Jan Lotvall

Summary

Country: Sweden

Publications

  1. doi request reprint Reviewer acknowledgement 2013
    Jan Lotvall
    University of Gothenburg, Krefting Research Centre, Box 424, Goteborg, Sweden
    Respir Res 15:7. 2014
  2. doi request reprint Efficacy and safety of fluticasone furoate 100 μg once-daily in patients with persistent asthma: A 24-week placebo and active-controlled randomised trial
    Jan Lotvall
    Krefting Research Centre, University of Gothenburg, Box 424, SE 40530 Gothenburg, Sweden Electronic address
    Respir Med 108:41-9. 2014
  3. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  4. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
  5. doi request reprint 24-h duration of the novel LABA vilanterol trifenatate in asthma patients treated with inhaled corticosteroids
    Jan Lotvall
    Krefting Research Centre, University of Gothenburg, Box 424, SE 40530 Gothenburg, Sweden
    Eur Respir J 40:570-9. 2012
  6. pmc Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma
    Ashley Woodcock
    School of Translational Medicine, University of Manchester, Manchester, UK
    Respir Res 12:160. 2011
  7. pmc Comparing the effects of two inhaled glucocorticoids on allergen-induced bronchoconstriction and markers of systemic effects, a randomised cross-over double-blind study
    Jan Lotvall
    Krefting Research Centre, University of Gothenburg, Box 424, SE 40530 Goteborg, Sweden
    Clin Transl Allergy 1:12. 2011
  8. pmc Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial
    Ashley Woodcock
    School of Translational Medicine, Manchester Academic Health Science Centre, University of Manchester, UK
    Respir Res 12:132. 2011
  9. pmc Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD
    Agne Babusyte
    Laboratory of Pulmonology, Institute for Biomedical Research, Kaunas University of Medicine, Eiveniu 4, LT 50009, Kaunas, Lithuania
    Respir Res 8:81. 2007
  10. pmc Motivational foci and asthma medication tactics directed towards a functional day
    Malin Axelsson
    Department of Nursing, Health and Culture, University West, SE 461 86 Trollhättan, Sweden
    BMC Public Health 11:809. 2011

Collaborators

Detail Information

Publications58

  1. doi request reprint Reviewer acknowledgement 2013
    Jan Lotvall
    University of Gothenburg, Krefting Research Centre, Box 424, Goteborg, Sweden
    Respir Res 15:7. 2014
    ..The editors of Respiratory Research would like to thank all of our reviewers who have contributed to the journal in Volume 14 (2013)...
  2. doi request reprint Efficacy and safety of fluticasone furoate 100 μg once-daily in patients with persistent asthma: A 24-week placebo and active-controlled randomised trial
    Jan Lotvall
    Krefting Research Centre, University of Gothenburg, Box 424, SE 40530 Gothenburg, Sweden Electronic address
    Respir Med 108:41-9. 2014
    ..036) relative to placebo. FF100 μg OD, administered in the evening, achieves significant improvements in lung function and rescue inhaler use over 24 weeks, comparable to FP250 μg BD with similar safety profile. ..
  3. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  4. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
    ....
  5. doi request reprint 24-h duration of the novel LABA vilanterol trifenatate in asthma patients treated with inhaled corticosteroids
    Jan Lotvall
    Krefting Research Centre, University of Gothenburg, Box 424, SE 40530 Gothenburg, Sweden
    Eur Respir J 40:570-9. 2012
    ..5-50 μg resulted in prolonged bronchodilation of at least 24 h with good tolerability in asthma patients receiving ICS. Based on the overall efficacy and adverse event profile from this study, the optimum dose of VI appears to be 25 μg...
  6. pmc Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma
    Ashley Woodcock
    School of Translational Medicine, University of Manchester, Manchester, UK
    Respir Res 12:160. 2011
    ..The objectives of this study were to compare the efficacy and safety of once-daily (OD) evening and twice-daily (BD) regimens of the novel inhaled corticosteroid fluticasone furoate (FF) in asthma patients...
