A Moustakas

Summary

Affiliation: Ludwig Institute for Cancer Research
Country: Sweden

Publications

  1. ncbi request reprint Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation
    Aristidis Moustakas
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Immunol Lett 82:85-91. 2002
  2. pmc TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
    Ulrich Valcourt
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Mol Biol Cell 16:1987-2002. 2005
  3. pmc TGFbeta induces SIK to negatively regulate type I receptor kinase signaling
    Marcin Kowanetz
    Ludwig Institute for Cancer Research, Uppsala University, Box 595 Biomedical Center, Uppsala, Sweden
    J Cell Biol 182:655-62. 2008
  4. pmc Notch signaling is necessary for epithelial growth arrest by TGF-beta
    Hideki Niimi
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    J Cell Biol 176:695-707. 2007
  5. pmc Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition
    Sylvie Thuault
    Ludwig Institute for Cancer Research, Uppsala University, SE 751 24 Uppsala, Sweden, and Institut National de la Sante et de la Recherche Medicale, Hopital E Herriot, Lyon Cedex, France
    J Cell Biol 174:175-83. 2006
  6. pmc Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1
    Anita Morén
    Ludwig Institute for Cancer Research, Uppsala University, Box 595, Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    J Biol Chem 286:341-53. 2011
  7. doi request reprint Coordination of TGF-β signaling by ubiquitylation
    Aristidis Moustakas
    Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Box 582, 751 23 Uppsala, Sweden Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, Box 595, 751 24 Uppsala, Sweden Electronic address
    Mol Cell 51:555-6. 2013
  8. doi request reprint Induction of epithelial-mesenchymal transition by transforming growth factor β
    Aristidis Moustakas
    Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE 751 24 Uppsala, Sweden
    Semin Cancer Biol 22:446-54. 2012
  9. pmc Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom
    Lukasz Huminiecki
    Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden
    BMC Evol Biol 9:28. 2009
  10. pmc Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling
    Nieves Ibarrola
    McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA
    BMC Cell Biol 5:2. 2004

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation
    Aristidis Moustakas
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Immunol Lett 82:85-91. 2002
    ....
  2. pmc TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
    Ulrich Valcourt
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Mol Biol Cell 16:1987-2002. 2005
    ....
  3. pmc TGFbeta induces SIK to negatively regulate type I receptor kinase signaling
    Marcin Kowanetz
    Ludwig Institute for Cancer Research, Uppsala University, Box 595 Biomedical Center, Uppsala, Sweden
    J Cell Biol 182:655-62. 2008
    ..Loss of endogenous SIK results in enhanced gene responses of the fibrotic and cytostatic programs of TGFbeta. We thus identify in SIK a negative regulator that controls TGFbeta receptor turnover and physiological signaling...
  4. pmc Notch signaling is necessary for epithelial growth arrest by TGF-beta
    Hideki Niimi
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    J Cell Biol 176:695-707. 2007
    ..We establish an intimate involvement of Notch signaling in the epithelial cytostatic response to TGF-beta...
  5. pmc Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition
    Sylvie Thuault
    Ludwig Institute for Cancer Research, Uppsala University, SE 751 24 Uppsala, Sweden, and Institut National de la Sante et de la Recherche Medicale, Hopital E Herriot, Lyon Cedex, France
    J Cell Biol 174:175-83. 2006
    ..This network of signaling/transcription factors that work sequentially to establish EMT suggests that combinatorial detection of these proteins could serve as a new tool for EMT analysis in cancer patients...
  6. pmc Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1
    Anita Morén
    Ludwig Institute for Cancer Research, Uppsala University, Box 595, Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    J Biol Chem 286:341-53. 2011
    ..Accordingly, LKB1 negatively regulates TGFβ gene responses and epithelial-mesenchymal transition. Thus, LKB1 and LIP1 provide negative control of TGFβ signaling...
