Thomas Perlmann

Summary

Affiliation: Ludwig Institute for Cancer Research
Country: Sweden

Publications

  1. ncbi request reprint Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells
    Thomas Perlmann
    The Ludwig Institute, Stockholm, Sweden
    Cell Tissue Res 318:45-52. 2004
  2. doi request reprint Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development
    Qiaolin Deng
    Karolinska Institutet, Department of Cell and Molecular Biology, Stockholm, Sweden
    Development 138:3399-408. 2011
  3. ncbi request reprint Identification of intrinsic determinants of midbrain dopamine neurons
    Elisabet Andersson
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    Cell 124:393-405. 2006
  4. doi request reprint Rapid increase of Nurr1 mRNA expression in limbic and cortical brain structures related to coping with depression-like behavior in mice
    Patricia Rojas
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurosci Res 88:2284-93. 2010
  5. ncbi request reprint Neuropilin1 is a direct downstream target of Nurr1 in the developing brain stem
    Elisabet Hermanson
    Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, Sweden
    J Neurochem 97:1403-11. 2006
  6. pmc p57(Kip2) cooperates with Nurr1 in developing dopamine cells
    Bertrand Joseph
    The Ludwig Institute for Cancer Research, Box 240, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:15619-24. 2003
  7. pmc Tracing lineages to uncover neuronal identity
    Lia Panman
    Ludwig Institute for Cancer Research Ltd, Stockholm, Sweden
    BMC Biol 9:51. 2011
  8. doi request reprint NR4A orphan nuclear receptors influence retinoic acid and docosahexaenoic acid signaling via up-regulation of fatty acid binding protein 5
    Nikolaos Volakakis
    Ludwig Institute for Cancer Research Ltd, Box 240, S 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 390:1186-91. 2009
  9. doi request reprint Running increases neurogenesis without retinoic acid receptor activation in the adult mouse dentate gyrus
    Elin Aberg
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Hippocampus 18:785-92. 2008
  10. doi request reprint SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation
    Johan Holmberg
    Ludwig Institute for Cancer Research, Karolinska Institute, Box 240, SE 171 77 Stockholm, Sweden
    Development 135:1843-51. 2008

Collaborators

  • Patricia Rojas
  • Lia Panman
  • Benoit Robert
  • Sven Ove Ogren
  • Stefan Brene
  • Elin Aberg
  • Asa Wallen-Mackenzie
  • Stina Friling
  • Jean Francois Brunet
  • Lars Olson
  • Jinsong Liu
  • Ernest Arenas
  • Eva Hedlund
  • Peter Ordentlich
  • C Backman
  • Asa Wallén
  • Jean Christophe Roux
  • Nikolaos Volakakis
  • Gerard Benoit
  • Elisabet Hermanson
  • Piia Aarnisalo
  • Eliza Joodmardi
  • Qiaolin Deng
  • Bertrand Joseph
  • Elisabet Andersson
  • Michal Malewicz
  • Maria Bergsland
  • Martin Werme
  • Zhanna Alekseenko
  • Johan Ericson
  • Johan Holmberg
  • Johanna Lammi
  • Jonas Muhr
  • Ulrika Nyman
  • Anna Codina
  • Elise Nsegbe
  • Mariette Nordzell
  • Shanthini Sockanathan
  • Alexander Mata de Urquiza
  • Zhulun Wang
  • Nina Tornqvist
  • Johan Lengqvist
  • James H Millonig
  • Eva Coppola
  • Bruce M Spiegelman
  • Banafsheh Kadkhodaei
  • Karin Wallis
  • Jessica Silvaggi
  • Magnus Sandberg
  • Emil Hansson
  • Urban Lendahl
  • Banafsheh Kadkhodai
  • Lotta Borgius
  • Ulrika Tryggvason
  • Pinelopi Vlachos
  • Boris Zhivotovsky
  • Agnieszka Sobczak-Pluta
  • David Neuhaus
  • John T Gooch
  • John W R Schwabe
  • Diogo S Castro
  • Hugo Lagercrantz
  • Yuri Shvarev
  • Stephane Dauger
  • Eric Herlenius
  • Diogo Castro
  • Xiaohong Liu
  • Eva Lindqvist
  • Takashi Murata
  • Peter Thoren
  • Srividya Prasad
  • Andrea Carmine
  • Nigel P C Walker
  • Silvia Buervenich
  • Sam Okret
  • Bastian Hengerer
  • Thomas M Jessell
  • Rolf H Zetterström
  • Haoda Xu
  • Jan Sjövall
  • William J Griffiths
  • Chae Hee Kim
  • Jae Woon Lee
  • Ingrid Stromberg