  7. pmc Comparing the effects of two inhaled glucocorticoids on allergen-induced bronchoconstriction and markers of systemic effects, a randomised cross-over double-blind study
    Jan Lotvall
    Krefting Research Centre, University of Gothenburg, Box 424, SE 40530 Goteborg, Sweden
    Clin Transl Allergy 1:12. 2011
    ..abstract:..
  8. pmc Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial
    Ashley Woodcock
    School of Translational Medicine, Manchester Academic Health Science Centre, University of Manchester, UK
    Respir Res 12:132. 2011
    ....
  9. pmc Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD
    Agne Babusyte
    Laboratory of Pulmonology, Institute for Biomedical Research, Kaunas University of Medicine, Eiveniu 4, LT 50009, Kaunas, Lithuania
    Respir Res 8:81. 2007
    ..We aimed to analyse airway inflammatory cell patterns in induced sputum (IS) and bronchoalveolar lavage (BAL) from COPD patients who are active smokers and who have ceased smoking >2 years ago...
  10. pmc Motivational foci and asthma medication tactics directed towards a functional day
    Malin Axelsson
    Department of Nursing, Health and Culture, University West, SE 461 86 Trollhättan, Sweden
    BMC Public Health 11:809. 2011
    ..Thus, the aim was to elucidate adherence reasoning in relation to asthma medication...
  11. pmc West Sweden Asthma Study: prevalence trends over the last 18 years argues no recent increase in asthma
    Jan Lotvall
    Department of Internal Medicine, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Respir Res 10:94. 2009
    ..Therefore, our data argues that the continued increase in asthma prevalence that has been observed over the last half century is over...
  12. pmc Multi-symptom asthma is closely related to nasal blockage, rhinorrhea and symptoms of chronic rhinosinusitis-evidence from the West Sweden Asthma Study
    Jan Lotvall
    Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Sweden
    Respir Res 11:163. 2010
    ..The aim of this study was to determine whether multi-symptom asthma is related to signs of severe asthma, and to investigate the association between multi-symptom asthma and different symptoms of allergic and chronic rhinosinusitis...
  13. ncbi request reprint Long duration of airway but not systemic effects of inhaled formoterol in asthmatic patients
    Jan Lotvall
    Department of Internal Medicine Respiratory Medicine and Allergology, Goteborg University, Sahlgrenska Hospital, Sweden
    Respir Med 102:449-56. 2008
    ..Formoterol is approved as asthma rescue medication in many countries. The exact duration of the airway vs. systemic effects of formoterol compared with another rescue medication, salbutamol, has not been evaluated...
  14. doi request reprint Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome
    Jan Lotvall
    Krefting Research Center, University of Gothenburg, Goteborg, Sweden
    J Allergy Clin Immunol 127:355-60. 2011
    ..This PRACTALL (PRACtical ALLergy) consensus report was produced by experts from the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology...
  15. pmc Cell to cell signalling via exosomes through esRNA
    Jan Lotvall
    Department of Internal Medicine, Goteborg University, Goteborg, Sweden
    Cell Adh Migr 1:156-8. 2007
    ..The RNA shuttled between cells via exosomes is called esRNA. We propose that several types of exosomes may exist, and that an additional function of exosomes is to communicate to neighbouring cells through delivery of RNA-signals...
  16. pmc Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis
    Madeleine Radinger
    Lung Pharmacology Group, Department of Internal Medicine Respiratory Medicine and Allergology, Goteborg University, Goteborg, Sweden
    Respir Res 7:83. 2006
    ..Since bone marrow (BM) responses are intricately involved in the induction of airway eosinophilia, we hypothesized that CD8+ T lymphocytes, as well as CD4+ T lymphocytes, may be involved in this process...
  17. ncbi request reprint Regulation of bone marrow and airway CD34+ eosinophils by interleukin-5
    Brigita Sitkauskiene
    The Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Guldhedsgatan 10A, 413 46 Gothenburg, Sweden
    Am J Respir Cell Mol Biol 30:367-78. 2004
    ..These data argue that anti-IL-5 downregulates eosinophilopoiesis within 3 d by action in the bone marrow, by inhibition of the early stages of eosinophil maturation from CD34(+) cells...