  7. doi request reprint Coordination of TGF-β signaling by ubiquitylation
    Aristidis Moustakas
    Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Box 582, 751 23 Uppsala, Sweden Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, Box 595, 751 24 Uppsala, Sweden Electronic address
    Mol Cell 51:555-6. 2013
    ..2013) demonstrate that the ubiquitin ligase TRAF4 associates with the TGF-β receptors, rescuing them from degradation and ubiquitylating TAK1 to activate non-Smad signaling, which together promote metastasis of breast cancer cells. ..
  8. doi request reprint Induction of epithelial-mesenchymal transition by transforming growth factor β
    Aristidis Moustakas
    Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE 751 24 Uppsala, Sweden
    Semin Cancer Biol 22:446-54. 2012
    ....
  9. pmc Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom
    Lukasz Huminiecki
    Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden
    BMC Evol Biol 9:28. 2009
    ..Herein, we focus on the diversification of the transforming growth factor-beta (TGF-beta) pathway -- one of the fundamental and versatile metazoan signal transduction engines...
  10. pmc Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling
    Nieves Ibarrola
    McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA
    BMC Cell Biol 5:2. 2004
    ..Signaling by these factors is mediated chiefly by the Smad family of latent transcription factors...
  11. ncbi request reprint Ecsit-ement on the crossroads of Toll and BMP signal transduction
    Aristidis Moustakas
    Ludwig Institute for Cancer Research, SE 751 24 Uppsala, Sweden
    Genes Dev 17:2855-9. 2003
  12. ncbi request reprint TGF-beta targets PAX3 to control melanocyte differentiation
    Aristidis Moustakas
    Ludwig Institute for Cancer Research, Uppsala University, Box 595 Biomedical Center, Uppsala, Sweden
    Dev Cell 15:797-9. 2008
    ..In the presence of UV radiation, a Jnk/AP-1 pathway represses TGF-beta, which together with a UV-induced p53 pathway promotes melanocyte differentiation...
  13. doi request reprint The regulation of TGFbeta signal transduction
    Aristidis Moustakas
    Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden
    Development 136:3699-714. 2009
    ..Signaling is modulated by negative-feedback regulation via inhibitory Smads. We review here the mechanisms of TGFbeta signal transduction in metazoans and emphasize events crucial for embryonic development...
  14. doi request reprint Dynamic control of TGF-beta signaling and its links to the cytoskeleton
    Aristidis Moustakas
    Ludwig Institute for Cancer Research, Uppsala University, P O Box 595, Biomedical Center, SE 751 24 Uppsala, Sweden
    FEBS Lett 582:2051-65. 2008
    ..We discuss mechanisms and models that aim at explaining the coordination between several components of the signaling network downstream of the TGF-beta signal...
  15. ncbi request reprint Non-Smad TGF-beta signals
    Aristidis Moustakas
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, Box 595, SE 751 24 Uppsala, Sweden
    J Cell Sci 118:3573-84. 2005
    ....
  16. pmc Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner
    A Kurisaki
    Ludwig Institute for Cancer Research, SE 751 24 Uppsala, Sweden
    Mol Biol Cell 12:1079-91. 2001
    ..The import mechanism of Smad3 shows distinct features from that of the related Smad2 and the structural basis for this difference maps to the divergent sequences of their N-terminal domains...
  17. ncbi request reprint Smad regulation in TGF-beta signal transduction
    A Moustakas
    Ludwig Institute for Cancer Research, Box 595, SE 751 24 Uppsala, Sweden
    J Cell Sci 114:4359-69. 2001
    ..Finally, the inhibitory Smads (I-Smads) block phosphorylation of R-Smads by the receptors and promote ubiquitination and degradation of receptor complexes, thus inhibiting signalling...
  18. ncbi request reprint Smad signalling network
    Aristidis Moustakas
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, Husargatan 3, SE 751 24 Uppsala, Sweden
    J Cell Sci 115:3355-6. 2002
  19. ncbi request reprint From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction
    Aristidis Moustakas
    Ludwig Institute for Cancer Research, SE 751 24 Uppsala, Sweden
    Genes Dev 16:1867-71. 2002
  20. ncbi request reprint Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4
    A Moren
    Ludwig Institute for Cancer Research, Box 595, S 751 24 Uppsala, Sweden
    Oncogene 19:4396-404. 2000
    ..In conclusion, mutations in the amino-terminal domain of Smad4, that are found in cancer, show loss of multiple functional properties which may contribute to tumorigenesis...
