reprint Reduced insulin clearance contributes to the increased insulin levels after administration of glucagon-like peptide 1 in mice
    B Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Diabetologia 48:2140-6. 2005
    ..The estimated beta cell secretion was then related to plasma insulin levels to allow determination of clearance rate of endogenously produced insulin...
  34. ncbi request reprint Beta-cell expression of a dominant-negative HNF-1alpha compromises the ability of inhibition of dipeptidyl peptidase-4 to elicit a long-term augmentation of insulin secretion in mice
    Bo Ahren
    Department of Medicine, Lund University, B11 BMC, SE 221 84 Lund, Sweden
    Eur J Pharmacol 521:164-8. 2005
    ..We conclude that DPP-4 inhibition improves islet function and increases beta cell secretory responses on a long-term basis and that this is dependent on intact expression of HNF-1alpha...
  35. ncbi request reprint Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes
    Bo Ahren
    Department of Medicine, Lund University B11 BMC, SE 221 84 Lund, Sweden
    Diabetes Care 27:2874-80. 2004
    ..To assess the 12- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 versus placebo in patients with type 2 diabetes continuing metformin treatment...
  36. ncbi request reprint A novel approach to assess insulin sensitivity reveals no increased insulin sensitivity in mice with a dominant-negative mutant hepatocyte nuclear factor-1alpha
    B Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Am J Physiol Regul Integr Comp Physiol 291:R131-7. 2006
    ....
  37. ncbi request reprint Vildagliptin: an inhibitor of dipeptidyl peptidase-4 with antidiabetic properties
    Bo Ahren
    Department of Medicine, Lund University, B11 BMC, SE 221 84 Lund, Sweden
    Expert Opin Investig Drugs 15:431-42. 2006
    ..Further studies are now required to evaluate its long-term durability, effects, safety and tolerability in comparison with other antidiabetic agents and in different patient subgroups...
  38. ncbi request reprint [Clinical research must be based on teaming physician and researcher]
    Bo Ahren
    Lakartidningen 103:2575. 2006
  39. ncbi request reprint Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice
    Bo Ahren
    Department of Medicine, Lund University, B11 Biomedical Centre, SE 221 84 Lund, Sweden
    Endocrinology 145:3190-6. 2004
    ..032). We conclude that 1) galanin may contribute to sympathetic influences inhibiting insulin secretion in mice, and 2) galanin KO mice have a reduced glucose-induced insulin secretion...
  40. ncbi request reprint Serum cholesteryl fatty acid composition and plasma glucose concentrations in Amerindian women
    Folke Lindgärde
    Department of Vascular Medicine, Malmö University Hospital and the Department of Medicine, Lund University, Lund, Sweden
    Am J Clin Nutr 84:1009-13. 2006
    ..Diabetes mellitus has reached epidemic proportions in women of Amerindian origin. The risk of developing diabetes has been found to be related to the serum fatty acid composition in whites...
  41. ncbi request reprint Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess beta cell function in clinical studies
    Bo Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Eur J Endocrinol 150:97-104. 2004
    ..Acknowledging this inverse relationship between insulin secretion and insulin sensitivity therefore requires estimation of both variables for correct assessment in any individual...
  42. pmc Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin
    Bo Ahren
    Department of Clinical Sciences, Division of Medicine, Lund University, Lund, Sweden
    Vasc Health Risk Manag 4:383-94. 2008
    ..Hence, DPP-4 inhibition in combination with metformin is an efficient, safe and tolerable combination therapy for type 2 diabetes...
  43. ncbi request reprint Impaired glucose tolerance (IGT) is associated with reduced insulin-induced suppression of glucagon concentrations
    B Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Diabetologia 44:1998-2003. 2001
    ..We aimed to examine whether impaired glucose tolerance is associated with reduced suppression of glucagon concentrations...
  44. pmc Disturbed alpha-cell function in mice with beta-cell specific overexpression of human islet amyloid polypeptide
    Bo Ahren
    Department of Clinical Sciences, Lund University, 22184 Lund, Sweden
    Exp Diabetes Res 2008:304513. 2008
    ..The reduced glucagon response to protein challenge may reflect a direct inhibitory influence of hIAPP on glucagon secretion...