  18. pmc Inhaled steroid/long-acting beta 2 agonist combination products provide 24 hours improvement in lung function in adult asthmatic patients
    Jan Lotvall
    Department of Internal Medicine Respiratory Medicine and Allergology, Sahlgrenska Academy, Goteborg University, Sweden
    Respir Res 7:110. 2006
    ..Two such combination products, salmeterol/fluticasone propionate (SFC, Seretide GSK, UK) and formoterol/budesonide (FBC, Symbicort, AstraZeneca, UK) are commercially available...
  19. ncbi request reprint Allergen-induced traffic of bone marrow eosinophils, neutrophils and lymphocytes to airways
    Anna Karin Johansson
    Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Goteborg, Sweden
    Eur J Immunol 34:3135-45. 2004
    ..In conclusion, allergen exposure induces traffic of not only newly produced eosinophils but also newly produced neutrophils and lymphocytes into the airways...
  20. doi request reprint Rhinitis phenotypes correlate with different symptom presentation and risk factor patterns of asthma
    Jonas Eriksson
    Krefting Research Centre, Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Respir Med 105:1611-21. 2011
    ..Asthma and rhinitis frequently coexist, but no population study has previously determined the relationship between nasal comorbidities and symptom expression and risk factors of asthma...
  21. ncbi request reprint Eotaxin-2 regulates newly produced and CD34 airway eosinophils after allergen exposure
    Madeleine Radinger
    Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Guldhedsgatan 10A, SE 413 46 Gothenburg, Sweden
    J Allergy Clin Immunol 113:1109-16. 2004
    ..Moreover, it has been shown that the number of CD34+ progenitors in bronchial tissue correlates with asthma severity. To date, however, little is known about how these cells are recruited into the airways...
  22. doi request reprint Alarmingly high prevalence of smoking and symptoms of bronchitis in young women in Sweden: a population-based questionnaire study
    Göran Wennergren
    Krefting Research Centre, Department of Medicine, University of Gothenburg, Gothenburg, Sweden
    Prim Care Respir J 22:214-20. 2013
    ..After 10 years of a decrease in smoking among young people in Sweden, we now have indications of increased smoking...
  23. pmc Immunophenotyping of circulating T helper cells argues for multiple functions and plasticity of T cells in vivo in humans--possible role in asthma
    Carina Malmhäll
    Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 7:e40012. 2012
    ..In addition, determine the relationship between eosinophilia and circulating Th cell subsets...
  24. pmc Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression
    You Lu
    Department of Internal Medicine, Krefting Research Centre, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 6:e19889. 2011
    ..Our study shows that allergen exposure affects all T effector cells in lung, with a dominant of Th2 cells, but with different local cell distribution, probably due to a distinguished local inflammatory milieu...
  25. doi request reprint Asthma in late adolescence--farm childhood is protective and the prevalence increase has levelled off
    Göran Wennergren
    Krefting Research Centre, Department of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Pediatr Allergy Immunol 21:806-13. 2010
    ..In line with the hygiene hypothesis, a farm childhood significantly reduced the likelihood of asthma. The adverse effects of smoking could already be seen at this young age...
  26. pmc Questionnaire layout and wording influence prevalence and risk estimates of respiratory symptoms in a population cohort
    Linda Ekerljung
    Department of Internal Medicine, Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Clin Respir J 7:53-63. 2013
    ..Results of epidemiological studies are greatly influenced by the chosen methodology. The study aims to investigate how two frequently used questionnaires (Qs), with partly different layout, influence the prevalence of respiratory symptoms...
  27. doi request reprint Adult-onset asthma in west Sweden--incidence, sex differences and impact of occupational exposures
    Kjell Toren
    Section of Occupational and Environmental Medicine, University of Gothenburg, Box 414, S 405 30 Goteborg, Sweden
    Respir Med 105:1622-8. 2011
    ..1% among women. The incidence rate of asthma was higher among women than among men, and the rate declined with increasing age. A substantial proportion of the new-onset asthma cases could be attributed to occupational exposures...