  21. ncbi request reprint TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
    E Piek
    Ludwig Institute for Cancer Research, Box 595, S 75124 Uppsala, Sweden
    J Cell Sci 112:4557-68. 1999
    ..Activin A does not induce mesenchymal transformation, presumably because the number of activin receptors is limited, while BMP-7-initiated signalling cannot mediate transdifferentiation...
  22. pmc Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein
    Marcin Kowanetz
    Ludwig Institute for Cancer Research, SE 751 24 Uppsala, Sweden
    Mol Cell Biol 24:4241-54. 2004
    ..Thus, Id genes sense Smad signals and create a permissive or refractory nuclear environment that defines decisions of cell fate and proliferation...
  23. pmc Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation
    Keiko Kurisaki
    Ludwig Institute for Cancer Research, Biomedical Center, SE 751 24 Uppsala, Sweden
    Mol Cell Biol 23:4494-510. 2003
    ..In conclusion, YY1 represses Smad transcriptional activities in a gene-specific manner and thus regulates cell differentiation induced by TGF-beta superfamily pathways...
  24. ncbi request reprint Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1)
    Katerina Pardali
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    J Cell Physiol 204:260-72. 2005
    ..Thus, p21 is a common target of all TGF-beta superfamily pathways. However, the ability of TGF-beta superfamily members to induce cell growth arrest depends on the regulation of additional gene targets...
  25. ncbi request reprint Differential ubiquitination defines the functional status of the tumor suppressor Smad4
    Anita Morén
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, SE 751 24 Uppsala, Sweden
    J Biol Chem 278:33571-82. 2003
    ..These data suggest that oligo-ubiquitination positively regulates Smad4 function, whereas poly-ubiquitination primarily occurs in unstable cancer mutants and leads to protein degradation...
  26. ncbi request reprint Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta
    K Pardali
    Ludwig Institute for Cancer Research, Box 595, SE 751 24 Uppsala, Sweden
    J Biol Chem 275:29244-56. 2000
    ..In conclusion, Smad proteins play important roles in regulation of the p21 gene by TGF-beta, and the functional cooperation of Smad proteins with Sp1 involves the physical interaction of these two types of transcription factors...
  27. pmc HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
    Sylvie Thuault
    Ludwig Institute for Cancer Research, Box 595 Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    J Biol Chem 283:33437-46. 2008
    ..The data propose that HMGA2 acts in a gene-specific manner to orchestrate the transcriptional network necessary for the EMT program...
  28. ncbi request reprint Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer
    Katerina Pardali
    Ludwig Institute for Cancer Research, Box 595 Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    Biochim Biophys Acta 1775:21-62. 2007
    ..In conclusion, TGF-beta signaling is intimately implicated in tumor development and contributes to all cardinal features of tumor cell biology...
  29. pmc Snail depletes the tumorigenic potential of glioblastoma
    K Savary
    Ludwig Institute for Cancer Research, Science for Life Laboratory, Biomedical Center, Uppsala University, Uppsala, Sweden
    Oncogene 32:5409-20. 2013
    ..Thus Snail, acting downstream of BMP signaling, dissociates the invasive capacity of GBM cells from their tumorigenic potential. ..
  30. ncbi request reprint Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis
    A Gal
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Oncogene 27:1218-30. 2008
    ..Thus, TGFbeta may modulate its own signalling to facilitate switching from tumour suppression to tumour progression...
  31. doi request reprint Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition
    Carl Henrik Heldin
    Ludwig Institute for Cancer Research, Uppsala University, BMC, Uppsala, Sweden
    Curr Opin Cell Biol 21:166-76. 2009
    ..The aim of this review is to summarize some of the recent findings on the mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition...
  32. ncbi request reprint TGF-beta signaling from a three-dimensional perspective: insight into selection of partners
    Serhiy Souchelnytskyi
    Ludwig Institute for Cancer Research, Box 595, Husargatan 3, SE 751 24, Uppsala, Sweden
    Trends Cell Biol 12:304-7. 2002
    ....