Detail Information

Publications29

  1. ncbi request reprint Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells
    Thomas Perlmann
    The Ludwig Institute, Stockholm, Sweden
    Cell Tissue Res 318:45-52. 2004
    ..However, Nurr1 is probably also important for the maintenance of adult DA neurons and plays additional less-well-elucidated roles in other regions of the central nervous system and in peripheral tissues...
  2. doi request reprint Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development
    Qiaolin Deng
    Karolinska Institutet, Department of Cell and Molecular Biology, Stockholm, Sweden
    Development 138:3399-408. 2011
    ..Our data therefore establish that Lmx1b influences the differentiation of multiple neuronal subtypes in the ventral midbrain, whereas Lmx1a appears to be exclusively devoted to the differentiation of the DN lineage...
  3. ncbi request reprint Identification of intrinsic determinants of midbrain dopamine neurons
    Elisabet Andersson
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    Cell 124:393-405. 2006
    ..These data establish that Lmx1a and Msx1 are critical intrinsic dopamine-neuron determinants in vivo and suggest that they may be essential tools in cell replacement strategies in Parkinson's disease...
  4. doi request reprint Rapid increase of Nurr1 mRNA expression in limbic and cortical brain structures related to coping with depression-like behavior in mice
    Patricia Rojas
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurosci Res 88:2284-93. 2010
    ..These results suggest that the increase in Nurr1 expression might be a compensatory mechanism to counteract the changes in forebrain dopamine transmission in coping with acute stress...
  5. ncbi request reprint Neuropilin1 is a direct downstream target of Nurr1 in the developing brain stem
    Elisabet Hermanson
    Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, Sweden
    J Neurochem 97:1403-11. 2006
    ..Taken together, our findings suggest that Nurr1 might influence the processes of axon guidance and/or angiogenesis via the regulation of Nrp1 expression...
  6. pmc p57(Kip2) cooperates with Nurr1 in developing dopamine cells
    Bertrand Joseph
    The Ludwig Institute for Cancer Research, Box 240, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:15619-24. 2003
    ..Thus, in addition to its established function in control of proliferation, these results reveal a mechanism whereby p57Kip2 influences postmitotic differentiation of dopamine neurons...
  7. pmc Tracing lineages to uncover neuronal identity
    Lia Panman
    Ludwig Institute for Cancer Research Ltd, Stockholm, Sweden
    BMC Biol 9:51. 2011
    ....
  8. doi request reprint NR4A orphan nuclear receptors influence retinoic acid and docosahexaenoic acid signaling via up-regulation of fatty acid binding protein 5
    Nikolaos Volakakis
    Ludwig Institute for Cancer Research Ltd, Box 240, S 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 390:1186-91. 2009
    ..We also found that other members of the NR4A orphan NRs can up-regulate FABP5. Thus, our findings suggest that NR4A orphan NRs can influence signaling events of other NRs via control of FABP5 expression levels...
  9. doi request reprint Running increases neurogenesis without retinoic acid receptor activation in the adult mouse dentate gyrus
    Elin Aberg
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Hippocampus 18:785-92. 2008
    ..Thus, our data suggest that the effects of exercise on neurogenesis and other plasticity changes in the hippocampal formation are mediated by mechanisms that do not involve retinoid receptor activation...
  10. doi request reprint SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation
    Johan Holmberg
    Ludwig Institute for Cancer Research, Karolinska Institute, Box 240, SE 171 77 Stockholm, Sweden
    Development 135:1843-51. 2008
    ..Together, these data reveal that Notch signaling and SoxB1 transcription factors use distinct regulatory mechanisms to control proneural protein function and to preserve neural cells as undifferentiated precursors...
  11. ncbi request reprint Defining an N-terminal activation domain of the orphan nuclear receptor Nurr1
    Mariette Nordzell
    Ludwig Institute for Cancer Research, Stockholm Branch, Box 240, Stockholm S 171 77, Sweden
    Biochem Biophys Res Commun 313:205-11. 2004
    ..The results indicate that mitogen-activated protein kinase activity (MAPK) positively influences Nurr1 AF1-dependent transcriptional activation via a conserved phosphorylation site outside the core activation region...
  12. ncbi request reprint Characterization of the Nurr1 ligand-binding domain co-activator interaction surface
    Nikolaos Volakakis
    Ludwig Institute for Cancer Research, Stockholm Branch, Box 240, S 171 77 Stockholm, Sweden
    J Mol Endocrinol 37:317-26. 2006
    ..These data provide novel insights into the mechanisms of transcription via the Nurr1 LBD and identify an alternative co-activator-binding surface that is unique to the NR4A family of NRs...
  13. pmc NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection
    Nikolaos Volakakis
    Ludwig Institute for Cancer Research, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:12317-22. 2010
    ..These data identify NR4A nuclear orphan receptors as essential mediators of neuroprotection after exposure to neuropathological stress...
  14. ncbi request reprint Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells
    Elisabet Hermanson
    Ludwig Institute for Cancer Research, Stockholm Branch, P O Box 240, S 171 77 Stockholm, Sweden
    Exp Cell Res 288:324-34. 2003