  28. doi request reprint RNA-containing exosomes in human nasal secretions
    Cecilia Lässer
    Krefting Research Centre, Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
    Am J Rhinol Allergy 25:89-93. 2011
    ..The aim of this study was to determine whether nasal secretions harbor exosomes and furthermore, whether these exosomes contain RNA...
  29. doi request reprint Respiratory symptoms and respiratory-related absence from work among health care workers in Sweden
    Jeong Lim Kim
    Section of Occupational and Environmental Medicine, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Asthma 50:174-9. 2013
    ..To investigate respiratory symptoms and respiratory-related absence from work among Swedish health care workers (HCWs)...
  30. ncbi request reprint Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation
    Svetlana Sergejeva
    The Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Sahlgrenska Academy at Goteborg University, Gothenburg, Sweden
    Am J Respir Cell Mol Biol 33:248-53. 2005
    ..Furthermore, IL-17 is involved in controlling the proteolytic activity of macrophages and neutrophils in allergen-induced airway inflammation...
  31. pmc Local proliferation and mobilization of CCR3(+)  CD34(+) eosinophil-lineage-committed cells in the lung
    Madeleine Radinger
    Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Immunology 132:144-54. 2011
    ..Hence, targeting both IL-5 and CCR3-mediated signalling pathways may be required to control the inflammation associated with allergen-induced asthma...
  32. pmc Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages
    Cecilia Lässer
    Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Box 424, 405 30 Gothenburg, Sweden
    J Transl Med 9:9. 2011
    ..Our aim was therefore to determine the presence of RNA in exosomes from human saliva, plasma and breast milk and whether these exosomes can be taken up by macrophages...
  33. pmc Network analysis of quantitative proteomics on asthmatic bronchi: effects of inhaled glucocorticoid treatment
    Serena E O'Neil
    Krefting Research Centre, Department of Internal Medicine, University of Gothenburg, Sweden
    Respir Res 12:124. 2011
    ..The aim of the current study was to determine if quantitative proteomics of bronchial biopsies from asthmatics can distinguish relevant biological functions and whether inhaled glucocorticoid treatment affects these functions...
  34. doi request reprint Large scale questionnaire survey on respiratory health in Sweden: effects of late- and non-response
    Erik P Rönmark
    VBG Group Center for Asthma and Allergy Research, Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Respir Med 103:1807-15. 2009
    ..This can lead to an increased risk for selection bias. The aim of this study was to examine cause and effect of non-response in a large cross sectional study assessing respiratory health in western Sweden...
  35. ncbi request reprint Intranasal fluticasone propionate inhibits allergen induced bone marrow eosinophilia in mice
    Svetlana Sergejeva
    The Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Gothenburg, Sweden
    Pulm Pharmacol Ther 15:129-34. 2002
    ..28 and 0.07, respectively). In this murine allergy model intranasal corticosteroid reduced number of bone marrow mature eosinophils, but did not significantly affect airways cell populations...
  36. ncbi request reprint Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and antihistamine in the treatment of seasonal allergic rhinitis
    Teet Pullerits
    Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Gothenburg, Sweden
    J Allergy Clin Immunol 109:949-55. 2002
    ..Allergic rhinitis requires active intervention for symptom relief. A combination of antileukotriene and antihistamine drugs has been suggested to provide additive treatment benefits for patients with allergic rhinitis...
  37. pmc Higher risk of wheeze in female than male smokers. Results from the Swedish GA 2 LEN study
    Anders Bjerg
    Krefting Research Centre, Department of Internal Medicine, University of Gothenburg, Goteborg, Sweden
    PLoS ONE 8:e54137. 2013
    ..An influence of sex hormones has been demonstrated, but the mechanisms are unclear and the associations often subject to confounding. This was a study of wheeze in relation to smoking and sex with adjustment for important confounders...
