Johnny Ludvigsson

Summary

Country: Sweden

Publications

  1. doi The latest pharmacotherapy options for type 1 diabetes
    Johnny Ludvigsson
    Linkoping University, Department of Clinical and Experimental Medicine, SE 581 85 Linkoping, Sweden
    Expert Opin Pharmacother 15:37-49. 2014
  2. doi Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents
    Johnny Ludvigsson
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Linkoping University, and Pediatric Clinic, Östergötland County Council, Linkoping, Sweden
    Diabetes Res Clin Pract 100:203-9. 2013
  3. ncbi C-peptide in diabetes diagnosis and therapy
    Johnny Ludvigsson
    Divison of Pediatrics, Linkoping University, SE 58185 Linkoping, Sweden
    Front Biosci (Elite Ed) 5:214-23. 2013
  4. doi GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus
    Johnny Ludvigsson
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Linkoping University, 58185 Linkoping, Sweden
    N Engl J Med 366:433-42. 2012
  5. pmc Exclusive breastfeeding of Swedish children and its possible influence on the development of obesity: a prospective cohort study
    Karina Huus
    Division of Pediatrics, Diabetes Research Centre, Linkoping University, Sweden
    BMC Pediatr 8:42. 2008
  6. doi Good glycemic control remains crucial in prevention of late diabetic complications--the Linköping Diabetes Complications Study
    Maria Nordwall
    Division of Pediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 10:168-76. 2009
  7. doi GAD-alum treatment induces GAD65-specific CD4+CD25highFOXP3+ cells in type 1 diabetic patients
    Maria Hjorth
    Division of Pediatrics and Diabetes Research Center, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Clin Immunol 138:117-26. 2011
  8. ncbi Web 2.0 systems supporting childhood chronic disease management: design guidelines based on information behaviour and social learning theories
    Joakim Ekberg
    Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
    J Med Syst 34:107-17. 2010
  9. doi GAD treatment and insulin secretion in recent-onset type 1 diabetes
    Johnny Ludvigsson
    Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    N Engl J Med 359:1909-20. 2008
  10. doi Health-related quality of life in intensively treated young patients with type 1 diabetes
    Lena Hanberger
    Diabetes Research Centre, Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 10:374-81. 2009

Detail Information

Publications75

  1. doi The latest pharmacotherapy options for type 1 diabetes
    Johnny Ludvigsson
    Linkoping University, Department of Clinical and Experimental Medicine, SE 581 85 Linkoping, Sweden
    Expert Opin Pharmacother 15:37-49. 2014
    ..Pharmacotherapy of type 1 diabetes (T1D) is mainly restricted to insulin treatment. Insulin analogues have replaced human insulin sometimes without reason. A broader approach is needed...
  2. doi Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents
    Johnny Ludvigsson
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Linkoping University, and Pediatric Clinic, Östergötland County Council, Linkoping, Sweden
    Diabetes Res Clin Pract 100:203-9. 2013
    ..We studied the decline of C-peptide during the first year after diagnosis of Type 1 diabetes (T1D), and its relation to various factors...
  3. ncbi C-peptide in diabetes diagnosis and therapy
    Johnny Ludvigsson
    Divison of Pediatrics, Linkoping University, SE 58185 Linkoping, Sweden
    Front Biosci (Elite Ed) 5:214-23. 2013
    ..Finally, although still under debate, C-peptide seems to have several effects on different organs suggesting that it is an important hormone, interesting per se, and not only as a reflection of insulin secretion...
  4. doi GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus
    Johnny Ludvigsson
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Linkoping University, 58185 Linkoping, Sweden
    N Engl J Med 366:433-42. 2012
    ..The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 (GAD-alum) can preserve beta-cell function in patients with recent-onset type 1 diabetes...
  5. pmc Exclusive breastfeeding of Swedish children and its possible influence on the development of obesity: a prospective cohort study
    Karina Huus
    Division of Pediatrics, Diabetes Research Centre, Linkoping University, Sweden
    BMC Pediatr 8:42. 2008
    ..The aim of our study was to examine the relationship between exclusive breastfeeding and obesity when potential confounders, such as socioeconomic factors, are considered...