  33. ncbi request reprint Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases
    Anita Morén
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    J Biol Chem 280:22115-23. 2005
    ..Such mechanisms of down-regulation of TGF-beta signaling may be critical for proper physiological response to this pathway...
  34. pmc TGFbeta activates mitogen- and stress-activated protein kinase-1 (MSK1) to attenuate cell death
    Lars P van der Heide
    Department of Molecular Cell Biology, and Centre for Biomedical Genetics, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands
    J Biol Chem 286:5003-11. 2011
    ..Monitoring the status of MSK1 activity in cancer promises new therapeutic targets as inactivating both MSK1 and EGF signaling may (re)-sensitize cells to TGFβ-induced cell death...
  35. pmc The mechanism of nuclear export of Smad3 involves exportin 4 and Ran
    Akira Kurisaki
    Ludwig Institute for Cancer Research, Box 595 Biomedical Center, SE 751 24 Uppsala, Sweden
    Mol Cell Biol 26:1318-32. 2006
    ..A short peptide representing the minimal interaction domain in Smad3 effectively competes with Smad3 association to exportin 4 and blocks nuclear export of Smad3 in vivo. We thus delineate a novel nuclear export pathway for Smad3...
  36. ncbi request reprint Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression
    Aristidis Moustakas
    Ludwig Institute for Cancer Research, Uppsala University, Box 595 Biomedical Center, SE 751 24 Uppsala, Sweden
    Cancer Sci 98:1512-20. 2007
    ..Here we present some of the current mechanisms that mediate the process of EMT and discuss their relevance to cancer progression...
  37. pmc A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition
    Theresa Vincent
    Ludwig Institute for Cancer Research, Stockholm Branch, 17177 Stockholm, Sweden
    Nat Cell Biol 11:943-50. 2009
    ..We propose that activation of a SNAIL1-SMAD3/4 transcriptional complex represents a mechanism of gene repression during EMT...
  38. doi request reprint Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: a useful in vitro model for testing new treatments
    J C Chamcheu
    Department of Medical Sciences, Dermatology and Venereology, University Hospital, Uppsala University, SE 751 85 Uppsala, Sweden
    Br J Dermatol 164:263-72. 2011
    ..While the aetiology of EI is known, model systems are needed for pathophysiological studies and development of novel therapies...
  39. doi request reprint Functional role of Meox2 during the epithelial cytostatic response to TGF-beta
    Ulrich Valcourt
    Ludwig Institute for Cancer Research, Uppsala University, Box 595, Biomedical Center, SE 751 24 Uppsala, Sweden
    Mol Oncol 1:55-71. 2007
    ..Thus, Meox2 is primarily involved in the TGF-beta tumor suppressor pathway...
  40. doi request reprint Regulating the stability of TGFbeta receptors and Smads
    Peter Lönn
    Ludwig Institute for Cancer Research, Uppsala University, Box 595, Biomedical Center, SE 751 24 Uppsala, Sweden
    Cell Res 19:21-35. 2009
    ..We highlight links between these mechanisms and human diseases, such as tissue fibrosis and cancer...
  41. doi request reprint PARP-1 attenuates Smad-mediated transcription
    Peter Lönn
    Ludwig Institute for Cancer Research, Uppsala University, Box 595 Biomedical Center, SE 751 24 Uppsala, Sweden
    Mol Cell 40:521-32. 2010
    ..Thus, our results identify ADP-ribosylation of Smad proteins by PARP-1 as a key step in controlling the strength and duration of Smad-mediated transcription...
  42. pmc Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin
    Rosita Bergstrom
    Ludwig Institute for Cancer Research, Uppsala University, SE 751 24 Uppsala, Sweden
    J Biol Chem 285:19727-37. 2010
    ..Because the CTCF-Smad complex is not essential for the chromatin insulator function of the H19 ICR, we propose that it can play a role in chromatin cross-talk organized by the H19 ICR...