    ..Together, the results provide evidence indicating an instructive role for Nurr1 in controlling DA synthesis and storage...
  15. ncbi request reprint Generation of tyrosine hydroxylase-immunoreactive neurons in ventral mesencephalic tissue of Nurr1 deficient mice
    Nina Tornqvist
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Brain Res Dev Brain Res 133:37-47. 2002
    ..In conclusion, TH-positive neurons may be generated in ventral mesencephalic tissue of Nurr1 deficient mice, suggesting that Nurr1 is not required for TH gene expression in ventral midbrain in vitro...
  16. ncbi request reprint Decreased ethanol preference and wheel running in Nurr1-deficient mice
    Martin Werme
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Eur J Neurosci 17:2418-24. 2003
    ..Together, our data thus imply involvement of Nurr1 in the transition to a state of high ethanol consumption as well as in the development of a high amount of wheel running in mice...
  17. pmc Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells
    Asa Wallen-Mackenzie
    The Ludwig Institute for Cancer Research, Stockholm Branch, S 171 77 Stockholm, Sweden
    Genes Dev 17:3036-47. 2003
    ..Finally, our findings identify RXR-Nurr1 heterodimers as a potential target in the treatment of neurodegenerative disease...
  18. ncbi request reprint Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting
    Anna Codina
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Biol Chem 279:53338-45. 2004
    ..This binding surface involves a groove between helices 11 and 12. Mutations in this site abolish activation by the Nurr1 LBD. These findings give insight into the unique mechanism of action of this class of nuclear receptors...
  19. ncbi request reprint Elevated locomotor activity without altered striatal dopamine contents in Nurr1 heterozygous mice after acute exposure to methamphetamine
    Cristina Backman
    Cellular Neurobiology Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21221, USA
    Behav Brain Res 143:95-100. 2003
    ....
  20. ncbi request reprint Transcriptional control of dopamine neuron development
    Asa Wallén
    The Ludwig Institute for Cancer Research, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Ann N Y Acad Sci 991:48-60. 2003
    ....
  21. ncbi request reprint Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1
    Piia Aarnisalo
    Ludwig Institute for Cancer Research, Karolinska Institute, Stockholm, Sweden SE 171 77
    J Biol Chem 277:35118-23. 2002
    ..In conclusion, our data show unique structural and functional properties of RXR-Nurr1 heterodimers and also demonstrate that specific mutations in Nurr1 can abolish heterodimerization without affecting other essential functions...
  22. ncbi request reprint Retinoid receptor signaling in postmitotic motor neurons regulates rostrocaudal positional identity and axonal projection pattern
    Shanthini Sockanathan
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 40:97-111. 2003
    ..These findings provide evidence for a regionally restricted role for retinoid signaling in the postmitotic specification of motor neuron columnar identity...
  23. ncbi request reprint Detection of a receptor-ligand non-covalent complex using a triple quadrupole mass spectrometer
    Johan Lengqvist
    Rapid Commun Mass Spectrom 16:2003-6. 2002
  24. ncbi request reprint In vivo and in vitro reporter systems for studying nuclear receptor and ligand activities
    Alexander Mata de Urquiza
    Ludwig Institute for Cancer Research, Stockholm Branch, S 171 77 Stockholm, Sweden
    Methods Enzymol 364:463-75. 2003
  25. ncbi request reprint Full-length p73alpha represses drug-induced apoptosis in small cell lung carcinoma cells
    Ulrika Nyman
    Karolinska Institutet, Institute of Environmental Medicine, S 171 77 Stockholm, Sweden
    J Biol Chem 280:34159-69. 2005
    ..In conclusion, the reported overexpression of p73alpha in certain tumor types, and our findings that p73alpha exerts anti-apoptotic functions, indicate a potential oncogenic activity for p73...
  26. doi request reprint Corepressor interaction differentiates the permissive and non-permissive retinoid X receptor heterodimers
    Johanna Lammi
    Institute of Biomedicine Physiology, Biomedicum Helsinki, University of Helsinki, P O Box 63, 00014 Helsinki, Finland
    Arch Biochem Biophys 472:105-14. 2008
    ..The corepressors were released only upon binding of RAR ligand. In conclusion, corepressor interaction differentiates the permissive RXR-Nurr1 heterodimers from the non-permissive RXR-RAR heterodimers...
  27. pmc The establishment of neuronal properties is controlled by Sox4 and Sox11
    Maria Bergsland
    Ludwig Institute for Cancer Research, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Genes Dev 20:3475-86. 2006
    ..Together, these findings demonstrate a central regulatory role of Sox4 and Sox11 during neuronal maturation and mechanistically separate cell cycle withdrawal from the establishment of neuronal properties...
  28. pmc Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice
    Elise Nsegbe
    Karolinska Institutet, Neonatal Unit, Astrid Lindgren Children s Hospital, S 171 76 Stockholm, Sweden
    J Physiol 556:43-59. 2004
    ....
  29. ncbi request reprint Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors
    Zhulun Wang
    Department of Structural Biology, Tularik Inc, 1120 Veterans Blvd, South San Francisco, California 94080, USA
    Nature 423:555-60. 2003
    ..Notably, transcriptional activity is correlated with the Nurr1 LBD adopting a more stable conformation. Our findings highlight a unique structural class of NRs and define a model for ligand-independent NR function...