  6. doi Good glycemic control remains crucial in prevention of late diabetic complications--the Linköping Diabetes Complications Study
    Maria Nordwall
    Division of Pediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 10:168-76. 2009
    ..The aim of the present study was to analyze possible risk factors, which could explain the improved prognosis...
  7. doi GAD-alum treatment induces GAD65-specific CD4+CD25highFOXP3+ cells in type 1 diabetic patients
    Maria Hjorth
    Division of Pediatrics and Diabetes Research Center, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Clin Immunol 138:117-26. 2011
    ..These new data suggest that GAD-alum treatment induced GAD(65)-specific T cells with regulatory features...
  8. ncbi Web 2.0 systems supporting childhood chronic disease management: design guidelines based on information behaviour and social learning theories
    Joakim Ekberg
    Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
    J Med Syst 34:107-17. 2010
    ..After integration with the key elements derived from theories of information behaviour, a preliminary design guideline document was formulated...
  9. doi GAD treatment and insulin secretion in recent-onset type 1 diabetes
    Johnny Ludvigsson
    Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    N Engl J Med 359:1909-20. 2008
    ..This trial assessed the ability of alum-formulated GAD (GAD-alum) to reverse recent-onset type 1 diabetes in patients 10 to 18 years of age...
  10. doi Health-related quality of life in intensively treated young patients with type 1 diabetes
    Lena Hanberger
    Diabetes Research Centre, Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 10:374-81. 2009
    ..28, p = 0.045). We conclude that the diabetes team can influence the HRQOL of the patients as there was a centre difference and because HRQOL is influenced by glycaemic control and insulin regimen. Girls seem to need extra support...
  11. ncbi Psychological stress may induce diabetes-related autoimmunity in infancy
    Anneli Sepa
    Division of Paediatrics, Department of Molecular and Clinical Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
    Diabetes Care 28:290-5. 2005
    ..Our aim was to investigate whether psychological stress, measured as psychosocial strain in families, is associated with diabetes-related autoimmunity during infancy...
  12. ncbi Nicotinamide reduces high secretion of IFN-gamma in high-risk relatives even though it does not prevent type 1 diabetes
    Maria Hedman
    Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    J Interferon Cytokine Res 26:207-13. 2006
    ..Nicotinamide caused decreased spontaneous (p = 0.05) and in vitro autoantigen-induced IFN-gamma secretion (p < 0.05) and may play a role in immune regulation, even though it has not been shown to prevent T1D...
  13. ncbi Environmental factors related to the induction of beta-cell autoantibodies in 1-yr-old healthy children
    Jeanette Wahlberg
    Division of Pediatrics and Diabetes Research Center, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 6:199-205. 2005
    ..6), whereas type 2 diabetes in grandparents was associated with GADA (OR 2.1). Exposure to cow's milk formulas <2 months of age implied an OR of 2.9 for IA-2A above the 99th percentile...
  14. doi GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response
    Mikael Chéramy
    Division of Paediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Linkoping University, Sweden
    Clin Immunol 137:31-40. 2010
    ..In the GAD-alum group, higher pre-treatment GADA were associated to more pronounced C-peptide preservation. The induced IgG3/IgG4 and reduced IgG1 suggest a Th2 deviation of the immune response...
  15. ncbi Dietary risk factors for the emergence of type 1 diabetes-related autoantibodies in 21/2 year-old Swedish children
    Jeanette Wahlberg
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Br J Nutr 95:603-8. 2006
    ....
  16. ncbi Continuous insulin infusion (CSII) or modern type of multiple daily injections (MDI) in diabetic children and adolescents a critical review on a controversial issue
    Johnny Ludvigsson
    Division of Pediatrics and Diabetes Research Centre, Linkoping University, Linkoping, Sweden
    Pediatr Endocrinol Rev 5:666-78. 2007
    ..CSII offers the most physiological insulin substitution. Method: Review of recent publications (Cochrane criteria), on modern multiple daily injections (MDI) based on insulin analogues, modern self-control and education...
  17. ncbi Progression to type 1 diabetes and autoantibody positivity in relation to HLA-risk genotypes in children participating in the ABIS study
    Camilla Gullstrand
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 9:182-90. 2008
    ..In this study, we have investigated the role of HLA-risk and -protective genotypes for development of beta-cell autoantibodies and progression to T1D in healthy children...
