Eva Hedlund

Summary

Affiliation: Ludwig Institute for Cancer Research
Location: Stockholm, Sweden
Grants:

Publications

  1. doi Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cells
    Lia Panman
    Ludwig Institute for Cancer Research, Box 240, 171 77 Stockholm, Sweden
    Cell Stem Cell 8:663-75. 2011
  2. doi ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells
    Eva Hedlund
    Department of Cell and Molecular Biology, Ludwig Institute for Cancer Research, Karolinska Institute, Nobelsv 3, 171 77 Stockholm, Sweden
    Cell Stem Cell 3:575-6. 2008
  3. pmc Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
    Marius Wernig
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:5856-61. 2008
  4. pmc Selection of embryonic stem cell-derived enhanced green fluorescent protein-positive dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations
    Eva Hedlund
    Udall Parkinson s Disease Research Center for Excellence, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Stem Cells 25:1126-35. 2007
  5. pmc A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene
    B B Kelly
    Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, NC 27710, USA
    Neuroscience 142:343-54. 2006
  6. pmc Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation
    S Chung
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, Belmont, MA 02178, USA
    J Neurochem 97:1467-80. 2006
  7. ncbi L1 CAM expression is increased surrounding the lesion site in rats with complete spinal cord transection as neonates
    M D Kubasak
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1606, USA
    Exp Neurol 194:363-75. 2005
  8. ncbi Differential Pax6 promoter activity and transcript expression during forebrain development
    Tonya R Anderson
    UCLA Neuroscience IDP and Department of Psychiatry and Biobehavioral Science, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Mech Dev 114:171-5. 2002
  9. ncbi Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development
    Eva Hedlund
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurosci Res 75:307-19. 2004
  10. ncbi The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons
    S Chung
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, Belmont, MA 02178, USA
    Mol Cell Neurosci 28:241-52. 2005

Collaborators

Detail Information

Publications17

  1. doi Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cells
    Lia Panman
    Ludwig Institute for Cancer Research, Box 240, 171 77 Stockholm, Sweden
    Cell Stem Cell 8:663-75. 2011
    ....
  2. doi ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells
    Eva Hedlund
    Department of Cell and Molecular Biology, Ludwig Institute for Cancer Research, Karolinska Institute, Nobelsv 3, 171 77 Stockholm, Sweden
    Cell Stem Cell 3:575-6. 2008
    ..In these human ALS models, motor neurons are selectively destroyed by mutant astrocyte-secreted factors, and potential neuroprotective pathways are revealed...
  3. pmc Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
    Marius Wernig
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:5856-61. 2008
    ..Our results demonstrate the therapeutic potential of directly reprogrammed fibroblasts for neuronal cell replacement in the animal model...
  4. pmc Selection of embryonic stem cell-derived enhanced green fluorescent protein-positive dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations
    Eva Hedlund
    Udall Parkinson s Disease Research Center for Excellence, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Stem Cells 25:1126-35. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  5. pmc A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene
    B B Kelly
    Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, NC 27710, USA
    Neuroscience 142:343-54. 2006
    ..Our results suggest that the first intron of the rodent TH gene may be important for accurate expression of TH...
  6. pmc Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation
    S Chung
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, Belmont, MA 02178, USA
    J Neurochem 97:1467-80. 2006
    ..Taken together, our results demonstrate that genetic purification of neural precursor cells using FACS isolation can effectively remove unwanted proliferating cell types and avoid tumor formation after transplantation...
  7. ncbi L1 CAM expression is increased surrounding the lesion site in rats with complete spinal cord transection as neonates
    M D Kubasak
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1606, USA
    Exp Neurol 194:363-75. 2005
    ..Thus, spinal cord transection at an early age induced substantial L1 expression on axons near the lesion site, but was not additionally augmented by exercise...
  8. ncbi Differential Pax6 promoter activity and transcript expression during forebrain development
    Tonya R Anderson
    UCLA Neuroscience IDP and Department of Psychiatry and Biobehavioral Science, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Mech Dev 114:171-5. 2002
    ..Additionally, we identified a novel P0-initiated transcript and detected a developmentally regulated antisense transcript...
  9. ncbi Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development
    Eva Hedlund
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurosci Res 75:307-19. 2004
    ....
  10. ncbi The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons
    S Chung
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, Belmont, MA 02178, USA
    Mol Cell Neurosci 28:241-52. 2005
    ..These findings may be important for modifying ES cells to generate an optimal cell source for transplantation therapy of PD...
  11. ncbi Cell therapy and stem cells in animal models of motor neuron disorders
    Eva Hedlund
    Neuroregeneration Laboratory, Center for Neuroregeneration Research, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Eur J Neurosci 26:1721-37. 2007
    ..This review evaluates approaches used in animal models of motor neuron disorders and their therapeutic relevance...
  12. doi Neuronal cell replacement in Parkinson's disease
    E Hedlund
    Ludwig Institute for Cancer Research Ltd, Stockholm, Sweden
    J Intern Med 266:358-71. 2009
    ..Finally, a number of practical and ethical issues are associated with the use of foetal tissue sources. Thus, future cell therapy is aiming towards the use of embryonic stem cell or induced pluripotent stem cell derived dopamine neurons...
  13. pmc Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection
    Eva Hedlund
    Center for Neuroregeneration Research, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Brain 133:2313-30. 2010
    ..001, ANOVA), indicating that our approach can identify factors that protect or make neurons more susceptible to degeneration...
  14. ncbi The protective effects of β-lactam antibiotics in motor neuron disorders
    Eva Hedlund
    Ludwig Institute for Cancer Research, Karolinska Institutet, Nobelsv 3, 171 77 Stockholm, Sweden
    Exp Neurol 231:14-8. 2011
    ..Here I review their main findings and the relevance to previous and future work on motor neuron disorders and for developing therapeutic strategies...
  15. pmc Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease
    Eva Hedlund
    Udall Parkinson s Disease Research Center for Excellence, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Stem Cells 26:1526-36. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  16. ncbi Region-specific cell grafting into cervical and lumbar spinal cord in rat: a qualitative and quantitative stereological study
    Osamu Kakinohana
    Anesthesiology Research Laboratory, University of California San Diego 0818, La Jolla, CA 92093, USA
    Exp Neurol 190:122-32. 2004
    ..Good survival of implanted cells for the three different cell lines used indicate that this grafting technique coupled with a systematic analysis of the individual grafting sites can represent a valuable implantation-analytical system...