Pontus Aspenstrom

Summary

Affiliation: Ludwig Institute for Cancer Research
Country: Sweden

Publications

  1. ncbi request reprint A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton
    P Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Box 595, S 751 24, Uppsala, Sweden
    Curr Biol 7:479-87. 1997
  2. ncbi request reprint The mammalian verprolin homologue WIRE participates in receptor-mediated endocytosis and regulation of the actin filament system by distinct mechanisms
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Research, S 751 24 Uppsala, Sweden
    Exp Cell Res 298:485-98. 2004
  3. pmc Rho GTPases have diverse effects on the organization of the actin filament system
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Box 595, S 751 24 Uppsala, Sweden
    Biochem J 377:327-37. 2004
  4. ncbi request reprint The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, Box 595, S 751 24 Uppsala, Sweden
    Exp Cell Res 312:2180-94. 2006
  5. ncbi request reprint Pombe Cdc15 homology proteins: regulators of membrane dynamics and the actin cytoskeleton
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    Trends Biochem Sci 31:670-9. 2006
  6. ncbi request reprint Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    Exp Cell Res 313:3673-9. 2007
  7. ncbi request reprint The Rho GTPases have multiple effects on the actin cytoskeleton
    P Aspenstrom
    Ludwig Institute for Cancer Research, Uppsala, S 751 24, Sweden
    Exp Cell Res 246:20-5. 1999
  8. ncbi request reprint Integration of signalling pathways regulated by small GTPases and calcium
    Pontus Aspenstrom
    Biomedical Center, Ludwig Institute for Cancer Research, Box 595, S 751 24 Uppsala, Sweden
    Biochim Biophys Acta 1742:51-8. 2004
  9. ncbi request reprint Effectors for the Rho GTPases
    P Aspenstrom
    Ludwig Institute for Cancer Research Box 595 Biomedical Center S 752 24 Uppsala Sweden
    Curr Opin Cell Biol 11:95-102. 1999
  10. ncbi request reprint Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42
    Sofia Edlund
    Ludwig Institute for Cancer Research, Biomedical Center, Box 595, 751 24 Uppsala, Sweden
    J Cell Sci 117:1835-47. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton
    P Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Box 595, S 751 24, Uppsala, Sweden
    Curr Biol 7:479-87. 1997
    ..In order to understand the mechanisms underlying the effects of Rho GTPases on these processes, the yeast two-hybrid system has been used to identify proteins that bind to an activated mutant of Cdc42, a Rho-family member...
  2. ncbi request reprint The mammalian verprolin homologue WIRE participates in receptor-mediated endocytosis and regulation of the actin filament system by distinct mechanisms
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Research, S 751 24 Uppsala, Sweden
    Exp Cell Res 298:485-98. 2004
    ..Moreover, WIRE was more efficient than WIP in inhibiting the receptor endocytosis, implicating that these two mammalian verprolins have distinct roles in mammalian cells...
  3. pmc Rho GTPases have diverse effects on the organization of the actin filament system
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Box 595, S 751 24 Uppsala, Sweden
    Biochem J 377:327-37. 2004
    ..Collectively, the data obtained in this study to some extent confirm earlier observations, but also allow the identification of previously undetected roles of the different members of the Rho GTPases...
  4. ncbi request reprint The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, Box 595, S 751 24 Uppsala, Sweden
    Exp Cell Res 312:2180-94. 2006
    ..Taken together, our data indicate that DAAM1 communicates with Rho GTPases, CIP4 and Src in the regulation of the signalling pathways that co-ordinate the dynamics of the actin filament system...
  5. ncbi request reprint Pombe Cdc15 homology proteins: regulators of membrane dynamics and the actin cytoskeleton
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    Trends Biochem Sci 31:670-9. 2006
    ..Intriguingly, some members of the PCH protein family are mutated in neurodegenerative and inflammatory diseases, which has implications for the identification of cures for such disorders...
  6. ncbi request reprint Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    Exp Cell Res 313:3673-9. 2007
    ..We will also discuss the roles of atypical Rho GTPases as oncogenes or tumour suppressors, as well as their potential involvement in human diseases...
  7. ncbi request reprint The Rho GTPases have multiple effects on the actin cytoskeleton
    P Aspenstrom
    Ludwig Institute for Cancer Research, Uppsala, S 751 24, Sweden
    Exp Cell Res 246:20-5. 1999
    ..This raises important questions regarding how specificity is achieved in cell signaling employing Rho GTPases...
  8. ncbi request reprint Integration of signalling pathways regulated by small GTPases and calcium
    Pontus Aspenstrom
    Biomedical Center, Ludwig Institute for Cancer Research, Box 595, S 751 24 Uppsala, Sweden
    Biochim Biophys Acta 1742:51-8. 2004
    ..In addition, several small GTPases collaborate with calcium signalling in regulating cellular processes, such as cell adhesion, cell migration and exocytosis...
  9. ncbi request reprint Effectors for the Rho GTPases
    P Aspenstrom
    Ludwig Institute for Cancer Research Box 595 Biomedical Center S 752 24 Uppsala Sweden
    Curr Opin Cell Biol 11:95-102. 1999
    ..Recent implications of Rho effectors in human disease, however, might give important clues to how specificity is achieved in cell signalling pathways employing Rho GTPases...
  10. ncbi request reprint Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42
    Sofia Edlund
    Ludwig Institute for Cancer Research, Biomedical Center, Box 595, 751 24 Uppsala, Sweden
    J Cell Sci 117:1835-47. 2004
    ..These observations propose a novel role for Smad7 in TGF-beta-dependent activation of Rho GTPases...
  11. ncbi request reprint Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects
    Jan Saras
    Ludwig Institute for Cancer Research, Biomedical Center, S 75124 Uppsala, Sweden