  18. doi Psychological stress and obesity
    Felix Sebastian Koch
    Division of Pediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    J Pediatr 153:839-44. 2008
    ..To examine whether there is a relationship between psychological stress in the family and obesity in 5- to 6-year-old children...
  19. pmc Long-lasting immune responses 4 years after GAD-alum treatment in children with type 1 diabetes
    Stina Axelsson
    Division of Paediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    PLoS ONE 6:e29008. 2011
    ..In parallel to a GAD(65)-induced T-cell activation, our results show induction of T-cell inhibitory pathways important for regulating the GAD(65) immunity...
  20. doi Tobacco exposure and diabetes-related autoantibodies in children: results from the ABIS study
    AnnaKarin Johansson
    Department of Clinical and Experimental Medicine, Division of Pediatrics, Faculty of Health Sciences, Diabetes Research Center, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 1150:197-9. 2008
    ..It was concluded that passive smoking does not seem to influence development of diabetes-related autoantibodies early in life...
  21. doi Early induction of GAD(65)-reactive Th2 response in type 1 diabetic children treated with alum-formulated GAD(65)
    Stina Axelsson
    Division of Paediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Diabetes Metab Res Rev 26:559-68. 2010
    ....
  22. ncbi Mothers' experiences of serious life events increase the risk of diabetes-related autoimmunity in their children
    Anneli Sepa
    Division of Paediatrics, Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, SE 581 85, Linkoping, Sweden
    Diabetes Care 28:2394-9. 2005
    ..e., irrespective of genetic risk for type 1 diabetes) whether mothers' experiences of serious life events, such as divorce and violence, were associated with diabetes-related autoimmunity in their children at age 2.5 years...
  23. ncbi Decreased in vitro type 1 immune response against coxsackie virus B4 in children with type 1 diabetes
    Susanne Skarsvik
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Linkoping University, S 581 85 Linkoping, Sweden
    Diabetes 55:996-1003. 2006
    ..This may lead to a delayed clearance of the virus and, at least partly, explain why children with type 1 diabetes may be more prone to CVB4 infections and related complications, such as beta-cell damage...
  24. ncbi Mothers' attachment insecurity and diabetes-related autoantibodies in their infants
    Anneli Sepa
    Division of Pediratrics, Dept of Molecular and Clinical Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
    Ann N Y Acad Sci 1037:110-3. 2004
    ..If an association exists between maternal attachment insecurity and diabetes-related autoimmunity during infancy, it does not appear to be strong...
  25. pmc High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus
    Johan F Paulsson
    Department of Clinical and Experimental Medicine, Division of Pediatrics and Diabetes Research Centre, Linkoping University Hospital, Linkoping, Sweden
    PLoS ONE 9:e93053. 2014
    ..Even though IAPP and amyloid formation are much discussed in type 2 diabetes, our aim was to study the significance of IAPP in type 1 diabetes...
  26. ncbi Probiotics for the prevention of beta cell autoimmunity in children at genetic risk of type 1 diabetes--the PRODIA study
    Martin Ljungberg
    Centre of Clinical Experimental Research, Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    Ann N Y Acad Sci 1079:360-4. 2006
    ..The prevalence of autoantibodies among the study subjects at 6, 12, and 24 months of age was at levels close to the expected and the clinical follow-up did not either indicate problems in the feasibility of the study...
  27. ncbi Clinical manifestations and beta cell function in Swedish diabetic children have remained unchanged during the last 25 years
    Maria Nordwall
    Division of Paediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    Diabetes Metab Res Rev 24:472-9. 2008
    ..The aim of this study was to examine the clinical characteristics at onset, C-peptide secretion during the first years after diagnosis and if there was any secular trends during the last 25 years...
  28. ncbi The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children
    Carl Oscar Jonson
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 8:185-92. 2007
    ..Genetic and environmental risk factors precede the onset of T1D, which is characterized by a T helper 1 cell-dominating cytokine response to diabetes-related autoantigens...
  29. ncbi Early diabetic complications in a population of young patients with type 1 diabetes mellitus despite intensive treatment
    Maria Nordwall
    Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, University Hospital, Linkoping, Sweden
    J Pediatr Endocrinol Metab 19:45-54. 2006
    ..To describe the prevalence of early complications in an unselected population of patients with type 1 diabetes mellitus (DM1) diagnosed in childhood with intensive insulin treatment from diagnosis...