  45. doi request reprint Role of pituitary adenylate cyclase-activating polypeptide in the pancreatic endocrine system
    Bo Ahren
    Department of Clinical Sciences, Division of Medicine, Lund University, Lund, Sweden
    Ann N Y Acad Sci 1144:28-35. 2008
    ..Hence, PACAP is an islet neuropeptide with a potential role in islet physiology and as a basis for development of islet-promoting therapy in type 2 diabetes...
  46. ncbi request reprint Glucagon secretion in relation to insulin sensitivity in healthy subjects
    B Ahren
    Department of Medicine, Lund University, B11 BMC, SE 221 84 Lund, Sweden
    Diabetologia 49:117-22. 2006
    ..The study evaluated whether glucagon secretion is regulated by changes in insulin sensitivity under normal conditions...
  47. pmc Study on administration of 1,5-anhydro-D-fructose in C57BL/6J mice challenged with high-fat diet
    Jie Mei
    Department of Medicine, B11 BMC, S 221 84, Lund University, Lund, Sweden
    BMC Endocr Disord 10:17. 2010
    ..We therefore conclude that when given through drinking water for 8 weeks at 1.5 g/kg/day, AF has no effect on glucose-stimulated insulin secretion in C57BL/6J mice challenged with a high-fat diet...
  48. pmc Beta- and alpha-cell dysfunction in subjects developing impaired glucose tolerance: outcome of a 12-year prospective study in postmenopausal Caucasian women
    B Ahren
    Department of Clinical Sciences in Lund, Division of Medicine, Lund University, Lund, Sweden
    Diabetes 58:726-31. 2009
    ..This study assessed insulin and glucagon secretion in relation to insulin sensitivity in Caucasian women who develop impaired glucose tolerance (IGT) versus those who maintain normal glucose tolerance (NGT) over a 12-year period...
  49. doi request reprint Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetes
    Bo Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    J Clin Endocrinol Metab 94:1236-43. 2009
    ..However, their effects on the glucagon response to hypoglycemia are not established...
  50. doi request reprint Clinical evidence and mechanistic basis for vildagliptin's action when added to metformin
    B Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    Diabetes Obes Metab 13:193-203. 2011
    ..Therefore, vildagliptin offers a clinically important outcome when added to metformin with a twice daily dose regimen, taking advantage of its tight binding and slow dissociation characteristics that lead to a sustained overnight effect...
  51. pmc Changes in prandial glucagon levels after a 2-year treatment with vildagliptin or glimepiride in patients with type 2 diabetes inadequately controlled with metformin monotherapy
    Bo Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Diabetes Care 33:730-2. 2010
    ..To determine if the dipeptidyl peptidase-4 inhibitor vildagliptin more effectively inhibits glucagon levels than the sulfonylurea glimepiride during a meal...
  52. doi request reprint Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
    Bo Ahren
    Department of Clinical Sciences, Division of Medicine, Lund University, SE 221 84 Lund, Sweden
    Nat Rev Drug Discov 8:369-85. 2009
    ..This Review summarizes islet GPCR expression, signalling and function, and highlights their potential as targets for the treatment of type 2 diabetes...
  53. doi request reprint Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin--diabetes control and potential adverse events
    Bo Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    Best Pract Res Clin Endocrinol Metab 23:487-98. 2009
    ..DPP-4 inhibition may also be used in combination with sulphonylurea and thiazolidinediones and potentially also in combination with insulin. The durability and long-term safety of DPP-4 inhibitors remain to be established...
  54. doi request reprint Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men
    B Ahren
    Division of Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
    Eur J Clin Nutr 63:778-86. 2009
    ..Thus, the potential of CLA plus n-3 LC-PUFA to affect insulin secretion and sensitivity in non-diabetic young and old, lean and obese subjects was tested...
  55. doi request reprint GLP-1 for type 2 diabetes
    Bo Ahren
    Department of Clinical Sciences, Division of Medicine, Lund University, B11 BMC, SE 221 84 Lund, Sweden
    Exp Cell Res 317:1239-45. 2011
    ..GLP-1 based therapy is thus a novel and now well established therapy of type 2 diabetes, with a particular value in combination with metformin in patients who are inadequately controlled by metformin alone...
