Research Topics
| Kristian PietrasSummaryAffiliation: Ludwig Institute for Cancer Research Country: Sweden Publications
| Collaborators
|
Detail Information
Publications
PDGF receptors as cancer drug targetsKristian Pietras
Ludwig Institute for Cancer Research, Uppsala, Sweden
Cancer Cell 3:439-43. 2003
Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targetingKristian Pietras
Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States ofAmerica
PLoS Med 5:e19. 2008..We postulated that pharmacological targeting of putative stromal support functions, in particular those of cancer-associated fibroblasts, could have therapeutic utility, and sought to assess the possibility in a pre-clinical setting...- A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancerKristian Pietras
Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California San Francisco, 513 Parnassas Avenue, San Francisco, CA 94143, USA
J Clin Oncol 23:939-52. 2005.... - Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-BBeverly L Falcon
Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, California, USA
Am J Pathol 178:2920-30. 2011..Together, these findings indicate that inhibition of PDGF-B signaling promotes the delivery and efficacy of chemotherapeutic agents by increasing the efficiency of tumor blood vessels... - Effect of platelet-derived growth factor receptor-beta inhibition with STI571 on radioimmunotherapyJanina Baranowska-Kortylewicz
Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6850, USA
Cancer Res 65:7824-31. 2005..Two related causes were also identified: (a) the improved homogeneity of monoclonal antibody distribution in tumor and (b) the increased tumor radiosensitivity resulting from the improved tumor oxygenation... - STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptakeKristian Pietras
Ludwig Institute for Cancer Research, SE-751 24 Uppsala, Sweden
Clin Cancer Res 9:3779-87. 2003..The study thus validates STI571 for combination treatment to enhance the therapeutic index of EPO906 in particular and, possibly, of chemotherapeutics in general... - Increasing tumor uptake of anticancer drugs with imatinibKristian Pietras
University of California at San Francisco, Diabetes Center, 94143, USA
Semin Oncol 31:18-23. 2004.... - Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic strokeEnming J Su
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor Michigan 48109 0644, USA
Nat Med 14:731-7. 2008..These data demonstrate that PDGF signaling regulates blood-brain barrier permeability and suggest potential new strategies for stroke treatment... - Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapyKristian Pietras
Ludwig Institute for Cancer Research, SE-751 24 Uppsala, Sweden
Cancer Res 62:5476-84. 2002..In conclusion, our study identifies inhibition of PDGF signaling in tumor stroma as a novel, possibly general strategy for enhancement of the therapeutic effects chemotherapy... - A stroma targeted therapy enhances castration effects in a transplantable rat prostate cancer modelAnna Johansson
Department of Medical Bioscience, Pathology, Umea University, Sweden
Prostate 67:1664-76. 2007..We therefore used animal tumor models to explore the importance of stroma and vascular effects, and if castration effects could be enhanced by a simultaneous therapy targeting the tumor stroma... - Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic miceAnnica Pontén
Ludwig Institute for Cancer Research, S 17177 Stockholm, Sweden
Circ Res 97:1036-45. 2005..Our data raise the possibility that this growth factor may be involved in cardiac fibrosis and atherosclerosis... - Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptorsRenhai Cao
Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77 Stockholm, Sweden
FASEB J 16:1575-83. 2002..Thus, the PDGF-CC-mediated angiogenic response is most likely transduced by PDGF-alphaalpha and -alphabeta receptors. These data demonstrate that the PDGF family is a complex and important group of proangiogenic factors... - High interstitial fluid pressure - an obstacle in cancer therapyCarl Henrik Heldin
Ludwig Institute for Cancer Research, Box 595, SE 751 24 Uppsala, Sweden
Nat Rev Cancer 4:806-13. 2004..Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy... - Protein detection using proximity-dependent DNA ligation assaysSimon Fredriksson
The Beijer Laboratory, Department of Genetics and Pathology, Rudbeck Laboratory, SE-75185 Uppsala, Sweden
Nat Biotechnol 20:473-7. 2002..This proximity ligation assay detects zeptomole (40 x 10(-21) mol) amounts of the cytokine platelet-derived growth factor (PDGF) without washes or separations, and the mechanism can be generalized to other forms of protein analysis...