  30. doi A1C in children and adolescents with diabetes in relation to certain clinical parameters: the Swedish Childhood Diabetes Registry SWEDIABKIDS
    Lena Hanberger
    Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Diabetes Care 31:927-9. 2008
    ..We explored the relationship between A1C and insulin regimen, duration of diabetes, age, sex, and BMI as well as the differences between clinical mean A1C levels at pediatric diabetes clinics in Sweden...
  31. ncbi Diminished IFN-gamma response to diabetes-associated autoantigens in children at diagnosis and during follow up of type 1 diabetes
    Maria Karlsson Faresjo
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    Diabetes Metab Res Rev 22:462-70. 2006
    ..Imbalance of T-helper (Th)1- and Th2-like cytokines has been associated with type 1 diabetes. We therefore studied the immune deviation in antigen-specific T cells from diagnosis onwards in type 1 diabetic children...
  32. pmc The role of immunomodulation therapy in autoimmune diabetes
    Johnny Ludvigsson
    Division of Pediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Linkoping University, Sweden
    J Diabetes Sci Technol 3:320-30. 2009
    ..The prospects of cure and prevention of T1DM will become less remote...
  33. doi Maternal influence on child HPA axis: a prospective study of cortisol levels in hair
    Jerker Karlén
    Division of Community Medicine, Department of Medicine and Health Sciences, Linkoping University, SE 581 83 Linkoping, Sweden
    Pediatrics 132:e1333-40. 2013
    ..To investigate cortisol concentrations in hair as biomarker of prolonged stress in young children and their mothers and the relation to perinatal and sociodemographic factors...
  34. ncbi Information and informed consent in a longitudinal screening involving children: a questionnaire survey
    Ulrica Gustafsson Stolt
    Department of Molecular and Clinical Medicine, Division of Paediatrics, Faculty of Health Sciences, SE 581 85 Linkoping, Sweden
    Eur J Hum Genet 13:376-83. 2005
    ....
  35. doi Cryopreserved peripheral blood mononuclear cells are suitable for the assessment of immunological markers in type 1 diabetic children
    Stina Axelsson
    Division of Paediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    Cryobiology 57:201-8. 2008
    ..Thus, cryopreserved PBMC were suitable to assess the immunological markers included in this study, even though their expression could differ from freshly handled cells...
  36. pmc GAD autoantibody epitope pattern after GAD-alum treatment in children and adolescents with type 1 diabetes
    Camilla Skoglund
    Division of Pediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 13:244-50. 2012
    ..The aim of this study was to investigate whether GAD-alum treatment affected the GADA epitope pattern...
  37. doi Low C-peptide levels and decreased expression of TNF and CD45 in children with high risk of type 1 diabetes
    Linda Akerman
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Clin Immunol 148:4-15. 2013
    ..Hence, expression of immune related genes seemed related not only to the autoimmune process but rather to residual β-cell function, which was decreased already during the pre-diabetic phase...
  38. doi The effect of gluten-free diet on Th1-Th2-Th3-associated intestinal immune responses in celiac disease
    Anne Lahdenperä
    Division of Paediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Scand J Gastroenterol 46:538-49. 2011
    ....
  39. ncbi Why diabetes incidence increases--a unifying theory
    Johnny Ludvigsson
    Division of Pediatrics, and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Ann N Y Acad Sci 1079:374-82. 2006
    ..However, we do know that low physical exercise, obesity, and stress, increases insulin demand resulting in insulin deficiency. Now we can therefore intervene to prevent the diabetic syndrome...
  40. ncbi Assessment of smoking behaviors in the home and their influence on children's passive smoking: development of a questionnaire
    AnnaKarin Johansson
    Division of Pediatrics, Department of Molecular and Clinical Medicine, Linkoping University, SE 58183 Linkoping, Sweden
    Ann Epidemiol 15:453-9. 2005
    ..To construct and validate a questionnaire aiming to measure children's exposure to environmental tobacco smoke (ETS) in the home...
  41. doi Immune intervention in children with type 1 diabetes
    Johnny Ludvigsson
    Department of Clinical and Experimental Medicine, Division of Pediatrics, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Curr Diab Rep 10:370-9. 2010
    ..Combination of immune intervention, protection of the beta cells, and stimulation of regeneration may lead to a milder disease or even a cure in the future, and prevention is no longer unrealistic...