  43. ncbi request reprint A new twist in Smad signaling
    Carl Henrik Heldin
    Ludwig Institute for Cancer Research, Uppsala University, Box 595, SE 751 24 Uppsala, Sweden
    Dev Cell 10:685-6. 2006
    ..New findings demonstrate that transcriptional intermediary factor 1gamma (TIF1gamma) also can bind to R-Smads, as an alternative to Smad4, and mediate different transcriptional effects...
  44. ncbi request reprint Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner
    Yoshinori Takahashi
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, Uppsala University, S 751 24 Uppsala, Sweden
    J Biol Chem 280:24195-204. 2005
    ..Our data show that hyaluronan fragments and FGF-2 affect endothelial cell morphogenesis by the induction of overlapping but also by distinct sets of genes...
  45. ncbi request reprint Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway
    Marek Dudas
    Developmental Biology Program, Department of Pathology of University of Southern California, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 266:96-108. 2004
    ..Based on these observations, we conclude that the Smad2-dependent Alk-5 signaling pathway is dominant in palatal fusion driven by Tgf-beta3...
  46. ncbi request reprint The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter
    George Koutsodontis
    Department of Basic Sciences, University of Crete Medical School and Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology of Hellas, Herakleion GR 71110, Greece
    Biochemistry 41:12771-84. 2002
    ....
  47. ncbi request reprint Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses
    Susumu Itoh
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 278:3751-61. 2003
    ..However, the TGF-beta-induced epithelial to mesenchymal transdifferentiation was found to require an intact L45 loop and is likely to be dependent on the Smad pathways...
  48. ncbi request reprint PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4
    Ulrich Kintscher
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, University of California, Los Angeles, School of Medicine, Los Angeles, Calif 90095, USA
    Circ Res 91:e35-44. 2002
    ..The full text of this article is available at http://www.circresaha.org...
  49. ncbi request reprint Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells
    Noora Kaivo-oja
    Program for Developmental and Reproductive Biology, Biomedicum Helsinki, and Department of Bacteriology, Haartman Institute, University of Helsinki, 00014 Helsinki, Finland
    J Clin Endocrinol Metab 88:755-62. 2003
    ....
  50. pmc Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4
    Wan Chih Chou
    Department of Basic Sciences, University of Crete Medical School and Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology of Hellas, Heraklion GR 71110, Greece
    Mol Biol Cell 14:1279-94. 2003
    ..Furthermore, the specificity of this interaction for certain target promoters may play an important role in various hepatocyte functions, which are regulated by TGFbeta and the Smads...
  51. ncbi request reprint Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes
    Ulrich Valcourt
    Institut de Biologie et Chimie des Proteines, UMR 5086 CNRS Université Claude Bernard Lyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France
    J Biol Chem 277:33545-58. 2002
    ....
  52. ncbi request reprint The nuts and bolts of IRF structure
    Aristidis Moustakas
    Nat Struct Biol 10:874-6. 2003
  53. ncbi request reprint LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta
    Lina Vardouli
    Department of Biochemistry, School of Medicine, University of Crete, GR 71110, Heraklion, Greece
    J Biol Chem 280:11448-57. 2005
    ..Our data define a novel pathway emanating from the TGF-beta type I receptor and leading to regulation of actin assembly, via the kinase LIMK2...
  54. ncbi request reprint Engagement of activin and bone morphogenetic protein signaling pathway Smad proteins in the induction of inhibin B production in ovarian granulosa cells
    Jonas Bondestam
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, P O Box 63 Haartmaninkatu 8, 00014, Helsinki, Finland
    Mol Cell Endocrinol 195:79-88. 2002
    ....
  55. pmc Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis
    Theocharis Panaretakis
    Department of Oncology and Pathology, Cancer Centrum Karolinska, Karolinska Hospital and Institute, S 171 76 Stockholm, Sweden
    Mol Biol Cell 16:3821-31. 2005
    ..The data thus support a sequential model involving caspase-2, PKCdelta, and JNK signaling in response to doxorubicin, leading to the activation of Bak and execution of apoptosis...