  38. doi request reprint Proteomics in asthma and COPD phenotypes and endotypes for biomarker discovery and improved understanding of disease entities
    Serena E O'Neil
    Krefting Research Centre, Department of Internal Medicine, University of Gothenburg, Sweden
    J Proteomics 75:192-201. 2011
    ..The utilisation of modern advanced proteomics in endotypes of asthma and COPD will likely contribute to the increased understanding of disease mechanisms, establishment of biomarkers for these endotypes and improved patient care...
  39. doi request reprint Prevalence of chronic nasal symptoms in West Sweden: risk factors and relation to self-reported allergic rhinitis and lower respiratory symptoms
    Jonas Eriksson
    Department of Internal Medicine Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Int Arch Allergy Immunol 154:155-63. 2011
    ..There are few population-based studies on chronic nasal symptoms and little is known about their prevalence and determinants, or their association with allergic rhinitis and asthma...
  40. ncbi request reprint A synthetic VIP peptide analogue inhibits neutrophil recruitment in rat airways in vivo
    Svetlana Sergejeva
    Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Goteborg University, Guldhedsgatan 10A, SE 41346 Gothenburg, Sweden
    Regul Pept 117:149-54. 2004
    ..This action is exerted without severe, sustained cardiovascular side effects, and deserves to be further evaluated in obstructive pulmonary diseases in human...
  41. ncbi request reprint Combination therapy in asthma--fixed or variable dosing in different patients?
    Jan Lotvall
    Department of Respiratory Medicine and Allergology, Goteborg University, Goteborg, Sweden
    Curr Med Res Opin 20:1711-27. 2004
    ..It is possible that different treatment options will be used for different patients, depending on their disease severity, personality and ability to adhere to therapy...
  42. pmc Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA
    Maria Eldh
    Krefting Research Centre, Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 5:e15353. 2010
    ..Exosomes differ compared to their donor cells, not only in size, but also in their RNA, protein and lipid composition...
  43. doi request reprint The future of combining inhaled drugs for COPD
    Anders Bjerg
    Department of Internal Medicine, Krefting Research Centre, University of Gothenburg, Box 424, S 40530 Göteborg, Sweden
    Curr Opin Pharmacol 12:252-5. 2012
    ..Also, improved understanding of subgroups within the clinical spectrum of COPD, is likely to offer new potentials to improve COPD care...
  44. pmc Airway allergen exposure stimulates bone marrow eosinophilia partly via IL-9
    Brigita Sitkauskiene
    The Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Guldhedsgatan 10A, 413 46 Gothenburg, Sweden
    Respir Res 6:33. 2005
    ..We aimed to evaluate the therapeutic effect of a neutralizing anti-IL-9 antibody in a mouse model of airway eosinophilic inflammation and compared any such effect with anti-IL-5 treatment...
  45. ncbi request reprint Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways
    Masahide Miyamoto
    Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Gothenburg, Sweden
    J Immunol 170:4665-72. 2003
    ..These IL-17-related mechanisms constitute potential targets for pharmacotherapy against exaggerated neutrophil recruitment in airway disease...
  46. doi request reprint Importance of RNA isolation methods for analysis of exosomal RNA: evaluation of different methods
    Maria Eldh
    Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Sweden
    Mol Immunol 50:278-86. 2012
    ..As the different isolation methods give extensive variation in exosomal RNA yield and patterns, it is crucial to select an isolation approach depending on the research question at hand...
  47. pmc Quantitative expression of osteopontin in nasal mucosa of patients with allergic rhinitis: effects of pollen exposure and nasal glucocorticoid treatment
    Serena E O'Neil
    Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Sweden
    Allergy Asthma Clin Immunol 6:28. 2010
    ..Recently, it has also been implicated in Th2-mediated allergic diseases, such as asthma. The expression of OPN in allergic rhinitis (AR) is currently unknown, as is the effect of intranasal glucocorticosteroids (GCs) on that expression...
  48. doi request reprint The duration of bronchodilation of salmeterol and salbutamol as measured by specific airway conductance in healthy subjects
    Teet Pullerits
    Krefting Research Centre, Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Pulm Pharmacol Ther 24:55-8. 2011
    ..Using this method we could demonstrate that salmeterol 200 μg provides significant increase in specific airway conductance up to 24 h after a single dose...