  42. ncbi Psychosocial correlates of parenting stress, lack of support and lack of confidence/security
    Anneli Sepa
    Division of Pediatrics, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Scand J Psychol 45:169-79. 2004
    ..These risk factors can be used both in efforts to prevent stress and in studies of stress effects...
  43. doi An indirect competitive immunoassay for insulin autoantibodies based on surface plasmon resonance
    Jenny Carlsson
    Division of Sensor Science and Molecular Physics, Department of Physics, Chemistry and Biology IFM, Linkoping University, SE 581 83 Linkoping, Sweden
    Biosens Bioelectron 24:882-7. 2008
    ..With our SPR-based immunoassay the overall assay time is reduced by a factor of >100 (4 days to 50min), while sensitivity is maintained at a level comparable to that offered by RIA...
  44. ncbi Parents' attitudes to children's tobacco smoke exposure and how the issue is handled in health care
    AnnaKarin Johansson
    Division of Paediatrics, Department of Molecular and Clinical Medicine, Linkoping University, Linkoping, Sweden
    J Pediatr Health Care 18:228-35. 2004
    ....
  45. ncbi Quality of care from the patient's perspective in pediatric diabetes care
    Lena Hanberger
    Diabetes Research Centre, Division of Pediatrics, IMK, Faculty of Health Sciences, S 581 85 Linkoping, Sweden
    Diabetes Res Clin Pract 72:197-205. 2006
    ..In our setting, improvements are needed regarding patient information, access to care and waiting time...
  46. pmc Use of a web 2.0 portal to improve education and communication in young patients with families: randomized controlled trial
    Lena Hanberger
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    J Med Internet Res 15:e175. 2013
    ..Web 2.0 systems have great potential to enhance health information and open new ways for patients and practitioners to communicate...
  47. ncbi GAD-treatment of children and adolescents with recent-onset type 1 diabetes preserves residual insulin secretion after 30 months
    Johnny Ludvigsson
    Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden Pediatric Clinic, County Council of Ostergotland, Linkoping, Sweden
    Diabetes Metab Res Rev 30:405-14. 2014
    ....
  48. ncbi When should determination of ketonemia be recommended?
    Ulf Samuelsson
    Division of Pediatrics, Department of Health and Environment, Linkoping University, Linkoping, Sweden
    Diabetes Technol Ther 4:645-50. 2002
    ..Monitoring beta-OHB should be routine for patients on pump therapy...
  49. doi Adverse health effects related to tobacco smoke exposure in a cohort of three-year olds
    AnnaKarin Johansson
    Department of Medicine and Health Sciences, Division of Nursing Science, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Paediatr 97:354-7. 2008
    ..To analyse the importance of mothers' smoking during pregnancy and/or environmental tobacco smoke (ETS) exposure in early childhood for children's health and well-being at the age of 3 years...
  50. ncbi Induction of diabetes-related autoantibodies below cutoff for "positivity" in young nondiabetic children
    Hanna Holmberg
    Department of Molecular and Clinical Medicine, Division of Pediatrics, Clinical Research Center, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 1005:269-74. 2003
    ..We conclude that there is a natural induction of humoral immune response to beta cell autoantigens early in life. Our results suggest that the mechanisms of beta cell tolerance to GAD and IA-2 differ in healthy children...
  51. doi Relationship of food frequencies as reported by parents to overweight and obesity at 5 years
    Karina Huus
    Department of Clinical and Experimental Medicine, Division of Paediatrics and Diabetes Research Centre, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Paediatr 98:139-43. 2009
    ..To investigate if food frequencies are related to overweight/obesity in 5-year-old children...
  52. doi Asthma and allergic symptoms and type 1 diabetes-related autoantibodies in 2.5-yr-old children
    Jeanette Wahlberg
    Division of Cardiovascular Medicine, Department of Medical and Health Sciences Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 12:604-10. 2011
    ..1-3.8; p = 0.031] and both GADA and IA-2A (OR 10.7, CI 3.9-29.4; p = 0.000). We conclude that allergic symptoms are associated with the development of T1D-related autoantibodies during the first years of life...
  53. ncbi Risk factors in childhood obesity-findings from the All Babies In Southeast Sweden (ABIS) cohort
    Karina Huus
    Division of Pediatrics and Diabetes Research Centre, Linkoping University, Sweden
    Acta Paediatr 96:1321-5. 2007
    ....