  56. ncbi request reprint [Two breakthroughs in the treatment of type 2 diabetes. Both the receptor agonist and enzyme inhibitors now available in the clinic]
    Bo Ahren
    Institutionen för kliniska vetenskaper i Lund, Avdelningen för medicin, Lunds universitet
    Lakartidningen 104:3763-4. 2007
  57. doi request reprint The future of incretin-based therapy: novel avenues--novel targets
    B Ahren
    Department of Clinical Sciences Lund, Lund University, Lund, Sweden
    Diabetes Obes Metab 13:158-66. 2011
    ..We can therefore expect a dynamic development within this field in the coming years...
  58. doi request reprint The augmenting effect on insulin secretion by oral versus intravenous glucose is exaggerated by high-fat diet in mice
    Bo Ahren
    Department of Clinical Sciences, Lund University, BMC B11, SE 221 84 Lund, Sweden Metabolic Unit, Institute of Biomedical Engineering ISIB CNR, Padova, Italy
    J Endocrinol 197:181-7. 2008
    ....
  59. ncbi request reprint The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia
    B Ahren
    Department of Medicine, Lund University, Sweden
    Diabetes 50:1030-8. 2001
    ....
  60. doi request reprint Evidence that autonomic mechanisms contribute to the adaptive increase in insulin secretion during dexamethasone-induced insulin resistance in humans
    B Ahren
    Department of Clinical Sciences, Lund University, B11 BMC, Solvegatan 19, 221 84 Lund, Sweden
    Diabetologia 51:1018-24. 2008
    ..This study examined whether autonomic mechanisms contribute to adaptively increased insulin secretion in insulin-resistant humans, as has been proposed from studies in animals...
  61. doi request reprint Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans
    B Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden Novartis Pharma AG, Basel, Switzerland
    Diabetes Obes Metab 13:775-83. 2011
    ....
  62. ncbi request reprint Clinical measures of islet function: usefulness to characterize defects in diabetes
    Bo Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Curr Diabetes Rev 4:129-45. 2008
    ....
  63. ncbi request reprint Inhibition of dipeptidyl peptidase-4 augments insulin secretion in response to exogenously administered glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, pituitary adenylate cyclase-activating polypeptide, and gastrin-releasing peptid
    Bo Ahren
    Department of Medicine, Lund University, B11 BMC, SE 221 84 Lund, Sweden
    Endocrinology 146:2055-9. 2005
    ..We conclude that DPP-4 inhibition augments the insulin response not only to GLP-1 but also to GIP, PACAP38, and GRP...
  64. ncbi request reprint Insulin secretion and incretin hormones after oral glucose in non-obese subjects with impaired glucose tolerance
    E Rask
    Department of Medicine, Umea University, Umea, Sweden
    Metabolism 53:624-31. 2004
    ..This defective beta-cell function is associated with, and may be caused by, a reduced early GLP-1 response...
  65. ncbi request reprint Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women
    S Soderberg
    Department of Medicine, Umea University Hospital, Sweden
    Eur J Endocrinol 144:283-90. 2001
    ..We therefore examined the relationship between leptin, IGF-I, IGFBP-1, insulin and proinsulin in men and women with or without obesity in a population study...
  66. ncbi request reprint Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice
    M Kvist Reimer
    Department of Medicine, Lund University, Sweden
    Eur J Endocrinol 146:717-27. 2002
    ..We examined the long-term influence of a selective, orally active inhibitor of DPPIV (NVP DPP728), in normal female C57BL/6J mice and such mice rendered glucose-intolerant and insulin-resistant by feeding a high-fat diet...
  67. ncbi request reprint The cyclic AMP-protein kinase A pathway restrains islet phospholipase A(2) activation
    E Simonsson
    Wallenberg Laboratory, Department of Medicine, Lund University, University Hospital of Malmo, Malmo, SE 205 02, Sweden
    Biochem Biophys Res Commun 269:242-6. 2000
    ..In conclusion, the cAMP-PKA pathway restrains both Ca(2+)-dependent and Ca(2+)-independent PLA(2) activation, indicating a regulating crosstalk between these two pathways...
  68. ncbi request reprint A strong association between biologically active testosterone and leptin in non-obese men and women is lost with increasing (central) adiposity
    S Soderberg
    Department of Medicine, Umea University Hospital, Umea, Sweden
    Int J Obes Relat Metab Disord 25:98-105. 2001
    ..In the present study we have characterized the relationship between biologically active testosterone and leptin after careful stratification for gender and adiposity...