  49. doi request reprint Self-efficacy and adherence as mediating factors between personality traits and health-related quality of life
    Malin Axelsson
    Krefting Research Centre, Institute of Medicine, Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Box 424, 405 30, Goteborg, Sweden
    Qual Life Res 22:567-75. 2013
    ..The present aim was to explore the function of self-efficacy and adherence as mediators for the influencing effect of personality traits on HRQL in people with chronic disease...
  50. doi request reprint A personality and gender perspective on adherence and health-related quality of life in people with asthma and/or allergic rhinitis
    Malin Axelsson
    Krefting Research Centre, Institute of Medicine and Clinical Nutrition, Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Department of Nursing, Health and Culture, University West, Trollhattan, Sweden
    J Am Assoc Nurse Pract 26:32-9. 2014
    ..Both personality and gender could influence adherence and perceptions of HRQL. The purpose was to clarify the role of personality and gender in relation to adherence and HRQL in people with asthma and/or rhinitis...
  51. ncbi request reprint Allergen exposure-induced differences in CD34+ cell phenotype: relationship to eosinophilopoietic responses in different compartments
    Svetlana Sergejeva
    Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Sweden
    Blood 103:1270-7. 2004
    ..We further demonstrate in vitro that ability to multiply persists in BALf CD34(+) cells but not CD34(-) cells, likely via autocrine IL-5 release and IL-5-induced up-regulation of IL-5R alpha...
  52. ncbi request reprint Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells
    Olof Prause
    Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Guldhedsgatan 10A, 413 46 Goteborg, Sweden
    Eur J Pharmacol 462:193-8. 2003
    ..Inhibition of the p38 MAP kinase pathway and glucocorticoid receptor stimulation constitute two credible therapeutic strategies against this interleukin-17-induced release of neutrophil-recruiting cytokines...
  53. pmc Repeated allergen exposure reduce early phase airway response and leukotriene release despite upregulation of 5-lipoxygenase pathways
    Zhi Hua Cui
    Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
    Clin Transl Allergy 2:7. 2012
    ..abstract:..
  54. doi request reprint B cells: from early development to regulating allergic diseases
    Konstantinos Samitas
    Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Box 480, 405 30 Gothenburg, Sweden
    Arch Immunol Ther Exp (Warsz) 58:209-25. 2010
    ..This review focuses on the developmental processes responsible for the numerous phenotypes and functions of the B-lymphocyte pool and the different aspects of effector B cell functionality in the context of allergy...
  55. pmc The influence of personality traits on reported adherence to medication in individuals with chronic disease: an epidemiological study in West Sweden
    Malin Axelsson
    Krefting Research Centre, Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 6:e18241. 2011
    ..Since non-adherence is a major obstacle in treating prevalent chronic diseases the aim was to determine whether personality traits are related to reported adherence to medication in individuals with chronic disease...
  56. pmc Reviewer acknowledgement 2012
    Jan Lotvall
    Goteborg University, Vasagatan 33, 411 37, Goteborg, Sweden
    Respir Res 14:12. 2013
    ..CONTRIBUTING REVIEWERS: The editors of Respiratory Research would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2012)...
  57. pmc Recent educational interventions for improvement of asthma medication adherence
    Malin Axelsson
    Krefting Research Center, Institute of Medicine, Internal Medicine, Sahlgrenska Academy, University of Gothenburg, SE 405 30 Gothenburg, Sweden
    Asia Pac Allergy 2:67-75. 2012
    ....
  58. ncbi request reprint Comparison of effects of anti-IL-3, IL-5 and GM-CSF treatments on eosinophilopoiesis and airway eosinophilia induced by allergen
    Masafumi Tomaki
    The Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Heart and Lung Diseases, Goteborg University, Guldhedsgatan 10A, S 413 46 Gothenburg, Sweden
    Pulm Pharmacol Ther 15:161-8. 2002
    ..These data suggest that the efficacy of treatments with anti-IL-3 and anti-GM-CSF is much weaker than that with anti-IL-5. IL-5 may be the preferred target to block eosinophilia in allergic diseases...