    Exp Cell Res 299:356-69. 2004
    ..Interestingly, the interaction to NCKbeta was shown to be mediated via PxxP motifs present in an N-terminal extension of Wrch1 to the second and third SH3 domains of NCKbeta...
  12. pmc Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis
    Sofia Edlund
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, SE 751 24 Uppsala, Sweden
    Mol Cell Biol 25:1475-88. 2005
    ....
  13. ncbi request reprint RICH-1 has a BIN/Amphiphysin/Rvsp domain responsible for binding to membrane lipids and tubulation of liposomes
    Ninna Richnau
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, 751 24 Uppsala, Sweden
    Biochem Biophys Res Commun 320:1034-42. 2004
    ..In support of this notion, we show that RICH-1 forms oligomers in the presence of the chemical cross-linker BS3. These results point to an involvement of RICH-1 in membrane deformation events...
  14. pmc The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics
    Aino Ruusala
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    Mol Cell Biol 28:1802-14. 2008
    ..We propose a model in which Pyk2 and Src function to coordinate the Wrch1-dependent effects on cytoskeletal dynamics...
  15. pmc Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3
    Sofia Edlund
    Ludwig Institute for Cancer Research, Biomedical Centre, 75124 Uppsala, Sweden
    Mol Biol Cell 14:529-44. 2003
    ..Moreover, ectopically expressed Smad7 enhanced the coimmunoprecipitation of HA-MKK3 and Flag-p38, supporting the notion that Smad7 may act as a scaffolding protein and facilitate TAK1- and MKK3-mediated activation of p38...
  16. ncbi request reprint A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity
    Federica Chiara
    Ludwig Institute for Cancer Research, Box 595, Uppsala S 751 24, Sweden
    J Biol Chem 279:42516-27. 2004
    ..Our findings support a model whereby an activating point mutation results in a deregulated PDGFRbeta with oncogenic predisposition...
  17. ncbi request reprint Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology
    Aino Ruusala
    Ludwig Institute for Cancer Research, Biomedical Center, Box 595, S 751 24 Uppsala, Sweden
    FEBS Lett 572:159-66. 2004
    ..Interestingly, these vesicles also contained filamentous actin. These data suggest an involvement of DOCK8 in processes that affect the organisation of filamentous actin...
  18. doi request reprint Roles of F-BAR/PCH proteins in the regulation of membrane dynamics and actin reorganization
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Uppsala University, SE 751 24 Uppsala, Sweden
    Int Rev Cell Mol Biol 272:1-31. 2009
    ..Interestingly, some members of the F-BAR proteins are implicated in inflammatory or neurodegenerative disorders and the observations can be expected to have clinical implications for the treatment of the diseases...
  19. ncbi request reprint Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis
    Asa Fransson
    Ludwig Institute for Cancer Research, Biomedical Center, Box 595, S 751 24 Uppsala, Sweden
    J Biol Chem 278:6495-502. 2003
    ..These data indicate a novel role for Rho-like GTPases in mitochondrial homeostasis and apoptosis...
  20. ncbi request reprint The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking
    Sa Fransson
    Ludwig Institute for Cancer Research, Uppsala University, Biomedical Center, Box 595, S 751 24 Uppsala, Sweden
    Biochem Biophys Res Commun 344:500-10. 2006
    ..Moreover, we show that Miro interacts with the Kinesin-binding proteins, GRIF-1 and OIP106, suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules...
  21. pmc Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor
    Aino Ruusala
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    J Biol Chem 283:30034-44. 2008
    ..Moreover, signaling involving the Rho GTPases was defective in KO cells. In summary, our observations suggest that the Nck adapters are needed for signaling to Rho GTPases and actin dynamics downstream of the PDGFbeta receptor...
  22. pmc Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA
    Sofia Edlund
    Ludwig Institute for Cancer Research, Biomedical Center, S 751 24 Uppsala, Sweden
    Mol Biol Cell 13:902-14. 2002
    ..Collectively, these data indicate that TGF-beta-induced membrane ruffles occur via Rho GTPase-dependent pathways, whereas long-term effects require cooperation between Smad and Rho GTPase signaling pathways...
  23. ncbi request reprint Effect of transforming growth factor-beta on calcium homeostasis in prostate carcinoma cells
    Zemfira Z Gizatullina
    Biomedical Center, The Ludwig Institute for Cancer Research, Box 595, SE 751 24 Uppsala, Sweden
    Biochem Biophys Res Commun 304:643-9. 2003
    ..The results implicate that TGF-beta1 affects the function of the mitochondria and may be of significance for the understanding of the proapoptotic effect of TGF-beta1 in these cells...
  24. ncbi request reprint The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Box 595, S 751 24, Uppsala, Sweden
    Exp Cell Res 279:21-33. 2002
    ..Taken together, the data presented indicate that WIRE has a role in the WASP-mediated organization of the actin cytoskeleton and that WIRE is a potential link between the activated PDGF receptor and the actin polymerization machinery...
  25. ncbi request reprint The verprolin family of proteins: regulators of cell morphogenesis and endocytosis
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, Sweden
    FEBS Lett 579:5253-9. 2005
    ..Interestingly, also the vertebrate verprolins have been implicated in endocytosis, demonstrating that most of the functional modules in this fascinating group of proteins have been conserved from yeast to man...
  26. pmc RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules
    Annica K B Gad
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Mol Biol Cell 23:4807-19. 2012
    ..In agreement with this notion, our data suggest that RhoD coordinates Arp2/3-dependent and FLNa-dependent mechanisms to control the actin filament system, cell adhesion, and cell migration...