  69. ncbi request reprint Islet phospholipase A(2) activation is potentiated in insulin resistant mice
    E Simonsson
    Department of Medicine, Lund University, Malmo, Sweden
    Biochem Biophys Res Commun 272:539-43. 2000
    ..002). The results suggest that exaggerated non-glucose-induced PLA(2) activation contributes to the islet compensation in insulin resistance...
  70. ncbi request reprint Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line (INS-1 cells)
    B Ahren
    Department of Medicine, Lund University, Malmo, SE 205 02 Sweden
    Am J Physiol 277:R959-66. 1999
    ..This suggests that the cAMP-protein kinase A signal transduction pathway is a target for leptin to inhibit insulin secretion in insulin-producing cells...
  71. ncbi request reprint Plasma leptin levels are associated with abnormal fibrinolysis in men and postmenopausal women
    S Soderberg
    Department of Medicine, Umea University Hospital, Sweden
    J Intern Med 245:533-43. 1999
    ..This indicates that leptin may be an important link in metabolic consequences of the insulin resistance syndrome. Whether this includes abnormalities in fibrinolysis has not been studied...
  72. ncbi request reprint Islet dysfunction in insulin resistance involves impaired insulin secretion and increased glucagon secretion in postmenopausal women with impaired glucose tolerance
    H Larsson
    Department of Medicine, Lund University, Malmo, Sweden
    Diabetes Care 23:650-7. 2000
    ..To characterize in detail the association between insulin sensitivity and islet function in relation to glucose tolerance in nondiabetic subjects...
  73. ncbi request reprint Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice
    B Ahren
    Department of Medicine, Malmo University Hospital, Lund University, S 205 02, Malmo, Sweden
    Eur J Pharmacol 404:239-45. 2000
    ..Therefore, inhibition of dipeptidyl peptidase IV activity is feasible to exploit as a treatment for glucose intolerance and type 2 diabetes...
  74. ncbi request reprint Glucagon-like peptide-1 and islet lipolysis
    M Sorhede Winzell
    Department of Medicine, Lund University, SE 22184 Lund, Sweden
    Horm Metab Res 36:795-803. 2004
    ..From these results we conclude that while GLP-1 does not seem to induce beta-cell lipolysis acutely in mouse islets, the peptide affects beta-cell fat metabolism after long-term adaptation to GLP-1 receptor stimulation...
  75. ncbi request reprint Temporal and dietary fat content-dependent islet adaptation to high-fat feeding-induced glucose intolerance in mice
    Maria Sörhede Winzell
    Department of Clinical Sciences, Medicine, Lund University, SE 22184, Lund, Sweden
    Metabolism 56:122-8. 2007
    ..We conclude that time- and dietary fat-dependent dynamic adaptive islet compensation evolves after introducing HFD in mice and that MFD-fed mice is a novel nonobese model of glucose intolerance...
  76. ncbi request reprint Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact
    Hindrik Mulder
    Department of Cell and Molecular Biology, Physiological Sciences, and Medicine, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 278:36380-8. 2003
    ..Thus, HSL deficiency results in a moderate impairment of insulin sensitivity in multiple target tissues of the hormone but is compensated by hyperinsulinemia...
  77. ncbi request reprint Pancreatic beta-cell lipotoxicity induced by overexpression of hormone-sensitive lipase
    Maria Sörhede Winzell
    Department of Cell and Molecular Biology, Lund University, Lund, Sweden
    Diabetes 52:2057-65. 2003
    ..One such gene might be uncoupling protein-2, which was found to be upregulated in transgenic islets, a change that was accompanied by decreased ATP levels...
  78. ncbi request reprint Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes
    Bo Ahren
    Department of Medicine, Lund University B11 Biomedical Centre, SE 21184 Lund, Sweden
    J Clin Endocrinol Metab 89:2078-84. 2004
    ..008). No such association was observed for insulin. Thus, improved metabolic control by DPP-4 inhibition in type 2 diabetes is seen in association with reduced glucagon levels and, despite the lower glycemia, unaltered insulin levels...
  79. ncbi request reprint Increased insulin secretion and normalization of glucose tolerance by cholinergic agonism in high fat-fed mice
    B Ahren
    Department of Medicine, Lund University, S 205 02 Malmo, Sweden
    Am J Physiol 277:E93-102. 1999
    ..We conclude that carbachol normalizes glucose tolerance in insulin resistance...
