Kristian Pietras

Summary

Affiliation: Ludwig Institute for Cancer Research
Country: Sweden

Publications

  1. ncbi request reprint PDGF receptors as cancer drug targets
    Kristian Pietras
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Cancer Cell 3:439-43. 2003
  2. pmc Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
    Kristian Pietras
    Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States ofAmerica
    PLoS Med 5:e19. 2008
  3. ncbi request reprint A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    Kristian Pietras
    Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California San Francisco, 513 Parnassas Avenue, San Francisco, CA 94143, USA
    J Clin Oncol 23:939-52. 2005
  4. pmc Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B
    Beverly L Falcon
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, California, USA
    Am J Pathol 178:2920-30. 2011
  5. pmc Effect of platelet-derived growth factor receptor-beta inhibition with STI571 on radioimmunotherapy
    Janina Baranowska-Kortylewicz
    Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6850, USA
    Cancer Res 65:7824-31. 2005
  6. ncbi request reprint STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake
    Kristian Pietras
    Ludwig Institute for Cancer Research, SE 751 24 Uppsala, Sweden
    Clin Cancer Res 9:3779-87. 2003
  7. ncbi request reprint Increasing tumor uptake of anticancer drugs with imatinib
    Kristian Pietras
    University of California at San Francisco, Diabetes Center, 94143, USA
    Semin Oncol 31:18-23. 2004
  8. pmc Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
    Enming J Su
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor Michigan 48109 0644, USA
    Nat Med 14:731-7. 2008
  9. ncbi request reprint Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy
    Kristian Pietras
    Ludwig Institute for Cancer Research, SE 751 24 Uppsala, Sweden
    Cancer Res 62:5476-84. 2002
  10. ncbi request reprint A stroma targeted therapy enhances castration effects in a transplantable rat prostate cancer model
    Anna Johansson
    Department of Medical Bioscience, Pathology, Umea University, Sweden
    Prostate 67:1664-76. 2007

Collaborators

Detail Information

Publications14

  1. ncbi request reprint PDGF receptors as cancer drug targets
    Kristian Pietras
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Cancer Cell 3:439-43. 2003
  2. pmc Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
    Kristian Pietras
    Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States ofAmerica
    PLoS Med 5:e19. 2008
    ..We postulated that pharmacological targeting of putative stromal support functions, in particular those of cancer-associated fibroblasts, could have therapeutic utility, and sought to assess the possibility in a pre-clinical setting...
  3. ncbi request reprint A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    Kristian Pietras
    Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California San Francisco, 513 Parnassas Avenue, San Francisco, CA 94143, USA
    J Clin Oncol 23:939-52. 2005
    ..Additionally, vascular endothelial growth factor receptor (VEGFR) inhibitors and metronomic chemotherapy show modest benefit against early- but not late-stage disease...
  4. pmc Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B
    Beverly L Falcon
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, California, USA
    Am J Pathol 178:2920-30. 2011
    ..Together, these findings indicate that inhibition of PDGF-B signaling promotes the delivery and efficacy of chemotherapeutic agents by increasing the efficiency of tumor blood vessels...
  5. pmc Effect of platelet-derived growth factor receptor-beta inhibition with STI571 on radioimmunotherapy
    Janina Baranowska-Kortylewicz
    Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6850, USA
    Cancer Res 65:7824-31. 2005
    ..Two related causes were also identified: (a) the improved homogeneity of monoclonal antibody distribution in tumor and (b) the increased tumor radiosensitivity resulting from the improved tumor oxygenation...
  6. ncbi request reprint STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake
    Kristian Pietras
    Ludwig Institute for Cancer Research, SE 751 24 Uppsala, Sweden
    Clin Cancer Res 9:3779-87. 2003
    ....
  7. ncbi request reprint Increasing tumor uptake of anticancer drugs with imatinib
    Kristian Pietras
    University of California at San Francisco, Diabetes Center, 94143, USA
    Semin Oncol 31:18-23. 2004
    ....
  8. pmc Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
    Enming J Su
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor Michigan 48109 0644, USA
    Nat Med 14:731-7. 2008
    ..These data demonstrate that PDGF signaling regulates blood-brain barrier permeability and suggest potential new strategies for stroke treatment...
  9. ncbi request reprint Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy
    Kristian Pietras
    Ludwig Institute for Cancer Research, SE 751 24 Uppsala, Sweden
    Cancer Res 62:5476-84. 2002
    ..In conclusion, our study identifies inhibition of PDGF signaling in tumor stroma as a novel, possibly general strategy for enhancement of the therapeutic effects chemotherapy...
  10. ncbi request reprint A stroma targeted therapy enhances castration effects in a transplantable rat prostate cancer model
    Anna Johansson
    Department of Medical Bioscience, Pathology, Umea University, Sweden
    Prostate 67:1664-76. 2007
    ..We therefore used animal tumor models to explore the importance of stroma and vascular effects, and if castration effects could be enhanced by a simultaneous therapy targeting the tumor stroma...
  11. ncbi request reprint Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice
    Annica Pontén
    Ludwig Institute for Cancer Research, S 17177 Stockholm, Sweden
    Circ Res 97:1036-45. 2005
    ..Our data raise the possibility that this growth factor may be involved in cardiac fibrosis and atherosclerosis...
  12. ncbi request reprint Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors
    Renhai Cao
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    FASEB J 16:1575-83. 2002
    ..Thus, the PDGF-CC-mediated angiogenic response is most likely transduced by PDGF-alphaalpha and -alphabeta receptors. These data demonstrate that the PDGF family is a complex and important group of proangiogenic factors...
  13. ncbi request reprint High interstitial fluid pressure - an obstacle in cancer therapy
    Carl Henrik Heldin
    Ludwig Institute for Cancer Research, Box 595, SE 751 24 Uppsala, Sweden
    Nat Rev Cancer 4:806-13. 2004
    ..Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy...
  14. ncbi request reprint Protein detection using proximity-dependent DNA ligation assays
    Simon Fredriksson
    The Beijer Laboratory, Department of Genetics and Pathology, Rudbeck Laboratory, SE 75185 Uppsala, Sweden
    Nat Biotechnol 20:473-7. 2002
    ..This proximity ligation assay detects zeptomole (40 x 10(-21) mol) amounts of the cytokine platelet-derived growth factor (PDGF) without washes or separations, and the mechanism can be generalized to other forms of protein analysis...