  54. ncbi Concern, pressure and lack of knowledge affect choice of not wanting to know high-risk status
    Ulrica Swartling
    Division of Paediatrics and Diabetes Research Centre, Faculty of Health Sciences, Department of Molecular and Clinical Medicine, Linkoping University, Linkoping, Sweden
    Eur J Hum Genet 15:556-62. 2007
    ..We conclude that this constitutes sufficient reason not to promote a default solution where people's expressed wishes not to know are taken at face value...
  55. doi Does modern high standard life style cause type 1 diabetes in children?
    Johnny Ludvigsson
    Linkoping University, Div of Pediatrics, Dept of Clin Exp Med, University Hospital, Linkoping, SE, Sweden
    Diabetes Metab Res Rev 29:161-5. 2013
    ..Several large epidemiological studies, mainly restricted to children with increased genetic risk for type 1 diabetes, have so far given no clue...
  56. doi Could the social environment trigger the induction of diabetes related autoantibodies in young children?
    Jerker Karlén
    Department of Medical and Health Sciences Community Medicine, Linkoping University, Sweden
    Scand J Public Health 40:177-82. 2012
    ..We have implemented a study design where 1-year-old children, from two equally sized, neighbouring but socioeconomically different cities, were compared for the induction of beta-cell autoantibodies...
  57. doi GAD-alum (Diamyd)--a new concept for preservation of residual insulin secretion
    Johnny Ludvigsson
    Department of Clinical and Experimental Medicine, Division of Pediatrics and Diabetes Research Center, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Expert Opin Biol Ther 10:787-99. 2010
    ..This review covers a new type of immune intervention using auto-antigen treatment...
  58. doi Parents' psychological stress over time may affect children's cortisol at age 8
    Felix Sebastian Koch
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    J Pediatr Psychol 35:950-9. 2010
    ..To examine possible relations between parents' psychological stress and children's saliva cortisol levels in connection with a mild stressor (drawing a blood sample)...
  59. doi Therapy with GAD in diabetes
    Johnny Ludvigsson
    Division of Pediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Diabetes Metab Res Rev 25:307-15. 2009
    ..With this promising background further studies are on their way, both intervention in newly diagnosed type 1 diabetic patients, and trials to prevent the disease...
  60. ncbi The immunological effect of photopheresis in children with newly diagnosed type 1 diabetes
    Maria Karlsson Faresjo
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    Pediatr Res 58:459-66. 2005
    ..Photopheresis has an immune-modulating effect in children with type 1 diabetes, causing a Th2-like deviation...
  61. pmc Web 2.0 systems supporting childhood chronic disease management: a pattern language representation of a general architecture
    Toomas Timpka
    Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
    BMC Med Inform Decis Mak 8:54. 2008
    ....
  62. doi Parent perceptions of child sleep: a study of 10,000 Swedish children
    Peder Palmstierna
    Department of Clinical and Experimental Medicine, Diabetes Research Centre, Linkoping University, Linkoping, Sweden
    Acta Paediatr 97:1631-9. 2008
    ..To gather normative data on parent-reported child sleep and investigate what influences it...
  63. ncbi Nurses' views of longitudinal genetic screening of and research on children
    Ulrica Gustafsson Stolt
    Faculty of Health Sciences, Linkoping University, Sweden
    Br J Nurs 14:71-7. 2005
    ..It is also suggested that the design of the information process, and especially in longitudinal research involving young children, is of utmost importance before such studies are commenced...
  64. ncbi Fear and other disturbances of severe hypoglycaemia in children and adolescents with type 1 diabetes mellitus
    Sam Nordfeldt
    Center for Medical Technology Assessment, Department of Health and Society, Linkoping University, Linkoping, Sweden
    J Pediatr Endocrinol Metab 18:83-91. 2005
    ..To study perceived occurrence and magnitude of fear and other disturbances of severe hypoglycaemia in children and adolescents with type 1 diabetes mellitus (DM) receiving intensive treatment with active education and psychosocial support...