  80. ncbi request reprint Downregulation of islet hormone-sensitive lipase during long-term high-fat feeding
    Maria Sörhede Winzell
    Department of Cell and Molecular Biology, Sec for Molecular Signalling, Biomedical Center, Lund University, S 221 84, Lund, Sweden
    Biochem Biophys Res Commun 304:273-8. 2003
    ....
  81. ncbi request reprint Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice
    Eva Degerman
    Department of Cell and Molecular Biology, Biomedical Center, C11, 22184 Lund, Sweden
    Eur J Pharmacol 498:319-23. 2004
    ....
  82. ncbi request reprint Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice
    B Ahren
    Department of Medicine, Lund University, S 205 02 Malmo, Sweden
    Am J Physiol 277:E996-E1004. 1999
    ..Finally, the GLP-1 receptor antagonist exendin-3-(9-39) inhibited the actions of GLP-1. We conclude that GLP-1 increases glucose tolerance in the mouse mainly by potently stimulating insulin secretion...
  83. doi request reprint Reappraisal of the intravenous glucose tolerance index for a simple assessment of insulin sensitivity in mice
    Giovanni Pacini
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Am J Physiol Regul Integr Comp Physiol 296:R1316-24. 2009
    ..This easily usable formula for calculating CS(I) overcomes many experimental obstacles and may be a simple alternative to more complex procedures when large numbers of mice or repeated experiments in the same animals are required...
  84. ncbi request reprint VPAC2-R mediates the lipolytic effects of pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide in primary rat adipocytes
    Lina Akesson
    Section for Molecular Signaling, Department of Cell and Molecular Biology, Biomedical Center C11, Lund University, SE 221 84 Lund, Sweden
    Endocrinology 146:744-50. 2005
    ..These results therefore provide evidence that all three PACAP/VIP receptor subtypes are expressed in primary rat adipocytes, but that the VPAC2-R subtype is responsible for mediating the lipolytic effects induced by PACAP38 and VIP...
  85. ncbi request reprint Differential impairment of glucagon responses to hypoglycemia, neuroglycopenia, arginine, and carbachol in alloxan-diabetic mice
    Bo Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Metabolism 51:12-9. 2002
    ....
  86. ncbi request reprint Quantification of insulin secretion in relation to insulin sensitivity in nondiabetic postmenopausal women
    Bo Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Diabetes 51:S202-11. 2002
    ....
  87. ncbi request reprint 1,5-Anhydro-D-fructose increases glucose tolerance by increasing glucagon-like peptide-1 and insulin in mice
    B Ahren
    Department of Medicine, Lund University, Malmo University Hospital, SE 205 02, Malmo, Sweden
    Eur J Pharmacol 397:219-25. 2000
    ..The sugar may therefore be explored for increasing endogenous GLP-1 secretion in the treatment of type 2 diabetes...
  88. ncbi request reprint GLP-1 and GLP-1(7-36) amide: influences on basal and stimulated insulin and glucagon secretion in the mouse
    T Fridolf
    Department of Pharmacology, Lund University, Sweden
    Pancreas 6:208-15. 1991
    ..We conclude that GLP-1(7-36) has the potential for being a modulator of islet hormone secretion...
  89. ncbi request reprint The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes
    Maria Sörhede Winzell
    Dept of Medicine, Biomedical Center BMC, B11, S 221 84 Lund, Sweden
    Diabetes 53:S215-9. 2004
    ..We conclude that the high-fat diet-fed C57BL/6J mouse model is a robust model for IGT and early type 2 diabetes, which may be used for studies on pathophysiology and development of new treatment...
  90. doi request reprint Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men
    Ola Lindgren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    J Clin Endocrinol Metab 94:2887-92. 2009
    ..The insulin response to meal ingestion is more rapid in the morning than in the afternoon. Whether this is explained by a corresponding variation in the incretin hormones is not known...
  91. ncbi request reprint Dual effects of pituitary adenylate cyclase-activating polypeptide and isoproterenol on lipid metabolism and signaling in primary rat adipocytes
    Lina Akesson
    Section for Molecular Signaling, Department of Cell and Molecualar Biology, Lund University, Lund, Sweden
    Endocrinology 144:5293-9. 2003
    ..e. storage of triglycerides...
  92. ncbi request reprint Effects of chemical sympathectomy by means of 6-hydroxydopamine on insulin secretion and islet morphology in alloxan-diabetic mice
    Martina Kvist-Reimer
    Department of Medicine, Lund University, B11 BMC, 221 84 Lund, Sweden
    Cell Tissue Res 307:203-9. 2002
    ..Alone, however, sympathectomy reduces insulin gene expression and induces increased islet size, suggesting that sympathetic nerves are of importance for long-term islet function...
  93. ncbi request reprint Survivors of childhood acute lymphoblastic leukaemia, with radiation-induced GH deficiency, exhibit hyperleptinaemia and impaired insulin sensitivity, unaffected by 12 months of GH treatment
    Birgitta Bulow
    Department of Medicine, Lund University, Lund, Sweden
    Clin Endocrinol (Oxf) 61:683-91. 2004
    ..It is not known whether the observed risk for adiposity in these patients is associated with impaired insulin sensitivity and whether the insulin sensitivity is affected by GH replacement therapy...
  94. ncbi request reprint PACAP contributes to insulin secretion after gastric glucose gavage in mice
    K Filipsson
    Department of Medicine, Lund University, Malmo, Sweden
    Am J Physiol Regul Integr Comp Physiol 279:R424-32. 2000
    ..We conclude that PACAP contributes to the insulin response to gastric glucose in mice and suggest that PACAP is involved in the regulation of prandial insulin secretion...
  95. ncbi request reprint Differential changes in islet amyloid polypeptide (amylin) and insulin mRNA expression after high-fat diet-induced insulin resistance in C57BL/6J mice
    H Mulder
    Department of Physiological Sciences, Lund University, Sweden
    Metabolism 49:1518-22. 2000
    ..Availability of this peptide for amyloid formation may be enhanced by increased islet expression of IAPP. In the insulin resistant state, euglycemia is maintained by hypersecretion of insulin. Whether..
  96. ncbi request reprint Large differences in serum leptin levels between nonwesternized and westernized populations: the Kitava study
    S Lindeberg
    Department of Community Medicine, Lund University, Malmo, Sweden
    J Intern Med 249:553-8. 2001
    ..To compare serum leptin between nonwesternized and westernized populations...
  97. ncbi request reprint Relative hyperproinsulinemia as a sign of islet dysfunction in women with impaired glucose tolerance
    H Larsson
    Department of Medicine, Lund University, Malmo, Sweden
    J Clin Endocrinol Metab 84:2068-74. 1999
    ..5 +/- 1.6% vs. 2.3 +/- 0.7%; P = 0.037). We conclude that women with IGT exhibit increased relative proinsulin secretion, suggesting a defect in the intracellular proinsulin processing before diabetes develops...
  98. ncbi request reprint Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test
    A Mari
    Metabolic Modelling Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Diabetologia 48:748-51. 2005
    ..We compared five surrogate insulin sensitivity (IS) methods against the euglycaemic-hyperinsulinaemic clamp. These methods were the homeostasis model assessment (HOMA) and four methods based on the OGTT (OGIS, MCRest, ISIcomp, SIORAL)...
  99. ncbi request reprint Androgen activity as a risk factor for impaired glucose tolerance in postmenopausal women
    H Larsson
    Department of Medicine, Lund University, Malmo, Sweden
    Diabetes Care 19:1399-403. 1996
    ..Our aim was to study the relationship between SHBG and androgen activity and glucose tolerance, as well as insulin sensitivity, in women with impaired glucose tolerance (IGT)...
  100. ncbi request reprint Inhibition of lipase activity and lipolysis in rat islets reduces insulin secretion
    Hindrik Mulder
    Department of Cell and Molecular Biology, Lund University, Lund, Sweden
    Diabetes 53:122-8. 2004
    ..Thus, beta-cell lipase activity is involved in GSIS, emphasizing the important role of beta-cell lipid metabolism for insulin secretion...
  101. ncbi request reprint Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin
    Linda Härndahl
    Department of Cell and Molecular Biology, Biomedical Centre, C11, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 277:37446-55. 2002
    ..The findings suggest a significant role of PDE3B as an important regulator of insulin secretory processes...