  65. doi Detection of global glycosylation changes of serum proteins in type 1 diabetes using a lectin panel and multivariate data analysis
    Jenny Carlsson
    Division of Sensor Science and Molecular Physics, Department of Physics, Chemistry and Biology IFM, Linkoping University, SE 581 83 Linkoping, Sweden
    Talanta 76:333-7. 2008
    ..Using an artificial neuronal net (ANN), it was possible to correctly categorize unknown serum samples into one of the three groups...
  66. doi "My parents decide if I can. I decide if I want to." Children's views on participation in medical research
    Ulrica Swartling
    Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    J Empir Res Hum Res Ethics 6:68-75. 2011
    ..This information should be provided out of respect for the children as persons, but also to promote their willingness to continue participating in longitudinal studies...
  67. doi Low zinc in drinking water is associated with the risk of type 1 diabetes in children
    Ulf Samuelsson
    Division of Paediatrics, Department of Molecular and Clinical Medicine, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 12:156-64. 2011
    ..To explore if drinking water may influence the development of type 1 diabetes in children, either via enterovirus spread via drinking water or quality of drinking water related to acidity or concentration of certain minerals...
  68. ncbi Psychological stress and the risk of diabetes-related autoimmunity: a review article
    Anneli Sepa
    Diabetes Research Centre, Division of Pediatrics, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Neuroimmunomodulation 13:301-8. 2006
    ..It seems much clearer that stress can precipitate manifest T1D, although the biological mechanisms are still not known...
  69. pmc No evidence for activation of T(H)1 or T(H)17 pathways in unstimulated peripheral blood mononuclear cells from children with β-cell autoimmunity or T1D
    Jenny Walldén
    Linkoping University, Faculty of Health Sciences, Department of Clinical and Experimental Medicine, Division of Pediatrics and Diabetes Research Center, Linkoping, Sweden
    J Inflamm Res 1:11-7. 2008
    ..We investigated this balance in peripheral blood mononuclear cells (PBMC) from children at risk of developing T1D and children with T1D...
  70. ncbi Mothers of children in ABIS, a population-based screening for prediabetes, experience few ethical conflicts and have a positive attitude
    Johnny Ludvigsson
    Division of Pediatrics, Department of Health and Environment, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 958:376-81. 2002
    ..We conclude that a well-designed screening program to detect individuals in the general population with high risk of developing diabetes does not evoke anxiety nor severe ethical conflicts...
  71. ncbi For debate: are we ready for GAD-vaccination in the treatment and/or prevention of type 1 diabetes?
    Johnny Ludvigsson
    Div of Pediatrics and Diabetes Research Centre, Dept of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Pediatr Endocrinol Rev 5:871-2. 2008
  72. pmc Aberrant regulation of interleukin-12 receptor beta2 chain on type 1 cytokine-stimulated T lymphocytes in type 1 diabetes
    Susanne Skarsvik
    Division of Pediatrics, Department of Molecular and Clinical Medicine, Clinical Research Centre, Linkoping University, Linkoping, Sweden
    Immunology 114:287-93. 2005
    ..006 and P=0.04) in a type 1 cytokine environment was seen in both groups of patients. Peripheral blood T cells from patients with both newly diagnosed and longstanding T1D showed poor polarization towards type 1 cells...
  73. ncbi How should parents protect their children from environmental tobacco-smoke exposure in the home?
    AnnaKarin Johansson
    Division of Paediatrics, Department of Molecular and Clinical Medicine, Linkoping University, Linkoping, Sweden
    Pediatrics 113:e291-5. 2004
    ..Children's exposure to tobacco smoke is known to have adverse health effects, and most parents try to protect their children...
  74. ncbi Cow-milk-free diet during last trimester of pregnancy does not influence diabetes-related autoantibodies in nondiabetic children
    Johnny Ludvigsson
    Department of Molecular and Clinical Medicine, Division of Pediatrics, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 1005:275-8. 2003
    ..Cow milk introduction between 3 and 6 months caused a transient increase in GADA at 6 months of age (p < 0.05). Children who developed atopic disease had significantly lower IA-2A at 6 months (p < 0.001)...
  75. doi Twenty years experiences of interprofessional education in Linkoping--ground-breaking and sustainable
    Margaretha Wilhelmsson
    Unit of Educational Development and Research, Faculty of Health Sciences, Linkoping University, Sweden
    J Interprof Care 23:121-33. 2009
    ..The article presents how the Linkoping model was developed, the outcomes, experiences and some outlines for future challenges...